N-Heteroarylmethyl-5-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylic acid a novel scaffold for the design of uncompetitive α-glucosidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 18, 2013, Pages 5811-5822

  Long, Sha ^a   Stefani, Francesca Romana ^b,d   Biondi, Stefano ^c   Ghiselli, Giancarlo ^b   Panunzio, Mauro ^a  

^a CNR   (Italy)

^b Glyconova Srl   (Italy)

^c Innovative Solution   (Italy)

^d LUND UNIVERSITY   (Sweden)

Author keywords

Glucosidase inhibitors; 1,2,5,6 Tetrahydropyridine 3 carboxylic acid; Azasugars; Iminosugars; Uncompetitive enzymatic inhibition

Indexed keywords

1 [(2,6 DIOXO 1,2,3,6 TETRAHYDROPYRIMIDIN 4 YL)METHYL] 5 HYDROXY 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID; 1 BENZYL 4 HYDROXYPIPERIDINE 3 CARBOXYLIC ACID; 1 BENZYL 5 HYDROXY 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID; 1 ETHYL 3 METHYL 5,6 DIHYDROPYRIDINE 1,3(4H) DICARBOXYLATE; 4 HYDROXY 1 (PYRIDIN 2 YLMETHYL)PIPERIDINE 3 CARBOXYLIC ACID; 4 HYDROXY 1 (PYRIDIN 3 YLMETHYL)PIPERIDINE 3 CARBOXYLIC ACID; 4 HYDROXY 1 (PYRIDIN 4 YLMETHYL)PIPERIDINE 3 CARBOXYLIC ACID; 5 HYDROXY 1 (PYRIDIN 2 YLMETHYL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID; 5 HYDROXY 1 (PYRIDIN 3 YLMETHYL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; ETHYL 1 BENZYL 4 HYDROXYPIPERIDINE 3 CARBOXYLATE; METHYL 1 [(2,6 DIOXO 1,2,3,6 TETRAHYDROPYRIMIDIN 4 YL)METHYL] 5 HYDROXY 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; METHYL 1 BENZYL 5 HYDROXY 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; METHYL 5 HYDROXY 1 (PYRIDIN 2 YLMETHYL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; METHYL 5 HYDROXY 1 (PYRIDIN 3 YLMETHYL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; N HETEROARYLMETHYL 5 HYDROXY 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID; SODIUM 1 (PYRIDIN 3 YLMETHYL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; SODIUM 1 (PYRIDIN 4 YLMETHYL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; SODIUM 1 [(1H BENZO[D]IMIDZOL 2 YL)METHYL] 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; SODIUM 1 [(2,6 DIOXO 1,2,3,6 TETRAHYDROPYRIMIDIN 4 YL)METHYL] 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; SODIUM 1 BENZYL 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLATE; SODIUM 1 BENZYL 4 HYDROXYPIPERIDINE 3 CARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; ENZYME INHIBITION;

1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID; AZASUGARS; IMINOSUGARS; UNCOMPETITIVE ENZYMATIC INHIBITION; Α-GLUCOSIDASE INHIBITORS;

ALPHA-GLUCOSIDASES; CARBOXYLIC ACIDS; DRUG DESIGN; ENZYME INHIBITORS; IMINO SUGARS; KINETICS; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 84882863188     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.07.012     Document Type: Article

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