Identification of Differential Responses to an Oral Glucose Tolerance Test in Healthy Adults

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Morris, Ciara ^a   O'Grada, Colm ^a   Ryan, Miriam ^a   Roche, Helen M ^a   Gibney, Michael J ^a   Gibney, Eileen R ^a   Brennan, Lorraine ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; C REACTIVE PROTEIN; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BIOCHEMISTRY; BODY COMPOSITION; BODY MASS; CELL FUNCTION; FAT TOLERANCE TEST; FEMALE; FITNESS; HUMAN; INSULIN RESISTANCE; MALE; METABOLISM; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; RISK ASSESSMENT;

ADULT; FEMALE; GLUCOSE TOLERANCE TEST; HEALTHY VOLUNTEERS; HUMANS; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE;

EID: 84882802778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072890     Document Type: Article

References (42)

1. German B, Young VR, (2004) Nutrition and genomics. Nestle Nutr Workshop Ser Clin Perform Programme 9: 243-261; discussion 261-243 doi:10.1159/000080668. PubMed: 15361690.
2. Go VL, Nguyen CT, Harris DM, Lee WN, (2005) Nutrient-gene interaction: metabolic genotype-phenotype relationship. J Nutr 135: 3016S-3020S. PubMed: 16317163.
3. Rezzi S, Martin FP, Alonso C, Guilarte M, Vicario M, et al. (2009) Metabotyping of biofluids reveals stress-based differences in gut permeability in healthy individuals. J Proteome Res 8: 4799-4809. doi:10.1021/pr900525w. PubMed: 19736998.
4. Kaddurah-Daouk R, Boyle S, Matson W, Sharma S, Matson S, et al. (2011) Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept. Transl Psychiatry 1.
5. O'Sullivan A, Gibney MJ, Connor AO, Mion B, Kaluskar S, et al. (2011) Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol Nutr Food Res 55: 679-690. doi:10.1002/mnfr.201000458. PubMed: 21240901.
6. Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK, (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci U S A 106: 14728-14733. doi:10.1073/pnas.0904489106. PubMed: 19667173.
7. Lindon JC, Holmes E, Nicholson JK, (2007) Metabonomics in pharmaceutical R&D. FEBS J 274: 1140-1151. doi:10.1111/j.1742-4658.2007.05673.x. PubMed: 17298438.
8. Nebert DW, Vesell ES, (2006) Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics. Trends Pharmacol Sci 27: 580-586. doi:10.1002/jps.3080270711. PubMed: 17005258.
9. Winnike JH, Li Z, Wright FA, Macdonald JM, O'Connell TM, et al. (2010) Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans. Clin Pharmacol Ther 88: 45-51. doi:10.1038/clpt.2009.240. PubMed: 20182423.
10. van Bochove K, van Schalkwijk DB, Parnell LD, Lai CQ, Ordovás JM, et al. (2012) Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy. PLoS ONE 7: e38072. doi:10.1371/journal.pone.0038072. PubMed: 22719863.
11. Berthiaume N, Zinker BA, (2002) Metabolic responses in a model of insulin resistance: Comparison between oral glucose and meal tolerance tests. Metab Clin Exp 51: 595-598. doi:10.1053/meta.2002.31989. PubMed: 11979391.
12. Lin SH, Yang Z, Liu HD, Tang LH, Cai ZW, (2011) Beyond glucose: metabolic shifts in responses to the effects of the oral glucose tolerance test and the high-fructose diet in rats. Mol Biosyst 7: 1537-1548. doi:10.1039/c0mb00246a. PubMed: 21350749.
13. Zhao XJ, Peter A, Fritsche J, Elcnerova M, Fritsche A, et al. (2009) Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab 296: E384-E393. PubMed: 19066319.
14. Pellis L, van Erk MJ, van Ommen B, Bakker GCM, Hendriks HFJ, et al. (2012) Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status. Metabolomics 8: 347-359. doi:10.1007/s11306-011-0320-5. PubMed: 22448156.
15. Krug S, Kastenmüller G, Stückler F, Rist MJ, Skurk T, et al. (2012) The dynamic range of the human metabolome revealed by challenges. FASEB J 26: 2607-2619. doi:10.1096/fj.11-198093. PubMed: 22426117.
16. Biaggi RR, Vollman MW, Nies MA, Brener CE, Flakoll PJ, et al. (1999) Comparison of air-displacement plethysmography with hydrostatic weighing and bioelectrical impedance analysis for the assessment of body composition in healthy adults. Am J Clin Nutr 69: 898-903. PubMed: 10232628.
17. Benaglia T, Chauveau D, Hunter DR, Young DS, (2009) mixtools: An R Package for Analyzing Finite Mixture Models. J Stat Softw 32: 1-29.
18. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, et al. (2002) beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US. Diabetes 51: 2170-2178.
19. Kahn SE, Mcculloch DK, Mcknight B, Schwartz MW, Bergman RN, et al. (1991) Quantification of the Relationship between Insulin Sensitivity and B-Cell Function. Clin Res 39: A306-A306.
20. Utzschneider KM, Prigeon RL, Faulenbach MV, Tong J, Carr DB, et al. (2009) Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 32: 335-341. PubMed: 18957530.
21. van Ommen B, Keijer J, Kleemann R, Elliott R, Drevon CA, et al. (2008) The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes Nutr 3: 51-59. doi:10.1007/s12263-008-0084-3. PubMed: 18850187.
22. van Ommen B, Keijer J, Heil SG, Kaput J, (2009) Challenging homeostasis to define biomarkers for nutrition related health. Mol Nutr Food Res 53: 795-804. doi:10.1002/mnfr.200800390. PubMed: 19517455.
23. Pellis L, van Erk MJ, van Ommen B, Bakker GC, Hendriks HF, et al. (2011) Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status. Metabolomics 8: 347-359. PubMed: 22448156.
24. Tschritter O, Fritsche A, Shirkavand F, Machicao F, Häring H, et al. (2003) Assessing the shape of the glucose curve during an oral glucose tolerance test. Diabetes Care 26: 1026-1033. doi:10.2337/diacare.26.4.1026. PubMed: 12663568.
25. Tura A, Morbiducci U, Sbrignadello S, Winhofer Y, Pacini G, et al. (2011) Shape of glucose, insulin, C-peptide curves during a 3-h oral glucose tolerance test: any relationship with the degree of glucose tolerance? Am J Physiol Regul Integr Comp Physiol 300: R941-R948. doi:10.1152/ajpregu.00650.2010. PubMed: 21248305.
26. Krishnan S, Newman JW, Hembrooke TA, Keim NL, (2012) Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful? Nutr Metab (Lond) 9: 26. doi:10.1186/1743-7075-9-26. PubMed: 22458475.
27. Porte D Jr,. (1991) Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes 40: 166-180.
28. Kahn SE, (2001) Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86: 4047-4058. doi:10.1210/jc.86.9.4047. PubMed: 11549624.
29. Pratley RE, Weyer C, (2001) The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus. Diabetologia 44: 929-945. doi:10.1007/s001250100580. PubMed: 11484070.
30. Haffner SM, Miettinen H, Gaskill SP, Stern MP, (1995) Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes 44: 1386-1391. doi:10.2337/diabetes.44.12.1386. PubMed: 7589843.
31. Harano Y, Miyawaki T, Nabiki J, Shibachi M, Adachi T, et al. (2006) Development of cookie test for the simultaneous determination of glucose intolerance, hyperinsulinemia, insulin resistance and postprandial dyslipidemia. Endocr J 53: 173-180. doi:10.1507/endocrj.53.173. PubMed: 16618974.
32. Wybranska I, Malczewska-Malec M, Partyka L, Kiec-Wilk B, Kosno K, et al. (2007) Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR). Clin Chem Lab Med 45: 1124-1132. PubMed: 17635072.
33. Lee Y, Hirose H, Ohneda M, Johnson JH, Mcgarry JD, et al. (1994) Beta-Cell Lipotoxicity in the Pathogenesis of Non-Insulin-Dependent Diabetes-Mellitus of Obese Rats- Impairment in Adipocyte-Beta-Cell Relationships. Proc Natl Acad Sci U S A 91: 10878-10882. doi:10.1073/pnas.91.23.10878. PubMed: 7971976.
34. Shimabukuro M, Zhou YT, Lee Y, Unger RH, (1998) Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 273: 3547-3550. doi:10.1074/jbc.273.6.3547. PubMed: 9452481.
35. Dobbins RL, Szczepaniak LS, Myhill J, Tamura Y, Uchino H, et al. (2002) The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. Diabetes 51: 1825-1833. doi:10.2337/diabetes.51.6.1825. PubMed: 12031970.
36. Giacca A, Xiao C, Oprescu AI, Carpentier AC, Lewis GF, (2011) Lipid-induced pancreatic beta-cell dysfunction: focus on in vivo studies. Am J Physiol Endocrinol Metab 300: E255-E262. doi:10.1152/ajpendo.00416.2010. PubMed: 21119027.
37. Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M, (2006) Fatty acid signaling in the beta-cell and insulin secretion. Diabetes 55 (Suppl 2):: S16-S23. doi:10.2337/db06-S003. PubMed: 17130640.
38. Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, et al. (1996) Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97: 2728-2735. doi:10.1172/JCI118727. PubMed: 8675683.
39. Warnotte C, Gilon P, Nenquin M, Henquin JC, (1994) Mechanisms of the stimulation of insulin release by saturated fatty acids. A study of palmitate effects in mouse beta-cells. Diabetes 43: 703-711. doi:10.2337/diabetes.43.5.703. PubMed: 8168648.
40. Zhou YP, Grill VE, (1994) Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93: 870-876. doi:10.1172/JCI117042. PubMed: 8113418.
41. Boden G, Shulman GI, (2002) Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32: 14-23. doi:10.1046/j.1365-2362.32.s3.3.x. PubMed: 12028371.
42. Unger RH, Zhou YT, Orci L, (1999) Regulation of fatty acid homeostasis in cells: Novel role of leptin. Proc Natl Acad Sci U S A 96: 2327-2332. doi:10.1073/pnas.96.5.2327. PubMed: 10051641.