Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells

Hormone and Metabolic Research

Volumn 45, Issue 9, 2013, Pages 640-645

  Ormazabal, P ^a   Romero, C ^b   Quest, A F G ^c   Vega, M ^b  

^a UNIVERSIDAD CATÓLICA DEL MAULE   (Chile)

^b HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

caveolin 1; DOG uptake; PCOS

Indexed keywords

CAVEOLIN 1; DEOXYGLUCOSE; GLUCOSE TRANSPORTER 1; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; PROTEIN KINASE B; TESTOSTERONE;

ARTICLE; CELL STIMULATION; ENDOMETRIUM CELL; FEMALE; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STROMA CELL; WESTERN BLOTTING;

CAVEOLIN 1; CELL LINE; DEOXYGLUCOSE; ENDOMETRIUM; FEMALE; GLUCOSE; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 84882885041     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0033-1345176     Document Type: Article

References (41)

1. Xita N., Georgiou I., Tsatsoulis A. The genetic basis of polycystic ovary syndrome. Eur J Endocrinol: 2002; 147 717 725 (Pubitemid 36032959)
2. Diamanti-kandarakis E., Papavassiliou A. G. Molecular mechanisms of insulin resistance in polycystic ovary syndrome. Trends Mol Med: 2006; 12 324 332 (Pubitemid 44094292)
3. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril: 2004; 81 19 25
4. Dunaif A., Segal K. R., Futterweit W., Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes: 1989; 38 1165 1174 (Pubitemid 19250404)
5. Poretsky L. Insulin resistance and hyperandrogenism: Update 1994. Endocr Rev: 1994; 2 125 129
6. Corbould A. Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women. J Endocrinol: 2007; 192 585 594 (Pubitemid 46455961)
7. Allemand M. C., Irving B. A., Asmann Y. W., Klaus K. A., Tatpati L., Coddington C. C., Nair K. S. Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes - a potential model for PCOS-related insulin resistance. PLoS One: 2009; 4 4274
8. Sato K., Iemitsu M., Aizawa K., Ajisaka R. Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. Am J Physiol Endocrinol Metab: 2008; 294 961 968
9. Perrini S., Natalicchio A., Laviola L., Belsanti G., Montrone C., Cignarelli A., Minielli V., Grano M., De Pergola G., Giorgino R., Giorgino F. Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane. Diabetes: 2004; 53 41 52 (Pubitemid 38044696)
10. Strowitzki T., von Eye H. C., Kellerer M., Häring H. U. Tyrosine kinase activity of insulin like growth factor I and insulin receptors in human endometrium during the menstrual cycle: cyclic variation of insulin receptor expression. Fertil Steril: 1993; 59 315 322 (Pubitemid 23057783)
11. Mozzanega B., Mioni R., Granzotto M., Chiarelli S., Xamin N., Zuliani L., Sicolo N., Marchesoni D., Vettor R. Obesity Reduces the Expression of GLUT4 in the Endometrium of Normoinsulinemic Women Affected by the Polycystic Ovary Syndrome. Ann NY Acad Sci: 2004; 1034 364 374 (Pubitemid 40362374)
12. Dugani C. B., Klip A. Glucose transporter 4: cycling, compartments and controversies. EMBO Rep: 2005; 6 1137 1142 (Pubitemid 41741696)
13. Wood I. S., Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr: 2003; 89 3 9 (Pubitemid 36187532)
14. Cohen A. W., Combs T. P., Scherer P. E., Lisanti M. P. Role of caveolin and caveolae in insulin signaling and diabetes. Am J Physiol Endocrinol Metab: 2003; 285 1151 1160
15. Kimura A., Mora S., Shigematsu S., Pessin J. E., Saltiel A. R. The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. J Biol Chem: 2002; 277 30153 30158
16. Fornes R., Ormazabal P., Rosas C., Gabler F., Vantman D., Romero C., Vega M. Changes in the expression of insulin signaling pathway molecules in endometria from polycystic ovary syndrome women with or without hyperinsulinemia. Mol Med: 2010; 16 129 136
17. Kohan K., Carvajal R., Gabler F., Vantman D., Romero C., Vega M. Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome. Reproduction: 2010; 140 123 131
18. Rosas C., Gabler F., Vantman D., Romero C., Vega M. Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometrial from hyperinsulinemic PCOS women. Hum Reprod: 2010; 25 2870 2877
19. Rivero R., Garin C. A., Ormazabal P., Silva A., Carvajal R., Gabler F., Romero C., Vega M. Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS). Reprod Biol Endocrinol: 2012; 10 1 11
20. Ormazabal P., Romero C., Gabler F., Quest A. F., Vega M. Decreased phosphorylation of Y14caveolin-1 in endometrial tissue of Polycystic Ovary Syndrome patients may be related with an insulin resistant state in this tissue. Horm Metab Res: 2013; 45 291 296
21. Zhang L., Liao Q. Effects of testosterone and metformin on 335 glucose metabolism in endometrium. Fertil Steril: 2010; 93 2295 2298
22. Castro M., Angulo C., Brauchi S., Nualart F., Concha I. Ascorbic acid participates in a general mechanism for concerted glucose transport inhibition and lactate transport stimulation. Eur J Physiol: 2008; 457 519 528
23. Azziz R. Androgen excess is the key element in polycystic ovary syndrome. Fertil Steril: 2003; 80 252 254 (Pubitemid 36959774)
24. von Wolff M., Ursel S., Hahn U., Steldinger R., Strowitzki T. Glucose transport protein (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab: 2003; 88 3885 3892 (Pubitemid 37034543)
25. Li L., Yang G., Ebara S., Satoh T., Nasu Y., Timme T. L., Ren C., Wang J., Tahir S. A., Thompson T. C. Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res: 2001; 61 4386 4392 (Pubitemid 32685764)
26. Su L., Mruk D. D., Lee W. M., Cheng C. Y. Differential effects of testosterone and TGF-β3 on endocytic vesicle-mediated protein trafficking events at the blood-testis barrier. Exp Cell Res: 2010; 316 2945 2960
27. Cohen A. W., Razani B., Wang X. B., Combs T. P., Williams T. M., Scherer P. E., Lisanti M. P. Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am J Physiol Cell Physiol: 2003; 285 C222 C235 (Pubitemid 36736354)
28. Quezada S., Avellaira C., Johnson M. C., Gabler F., Fuentes A., Vega M. Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Fertil Steril: 2006; 85 1017 1026
29. Maliqueo M., Clementi M., Gabler F., Johnson M., Palomino A., Sir Peterman T., Vega M. Expression of steroid receptors and proteins related to apoptosis in endometria of women with polycystic ovary syndrome. Fertil Steril: 2003; 80 812 819 (Pubitemid 37152398)
30. Avellaira C., Villavicencio A., Bacallao K., Gabler F., Wells P., Romero C., Vega M. Expresion of molecules associated with tissue homeostasis in secretory endometria from untreated women with polycystic ovary syndrome. Hum Reprod: 2006; 21 3116 3121 (Pubitemid 44811612)
31. Villavicencio A., Goyeneche A., Telleria C., Bacallao K., Gabler F., Fuentes A., Vega M. Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome. Gynecol Oncol: 2009; 115 102 107
32. Kanzaki M. Insulin Receptor Signals Regulating GLUT4 Translocation and Actin Dynamics. Endocr J: 2006; 53 267 293 (Pubitemid 43988156)
33. Lee H., Volonte D., Galbiati F., Iyengar P., Lublin D. M., Bregman D. B., Wilson M. T., Campos-Gonzalez R., Bouzahzah B., Pestell R. G., Scherer P. E., Lisanti M. P. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol: 2000; 14 1750 1775
34. Chen J., Capozza F., Wu A., Deangelis T., Sun H., Lisanti M., Baserga R. Regulation of insulin receptor substrate-1 expression levels by caveolin-1. J Cell Physiol: 2008; 217 281 289
35. Hou J. C., Pessin J. E. Ins (endocytosis) and outs (exocytosis) of GLUT4 379 trafficking. Curr Opin Cell Biol: 2007; 19 466 473 (Pubitemid 47268759)
36. Quest A. F., Leyton L., Párraga M. Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease. Biochem Cell Biol: 2004; 82 129 144 (Pubitemid 38580879)
37. Quest A. F., Gutierrez-Pajares J. L., Torres V. A. Caveolin-1: an ambiguous partner in cell signalling and cancer. J Cell Mol Med: 2008; 12 1130 1150
38. Hagiwara M., Shirai Y., Nomura R., Sasaki M., Kobayashi K., Tadokoro T., Yamamoto Y. Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction. Biochem Biophys Res Commun: 2009; 378 73 78
39. Porter T. F., Scott J. R. Evidence-based care of recurrent miscarriage. Best Practice & Research. Best Pract Res Clin Obstet Gynaecol: 2005; 19 85 101 (Pubitemid 40331408)
40. Cha J., Sun X., Dey S. K. Mechanisms of implantation: strategies for successful pregnancy. Nat Med: 2012; 18 1754 1767
41. Giudice L. C. Endometrium in PCOS: implantation and predisposition to endocrine CA. Best Pract Res Clin Obstet Gynaecol: 2006; 20 235 244 (Pubitemid 43842928)