Neurotrophic Factor Therapy: NGF, BDNF and NT-3

Encyclopedia of Neuroscience

Volumn , Issue , 2009, Pages 1093-1100

  Blesch, A ^a   Tuszynski, M H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Axonal growth; BDNF; Gene therapy; Neurotrophic; Neurotrophin; NGF; NT 3; NT 4; Peripheral nerve; Regeneration; Spinal cord injury; Transplantation

Indexed keywords

EID: 84882834681     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008045046-9.00030-9     Document Type: Chapter

References (11)

1. Blesch A., Tuszynski M.H. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Progress in Brain Research 2002, 137:415-423.
2. Hendriks W.T., Ruitenberg M.J., Blits B., Boer G.J., Verhaagen J. Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Progress in Brain Research 2004, 146:451-476.
3. Huang E.J., Reichardt L.F. Trk receptors: Roles in neuronal signal transduction. Annual Review of Biochemistry 2003, 72:609-642.
4. Lewin G.R., Barde Y.A. Physiology of the neurotrophins. Annual Review of Neuroscience 1996, 19:289-317.
5. Plunet W., Kwon B.K., Tetzlaff W. Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy. Journal of Neuroscience Research 2002, 68:1-6.
6. Ramer M.S., Priestley J.V., McMahon S.B. Functional regeneration of sensory axons into the adult spinal cord. Nature 2000, 403:312-316.
7. Ross C.A. Huntington's disease: New paths to pathogenesis. Cell 2004, 118:4-7.
8. Sofroniew M.V., Howe C.L., Mobley W.C. Nerve growth factor signaling, neuroprotection, and neural repair. Annual Review of Neuroscience 2001, 24:1217-1281.
9. Tuszynski M.H., Blesch A. Nerve growth factor: From animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease. Progress in Brain Research 2004, 146:441-449.
10. Tuszynski M.H., Thal L., Pay M., et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nature Medicine 2005, 11:551-555.
11. Zweifel L.S., Kuruvilla R., Ginty D.D. Functions and mechanisms of retrograde neurotrophin signalling. Nature Reviews Neuroscience 2005, 6:615-625.