Chemoreceptors, Breathing, and pH

Seldin and Giebisch's The Kidney

Volumn , Issue , 2008, Pages 1587-1600

  Nattie, Eugene ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882847138     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088488-9.50058-9     Document Type: Chapter

References (122)

1. 31P- nuclear magnetic resonance study. Am J Physiol 1990, 258:F34-F40.
2. Ahmad H.R., Loeschcke H.H. Fast bicarbonate-chloride exchange between brain cells and brain extracellular fluid in respiratory acidosis. Pflügers Arch 1982, 395:293-299.
3. 2. Pflügers Arch 1982, 395:300-305.
4. Akilesh M.R., Kamper M., Li A., Nattie E.E. Effects of unilateral lesions of the retrotrapezoid nucleus on breathing in awake rats. J Appl Physiol 1997, 82:469-479.
5. Ballantyne D., Scheid P. Central chemosensitivity of respiration: a brief overview. Respir Physiol 2001, 129:5-12.
6. Bernard D.G., Li A., Nattie E.E. Evidence for central chemoreception in the medullary raphé. J Appl Physiol 1996, 80:108-115.
7. Betz A.L. Sodium transport in capillaries isolated from rat brain. J Neurochem 1983, 41:1150-1157.
8. Betz A.L., Goldstein G.W. The basis for active transport at the blood-brain barrier. Advances in Experimental Medicine Biology 1981, 5-15. Plenum, New York. H.M. Eisenberg, R.L. Suddith (Eds.).
9. Borison H.L., Gonsalves S.F., Montgomery S.P., McCarthy L.E. Dynamics of respiratory VT response to isocapnic pHa forcing in chemodenervated cats. J Appl Physiol 1978, 45:502-511.
10. Borison H.L., Borison R., McCarthy L.E. Brain stem penetration by horseradish peroxidase from cerebrospinal fluid spaces in the cat. Exp Neurol 1980, 69:271-289.
11. Bradbury M.W.B. The blood-brain barrier. Transport across the cerebral endothelium. Circ Res 1985, 57:213-222.
12. Bradbury M.W.B., Stulcová B. Efflux mechanism contributing to the stability of the potassium concentration in cerebrospinal fluid. J Physiol (Lond) 1970, 208:415-430.
13. Bradley S.R., Pieribone V.A., Wang W., Severson C.A., Jacobs R.A., Richerson G.B. Chemosensitive serotonergic neurons are closely associated with large medullary arteries. Nat Neurosci 2003, 5:401-402.
14. Budzinska K., von E.uler C., Kao F.F., Panteleo T., Yamamoto Y. Effects of graded focal cold block in the rostral areas of the medulla. Acta Physiol Scand 1985, 124:329-340.
15. 2. J Physiol (Lond) 1991, 441:433-451.
16. Coates E.L., Li A., Nattie E.E. Widespread sites of brainstem ventilatory chemoreceptors. J Appl Physiol 1993, 75:5-14.
17. Cohen M.I. Tonic chemoreceptor input as the background for respiratory rhythm. Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure 1995, 797-799. Marcel Dekker, New York. C.O. Trouth, R.M. Millis, H.F. Kiwull-Schöne, M.E. Schläfke (Eds.).
18. Connelly C.A., Ellenberger H.H., Feldman J.L. Respiratory activity in retrotrapezoid nucleus in cat. Am J Physiol 1990, 258:L33-L44.
19. Cserr H.F., Cooper D.N., Suri P.K., Patlak C.S. Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol 1981, 240:F319-F328.
20. Cserr H.F., Patlak C.S. Secretion and bulk flow of interstitial fluid. Physiology and Pharmacology of the Blood-Brain Barrier 1992, 245-261. Springer-Verlag, New York. M.W.B. Bradbury (Ed.).
21. Davies D.G., Nolan W.F. Cerebral interstitial fluid acid-base status follows arterial acid-base perturbations. J Appl Physiol 1982, 53:1551-1555.
22. Davson H., Segal M.B. Acid-base relations in the central nervous system. Physiology of the CSF and Blood-Brain Barriers 1996, 459-488. CRC Press, Boca Raton, FL. H. Davson, M.B. Segal (Eds.).
23. Davson H., Welch K. The relations of blood, brain and cerebrospinal fluid. Ion Homeostasis of the Brain 1971, 9-28. 10, Academic Press, New York. B.K. Siesjö, S.C. Sorenson (Eds.).
24. 2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarius. Exp Brain Res 1989, 76:656-661.
25. 2 chemoreception and respiratory control. Am J Physiol Lung Cell Mol Physiol 2002, 283:L665-L670.
26. Dempsey J.A. Crossing the apnoeic threshold: causes and consequences. Exp Physiol 2004, 90:13-24.
27. Dobbins E.G., Feldman J.L. Brainstem network controlling descending drive to phrenic motoneurons in rat. J Comp Neurol 1994, 347:64-86.
28. 2. Respir Physiol 1998, 111:15-23.
29. Elam M., Yao T., Thorén P., Svensson T.H. Hypercapnia and hypoxia: chemoreceptor-mediated control of locus ceruleus neurons and splanchnic, sympathetic nerves. Brain Res 1981, 222:373-381.
30. Erlichman J.S., Li A., Nattie E.E. Ventilatory effects of glial dysfunction in a rat brain stem chemoreceptor region. J Appl Physiol 1998, 85:1599-1604.
31. Fatemian M., Nieuwenhuijs D.J., Teppema L.J., Meinesz S., van der Mey A.G., Dahan A., Robbins P.A. The respiratory response to carbon dioxide in humans with unilateral and bilateral resections of the carotid bodies. J Physiol (Lond) 2003, 549:965-973.
32. Feldman J.L., Mitchell G.S., Nattie E.E. Breathing: rhythmicity, plasticity, chemosensitivity. Ann Rev Neurosci 2003, 26:239-266.
33. Fencl V. Acid-base balance in cerebral fluids. Handbook of Physiology. Vol. II. Control of Breathing, Part 1 1986, 115-140. American Physiological Society, Bethesda, MD. A.P. Fishman (Ed.).
34. Fencl V., Miller T.B., Pappenheimer J.R. Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral fluids. Am J Physiol 1966, 210:459-472.
35. Filosa J.A., Dean J.B., Putnam R.W. Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol (Lond) 2002, 541:493-509.
36. Fishman R. Cerebrospinal Fluid in Diseases of the Nervous System 1992, WB Saunders, Philadelphia.
37. Forster H.V., Ohtake P.J., Pan L.G., Lowry T.F. Effects on breathing of ventrolateral medulla cooling in awake goats. J Appl Physiol 1995, 78:258-265.
38. Forster H.V., Pan L.G., Lowry T.F., Serra A., Wenninger J., Martino P. Important role of carotid chemoreceptor afferents in control of breathing of adult and neonatal mammals. Respir Physiol 2000, 119:199-208.
39. Fukuda Y., Honda Y. pH sensitivity of cells located at the ventrolateral surface of the cat medulla oblongata in vitro. Pflügers Arch 1976, 364:243-247.
40. 3 in respiratory acidosis. J Appl Physiol 1976, 40:559-567.
41. Haxhui M.A., Tolentino-Silva F., Pete G., Kc P., Mack S.O. Monoaminergic neurons, chemosensation and arousal. Respir Physiol 2001, 129:191-210.
42. 2 during hyperoxia. Respir Physiol 1979, 37:365-379.
43. Heymans C., Bouckaert C. Les chémo-récepteurs du sinus carotidien. Ergebn Physiol 1939, 41:28-55.
44. Hodges M.R., Klum L., Leekley T., Brozoski D.T., Bastasic J., Davis J., Davis S., Wenninger J.M., Feroah T.R., Pan L.G., Forster H.V. Effects on breathing in awake and sleeping goats of focal acidosis in the medullary raphe. J Appl Physiol 2004, 96:1815-1824.
45. Hodges M.R., Martino P., Davis S., Opansky C., Pan L.G., Forster H.V. Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats. J Appl Physiol 2004, 97:2303-2309.
46. Holleran J., Babbie M., Erlichman J.S. Ventilatory effects of impaired glial function in a brain stem chemoreceptor region in the conscious rat. J Appl Physiol 2001, 90:1539-1547.
47. Javaheri S., De Hemptine A., Vanheel B., Leusen I. Changes in brain ECF pH during metabolic acidosis and alkalosis: a microelectrode study. J Appl Physiol 1983, 55:1849-1853.
48. Johanson C.E. Ventricles and cerebrospinal fluid. Neuroscience in Medicine 1995, 171-196. JB Lippincott, Philadelphia. P.M. Conn (Ed.).
49. Jones H.C., Keep R.F. The control of potassium concentration in the cerebrospinal fluid and brain interstitial fluid of developing rats. J Physiol (Lond) 1987, 383:441-453.
50. Katsura K., Kristián T., Nair R., Siesjö B.K. Regulation of intra- and extracellular pH in the rat brain in acute hypercapnia: a re-appraisal. Brain Res 1994, 651:47-56.
51. Kazemi H., Johnson D.C. Regulation of cerebrospinal fluid acid-base balance. Physiol Rev 1986, 66:953-1037.
52. Keep R.F., Xiang J,, Betz A.L. Potassium transport at the blood-brain and blood-CSF barriers. Frontiers in Cerebral Vascular Biology: Transport and Its Regulation 1993, 43-54. Plenum Press, New York. L.R. Drewes, A.L. Betz (Eds.).
53. +-sensitive neurons. J Appl Physiol 1990, 69:1408-1412.
54. 2 and almitrine in the cat carotid chemoreceptors. J Appl Physiol 1989, 76:232-238.
55. 2 in the cerebral ventricles on respiration. Am J Physiol 1954, 176:39-44.
56. Loeschcke H.H. Central chemosensitivity and the reaction theory. J Physiol (Lond) 1982, 332:1-24.
57. 2 microdialysis in the retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep. J Appl Physiol 1999, 87:910-919.
58. Lipscomb W.T., Boyarski L.L. Neurophysiological investigations of medullary chemosensitive areas of respiration. Respir Physiol 1972, 16:362-376.
59. 2 response in newborn piglets. J Appl Physiol 2004, 96:1909-1919.
60. Mitchell R.A., Loeschcke H.H., Massion W.H., Severinghaus J.W. Respiratory responses mediated through superficial chemosensitive areas on the medulla. J Appl Physiol 1963, 18:523-533.
61. Mueller R.A., Towle A.C., Breese G.R. Supersensitivity to the respiratory stimulatory effect of TRH in 5,7-dihydroxytryptamine-treated rats. Brain Res 1984, 298:370-373.
62. Mulkey D.K., Stornetta R.L., Weston M.C., Simmons J.R., Parker A., Bayliss D.A., Guyenet P.G. Respiratory control by ventral surface chemoreceptor neurons in rats. Nat Neurosci 2004, 7:1360-1369.
63. Monteau R., Morin D., Hilaire G. Acetylcholine and central chemosensitivity: in vitro study in the newborn rat. Respir Physiol 1990, 81:241-254.
64. - exchange in choroid plexus and CSF in acute metabolic acidosis or alkalosis. Am J Physiol 1990, 258:F1528-F1537.
65. Nattie E.E. Brain and cerebrospinal fluid ionic composition and ventilation in acute hypercapnia. Respir Physiol 1980, 40:309-322.
66. Nattie E.E. Ionic mechanisms of cerebrospinal fluid acid-base regulation (brief review). J Appl Physiol 1983, 54:3-12.
67. Nattie E.E. Ventilation during acute HCl infusion in intact and chemodenervated conscious rabbits. Respir Physiol 1983, 54:97-107.
68. Nattie E.E. Control and disturbances of cerebrospinal fluid pH. pH and Brain Function 1998, 629-650. John Wiley and Sons, New York. B. Ransom, K. Kaila (Eds.).
69. Nattie E.E. Central chemoreceptors, pH, and respiratory control. pH and Brain Function 1998, 535-560. John Wiley and Sons, New York. B. Ransom, K. Kaila (Eds.).
70. 2, brainstem chemoreceptors and breathing. Prog Neurobiol 1999, 59:299-331.
71. Nattie E. Multiple sites for central chemoreception their roles in response sensitivity and in sleep and wakefulness. Respir Physiol 2000, 122:223-235.
72. Nattie E.E. Central chemosensitivity, sleep, and wakefulness. Respir Physiol 2001, 129:257-268.
73. 2 in awake rabbits. J Appl Physiol 1988, 64:397-403.
74. 3 and ventilation in hypercapnia. J Appl Physiol 1988, 65:242-248.
75. Nattie E.E., Li A. Ventral medulla sites of muscarinic receptor subtypes involved in cardiorespiratory control. J Appl Physiol 1990, 69:33-41.
76. Nattie E.E., Li A. Lesions in the retrotrapezoid nucleus decrease ventilatory output in anesthetized or decerebrate cats. J Appl Physiol 1991, 71:1363-1375.
77. 2 sensitivity in rats. Respir Physiol 1994, 97:63-77.
78. Nattie E.E., Li A. Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat. J Appl Physiol 2000, 89:153-162.
79. 2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol 2001, 90:1247-1257.
80. 2 dialysis in the nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness. J Appl Physiol 2002, 92:2119-2130.
81. Nattie E.E., Li A. Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity. J Physiol (Lond) 2002, 544:603-616.
82. 2. Respir Physiol 1993, 94:35-50.
83. Nattie E., Shi J., Li A. Bicuculline dialysis in the retrotrapezoid nucleus (RTN) region stimulates breathing in the awake rat. Respir Physiol 2001, 124:93-179.
84. Nattie E.E., Li A., Richerson G.B., Lappi D.A. Medullary serotonergic neurons and adjacent neurons that express neurokinin-1 receptors are both involved in chemoreception in vivo. J Physiol (Lond) 2004, 556:235-253.
85. 3. Respir Physiol 1978, 33:177-198.
86. 31P-NMR. J Appl Physiol 1989, 66:2181-2188.
87. Ohtake P.J., Forster H.V., Pan L.G., Lowry T.F., Korducki M.J., Aaron E.A., Weiss E.M. Ventilatory responses to cooling the ventrolateral medullary surface of awake and anesthetized goats. J Appl Physiol 1995, 78:247-257.
88. Okada Y., Chen Z., Jiang W., Kuwana S., Eldridge F.L. Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats. J Appl Physiol 2002, 93:427-439.
89. Pappenheimer J.R., Fencl V., Heisey S.R., Held D. Role of cerebral fluids in control of respiration as studied in unanesthetized goats. Am J Physiol 1965, 208:436-450.
90. 2-induced c-Fos expression in brainstem preprotachykinin mRNA containing neurons. Respir Physiol Neurobiol 2002, 130:265-374.
91. Pineda J., Aghajanian G.K. Carbon dioxide regulates the tonic activity of locus ceruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience 1997, 77:723-743.
92. Pollay M., Curl F. Secretion of cerebrospinal fluid by the ventricular ependyma of the rabbit. Am J Physiol 1967, 213:1031-1038.
93. 31P-NMR during hyper- and hypocapnia. J Appl Physiol 1991, 71:2168-2172.
94. 2 and acid signaling in chemosensitive neurons. Am J Physiol Cell Physiol 2004, 287:C1493-C1526.
95. --sensitive neurons in the caudal ventrolateral medulla of the rat. J Physiol (Lond) 2003, 549:181-194.
96. 2 of neurons in the rostral ventral medulla in vitro. J Neurophysiol 1995, 36:207-216.
97. Richerson G.B. Cellular mechanisms of sensitivity to pH in the mammalian respiratory system. pH and Brain Function 1998, 509-533. Wiley-Liss, New York. K. Kaila, B.R. Ransom (Eds.).
98. Richerson G.B., Wang W., Tiwari J., Bradley S.R. Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol 2001, 129:175-190.
99. 2 sensors that maintain pH homeostasis. Nat Rev Neurosci 2004, 5:449-461.
100. Rodman J.R., Curran A.K., Henderson K.S., Dempsey J.A., Smith C.A. Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 2001, 91:328-335.
101. Satinoff E. Neural organization and evolution of thermal regulation in mammals. Science 1978, 201:16-22.
102. 2 chemoreceptor neuron identification by c-fos immunohistochemistry. J Appl Physiol 1992, 73:96-100.
103. Schielke G.P., Betz A.L. Electrolyte transport. Physiology and Pharmacology of the Blood-Brain Barrier 1992, 221-243. Springer-Verlag, New York. M.W.B. Bradbury (Ed.).
104. Schielke G.P., Moises H.C., Betz A.L. Potassium activation of the Na,K-pump in isolated brain microvessels and synaptosomes. Brain Res 1990, 524:291-296.
105. Schläfke M.E. Central chemosensitivity: a respiratory drive. Rev Physiol Biochem Pharm 1981, 90:171-172.
106. Schläfke M.E., Kille J.F., Loeschcke H.H. Elimination of central chemosensitivity by coagulation of a bilateral area on the ventral medullary surface in awake cats. Pflügers Arch 1979, 378:231-241.
107. Siesjö B.K. The regulation of cerebrospinal fluid pH. Kidney Int 1972, 1:360-374.
108. Smith C.A., Saupe K.W., Henderson K.S., Dempsey J.A. Ventilatory effects of specific carotid body hypocapnia in dogs during wakefulness and sleep. J Appl Physiol 1995, 79:689-699.
109. Smith J.C., Morrison D.E., Ellenberger H.H., Otto M.R., Feldman JL.. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J Comp Neurol 1989, 281:69-96.
110. Smith Q.R., Rapoport S.I. Carrier-mediated transport of chloride across the blood-brain barrier. J Neurochem 1984, 42:754-763.
111. Somero G. Protons, osmolytes, and fitness of internal milieu for protein function. Am J Physiol 1986, 251:R197-R213.
112. Spyer K.M., Dale N., Gourine A.V. ATP is a key mediator of central and peripheral chemosensory transduction. Exp Physiol 2004, 89:53-59.
113. Szentistványi I., Patlak C.S., Ellis R.A., Cserr H.F. Drainage of interstitial fluid from different regions of rat brain. Am J Physiol 1984, 246:F835-F844.
114. 2. J Appl Physiol 2004, 97:1763-1773.
115. Teppema L.J., Barts P.W.J.A., Folgering H.T.H., Evers J.A.M. Effects of respiratory and (isocapnic) metabolic arterial acid-base disturbances on medullary extracellular fluid pH and ventilation in cats. Respir Physiol 1983, 53:379-395.
116. Teppema L.J., Veening J.G., Kranenburg A., Dahan A, Berkenbosch A.A.D., Olievier C. Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J Comp Neurol 1997, 388:169-190.
117. Trouth C.O., Loeschcke H.H., Berndt J. A superficial substrate on the ventral surface of the medulla oblongata influencing respiration. Pflügers Arch 1979, 339:135-152.
118. Vigne P., Champigny G., Marsault R., Barbry P., Frelin C., Lazdunski M. A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels. J Biol Chem 1989, 264:7663-7668.
119. Wang W., Richerson G.B. Development of chemosensitivity of rat medullary raphe neurons. Neuroscience 1999, 90:1001-1011.
120. Wang W., Pizzonia J.H., Richerson G.B. Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J Physiol (Lond) 1998, 511:433-450.
121. Wang W., Tiwari J.K., Bradley S.R., Zaykin A.V., Richerson G.B. Acidosis-stimulated neurons of the medullary raphé are serotonergic. J Neurophysiol 2001, 85:2224-2235.
122. Wichser J., Kazemi H. CSF bicarbonate regulation in respiratory acidosis and alkalosis. J Appl Physiol 1975, 38:504-511.