Regulation, mechanisms and proposed function of ferritin translocation ot cell nuclei

Journal of Cell Science

Volumn 115, Issue 10, 2002, Pages 2165-2177

  Thompson, Khristy J ^a   Fried, Michael G ^a   Ye, Zheng ^a   Boyer, Phillip ^a   Connor, James R ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

DNA protection; Iron; Nuclear translocation; Oxidative damage

Indexed keywords

CYTOKINE; DNA; FERRITIN; HISTIDINE; HYDROGEN PEROXIDE; LYSINE; METAL; IRON;

ACTIVE TRANSPORT; ARTICLE; ASTROCYTOMA CELL; CELL CULTURE; CELL LEVEL; CELL NUCLEUS; CELL PROTECTION; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; DNA DAMAGE; EXPERIMENTAL MODEL; GENOMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR STABILITY; NUCLEAR PORE; OXIDATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; ASTROCYTOMA; DRUG EFFECT; METABOLISM; PATHOLOGY; DRUG EFFECTS; TUMOR CELL CULTURE;

ACTIVE TRANSPORT, CELL NUCLEUS; ASTROCYTOMA; CELL NUCLEUS; CYTOKINES; DNA; DNA DAMAGE; FERRITIN; HUMAN; HYDROGEN PEROXIDE; IRON; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; FERRITINS; HUMANS;

EID: 0037092516     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Preparation of nuclear and cytoplasmic extracts from mammalian cells
2. Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope
3. Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors
4. Iron transport and storage proteins
5. Biochemical aspects of free radicals
6. Prooxidant activity of ferrioxamine in isolated rat hepatocytes and linolic acid micelles
7. Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones
8. Neuroblastoma sensitivity to growth inhibition by deferrioxamine: Evidence for a block in G1 phase of the cell cycle
9. Specific repression of beta-globin promoter activity by nuclear ferritin
10. Ferritin is a developmentally regulated nuclear protein of avian corneal epithelial cells
11. Nuclear ferritin protects DNA from UV damage in corneal epithelial cells
12. Nuclear translocation of ferritin in corneal epithelial cells
13. Development of a monoclonal antibody against human heart ferritin and its application in a immunoradiometric assay
14. Cellular distribution of ferritin subunits in postnatal rat brain
15. Hypoxic/ischemic insult alters ferritin expression and myelination in neonatal rat brains
16. Iron regulation in the brain at the cell and molecular level
17. Cellular management of iron in the brain
18. Proteins of iron storage and transport
19. The mechanism of nuclear transport of natural or artificial substrates in digitonin-permeablized cells
20. The nuclear pore complex
21. Iron and neoplasia
22. Effects of a single course of deferoxamine in neuroblastoma patients
23. Nuclear import of glycoconjugates is distinct from the classical NLS pathway
24. In vitro and in vivo effects of deferoxamine in neonatal acute leukemia
25. Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: Changes in transferrin uptake, iron handling and ferritin mRNA
26. Role of oxygen free radicals in carcinogenesis and brain ischemia
27. Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
28. CAP and RNA polymerase interactions with the lac promoter: Binding stoichiometry and long range effects
29. The electrophoretic Mobility Shift Assay (EMSA) for Detection and analysis of Protein-DNA Interactions
30. Oxygen radical chemistry of polyunsaturated fatty acids
31. Lactoferrin binding sites and nuclear localization in K562(S) cells
32. An ATP-dependent iron transport system in isolated rat liver nuclei
33. Ferrous ion formation by ferrioxamine prepared from aged desferrioxamine: A potential prooxidant property
34. Reactive oxygen species and the central nervous system
35. Effect of iron and desferoxamine on cell growth and in vitro ferritin synthesis in human hepatoma cell lines
36. Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA
37. Oxidative damage to DNA constituents by iron-mediated fenton reactions. The deoxyguanosine family
38. Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications
39. DNA damage and oxygen radical toxicity
40. Role for NF-kappa B in the regulation of ferritin H by tumor necrosis factor-alpha
41. Identification of the ferroxidase centre in ferritin
42. Tissue iron overload and mechanisms of iron-catalyzed oxidative injury
43. Characterization of human ferritin H chain synthetized in Escherichia coli
44. Mechanism of ferritin iron uptake: Afctivity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and deletion mutants
45. Expression and structural and functional properties of human ferritin L-chain from Escherichia coli
46. Mutagenesis by the autoxidation of iron with isolated DNA
47. Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA
48. Immunochemical characterization of human liver and heart ferritins with monoclonal antibodies
49. Iron-independent induction of ferritin H chain by tumor necrosis factor
50. In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins
51. The identification of ferritin in the nucleus of K562 cells, and investigation of a possible role in the transcriptional regulation of adult beta-globin gene expression
52. Ferritin as a source of iron for oxidative damage
53. Iron release from ferritin and lipid peroxidation by radiolytically generated reducing radicals
54. An in vitro model for analysis of oxidative death in primary mouse astrocytes
55. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells
56. Antibodies for denatured human H-ferritin stain only reticuloendothelial cells within the bone marrow
57. Release of iron from ferritin and its role in oxygen radical toxicities
58. Strategies of antioxidant defense
59. Characterization and accumulation of ferritin in hepatocyte nuclei of mice with iron overload
60. Mapping protein-DNA interactions in vivo with formaldehyde: Evidence that histone H4 is retained on a highly transcribed gene
61. Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences
62. Iron, radiation, and cancer
63. 2
64. Ferritin: Structure, gene regulation, and cellular function in animals, plants and microorganisms
65. Iron and ferritin in inflammation and cancer
66. Tumor cell cytotoxicity of a novel metal chelator
67. Iron-mediated DNA damage: Sensitive detection of DNA strand breakage catalyzed by iron
68. Phase I-II studies of yttrium-labeled antiferritin treatment for end-stage Hodgkin's disease
69. Practice guideline development task force of the College of American Pathologists. Hereditary hemochromatosis
70. Generation of hydroxyl radical from linoleic acid hydroperoxide in the presence of epinephrine and iron
71. Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors