Ferritin L and ferritin H are differentially located within hepatic and extra hepatic organs under physiological and acute phase conditions

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 4, 2013, Pages 622-629

  Ahmad, Shakil ^a   Moriconi, Federico ^a   Naz, Naila ^a   Sultan, Sadaf ^a   Sheikh, Nadeem ^a   Ramadori, Giuliano ^a   Malik, Ihtzaz Ahmed ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Acute phase; Ferritin; Iron regulation; Liver; Nuclear localization

Indexed keywords

APOFERRITIN; FERRITIN; IRON; TURPENTINE;

ACUTE PHASE; ACUTE PHASE RESPONSE; ANIMAL; ARTICLE; BRAIN; CELL NUCLEUS; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; CYTOPLASM; DISEASE MODEL; HEART MUSCLE; INTRAMUSCULAR DRUG ADMINISTRATION; IRON REGULATION; LIVER; METABOLISM; NUCLEAR LOCALIZATION; PATHOLOGY; RAT; SPLEEN;

ACUTE PHASE; FERRITIN; IRON REGULATION; LIVER; NUCLEAR LOCALIZATION;

ACUTE-PHASE REACTION; ANIMALS; APOFERRITINS; BRAIN; CELL NUCLEUS; CYTOPLASM; DISEASE MODELS, ANIMAL; INJECTIONS, INTRAMUSCULAR; IRON; LIVER; MYOCARDIUM; RATS; SPLEEN; TURPENTINE;

EID: 84882933115     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med 2012; 2: a011668.
2. Arosio P, Ingrassia R, Cavadini P. Ferritins: a family of molecules for iron storage, antioxidation and more. Biochim Biophys Acta 2009; 1790: 589-99.
3. Caskey JH, Jones C, Miller YE, Seligman PA. Human ferritin gene is assigned to chromosome 19. Proc Natl Acad Sci U S A 1983; 80: 482-6.
4. Worwood M, Brook JD, Cragg SJ, Hellkuhl B, Jones BM, Perera P, Roberts SH, Shaw DJ. Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter. Hum Genet 1985; 69: 371-4.
5. Sammarco MC, Ditch S, Banerjee A, Grabczyk E. Ferritin L and H subunits are differentially regulated on a post-transcriptional level. J Biol Chem 2008; 283: 4578-87.
6. Briat JF, Ravet K, Arnaud N, Duc C, Boucherez J, Touraine B, Cellier F, Gaymard F. New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants. Ann Bot 2010; 105: 811-22.
7. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Semin Hematol 1998; 35: 35-54.
8. Cozzi A, Corsi B, Levi S, Santambrogio P, Biasiotto G, Arosio P. Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin. Blood 2004; 103: 2377-83.
9. Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest 2012; 122: 1758-63.
10. Ramadori G, Christ B. Cytokines and the hepatic acute-phase response. Semin Liver Dis 1999; 19: 141-55.
11. Cairo G, Recalcati S, Mantovani A, Locati M. Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype. Trends Immunol 2011; 32: 241-7.
12. Malik IA, Naz N, Sheikh N, Khan S, Moriconi F, Blaschke M, Ramadori G. Comparison of changes in gene expression of transferrin receptor- 1 and other iron-regulatory proteins in rat liver and brain during acute-phase response. Cell Tissue Res 2011; 344: 299-312.
13. Naz N, Malik IA, Sheikh N, Ahmad S, Khan S, Blaschke M, Schultze F, Ramadori G. Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other irontransport proteins. Lab Invest 2012; 92: 842-56.
14. Ramadori P, Ahmad G, Ramadori G. Cellular and molecular mechanisms regulating the hepatic erythropoietin expression during acutephase response: a role for IL-6. Lab Invest 2010; 90: 1306-24.
15. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-5.
16. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 1979; 76: 4350-4.
17. Meyron-Holtz EG, Moshe-Belizowski S, Cohen LA. A possible role for secreted ferritin in tissue iron distribution. J Neural Transm 2011; 118: 337-47.
18. Surguladze N, Patton S, Cozzi A, Fried MG, Connor JR. Characterization of nuclear ferritin and mechanism of translocation. Biochem J 2005; 388: 731-40.
19. Cai CX, Linsenmayer TF. Nuclear translocation of ferritin in corneal epithelial cells. J Cell Sci 2001; 114: 2327-34.
20. Smith AG, Carthew P, Francis JE, Edwards RE, Dinsdale D. Characterization and accumulation of ferritin in hepatocyte nuclei of mice with iron overload. Hepatology 1990; 12: 1399- 405.
21. Thompson KJ, Fried MG, Ye Z, Boyer P, Connor JR. Regulation, mechanisms and proposed function of ferritin translocation to cell nuclei. J Cell Sci 2002; 115: 2165-77.
22. Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD. Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science 1987; 238: 1570-3.
23. Goralska M, Holley BL, McGahan MC. Overexpression of H- and L-Ferritin Subunits in Lens Epithelial Cells: Fe Metabolism and Cellular Response to UVB Irradiation. Invest Ophthalmol Vis Sci 2001; 42: 1721-7.
24. Sheikh N, Batusic DS, Dudas J, Tron K, Neubauer K, Saile B, Ramadori G. Hepcidin and hemojuvelin gene expression in rat liver damage: in vivo and in vitro studies. Am J Physiol Gastrointest Liver Physiol 2006; 291: G482- G490.
25. Darshan D, Vanoaica L, Richman L, Beermann F, Kuhn LC. Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Hepatology 2009; 50: 852-60.
26. Picard V, Epsztejn S, Santambrogio P, Cabantchik ZI, Beaumont C. Role of ferritin in the control of the labile iron pool in murine erythroleukemia cells. J Biol Chem 1998; 273: 15382- 6.
27. Magens B, Dullmann J, Schumann K, Wulfhekel U, Nielsen P. Nuclear iron deposits in hepatocytes of iron-loaded HFE-knock-out mice: a morphometric and immunocytochemical analysis. Acta Histochem 2005; 107: 57-65.