The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential

Cell Death and Differentiation

Volumn 19, Issue 9, 2012, Pages 1435-1445

  Melzer, I M ^a   Fernandez S B M ^a,g   Bosser S ^a   Lohrig, K ^b   Lewandrowski, U ^b   Wolters, D ^c   Kehrloesser, S ^a,h   Brezniceanu, M L ^a,i   Theos, A C ^d   Irusta, P M ^d   Impens, F ^e,f   Gevaert, K ^e,f   Zornig M ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^b LEIBNIZ INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN ISAS E V   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^f GHENT UNIVERSITY   (Belgium)

^g CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^h GOETHE UNIVERSITY   (Germany)

ⁱ CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Aven; Cathepsin D; mitochondrial apoptosis pathway; proteolysis

Indexed keywords

AVEN PROTEIN; BINDING PROTEIN; CASPASE 3; CATHEPSIN D; MITOMYCIN C; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ACUTE DISEASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CATHEPSIN D; CELL LINE, TUMOR; HUMANS; LEUKEMIA; MEMBRANE PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84865183802     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.17     Document Type: Article

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