Highly H+-sensitive neurons in the caudal ventrolateral medulla of the rat

Journal of Physiology

Volumn 549, Issue 1, 2003, Pages 181-194

  Ribas Salgueiro, J L ^a   Gaytan S P ^a   Crego, R ^a   Pasaro R ^a   Ribas, J ^b  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTON;

ACID BASE BALANCE; ACIDIFICATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; BRAIN SLICE; BRAIN STEM; BREATHING MECHANICS; CALCULATION; CALIBRATION; CELL PH; CHEMORECEPTOR; CHEMOSENSITIVITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FLUORESCENCE ANALYSIS; IONTOPHORESIS; MALE; MEDULLA OBLONGATA; MICROENVIRONMENT; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; RECORDING; RESPIRATION CONTROL; SENSITIVITY ANALYSIS; STEADY STATE; STIMULUS RESPONSE; ANIMAL EXPERIMENT; BREATHING PATTERN; EC50; EXTRACELLULAR SPACE; FIRING RATE; MICROIONTOPHORESIS; PH; ROSTRAL VENTROLATERAL MEDULLA;

EID: 0038526415     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.036624     Document Type: Article

References (72)

1. Ballantyne D & Scheid P (2000). Mammalian brainstem chemosensitive neurones: linking them to respiration in vitro. J Physiol 525, 567-577.
2. Bayliss DA, Talley EM, Sirois JE & Lei Q (2001). TASK-1 is a highly modulated pH-sensitive 'leak' K(+) channel expressed in brainstem respiratory neurons. Respir Physiol 129, 159-174.
3. Berndt J, Berger W, Berger K & Schmidt M (1972). Studies on the central chemosensitive mechanism of respiration. II. Control of respiration by the extracellular pH in medullary tissue. Pflugers Arch 332, 146-170.
4. Berquin P, Bodineau L, Gros F & Larnicol N (2000). Brainstem and hypothalamic areas involved in respiratory chemoreflexes: a Fos study in adult rats. Brain Res 857, 30-40.
5. Bevan S & Yeats J (1991). Protons activate a cation conductance in a sub-population of rat dorsal root ganglion neurones. J Physiol 433, 145-161.
6. Bodineau L, Cayetanot F & Frugiere A (2000). Possible role of retrotrapezoid nucleus and parapyramidal area in the respiratory response to anoxia: an in vitro study in neonatal rat. Neurosci Lett 295, 67-69.
7. Bradley SR, Pieribone VA, Wang W, Severson CA, Jacobs RA & Richerson G B (2002). Chemosensitive serotonergic neurons are closely associated with large medullary arteries. Nat Neurosci 5, 401-402.
8. Bright GR, Fisher W, Rogowska J & Taylor J (1987). Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH. J Cell Biol 104, 1019-1033.
9. Chatton JY & Spring KR (1994). Acidic pH of the lateral intercellular spaces of MDCK cells cultured on permeable supports. J Membr Biol 140, 89-99.
10. 2. J Physiol 441, 433-451.
11. Coates EI, Li A & Nattie EE (1993). Widespread sites-of brainstem ventilatory chemoreceptors. J Appl Physiol 75, 5-14.
12. + channels in pancreatic B-cells. Nature 311, 269-271.
13. Coulter KL, Perier F, Radeke CM & Vandenberg CA (1995). Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR. Neuron 15, 1157-1168.
14. Douglas RM, Trouth CO, James SD, Sexcius LM, Dehkordi O, Valladares ER & McKenzie JC (2001). Decreased CSF pH at ventral brain stem induces widespread c-Fos immunoreactivity in rat brain neurons. J App Physiol 90, 475-485.
15. + channel to sense external pH variations near physiological pH. EMBO J 16, 5464-5471.
16. Erlichman JS, Li A & Nattie EE (1998). Ventilatory effects of glial dysfunction in a rat brain stem chemoreceptor region. J Appl Physiol 85, 1599-1604.
17. Ezure K, Manabe M & Yamada H (1988). Distribution of medullary respiratory neurons in the rat. Brain Res 455, 262-270.
18. Filiano JJ (1994). Arcuate nucleus hypoplasia in sudden infant death syndrome: a review. Biol Neonate 65, 156-159.
19. Filosa JA, Dean JB & Putnam RW (2002). Role of intracellular and extracellular pH in the chemosensitive response of rat locus coeruleus neurones. J Physiol 541, 493-509.
20. Forster HV, Pan LG, Lowry TF, Feroah T, Gerahn WM, Whaley AA, Forster MM & Sprtel B (1998). Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons. J Appl Physiol 84, 129-140.
21. + on the membrane potential of silent cells in the ventral and dorsal surface layers of the rat medulla in vitro. Pflugers Arch 376, 229-235.
22. Gilson TP, Balko MG, Blisard FS & Taylor KL (1994). Morphologic variations of the external arcuate nucleus in infants dying of SIDS: a preliminary report. J Forensic Sci 39, 1076-1083.
23. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260, 3440-3450.
24. Hadziefendic S & Haxhiu MA (1999). CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus. J Auton Nerv Syst 76, 135-145.
25. Harada Y, Kuno M & Wang YZ (1985). Differential effects of carbon dioxide and pH on central chemoreceptors in the rat in vitro. J Physiol 368, 679-693.
26. Haxhiu MA, Cherniak NS & Loewy AD (1995). The ventral medullary network and airway control. In Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure. ed. Trouth CO, Millis RM, Kiwull-Schöne HF & Schläfke ME, pp. 157-179. Marcel Dekker, New York.
27. 2-induced c-fos expression in the catecholaminergic neurons. Respir Physiol 105, 35-45.
28. Heym J, Steinfels GF & Jacobs BL (1984). Chloral hydrate anesthesia alters the responsiveness of central serotonergic neurons in the cat. Brain Res 291, 63-72.
29. CO2. J Appl Physiol 72, 439-446.
30. Kawai A, Ballantyne D, Muckenhoff K & Scheid P (1996). Chemosensitive medullary neurones in the brainstem-spinal cord preparation of the neonatal rat. J Physiol 492, 277-292.
31. 2 diffusion pipette in vivo. J Appl Physiol 83, 420-428.
32. Loeschcke HH (1982). Central chemosensitivity and the reaction theory. J Physiol 332, 1-24.
33. Loeschcke HH, De Lattre J, Schläfke ME & Trouth CO (1970). Effects on respiration and circulation of electrically stimulating the ventral surface of the medulla oblongata. Respir Physiol 10, 184-197.
34. + iontophoresis on single cell activity in the cat brainstem. J Appl Physiol 38, 668-695.
35. Mason P (1997). Physiological identification of pontomedullary serotonergic neurons in the rat. J Neurophysiol 77, 1087-1098.
36. Matturri L, Biondo B, Mercurio, P & Rossi L (2000). Severe hypoplasia of medullary arcuate nucleus: quantitative analysis in sudden infant death syndrome. Acta Neuropathol 99, 371-375.
37. Middendorf T & Loeschcke HH (1978). Cooperation of the peripheral and central chemosensitive mechanisms in the control of the extracellular pH in brain in non-respiratory acidosis. Pflugers Arch 375, 257-260.
38. Millhorn DE & Eldridge FL (1986). Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J Appl Physiol 61, 1249-1263.
39. Nattie E (2000). Multiple sites for central chemoreception: their roles in response sensitivity and in sleep and wakefulness. Respir Physiol 122, 223-235.
40. 2. Respir Physiol 94, 35-50.
41. Nattie EE & Li A (1996). Central chemoreception in the region of the ventral respiratory group in the rat. J Appl Physiol 81, 1987-1995.
42. Okada Y, Muckenhoff K & Scheid P (1993). Hypercapnia and medullary neurons in the isolated brain stem-spinal cord of the rat. Respir Physiol 93, 327-336.
43. Pásaro R, Gaytán SP, Crego MR, Ribas-Salgueiro JL & Ribas J (2000). Neuronal connections between the parapyramidal region of the ventrolateral caudal medulla and the hypothalamus of the rat. Soc Neurosci Abs 26, 1086.
44. Paul AD, Gibbons A, Johnson EJ, McLean A, Webb L, Gardner O, Turner B, Lyseight N, Tomlin J & Douglas RM (1995). Neuronal connections of the ventral brainstem respiratory chemosensitive area. In Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, ed. Trouth CO, Millis RM, Kiwull-Schöne HF & Schläfke ME, pp. 517-523. Marcell Dekker, New York.
45. Paxinos G & Watson C (1997). The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
46. Podorski M (1976). Neurophysiological studies on central chemosensor in medullary ventrolateral areas. Am J Physiol 230, 1288-1295.
47. Putnam RW (2001). Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices. Respir Physiol 129, 37-56.
48. Rekling JC & Feldman JL (1998). PreBotzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu Rev Physiol 60, 385-405.
49. 2 of neurons in the rostral ventral medulla in vitro. J Neurophysiol 73, 933-944.
50. Richerson GB (1998). Cellular mechanisms of sensitivity to pH in the mammalian respiratory system. In pH and Brain Function, ed. Kalia K & Ramsom BRK, pp. 509-533. Wiley-Liss Inc., New York.
51. 2+ in lymphocytes. J Cell Biol 95, 189-196.
52. Ritucci NA, Chambers-Kersh L, Dean JB & Putnam RW (1998). Intracellular pH regulation in neurons from chemosensitive and nonchemosensitive areas of the medulla. Am J Physiol 274, R1152-1163.
53. Ritucci NA, Dean JB & Putnam RW (1997). Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla. Am J Physiol 273, R433-441.
54. St John WM (1999). Rostral medullary respiratory neuronal activities of decerebrate cats in eupnea, apneusis and gasping. Respir Physiol 116, 47-65.
55. St John WM & Wang SC (1977). Alteration from apneusis to more regular rhythmic respiration in decerebrate cats. Resp Physiol 31, 91-106.
56. Sanchez D & Ribas J (1991). Properties and ionic basis of the action potentials in the periaqueductal grey neurones of the guinea-pig. J Physiol 440, 167-187.
57. 2 chemoreceptor neuron identification by c-fos immunocytochemistry. J App Physiol 73, 96-100.
58. Schläfke ME (1981). Central chemosensitivity: a respiratory drive. Rev Physiol Biochem Pharmacol 90, 170-244.
59. Schläfke ME & Loeschcke HH (1967). Lokalisation eines an der Regulation von Atmung and Kreislauf beteiligten Gebietes an der ventralen Oberfläche der Medulla Oblongata durch Kälte-blockade. Pflugers Arch 297, 201-220.
60. + ion concentration in small areas of the ventral medullary surface. Respir Physiol 10, 198-212.
61. Street D, Bangsbo J & Carsten J (2001). Interstitial pH in human skeletal muscle during and after dynamic graded exercise. J Physiol 537, 993-998.
62. Thomas JA, Buchsbaum RN, Zimniak A & Racker E (1979). Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probe generated in situ. Biochemistry 18, 2210-2218.
63. +-ATPase regulate the intracellular pH of Trypanosoma brucei at different stages of its life cycle. Biochem J 346, 53-62.
64. CO2 and pH, and their role as chemostimulants in the isolated respiratory network of neonatal rats. J Physiol 499, 527-542.
65. Waldmann R, Champigny G, Bassilana F, Heurteaux C & Lazdunski M (1997). A proton-gated cation channel involved in acid-sensing. Nature 386, 173-177.
66. CO2. J Physiol 540, 951-970.
67. Wang W, Pizzonia JH & Richerson GB (1998). Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J Physiol 511, 433-450.
68. Wang W & Richerson GB (2000). Chemosensitivity of non-respiratory rat CNS neurons in tissue culture. Brain Res 860, 119-129.
69. + channels to central chemosensitivity in cultivated neurons of fetal rat medulla. J Neurophysiol 79, 2885-2894.
70. O2-sensitive medullary neurons: activation by intracellular acidification. Neuroreport 9, 167-170.
71. Wiemann M & Bingmann D (2001). Ventrolateral neurons of medullary organotypic cultures: intracellular pH regulation and bioelectric activity. Respir Physiol 129, 57-70.
72. +-sensitive medullary neurones. Pflugers Arch