메뉴 건너뛰기




Volumn 20, Issue 4, 2013, Pages

Aromatase inhibition 2013: Clinical state of the art and questions that remain to be solved

Author keywords

Adjuvant therapy; Aromatase inhibitors; Breast cancer; Endocrine therapy; Resistance

Indexed keywords

AMINOGLUTETHIMIDE; AMINOGLUTETHIMIDE PLUS FORMESTANE; ANASTROZOLE; AROMATASE; AROMATASE INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; ESTROGEN; EVEROLIMUS; EXEMESTANE; FADROZOLE; FORMESTANE; FULVESTRANT; GESTAGEN; GONADORELIN DERIVATIVE; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PLACEBO; PYRIDOGLUTETHIMIDE; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 84882756472     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-13-0099     Document Type: Review
Times cited : (89)

References (181)
  • 1
    • 0029820178 scopus 로고    scopus 로고
    • Use of alternative promoters to express the aromatase cytochrome p450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients
    • doi:10.1210/jc.81.11.3843
    • Agarwal VR, Bulun SE, Leitch M, Rohrich R & Simpson ER 1996 Use of alternative promoters to express the aromatase cytochrome p450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. Journal of Clinical Endocrinology and Metabolism 81 3843-3849. (doi:10.1210/jc.81.11.3843)
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , pp. 3843-3849
    • Agarwal, V.R.1    Bulun, S.E.2    Leitch, M.3    Rohrich, R.4    Simpson, E.R.5
  • 4
    • 0028821450 scopus 로고
    • Plasma levels of the atherogenic amino acid homocysteine in post-menopausal women with breast cancer treated with tamoxifen
    • doi:10.1002/ijc.2910600316
    • Anker G, Lønning PE, Ueland PM, Refsum H & Lien EA 1995 Plasma levels of the atherogenic amino acid homocysteine in post-menopausal women with breast cancer treated with tamoxifen. International Journal of Cancer 60 365-368. (doi:10.1002/ijc.2910600316)
    • (1995) International Journal of Cancer , vol.60 , pp. 365-368
    • Anker, G.1    Lønning, P.E.2    Ueland, P.M.3    Refsum, H.4    Lien, E.A.5
  • 5
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
    • doi:10.1200/JCO.2011.39.0708
    • Bachelot T, Bourgier C, Cropet C, Ray-Coquard I, Ferrero JM, Freyer G, Abadie-Lacourtoisie S, Eymard JC, Debled M, Spaëth D et al. 2012 Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study. Journal of Clinical Oncology 30 2718-2724. (doi:10.1200/JCO.2011.39.0708)
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3    Ray-Coquard, I.4    Ferrero, J.M.5    Freyer, G.6    Abadie-Lacourtoisie, S.7    Eymard, J.C.8    Debled, M.9    Spaëth, D.10
  • 6
    • 79959508436 scopus 로고    scopus 로고
    • Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer
    • doi:10.1634/theoncologist.2011-S1-12
    • Baselga J 2011 Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist 16 12-19. (doi:10.1634/theoncologist.2011-S1-12)
    • (2011) Oncologist , vol.16 , pp. 12-19
    • Baselga, J.1
  • 8
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma. Suggestions for a new method of treatment with illustrative cases
    • doi:10.1016/S0140-6736(01)72307-0
    • Beatson GT 1896 On the treatment of inoperable cases of carcinoma of the mamma. Suggestions for a new method of treatment with illustrative cases. Lancet 2 104-107. (doi:10.1016/S0140-6736(01)72307-0)
    • (1896) Lancet , vol.2 , pp. 104-107
    • Beatson, G.T.1
  • 10
    • 33745613829 scopus 로고    scopus 로고
    • Switching to anastrozole versus continued tamoxifen treatment of early breast cancer. Updated results of the Italian Tamoxifen Anastrozole (ITA) trial
    • doi:10.1093/annonc/mdl941
    • Boccardo F, Rubagotti A, Guglielmini P, Fini A, Paladini G, Mesiti M, Rinaldini M, Scali S, Porpiglia M, Benedetto C et al. 2006 Switching to anastrozole versus continued tamoxifen treatment of early breast cancer. Updated results of the Italian Tamoxifen Anastrozole (ITA) trial. Annals of Oncology 17 VII10-VII14. (doi:10.1093/annonc/mdl941)
    • (2006) Annals of Oncology , vol.17
    • Boccardo, F.1    Rubagotti, A.2    Guglielmini, P.3    Fini, A.4    Paladini, G.5    Mesiti, M.6    Rinaldini, M.7    Scali, S.8    Porpiglia, M.9    Benedetto, C.10
  • 11
    • 84876106789 scopus 로고    scopus 로고
    • Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: Long term results of the Italian Tamoxifen Anastrozole trial
    • doi:10.1016/j.ejca.2012.12.025
    • Boccardo F, Guglielmini P, Bordonaro R, Fini A, Massidda B, Porpiglia M, Roagna R, Serra P, Orzalesi L, Ucci G et al. 2013 Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: long term results of the Italian Tamoxifen Anastrozole trial. European Journal of Cancer 49 1546-1554. (doi:10.1016/j.ejca.2012.12.025)
    • (2013) European Journal of Cancer , vol.49 , pp. 1546-1554
    • Boccardo, F.1    Guglielmini, P.2    Bordonaro, R.3    Fini, A.4    Massidda, B.5    Porpiglia, M.6    Roagna, R.7    Serra, P.8    Orzalesi, L.9    Ucci, G.10
  • 13
    • 0017755181 scopus 로고
    • The effect of an aromatase inhibitor, 4-hydroxy-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer
    • doi:10.1210/endo-100-6-1684
    • Brodie AMH, Schwarzel WC, Shaikh AA & Brodie HJ 1977 The effect of an aromatase inhibitor, 4-hydroxy-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer. Endocrinology 100 1684-1695. (doi:10.1210/endo-100-6-1684)
    • (1977) Endocrinology , vol.100 , pp. 1684-1695
    • Brodie, A.M.H.1    Schwarzel, W.C.2    Shaikh, A.A.3    Brodie, H.J.4
  • 17
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor a - A new model for anti-estrogen resistance
    • doi:10.1074/jbc.M010840200
    • Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S & Nakshatri H 2001 Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor a - a new model for anti-estrogen resistance. Journal of Biological Chemistry 276 9817-9824. (doi:10.1074/jbc.M010840200)
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 18
    • 0014126253 scopus 로고
    • Aminoglutethimide (Elipten-Ciba) is an inhibitor of adrenal steroidogenesis: Mechanism of action and therapeutic trial
    • doi:10.1210/jcem-27-9-1239
    • Cash R, Brough AJ, Cohen MNP & Satoh PS 1967 Aminoglutethimide (Elipten-Ciba) is an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial. Journal of Clinical Endocrinology and Metabolism 27 1239-1248. (doi:10.1210/jcem-27-9-1239)
    • (1967) Journal of Clinical Endocrinology and Metabolism , vol.27 , pp. 1239-1248
    • Cash, R.1    Brough, A.J.2    Cohen, M.N.P.3    Satoh, P.S.4
  • 19
    • 33646371731 scopus 로고    scopus 로고
    • Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor-positive breast cancer - The Pre-Operative 'Arimidex' Compared to Tamoxilen (PROAC7) trial
    • doi:10.1002/cncr.21872
    • Cataliotti L, Buzdar AU, Noguchi S, Bines J, Takatsuka Y, Petrakova K, Dube P & de Oliveira CT 2006 Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor-positive breast cancer - The Pre-Operative 'Arimidex' Compared to Tamoxilen (PROAC7) trial. Cancer 106 2095-2103. (doi:10.1002/cncr.21872)
    • (2006) Cancer , vol.106 , pp. 2095-2103
    • Cataliotti, L.1    Buzdar, A.U.2    Noguchi, S.3    Bines, J.4    Takatsuka, Y.5    Petrakova, K.6    Dube, P.7    De Oliveira, C.T.8
  • 20
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: Results from EFECT
    • doi:10.1200/JCO.2007.13.5822
    • Chia S, Gradishar W, Mauriac L, Bines J, Amant F, Federico M, Fein L, Romieu G, Buzdar A, Robertson JF et al. 2008 Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT. Journal of Clinical Oncology 26 1664-1670. (doi:10.1200/JCO.2007.13.5822)
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3    Bines, J.4    Amant, F.5    Federico, M.6    Fein, L.7    Romieu, G.8    Buzdar, A.9    Robertson, J.F.10
  • 23
    • 33846545488 scopus 로고    scopus 로고
    • Skeletal effects of exemestane on bone-mineral density bone biomarkers and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): A randomised controlled study
    • doi:10.1016/S1470-2045(07)70003-7
    • Coleman R, Banks L, Girgis S, Kilburn L, Vrdoljak E, Fox J, Cawthorn SJ, Patel A, Snowdon CF, Hall E et al. 2007 Skeletal effects of exemestane on bone-mineral density bone biomarkers and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study. Lancet Oncology 8 119-127. (doi:10.1016/S1470-2045(07)70003-7)
    • (2007) Lancet Oncology , vol.8 , pp. 119-127
    • Coleman, R.1    Banks, L.2    Girgis, S.3    Kilburn, L.4    Vrdoljak, E.5    Fox, J.6    Cawthorn, S.J.7    Patel, A.8    Snowdon, C.F.9    Hall, E.10
  • 25
    • 0021712326 scopus 로고
    • 4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer
    • doi:10.1016/S0140-6736(84)92795-8
    • Coombes RC, Goss P, Dowsett M, Gazet J-C & Brodie A 1984 4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer. Lancet 324 1237-1239. (doi:10.1016/S0140-6736(84)92795-8)
    • (1984) Lancet , vol.324 , pp. 1237-1239
    • Coombes, R.C.1    Goss, P.2    Dowsett, M.3    Gazet, J.-C.4    Brodie, A.5
  • 26
    • 33846545851 scopus 로고    scopus 로고
    • Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): A randomised controlled trial
    • doi:10.1016/S0140-6736(07)60200-1
    • Coombes RC, Kilburn LS, Snowdon CF, Paridaens R, Coleman RE, Jones SE, Jassem J, Van de Velde CJ, Delozier T, Alvarez I et al. 2007 Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial. Lancet 369 559-570. (doi:10.1016/S0140-6736(07)60200-1)
    • (2007) Lancet , vol.369 , pp. 559-570
    • Coombes, R.C.1    Kilburn, L.S.2    Snowdon, C.F.3    Paridaens, R.4    Coleman, R.E.5    Jones, S.E.6    Jassem, J.7    Van De Velde, C.J.8    Delozier, T.9    Alvarez, I.10
  • 28
    • 84879478956 scopus 로고    scopus 로고
    • ATLAS - 10 v 5 years of adjuvant tamoxifen (TAM) in ER+ disease; effects on outcome in the first and second decade after diagnosis
    • Davies C, Pan HC, Godwin J, Gray R, Peto R & Collaboratives A 2012 ATLAS - 10 v 5 years of adjuvant tamoxifen (TAM) in ER+ disease; effects on outcome in the first and second decade after diagnosis. Cancer Research 72 (24 suppl) S81-S82.
    • (2012) Cancer Research , vol.72 , Issue.24 SUPPL.
    • Davies, C.1    Pan, H.C.2    Godwin, J.3    Gray, R.4    Peto, R.5    Collaboratives, A.6
  • 29
    • 84867038912 scopus 로고    scopus 로고
    • Impact of body mass index on survival outcome among women with early stage triple-negative breast cancer
    • doi:10.1016/j.clbc.2012.07.013
    • Dawood S, Lei XD, Litton JK, Buchholz TA, Hortobagyi GN & Gonzalez-Angulo AM 2012 Impact of body mass index on survival outcome among women with early stage triple-negative breast cancer. Clinical Breast Cancer 12 364-372. (doi:10.1016/j.clbc.2012.07.013)
    • (2012) Clinical Breast Cancer , vol.12 , pp. 364-372
    • Dawood, S.1    Lei, X.D.2    Litton, J.K.3    Buchholz, T.A.4    Hortobagyi, G.N.5    Gonzalez-Angulo, A.M.6
  • 31
    • 84868194269 scopus 로고    scopus 로고
    • Aromatase inhibitors in obese breast cancer patients are not associated with increased plasma estradiol levels
    • doi:10.1007/s10549-012-2278-z
    • Diorio C, Lemieux J, Provencher L, Hogue JC & Vachon E 2012 Aromatase inhibitors in obese breast cancer patients are not associated with increased plasma estradiol levels. Breast Cancer Research and Treatment 136 573-579. (doi:10.1007/s10549-012-2278-z)
    • (2012) Breast Cancer Research and Treatment , vol.136 , pp. 573-579
    • Diorio, C.1    Lemieux, J.2    Provencher, L.3    Hogue, J.C.4    Vachon, E.5
  • 35
    • 0023148339 scopus 로고
    • Use of the aromatase inhibitor 4-hydroxyandrostenedione postmenopausal breast cancer: Optimization of therapeutic dose and route
    • Dowsett M, Goss PE, Powles TJ, Hutchinson G, Brodie AMH, Jeffcoate SL & Coombes RC 1987 Use of the aromatase inhibitor 4-hydroxyandrostenedione in postmenopausal breast cancer: optimization of therapeutic dose and route. Cancer Research 47 1957-1961. (Pubitemid 17056706)
    • (1987) Cancer Research , vol.47 , Issue.7 , pp. 1957-1961
    • Dowsett, M.1    Goss, P.E.2    Powles, T.J.3
  • 36
    • 0023918411 scopus 로고
    • Suppression of postmenopausal ovarian steroidogenesis with the luteinizing hor-mone- releasing hormone agonist goserelin
    • doi:10.1210/jcem-66-4-672
    • Dowsett M, Cantwell B, Lal A, Jeffcoate SL & Harris AL 1988 Suppression of postmenopausal ovarian steroidogenesis with the luteinizing hor-mone- releasing hormone agonist goserelin. Journal of Clinical Endocrinology and Metabolism 66 672-677. (doi:10.1210/jcem-66-4-672)
    • (1988) Journal of Clinical Endocrinology and Metabolism , vol.66 , pp. 672-677
    • Dowsett, M.1    Cantwell, B.2    Lal, A.3    Jeffcoate, S.L.4    Harris, A.L.5
  • 37
    • 0029560237 scopus 로고
    • In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer
    • Dowsett M, Jones A, Johnston SRD, Jacobs S, Trunet P & Smith IE 1995 In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer. Clinical Cancer Research 1 1511-1515. (Pubitemid 26028086)
    • (1995) Clinical Cancer Research , vol.1 , Issue.12 , pp. 1511-1515
    • Dowsett, M.1    Jones, A.2    Johnston, S.R.D.3    Jacobs, S.4    Trunet, P.5    Smith, I.E.6
  • 40
    • 41949104971 scopus 로고    scopus 로고
    • Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial
    • doi:10.1200/JCO.2007.12.9437
    • Dowsett M, Allred C, Knox J, Quinn E, Salter J, Wale C, Cuzick J, Houghton J, Williams N, Mallon E et al. 2008 Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial. Journal of Clinical Oncology 26 1059-1065. (doi:10.1200/JCO.2007.12.9437)
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 1059-1065
    • Dowsett, M.1    Allred, C.2    Knox, J.3    Quinn, E.4    Salter, J.5    Wale, C.6    Cuzick, J.7    Houghton, J.8    Williams, N.9    Mallon, E.10
  • 44
    • 84857508799 scopus 로고    scopus 로고
    • Tamoxifen and anastrozole as a sequencing strategy: A randomized controlled trial in postmenopausal patients with endocrine-responsive early breast cancer From the Austrian Breast and Colorectal Cancer Study Group
    • doi:10.1200/JCO.2011.36.8993
    • Dubsky PC, Jakesz R, Mlineritsch B, Postlberger S, Samonigg H, Kwasny W, Tausch C, Stöger H, Haider K, Fitzal F et al. 2012 Tamoxifen and anastrozole as a sequencing strategy: a randomized controlled trial in postmenopausal patients with endocrine-responsive early breast cancer From the Austrian Breast and Colorectal Cancer Study Group. Journal of Clinical Oncology 30 722-728. (doi:10.1200/JCO.2011.36.8993)
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 722-728
    • Dubsky, P.C.1    Jakesz, R.2    Mlineritsch, B.3    Postlberger, S.4    Samonigg, H.5    Kwasny, W.6    Tausch, C.7    Stöger, H.8    Haider, K.9    Fitzal, F.10
  • 45
    • 41949094767 scopus 로고    scopus 로고
    • Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230
    • doi:10.1200/JCO.2007.11.0726
    • Eastell R, Adams JE, Coleman RE, Howell A, Hannon RA, Cuzick J, Mackey JR, Beckmann MW & Clack G 2008 Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230. Journal of Clinical Oncology 26 1051-1058. (doi:10.1200/JCO. 2007.11.0726)
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 1051-1058
    • Eastell, R.1    Adams, J.E.2    Coleman, R.E.3    Howell, A.4    Hannon, R.A.5    Cuzick, J.6    Mackey, J.R.7    Beckmann, M.W.8    Clack, G.9
  • 49
    • 0029081347 scopus 로고
    • Plasma changes in breast cancer patients during endocrine therapy - lipid measurements and nuclear magnetic resonance (NMR) spectroscopy
    • doi:10.1007/BF00713400
    • Engan T, Krane J, Johannessen DC, Lonning PE & Kvinnsland S 1995 Plasma changes in breast cancer patients during endocrine therapy - lipid measurements and nuclear magnetic resonance (NMR) spectroscopy. Breast Cancer Research and Treatment 36 287-297. (doi:10.1007/BF00713400)
    • (1995) Breast Cancer Research and Treatment , vol.36 , pp. 287-297
    • Engan, T.1    Krane, J.2    Johannessen, D.C.3    Lonning, P.E.4    Kvinnsland, S.5
  • 51
    • 84867891436 scopus 로고    scopus 로고
    • Targeted agents to reverse resistance to endocrine therapy in metastatic breast cancer: Where are we now and where are we going?
    • doi:10.1016/j.critrevonc.2012.03.004
    • Fedele P, Calvani N, Marino A, Orlando L, Schiavone P, Quaranta A & Cinieri S 2012 Targeted agents to reverse resistance to endocrine therapy in metastatic breast cancer: where are we now and where are we going? Critical Reviews in Oncology/Hematology 84 243-251. (doi:10.1016/j.critrevonc.2012.03. 004)
    • (2012) Critical Reviews in Oncology/Hematology , vol.84 , pp. 243-251
    • Fedele, P.1    Calvani, N.2    Marino, A.3    Orlando, L.4    Schiavone, P.5    Quaranta, A.6    Cinieri, S.7
  • 52
    • 84875697676 scopus 로고    scopus 로고
    • Results of a randomized phase 2 study of PD 0332991, a cyclin-dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ERC/HER2K advanced breast cancer (BC)
    • Finn RS, Crown JP, Lang I, Boer K, Bondarenko IM, Kulyk SO, Ettl J, Patel R, Pinter T, Schmidt M et al. 2012 Results of a randomized phase 2 study of PD 0332991, a cyclin-dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ERC/HER2K advanced breast cancer (BC). Cancer Research 72 (24 Suppl) S1-S6.
    • (2012) Cancer Research , vol.72 , Issue.24 SUPPL.
    • Finn, R.S.1    Crown, J.P.2    Lang, I.3    Boer, K.4    Bondarenko, I.M.5    Kulyk, S.O.6    Ettl, J.7    Patel, R.8    Pinter, T.9    Schmidt, M.10
  • 54
    • 70349952517 scopus 로고    scopus 로고
    • Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors
    • doi:10.1038/sj.bjc.6605324
    • Flageng MH, Moi LL, Dixon JM, Geisler J, Lien EA, Miller WR, Lønning PE & Mellgren G 2009 Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. British Journal of Cancer 101 1253-1260. (doi:10.1038/sj.bjc.6605324)
    • (2009) British Journal of Cancer , vol.101 , pp. 1253-1260
    • Flageng, M.H.1    Moi, L.L.2    Dixon, J.M.3    Geisler, J.4    Lien, E.A.5    Miller, W.R.6    Lønning, P.E.7    Mellgren, G.8
  • 55
    • 84865184360 scopus 로고    scopus 로고
    • Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer
    • doi:10.1200/JCO.2012.42.0273
    • Folkerd EJ, Dixon JM, Renshaw L, A'Hern RP & Dowsett M 2012 Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer. Journal of Clinical Oncology 30 2977-2980. (doi:10.1200/JCO.2012.42.0273)
    • (2012) Journal of Clinical Oncology , vol.30 , pp. 2977-2980
    • Folkerd, E.J.1    Dixon, J.M.2    Renshaw, L.3    A'Hern, R.P.4    Dowsett, M.5
  • 56
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • doi:10.1016/S1470-2045(07)70385-6
    • Forbes JF, Cuzick J, Buzdar A, Howell A, Tobias JS & Baum M 2008 Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncology 9 45-53. (doi:10.1016/S1470-2045(07)70385-6)
    • (2008) Lancet Oncology , vol.9 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3    Howell, A.4    Tobias, J.S.5    Baum, M.6
  • 57
    • 63649099281 scopus 로고    scopus 로고
    • Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways
    • doi:10.1016/j.steroids.2008.10.014
    • Fox EM, Andrade J & Shupnik MA 2009 Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways. Steroids 74 622-627. (doi:10.1016/j.steroids.2008.10.014)
    • (2009) Steroids , vol.74 , pp. 622-627
    • Fox, E.M.1    Andrade, J.2    Shupnik, M.A.3
  • 58
    • 0014135250 scopus 로고
    • The results of adrenalectomy in advanced breast cancer in 500 consecutive patients
    • Fracchia AA, Randall HT & Farrow JH 1967 The results of adrenalectomy in advanced breast cancer in 500 consecutive patients. Surgery, Gynecology & Obstetrics 125 747-756.
    • (1967) Surgery, Gynecology & Obstetrics , vol.125 , pp. 747-756
    • Fracchia, A.A.1    Randall, H.T.2    Farrow, J.H.3
  • 60
    • 17144423592 scopus 로고    scopus 로고
    • Aromatase inhibition: Translation into a successful therapeutic approach
    • doi:10.1158/1078-0432.CCR-04-2187
    • Geisler J & Lønning PE 2005 Aromatase inhibition: translation into a successful therapeutic approach. Clinical Cancer Research 11 2809-2821. (doi:10.1158/1078-0432.CCR-04-2187)
    • (2005) Clinical Cancer Research , vol.11 , pp. 2809-2821
    • Geisler, J.1    Lønning, P.E.2
  • 61
    • 0029093623 scopus 로고
    • Influence of treatment with the anti-oestrogen 3-hydroxytamoxifen (droloxifene) on plasma sex hormone levels in postmenopausal patients with breast cancer
    • doi:10.1677/joe.0.1460359
    • Geisler J, Haarstad H, Gundersen S, Raabe N, Kvinnsland S & Lonning PE 1995 Influence of treatment with the anti-oestrogen 3-hydroxytamoxifen (droloxifene) on plasma sex hormone levels in postmenopausal patients with breast cancer. Journal of Endocrinology 146 359-363. (doi:10.1677/joe.0.1460359)
    • (1995) Journal of Endocrinology , vol.146 , pp. 359-363
    • Geisler, J.1    Haarstad, H.2    Gundersen, S.3    Raabe, N.4    Kvinnsland, S.5    Lonning, P.E.6
  • 62
    • 0030007732 scopus 로고    scopus 로고
    • Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated cancer patients: Clinical and endocrine effects
    • doi:10.1016/0959-8049(95)00623-0
    • Geisler J, Johannessen DC, Anker G & Lønning PE 1996a Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated cancer patients: clinical and endocrine effects. European Journal of Cancer 32A 789-792. (doi:10.1016/0959-8049(95)00623-0)
    • (1996) European Journal of Cancer , vol.32 A , pp. 789-792
    • Geisler, J.1    Johannessen, D.C.2    Anker, G.3    Lønning, P.E.4
  • 63
    • 0029804714 scopus 로고    scopus 로고
    • Influence of anastrozole (arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer
    • doi:10.1038/bjc.1996.531
    • Geisler J, King N, Dowsett M, Ottestad L, Lundgren S, Walton P, Kormeset PO & Lønning PE 1996b Influence of anastrozole (arimidex), a selective, non-steroidal aromatase inhibitor, on in vivo aromatisation and plasma oestrogen levels in postmenopausal women with breast cancer. British Journal of Cancer 74 1286-1291. (doi:10.1038/bjc.1996.531)
    • (1996) British Journal of Cancer , vol.74 , pp. 1286-1291
    • Geisler, J.1    King, N.2    Dowsett, M.3    Ottestad, L.4    Lundgren, S.5    Walton, P.6    Kormeset, P.O.7    Lønning, P.E.8
  • 64
    • 0031663593 scopus 로고    scopus 로고
    • In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients
    • Geisler J, King N, Anker G, Ornati G, Di Salle E, Lønning PE & Dowsett M 1998 In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients. Clinical Cancer Research 4 2089-2093. (Pubitemid 28415652)
    • (1998) Clinical Cancer Research , vol.4 , Issue.9 , pp. 2089-2093
    • Geisler, J.1    King, N.2    Anker, G.3    Ornati, G.4    Di, S.E.5    Lonning, P.E.6    Dowsett, M.7
  • 65
    • 0034901971 scopus 로고    scopus 로고
    • Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer
    • Geisler J, Detre S, Berntsen H, Ottestad L, Lindtjørn B, Dowsett M & Lønning P 2001 Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer. Clinical Cancer Research 7 1230-1236. (Pubitemid 32708674)
    • (2001) Clinical Cancer Research , vol.7 , Issue.5 , pp. 1230-1236
    • Geisler, J.1    Detre, S.2    Berntsen, H.3    Ottestad, L.4    Lindtjorn, B.5    Dowsett, M.6    Lonning, P.E.7
  • 66
    • 0036467847 scopus 로고    scopus 로고
    • Influence of letrozole (Femara) and anastrozole (Arimidex) on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over-designed study
    • doi:10.1200/JCO.20.3.751
    • Geisler J, Haynes B, Anker G, Dowsett M & Lønning PE 2002 Influence of letrozole (Femara) and anastrozole (Arimidex) on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over-designed study. Journal of Clinical Oncology 20 751-757. (doi:10.1200/JCO.20.3.751)
    • (2002) Journal of Clinical Oncology , vol.20 , pp. 751-757
    • Geisler, J.1    Haynes, B.2    Anker, G.3    Dowsett, M.4    Lønning, P.E.5
  • 67
    • 33750522464 scopus 로고    scopus 로고
    • Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: A randomised, placebo-controlled study
    • doi:10.1016/j.ejca.2006.07.005
    • Geisler J, Lønning PE, Krag LE, Løkkevik E, Risberg T, Hagen AI, Schlichting E, Lien EA, Ofjord ES & Eide GE 2006 Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: a randomised, placebo-controlled study. European Journal of Cancer 42 2968-2975. (doi:10.1016/j.ejca.2006.07.005)
    • (2006) European Journal of Cancer , vol.42 , pp. 2968-2975
    • Geisler, J.1    Lønning, P.E.2    Krag, L.E.3    Løkkevik, E.4    Risberg, T.5    Hagen, A.I.6    Schlichting, E.7    Lien, E.A.8    Ofjord, E.S.9    Eide, G.E.10
  • 68
    • 40849123942 scopus 로고    scopus 로고
    • An optimised, highly sensitive radioimmunoassay for the simultaneous measurement of estrone, estradiol and estrone sulfate in the ultra-low range in human plasma samples
    • doi:10.1016/j.jsbmb.2007.12.011
    • Geisler J, Ekse D, Helle H, Duong N & Lønning P 2008a An optimised, highly sensitive radioimmunoassay for the simultaneous measurement of estrone, estradiol and estrone sulfate in the ultra-low range in human plasma samples. Journal of Steroid Biochemistry and Molecular Biology 109 90-95. (doi:10.1016/j.jsbmb.2007.12.011)
    • (2008) Journal of Steroid Biochemistry and Molecular Biology , vol.109 , pp. 90-95
    • Geisler, J.1    Ekse, D.2    Helle, H.3    Duong, N.4    Lønning, P.5
  • 69
    • 58149145625 scopus 로고    scopus 로고
    • Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels
    • doi:10.1158/1078-0432.CCR-07-5221
    • Geisler J, Helle H, Ekse D, Duong NK, Evans DB, Nordbø Y, Aas T & Lønning PE 2008b Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels. Clinical Cancer Research 14 6330-6335. (doi:10.1158/1078-0432.CCR-07-5221)
    • (2008) Clinical Cancer Research , vol.14 , pp. 6330-6335
    • Geisler, J.1    Helle, H.2    Ekse, D.3    Duong, N.K.4    Evans, D.B.5    Nordbø, Y.6    Aas, T.7    Lønning, P.E.8
  • 70
    • 49949115926 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy
    • doi:10.1016/S1470-2045(08)70204-3
    • Gnant M, Mlineritsch B, Luschin-Ebengreuth G, Kainberger F, Kässmann H, Piswanger-Sölkner JC, Seifert M, Ploner F, Menzel C, Dubsky P et al. 2008 Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. Lancet Oncology 9 840-849. (doi:10.1016/S1470-2045(08)70204-3)
    • (2008) Lancet Oncology , vol.9 , pp. 840-849
    • Gnant, M.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3    Kainberger, F.4    Kässmann, H.5    Piswanger-Sölkner, J.C.6    Seifert, M.7    Ploner, F.8    Menzel, C.9    Dubsky, P.10
  • 72
    • 0023709223 scopus 로고
    • High dose ketoconazole: Endocrine and therapeutic effects in postmenopausal breast cancer
    • doi:10.1038/bjc.1988.247
    • Harris AL, Cantwell BMJ & Dowsett M 1988 High dose ketoconazole: endocrine and therapeutic effects in postmenopausal breast cancer. British Journal of Cancer 58 493-496. (doi:10.1038/bjc.1988.247)
    • (1988) British Journal of Cancer , vol.58 , pp. 493-496
    • Harris, A.L.1    Cantwell, B.M.J.2    Dowsett, M.3
  • 75
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: A multinational, double-blind, randomized trial
    • doi:10.1200/JCO.2004.02.112
    • Howell A, Robertson JF, Abram P, Lichinitser MR, Elledge R, Bajetta E, Watanabe T, Morris C, Webster A, Dimery I et al. 2004 Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial. Journal of Clinical Oncology 22 1605-1613. (doi:10.1200/JCO.2004.02.112)
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3    Lichinitser, M.R.4    Elledge, R.5    Bajetta, E.6    Watanabe, T.7    Morris, C.8    Webster, A.9    Dimery, I.10
  • 76
    • 78651047933 scopus 로고
    • Adrenalectomy and oophorectomy in treatment of advanced carcinoma of the breast
    • Huggins C & Dao TL-Y 1953 Adrenalectomy and oophorectomy in treatment of advanced carcinoma of the breast. Journal of the American Medical Association 151 1388-1394.
    • (1953) Journal of the American Medical Association , vol.151 , pp. 1388-1394
    • Huggins, C.1    Dao, T.L.-Y.2
  • 77
    • 0032547326 scopus 로고    scopus 로고
    • Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
    • doi:10.1001/jama.280.7.605
    • Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B & Vittinghoff E 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Journal of the American Medical Association 280 605-613. (doi:10.1001/jama.280.7.605)
    • (1998) Journal of the American Medical Association , vol.280 , pp. 605-613
    • Hulley, S.1    Grady, D.2    Bush, T.3    Furberg, C.4    Herrington, D.5    Riggs, B.6    Vittinghoff, E.7
  • 79
  • 80
    • 0026090289 scopus 로고
    • Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo
    • doi:10.3109/14756369109030396
    • Jacobs S, Lønning PE, Haynes B, Griggs L & Dowsett M 1991 Measurement of aromatisation by a urine technique suitable for the evaluation of aromatase inhibitors in vivo. Journal of Enzyme Inhibition 4 315-325. (doi:10.3109/14756369109030396)
    • (1991) Journal of Enzyme Inhibition , vol.4 , pp. 315-325
    • Jacobs, S.1    Lønning, P.E.2    Haynes, B.3    Griggs, L.4    Dowsett, M.5
  • 81
    • 23444446523 scopus 로고    scopus 로고
    • Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: Combined results of ABCSG trial 8 and ARNO 95 trial
    • doi:10.1016/S0140-6736(05)67059-6
    • Jakesz R, Jonat W, Gnant M, Mittlboeck M, Greil R, Tausch C, Hilfrich J, Kwasny W, Menzel C, Samonigg H et al. 2005 Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial. Lancet 366 455-462. (doi:10.1016/S0140-6736(05)67059-6)
    • (2005) Lancet , vol.366 , pp. 455-462
    • Jakesz, R.1    Jonat, W.2    Gnant, M.3    Mittlboeck, M.4    Greil, R.5    Tausch, C.6    Hilfrich, J.7    Kwasny, W.8    Menzel, C.9    Samonigg, H.10
  • 82
    • 38449107897 scopus 로고    scopus 로고
    • Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: Results from the randomized Austrian Breast and Colorectal Cancer Study Group trial 6a
    • doi:10.1093/jnci/djm246
    • Jakesz R, Greil R, Gnant M, Schmid M, Kwasny W, Kubista E, Mlineritsch B, Tausch C, Stierer M, Hofbauer F et al. 2007 Extended adjuvant therapy with anastrozole among postmenopausal breast cancer patients: results from the randomized Austrian Breast and Colorectal Cancer Study Group trial 6a. Journal of the National Cancer Institute 99 1845-1853. (doi:10.1093/jnci/djm246)
    • (2007) Journal of the National Cancer Institute , vol.99 , pp. 1845-1853
    • Jakesz, R.1    Greil, R.2    Gnant, M.3    Schmid, M.4    Kwasny, W.5    Kubista, E.6    Mlineritsch, B.7    Tausch, C.8    Stierer, M.9    Hofbauer, F.10
  • 84
    • 20644465808 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole
    • doi:10.1158/0008-5472.CAN-04-4502
    • Jelovac D, Sabnis G, Long BJ, Macedo L, Goloubeva OG & Brodie AMH 2005 Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole. Cancer Research 65 5380-5389. (doi:10.1158/0008-5472.CAN-04-4502)
    • (2005) Cancer Research , vol.65 , pp. 5380-5389
    • Jelovac, D.1    Sabnis, G.2    Long, B.J.3    Macedo, L.4    Goloubeva, O.G.5    Brodie, A.M.H.6
  • 85
    • 0030748661 scopus 로고    scopus 로고
    • Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidai aromatase inhibitor, in postmenopausal breast cancer patients: A phase I study
    • Johannessen DC, Engan T, Di Salle E, Zurlo MG, Paolini J, Ornati G, Piscitelli G, Kvinnsland S & Lonning PE 1997 Endocrine and clinical effects of exemestane (PNU 155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients: a phase I study. Clinical Cancer Research 3 1101-1108. (Pubitemid 27319756)
    • (1997) Clinical Cancer Research , vol.3 , Issue.7 , pp. 1101-1108
    • Johannessen, D.C.1    Engan, T.2    Di, S.E.3    Zurlo, M.G.4    Paolini, J.5    Ornati, G.6    Piscitelli, G.7    Kvinnsland, S.8    Lonning, P.E.9
  • 87
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • doi:10.1200/JCO.2009.23.3734
    • Johnston S, Pippen J, Jr, Pivot X, Lichinitser M, Sadeghi S, Dieras V, Gomez HL, Romieu G, Manikhas A, Kennedy MJ et al. 2009 Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. Journal of Clinical Oncology 27 5538-5546. (doi:10.1200/JCO.2009.23.3734)
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3    Lichinitser, M.4    Sadeghi, S.5    Dieras, V.6    Gomez, H.L.7    Romieu, G.8    Manikhas, A.9    Kennedy, M.J.10
  • 88
    • 0026639780 scopus 로고
    • The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients
    • doi:10.1016/0959-8049(92)90074-C
    • Jones AL, MacNeill F, Jacobs S, Lønning PE, Dowsett M & Powles TJ 1992 The influence of intramuscular 4-hydroxyandrostenedione on peripheral aromatisation in breast cancer patients. European Journal of Cancer 28A 1712-1716. (doi:10.1016/0959-8049(92)90074-C)
    • (1992) European Journal of Cancer , vol.28 A , pp. 1712-1716
    • Jones, A.L.1    MacNeill, F.2    Jacobs, S.3    Lønning, P.E.4    Dowsett, M.5    Powles, T.J.6
  • 90
    • 4544352393 scopus 로고    scopus 로고
    • Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells
    • doi:10.1023/B:BREA.0000041623.21338.47
    • Jordan NJ, Gee JMW, Barrow D, Wakeling AE & Nicholson RI 2004 Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Research and Treatment 87 167-180. (doi:10.1023/B:BREA.0000041623.21338.47)
    • (2004) Breast Cancer Research and Treatment , vol.87 , pp. 167-180
    • Jordan, N.J.1    Gee, J.M.W.2    Barrow, D.3    Wakeling, A.E.4    Nicholson, R.I.5
  • 91
    • 0035991256 scopus 로고    scopus 로고
    • International variation in hip fracture probabilities: Implications for risk assessment
    • doi:10.1359/jbmr.2002.17.7.1237
    • Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A & Ogelsby AK 2002 International variation in hip fracture probabilities: implications for risk assessment. Journal of Bone and Mineral Research 17 1237-1244. (doi:10.1359/jbmr.2002.17.7.1237)
    • (2002) Journal of Bone and Mineral Research , vol.17 , pp. 1237-1244
    • Kanis, J.A.1    Johnell, O.2    De Laet, C.3    Jonsson, B.4    Oden, A.5    Ogelsby, A.K.6
  • 92
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the Randomized Phase III TAnDEM Study
    • doi:10.1200/JCO.2008.20.6847
    • Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova A et al. 2009 Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the Randomized Phase III TAnDEM Study. Journal of Clinical Oncology 27 5529-5537. (doi:10.1200/JCO.2008.20.6847)
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3    Bapsy, P.P.4    Vaid, A.5    Wardley, A.6    Tjulandin, S.7    Jahn, M.8    Lehle, M.9    Feyereislova, A.10
  • 93
    • 34447574894 scopus 로고    scopus 로고
    • Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: The ARNO 95 study
    • doi:10.1200/JCO.2006.08.8054
    • Kaufmann M, Jonat W, Hilfrich J, Eidtmann H, Gademann G & Zuna I 2007 Improved overall survival in postmenopausal women with early breast cancer after anastrozole initiated after treatment with tamoxifen compared with continued tamoxifen: the ARNO 95 study. Journal of Clinical Oncology 25 2664-2670. (doi:10.1200/JCO.2006.08.8054)
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 2664-2670
    • Kaufmann, M.1    Jonat, W.2    Hilfrich, J.3    Eidtmann, H.4    Gademann, G.5    Zuna, I.6
  • 94
    • 33645292020 scopus 로고    scopus 로고
    • Caution: Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors
    • doi:10.1093/annonc/mdj127
    • Kendall A, Dowsett M, Folkerd E & Smith I 2006 Caution: vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors. Annals of Oncology 17 584-587. (doi:10.1093/annonc/mdj127)
    • (2006) Annals of Oncology , vol.17 , pp. 584-587
    • Kendall, A.1    Dowsett, M.2    Folkerd, E.3    Smith, I.4
  • 96
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • doi:10.1210/en.2002-220620
    • Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE & Nicholson RI 2003 Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144 1032-1044. (doi:10.1210/en.2002-220620)
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.5    Harper, M.E.6    Barrow, D.7    Wakeling, A.E.8    Nicholson, R.I.9
  • 97
    • 0008523399 scopus 로고
    • The use of prednisolone in the treatment of disseminated breast carcinoma
    • doi:10.1002/1097-0142(195801/02)11:1〈226::AI
    • Kofman S, Nagamani D, Buenger RF & Taylor SG 1958 The use of prednisolone in the treatment of disseminated breast carcinoma. Cancer 11 226-232. (doi:10.1002/1097-0142(195801/02)11:1〈226::AID- CNCR2820110135〉3.0.CO;2-S)
    • (1958) Cancer , vol.11 , pp. 226-232
    • Kofman, S.1    Nagamani, D.2    Buenger, R.F.3    Taylor, S.G.4
  • 99
    • 0021931084 scopus 로고
    • Endogenous concentration and subcellular distribution of estrogens in normal and malignant breast tissue
    • van Landeghem AJJ, Poortman J, Nabuurs M & Thijssen JHH 1985 Endogenous concentration and subcellular distribution of estrogens in normal and malignant breast tissue. Cancer Research 45 2900-2904.
    • (1985) Cancer Research , vol.45 , pp. 2900-2904
    • Van Landeghem, A.J.J.1    Poortman, J.2    Nabuurs, M.3    Thijssen, J.H.H.4
  • 100
    • 17144427123 scopus 로고
    • Prednisone therapy of advanced mammary cancer
    • doi:10.1002/1097-0142(195901/02)12:1〈93::AID
    • Lemon HM 1959 Prednisone therapy of advanced mammary cancer. Cancer 12 93-107. (doi:10.1002/1097-0142(195901/02)12:1〈93::AID- CNCR2820120115〉3.0.CO;2-I)
    • (1959) Cancer , vol.12 , pp. 93-107
    • Lemon, H.M.1
  • 102
    • 0037338906 scopus 로고    scopus 로고
    • Study of suboptimum treatment response: Lessons from breast cancer
    • doi:10.1016/S1470-2045(03)01022-2
    • Lønning PE 2003 Study of suboptimum treatment response: lessons from breast cancer. Lancet Oncology 4 177-185. (doi:10.1016/S1470-2045(03)01022- 2)
    • (2003) Lancet Oncology , vol.4 , pp. 177-185
    • Lønning, P.E.1
  • 103
    • 3042545132 scopus 로고    scopus 로고
    • Aromatase inhibitors in breast cancer
    • doi:10.1677/erc.0.0110179
    • Lønning PE 2004 Aromatase inhibitors in breast cancer. Endocrine-Related Cancer 11 179-189. (doi:10.1677/erc.0.0110179)
    • (2004) Endocrine-Related Cancer , vol.11 , pp. 179-189
    • Lønning, P.E.1
  • 104
    • 31544458993 scopus 로고    scopus 로고
    • Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast cancer
    • doi:10.1093/annonc/mdj048
    • Lønning PE 2006 Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast cancer. Annals of Oncology 17 217-225. (doi:10.1093/annonc/mdj048)
    • (2006) Annals of Oncology , vol.17 , pp. 217-225
    • Lønning, P.E.1
  • 105
    • 0029583117 scopus 로고
    • A sensitive assay for measurement of plasma estrone sulphate in patients on treatment with aromatase inhibitors
    • doi:10.1016/0960-0760(95)00180-8
    • Lønning PE & Ekse D 1995 A sensitive assay for measurement of plasma estrone sulphate in patients on treatment with aromatase inhibitors. Journal of Steroid Biochemistry and Molecular Biology 55 409-412. (doi:10.1016/0960-0760(95)00180-8)
    • (1995) Journal of Steroid Biochemistry and Molecular Biology , vol.55 , pp. 409-412
    • Lønning, P.E.1    Ekse, D.2
  • 106
    • 44449175702 scopus 로고    scopus 로고
    • Indications and limitations of third-gene ration aromatase inhibitors
    • doi:10.1517/13543784.17.5.723
    • Lønning PE & Geisler J 2008 Indications and limitations of third-gene ration aromatase inhibitors. Expert Opinion on Investigational Drugs 17 723-739. (doi:10.1517/13543784.17.5.723)
    • (2008) Expert Opinion on Investigational Drugs , vol.17 , pp. 723-739
    • Lønning, P.E.1    Geisler, J.2
  • 107
    • 84888007767 scopus 로고    scopus 로고
    • Mapping genetic alterations causing chemoresistance in cancer; identifying the roads by tracking the drivers
    • in press. doi:10.1038/onc.2013.48
    • Lønning PE & Knappskog S 2013 Mapping genetic alterations causing chemoresistance in cancer; identifying the roads by tracking the drivers. Oncogene [in press]. (doi:10.1038/onc.2013.48)
    • (2013) Oncogene
    • Lønning, P.E.1    Knappskog, S.2
  • 108
    • 0023726485 scopus 로고
    • Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer
    • doi:10.2165/00003495-198835060-00005
    • Lønning PE & Kvinnsland S 1988 Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer. Drugs 35 685-710. (doi:10.2165/00003495-198835060-00005)
    • (1988) Drugs , vol.35 , pp. 685-710
    • Lønning, P.E.1    Kvinnsland, S.2
  • 109
    • 0023606126 scopus 로고
    • Alterations in the metabolism of oestrogens during treatment with aminoglutethimide in breast cancer patients. Preliminary findings
    • doi:10.2165/00003088-198713060-00004
    • Lønning PE, Kvinnsland S, Thorsen T & Ueland PM 1987 Alterations in the metabolism of oestrogens during treatment with aminoglutethimide in breast cancer patients. Preliminary findings. Clinical Pharmacokinetics 13 393-406. (doi:10.2165/00003088-198713060-00004)
    • (1987) Clinical Pharmacokinetics , vol.13 , pp. 393-406
    • Lønning, P.E.1    Kvinnsland, S.2    Thorsen, T.3    Ueland, P.M.4
  • 110
    • 0024321399 scopus 로고
    • Alterations in the production rate and the metabolism of oestrone and
    • doi:10.1038/bjc.1989.231
    • Lønning PE, Johannessen DC & Thorsen T 1989a Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide. British Journal of Cancer 60 107-111. (doi:10.1038/bjc.1989.231)
    • (1989) British Journal of Cancer , vol.60 , pp. 107-111
    • Lønning, P.E.1    Johannessen, D.C.2    Thorsen, T.3
  • 112
    • 0024581375 scopus 로고
    • Separation of urinary metabolites of radiolabelled estrogens in man by HPLC
    • doi:10.1016/0022-4731(89)90019-8
    • Lønning PE, Skulstad P, Sunde A & Thorsen T 1989b Separation of urinary metabolites of radiolabelled estrogens in man by HPLC. Journal of Steroid Biochemistry 32 91-97. (doi:10.1016/0022-4731(89)90019-8)
    • (1989) Journal of Steroid Biochemistry , vol.32 , pp. 91-97
    • Lønning, P.E.1    Skulstad, P.2    Sunde, A.3    Thorsen, T.4
  • 113
    • 0025305715 scopus 로고
    • Postmenopausal estrogen synthesis and metabolism: Alterations caused by aromatase inhibitors used for the treatment of breast cancer
    • doi:10.1016/0022-4731(90)90241-J
    • Lønning PE, Dowsett M & Powles TJ 1990 Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer. Journal of Steroid Biochemistry 35 355-366. (doi:10.1016/0022-4731(90)90241-J)
    • (1990) Journal of Steroid Biochemistry , vol.35 , pp. 355-366
    • Lønning, P.E.1    Dowsett, M.2    Powles, T.J.3
  • 116
    • 24644434439 scopus 로고    scopus 로고
    • Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer
    • doi:10.1200/JCO.2005.07.097
    • Lønning PE, Geisler J, Krag LE, Erikstein B, Bremnes Y, Hagen AI, Schlichting E, Lien EA, Ofjord ES, Paolini J et al. 2005 Effects of exemestane administered for 2 years versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer. Journal of Clinical Oncology 23 5126-5137. (doi:10.1200/JCO.2005.07.097)
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 5126-5137
    • Lønning, P.E.1    Geisler, J.2    Krag, L.E.3    Erikstein, B.4    Bremnes, Y.5    Hagen, A.I.6    Schlichting, E.7    Lien, E.A.8    Ofjord, E.S.9    Paolini, J.10
  • 117
    • 70249096223 scopus 로고    scopus 로고
    • Tissue estradiol is selectively elevated in receptor positive breast cancers while tumour estrone is reduced independent of receptor status
    • doi:10.1016/j.jsbmb.2009.06.005
    • Lønning PE, Helle H, Duong NK, Ekse D, Aas T & Geisler J 2009 Tissue estradiol is selectively elevated in receptor positive breast cancers while tumour estrone is reduced independent of receptor status. Journal of Steroid Biochemistry and Molecular Biology 117 31-41. (doi:10.1016/j.jsbmb.2009. 06.005)
    • (2009) Journal of Steroid Biochemistry and Molecular Biology , vol.117 , pp. 31-41
    • Lønning, P.E.1    Helle, H.2    Duong, N.K.3    Ekse, D.4    Aas, T.5    Geisler, J.6
  • 119
    • 0026698078 scopus 로고
    • The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer
    • doi:10.1038/bjc.1992.339
    • MacNeill FA, Jones AL, Jacobs S, Lønning PE, Powles TJ & Dowsett M 1992 The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer. British Journal of Cancer 66 692-697. (doi:10.1038/bjc.1992.339)
    • (1992) British Journal of Cancer , vol.66 , pp. 692-697
    • MacNeill, F.A.1    Jones, A.L.2    Jacobs, S.3    Lønning, P.E.4    Powles, T.J.5    Dowsett, M.6
  • 120
    • 0028275330 scopus 로고
    • Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: Effects on aromatase inhibition and oestrogen suppression
    • doi:10.1038/bjc.1994.230
    • MacNeill FA, Jacobs S, Lønning PE, Powles TJ & Dowsett M 1994 Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and oestrogen suppression. British Journal of Cancer 69 1171-1175. (doi:10.1038/bjc.1994.230)
    • (1994) British Journal of Cancer , vol.69 , pp. 1171-1175
    • MacNeill, F.A.1    Jacobs, S.2    Lønning, P.E.3    Powles, T.J.4    Dowsett, M.5
  • 121
    • 0029058421 scopus 로고
    • The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients
    • doi:10.1007/BF00685855
    • MacNeill FA, Jacobs S, Dowsett M, Lonning PE & Powles TJ 1995 The effects of oral 4-hydroxyandrostenedione on peripheral aromatisation in post-menopausal breast cancer patients. Cancer Chemotherapy and Pharmacology 36 249-254. (doi:10.1007/BF00685855)
    • (1995) Cancer Chemotherapy and Pharmacology , vol.36 , pp. 249-254
    • MacNeill, F.A.1    Jacobs, S.2    Dowsett, M.3    Lonning, P.E.4    Powles, T.J.5
  • 122
    • 42949104549 scopus 로고    scopus 로고
    • Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: Intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial
    • doi:10.1200/JCO.2007.14.0228
    • Mamounas EP, Jeong JH, Wickerham DL, Smith RE, Ganz PA, Land SR, Eisen A, Fehrenbacher L, Farrar WB, Atkins JN et al. 2008 Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trial. Journal of Clinical Oncology 26 1965-1971. (doi:10.1200/JCO.2007.14.0228)
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 1965-1971
    • Mamounas, E.P.1    Jeong, J.H.2    Wickerham, D.L.3    Smith, R.E.4    Ganz, P.A.5    Land, S.R.6    Eisen, A.7    Fehrenbacher, L.8    Farrar, W.B.9    Atkins, J.N.10
  • 127
    • 84859159091 scopus 로고    scopus 로고
    • Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2-3 years of tamoxifen: A retrospective analysis of the Intergroup Exemestane Study
    • doi:10.1016/S1470-2045(11)70328-X
    • Mieog JSD, Morden JP, Bliss JM, Coombes RC, van de Velde CJH & Comm IESS 2012 Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2-3 years of tamoxifen: a retrospective analysis of the Intergroup Exemestane Study. Lancet Oncology 13 420-432. (doi:10.1016/S1470-2045(11)70328-X)
    • (2012) Lancet Oncology , vol.13 , pp. 420-432
    • Mieog, J.S.D.1    Morden, J.P.2    Bliss, J.M.3    Coombes, R.C.4    Van De Velde, C.J.H.5    Comm, I.E.S.S.6
  • 128
    • 0031739178 scopus 로고    scopus 로고
    • Effects of letrozole as primary medical therapy on in situ oestrogen synthesis and endogenous oestrogen levels within the breast
    • doi:10.1016/S0960-9776(98)90095-9
    • Miller WR, Telford J, Love C, Leonard RCF, Hillier S, Gundacker H, Smith H & Dixon JM 1998 Effects of letrozole as primary medical therapy on in situ oestrogen synthesis and endogenous oestrogen levels within the breast. Breast 7 273-276. (doi:10.1016/S0960-9776(98)90095-9)
    • (1998) Breast , vol.7 , pp. 273-276
    • Miller, W.R.1    Telford, J.2    Love, C.3    Leonard, R.C.F.4    Hillier, S.5    Gundacker, H.6    Smith, H.7    Dixon, J.M.8
  • 130
    • 81755162797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
    • doi:10.1200/JCO.2010.34.4879
    • Miller TW, Balko JM & Arteaga CL 2011 Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. Journal of Clinical Oncology 29 4452-4461. (doi:10.1200/JCO.2010.34.4879)
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 4452-4461
    • Miller, T.W.1    Balko, J.M.2    Arteaga, C.L.3
  • 134
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • doi:10.1210/jc.80.12.3689
    • Morishima A, Grumbach MM, Simpson ER, Fisher C & Qin K 1995 Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. Journal of Clinical Endocrinology and Metabolism 80 3689-3698. (doi:10.1210/jc.80.12.3689)
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 3689-3698
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 137
    • 0038460245 scopus 로고    scopus 로고
    • Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: Analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    • doi:10.1200/JCO.2003.04.194
    • Mouridsen H, Gershanovich M, Sun Y, Perez-Carrion R, Boni C, Monnier A, Apffelstaedt J, Smith R, Sleeboom HP, Jaenicke F et al. 2003 Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group. Journal of Clinical Oncology 21 2101-2109. (doi:10.1200/JCO.2003.04.194)
    • (2003) Journal of Clinical Oncology , vol.21 , pp. 2101-2109
    • Mouridsen, H.1    Gershanovich, M.2    Sun, Y.3    Perez-Carrion, R.4    Boni, C.5    Monnier, A.6    Apffelstaedt, J.7    Smith, R.8    Sleeboom, H.P.9    Jaenicke, F.10
  • 139
    • 84868204904 scopus 로고    scopus 로고
    • Body size and breast cancer prognosis in relation to hormone receptor and menopausal status: A meta-analysis
    • doi:10.1007/s10549-012-2073-x
    • Niraula S, Ocana A, Ennis M & Goodwin PJ 2012 Body size and breast cancer prognosis in relation to hormone receptor and menopausal status: a meta-analysis. Breast Cancer Research and Treatment 134 769-781. (doi:10.1007/s10549-012-2073-x)
    • (2012) Breast Cancer Research and Treatment , vol.134 , pp. 769-781
    • Niraula, S.1    Ocana, A.2    Ennis, M.3    Goodwin, P.J.4
  • 141
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
    • doi:10.1200/JCO.2002.10.058
    • Osborne CK, Pippen J, Jones SE, Parker LM, Ellis M, Come S, Gertler SZ, May JT, Burton G, Dimery I et al. 2002 Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. Journal of Clinical Oncology 20 3386-3395. (doi:10.1200/JCO.2002.10.058)
    • (2002) Journal of Clinical Oncology , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3    Parker, L.M.4    Ellis, M.5    Come, S.6    Gertler, S.Z.7    May, J.T.8    Burton, G.9    Dimery, I.10
  • 144
    • 33747058527 scopus 로고    scopus 로고
    • Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: A companion study to NCICCTG MA.17
    • doi:10.1200/JCO.2005.05.4882
    • Perez EA, Josse RG, Pritchard KI, Ingle JN, Martino S, Findlay BP, Shenkier TN, Tozer RG, Palmer MJ, Shepherd LE et al. 2006 Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCICCTG MA.17. Journal of Clinical Oncology 24 3629-3635. (doi:10.1200/JCO.2005.05.4882)
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 3629-3635
    • Perez, E.A.1    Josse, R.G.2    Pritchard, K.I.3    Ingle, J.N.4    Martino, S.5    Findlay, B.P.6    Shenkier, T.N.7    Tozer, R.G.8    Palmer, M.J.9    Shepherd, L.E.10
  • 145
    • 79960128817 scopus 로고    scopus 로고
    • Impact of body mass index on the efficacy of endocrine therapy in premenopausal patients with breast cancer: An analysis of the prospective ABCSG-12 trial
    • doi:10.1200/JCO.2010.33.2585
    • Pfeiler G, Königsberg R, Fesl C, Mlineritsch B, Stoeger H, Singer CF, Pöstlberger S, Steger GG, Seifert M, Dubsky P et al. 2011 Impact of body mass index on the efficacy of endocrine therapy in premenopausal patients with breast cancer: an analysis of the prospective ABCSG-12 trial. Journal of Clinical Oncology 29 2653-2659. (doi:10.1200/JCO.2010.33.2585)
    • (2011) Journal of Clinical Oncology , vol.29 , pp. 2653-2659
    • Pfeiler, G.1    Königsberg, R.2    Fesl, C.3    Mlineritsch, B.4    Stoeger, H.5    Singer, C.F.6    Pöstlberger, S.7    Steger, G.G.8    Seifert, M.9    Dubsky, P.10
  • 146
    • 0019463514 scopus 로고
    • Plasma oestrone, oestradiol and androstenedione levels in post-menopausal women: Relation to body weight and height
    • doi:10.1016/0378-5122(81)90021-9
    • Poortman J, Thijssen JHH & Waard FD 1981 Plasma oestrone, oestradiol and androstenedione levels in post-menopausal women: relation to body weight and height. Maturitas 3 65-71. (doi:10.1016/0378-5122(81)90021-9)
    • (1981) Maturitas , vol.3 , pp. 65-71
    • Poortman, J.1    Thijssen, J.H.H.2    Waard, F.D.3
  • 147
    • 0030070093 scopus 로고    scopus 로고
    • Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women
    • Powles TJ, Hickish T, Kanis JA, Tidy A & Ashley S 1996 Effect of tamoxifen on bone mineral density measured by dual-energy X-ray absorptiometry in healthy premenopausal and postmenopausal women. Journal of Clinical Oncology 14 78-84. (Pubitemid 26022463)
    • (1996) Journal of Clinical Oncology , vol.14 , Issue.1 , pp. 78-84
    • Powles, T.J.1    Hickish, T.2    Kanis, J.A.3    Tidy, A.4    Ashley, S.5
  • 148
    • 78650969715 scopus 로고    scopus 로고
    • Effect of obesity on survival of women with breast cancer: Systematic review and meta-analysis
    • doi:10.1007/s10549-010-0990-0
    • Protani M, Coory M & Martin JH 2010 Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Research and Treatment 123 627-635. (doi:10.1007/s10549-010-0990-0)
    • (2010) Breast Cancer Research and Treatment , vol.123 , pp. 627-635
    • Protani, M.1    Coory, M.2    Martin, J.H.3
  • 149
    • 37549056583 scopus 로고    scopus 로고
    • Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrineresponsive early breast cancer: Supplementary results from the BIG 1-98 randomised trial
    • doi:10.1016/S1470-2045(07)70386-8
    • Rasmussen BB, Regan MM, Lykkesfeldt AE, Dell'Orto P, Del Curto B, Henriksen KL, Mastropasqua MG, Price KN, Méry E, Lacroix-Triki M et al. 2008 Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrineresponsive early breast cancer: supplementary results from the BIG 1-98 randomised trial. Lancet Oncology 9 23-28. (doi:10.1016/S1470-2045(07)70386-8)
    • (2008) Lancet Oncology , vol.9 , pp. 23-28
    • Rasmussen, B.B.1    Regan, M.M.2    Lykkesfeldt, A.E.3    Dell'Orto, P.4    Del Curto, B.5    Henriksen, K.L.6    Mastropasqua, M.G.7    Price, K.N.8    Méry, E.9    Lacroix-Triki, M.10
  • 150
    • 81255157751 scopus 로고    scopus 로고
    • Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: The BIG 1-98 randomised clinical trial at 8.1 years median follow-up
    • doi:10.1016/S1470-2045(11)70270-4
    • Regan MM, Neven P, Giobbie-Hurder A, Goldhirsch A, Ejlertsen B, Mauriac L, Forbes JF, Smith I, Láng I, Wardley A et al. 2011 Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8.1 years median follow-up. Lancet Oncology 12 1101-1108. (doi:10.1016/S1470-2045(11)70270-4)
    • (2011) Lancet Oncology , vol.12 , pp. 1101-1108
    • Regan, M.M.1    Neven, P.2    Giobbie-Hurder, A.3    Goldhirsch, A.4    Ejlertsen, B.5    Mauriac, L.6    Forbes, J.F.7    Smith, I.8    Láng, I.9    Wardley, A.10
  • 151
    • 84868207599 scopus 로고    scopus 로고
    • Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: Follow-up analysis from the randomized 'FIRST' study
    • doi:10.1007/s10549-012-2192-4
    • Robertson JF, Lindemann JP, Llombart-Cussac A, Rolski J, Feltl D, Dewar J, Emerson L, Dean A & Ellis MJ 2012 Fulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized 'FIRST' study. Breast Cancer Research and Treatment 136 503-511. (doi:10.1007/s10549-012-2192-4)
    • (2012) Breast Cancer Research and Treatment , vol.136 , pp. 503-511
    • Robertson, J.F.1    Lindemann, J.P.2    Llombart-Cussac, A.3    Rolski, J.4    Feltl, D.5    Dewar, J.6    Emerson, L.7    Dean, A.8    Ellis, M.J.9
  • 152
    • 70349570680 scopus 로고    scopus 로고
    • Aromatase deficiency in men: A clinical perspective. Nature Reviews
    • doi:10.1038/nrendo.2009.176
    • Rochira V & Carani C 2009 Aromatase deficiency in men: a clinical perspective. Nature Reviews. Endocrinology 5 559-568. (doi:10.1038/nrendo.2009. 176)
    • (2009) Endocrinology , vol.5 , pp. 559-568
    • Rochira, V.1    Carani, C.2
  • 153
    • 79960264282 scopus 로고    scopus 로고
    • Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance
    • doi:10.1016/j.mce.2010.09.005
    • Sabnis G & Brodie A 2011 Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance. Molecular and Cellular Endocrinology 340 142-147. (doi:10.1016/j.mce.2010.09. 005)
    • (2011) Molecular and Cellular Endocrinology , vol.340 , pp. 142-147
    • Sabnis, G.1    Brodie, A.2
  • 154
    • 0018904804 scopus 로고
    • Preservation of androgen secretion during estrogen suppression with aminoglutethimide in the treatment ofmetastatic breast carcinoma
    • doi:10.1172/JCI109705
    • Samojlik E, Veldhuis JD, Wells SA & Santen RJ 1980 Preservation of androgen secretion during estrogen suppression with aminoglutethimide in the treatment ofmetastatic breast carcinoma. Journal of Clinical Investigation 65 602-612. (doi:10.1172/JCI109705)
    • (1980) Journal of Clinical Investigation , vol.65 , pp. 602-612
    • Samojlik, E.1    Veldhuis, J.D.2    Wells, S.A.3    Santen, R.J.4
  • 155
    • 0019836937 scopus 로고
    • Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: A review
    • doi:10.1007/BF01806259
    • Santen RJ 1981 Suppression of estrogens with aminoglutethimide and hydrocortisone (medical adrenalectomy) as treatment of advanced breast carcinoma: a review. Breast Cancer Research 1 183-202. (doi:10.1007/BF01806259)
    • (1981) Breast Cancer Research , vol.1 , pp. 183-202
    • Santen, R.J.1
  • 156
    • 0016144225 scopus 로고
    • Successful medical adrenalectomy with aminoglutethimide
    • doi:10.1001/jama.1974.03240120029015
    • Santen RJ, Lipton A & Kendall J 1974 Successful medical adrenalectomy with aminoglutethimide. Journal of the American Medical Association 230 1661-1665. (doi:10.1001/jama.1974.03240120029015)
    • (1974) Journal of the American Medical Association , vol.230 , pp. 1661-1665
    • Santen, R.J.1    Lipton, A.2    Kendall, J.3
  • 157
    • 0018217717 scopus 로고
    • Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma
    • doi:10.1210/jcem-47-6-1257
    • Santen RJ, Santner S, Davis B, Veldhuis J, Samojlik E & Ruby E 1978 Aminoglutethimide inhibits extraglandular estrogen production in postmenopausal women with breast carcinoma. Journal of Clinical Endocrinology and Metabolism 47 1257-1265. (doi:10.1210/jcem-47-6-1257)
    • (1978) Journal of Clinical Endocrinology and Metabolism , vol.47 , pp. 1257-1265
    • Santen, R.J.1    Santner, S.2    Davis, B.3    Veldhuis, J.4    Samojlik, E.5    Ruby, E.6
  • 163
    • 77649129731 scopus 로고    scopus 로고
    • Aromatase inhibitor-induced carpal tunnel syndrome: Results from the ATAC trial
    • doi:10.1200/JCO.2009.22.0236
    • Sestak I, Sapunar F & Cuzick J 2009 Aromatase inhibitor-induced carpal tunnel syndrome: results from the ATAC trial. Journal of Clinical Oncology 27 4961-4965. (doi:10.1200/JCO.2009.22.0236)
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 4961-4965
    • Sestak, I.1    Sapunar, F.2    Cuzick, J.3
  • 164
    • 77955296639 scopus 로고    scopus 로고
    • Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: An exploratory analysis from the ATAC trial
    • doi:10.1200/JCO.2009.27.2021
    • Sestak I, Distler W, Forbes JF, Dowsett M, Howell A & Cuzick J 2010 Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial. Journal of Clinical Oncology 28 3411-3415. (doi:10.1200/JCO.2009.27.2021)
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 3411-3415
    • Sestak, I.1    Distler, W.2    Forbes, J.F.3    Dowsett, M.4    Howell, A.5    Cuzick, J.6
  • 165
    • 0029036407 scopus 로고
    • Endocrine activity of the postmenopausal ovary: The effects of pituitary down-regulation and oophorectomy
    • doi:10.1210/jc.80.7.2163
    • Sluijmer AV, Heineman MA, Jong FHD & Evers JLH 1995 Endocrine activity of the postmenopausal ovary: the effects of pituitary down-regulation and oophorectomy. Journal of Clinical Endocrinology and Metabolism 80 2163-2167. (doi:10.1210/jc.80.7.2163)
    • (1995) Journal of Clinical Endocrinology and Metabolism , vol.80 , pp. 2163-2167
    • Sluijmer, A.V.1    Heineman, M.A.2    Jong, F.H.D.3    Evers, J.L.H.4
  • 166
    • 24644490871 scopus 로고    scopus 로고
    • Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: The Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial
    • doi:10.1200/JCO.2005.04.005
    • Smith IE, Dowsett M, Ebbs SR, Dixon JM, Skene A, Blohmer JU, Ashley SE, Francis S, Boeddinghaus I & Walsh G 2005 Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. Journal of Clinical Oncology 23 5108-5116. (doi:10.1200/JCO.2005.04.005)
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 5108-5116
    • Smith, I.E.1    Dowsett, M.2    Ebbs, S.R.3    Dixon, J.M.4    Skene, A.5    Blohmer, J.U.6    Ashley, S.E.7    Francis, S.8    Boeddinghaus, I.9    Walsh, G.10
  • 168
    • 0035925617 scopus 로고    scopus 로고
    • Scottish adjuvant tamoxifen trial: A randomized study updated to 15 years
    • doi:10.1093/jnci/93.6.456
    • Stewart HJ, Prescott RJ & Forrest APM 2001 Scottish adjuvant tamoxifen trial: a randomized study updated to 15 years. Journal of the National Cancer Institute 93 456-462. (doi:10.1093/jnci/93.6.456)
    • (2001) Journal of the National Cancer Institute , vol.93 , pp. 456-462
    • Stewart, H.J.1    Prescott, R.J.2    Forrest, A.P.M.3
  • 169
    • 0030479062 scopus 로고    scopus 로고
    • Postchemotherapy adjuvant tamoxifen therapy beyond five years in patients with lymph node-positive breast cancer
    • doi:10.1093/jnci/88.24.1828
    • Tormey DC, Gray R & Falkson HC 1996 Postchemotherapy adjuvant tamoxifen therapy beyond five years in patients with lymph node-positive breast cancer. Journal of the National Cancer Institute 88 1828-1833. (doi:10.1093/jnci/88.24.1828)
    • (1996) Journal of the National Cancer Institute , vol.88 , pp. 1828-1833
    • Tormey, D.C.1    Gray, R.2    Falkson, H.C.3
  • 170
    • 0000320653 scopus 로고
    • Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial
    • doi:10.1001/jama.1995.03520270033028
    • Trial TW 1995 Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The postmenopausal estrogen/progestin interventions (PEPI) trial. Journal of the American Medical Association 273 199-208. (doi:10.1001/jama.1995.03520270033028)
    • (1995) Journal of the American Medical Association , vol.273 , pp. 199-208
    • Trial, T.W.1
  • 174
    • 84867138398 scopus 로고    scopus 로고
    • mTOR inhibitors in the management of hormone receptor-positive breast cancer: The latest evidence and future directions
    • doi:10.1093/annonc/mds075
    • Villarreal-Garza C, Cortes J, Andre F & Verma S 2012 mTOR inhibitors in the management of hormone receptor-positive breast cancer: the latest evidence and future directions. Annals of Oncology 23 2526-2535. (doi:10.1093/annonc/mds075)
    • (2012) Annals of Oncology , vol.23 , pp. 2526-2535
    • Villarreal-Garza, C.1    Cortes, J.2    Andre, F.3    Verma, S.4
  • 175
    • 20044380552 scopus 로고    scopus 로고
    • The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L)
    • doi:10.1093/annonc/mdi158
    • Wasan KM, Goss PE, Pritchard PH, Shepherd L, Palmer MJ, Liu S, Tu D, Ingle JN, Heath M, Deangelis D et al. 2005 The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L). Annals of Oncology 16 707-715. (doi:10.1093/annonc/mdi158)
    • (2005) Annals of Oncology , vol.16 , pp. 707-715
    • Wasan, K.M.1    Goss, P.E.2    Pritchard, P.H.3    Shepherd, L.4    Palmer, M.J.5    Liu, S.6    Tu, D.7    Ingle, J.N.8    Heath, M.9    Deangelis, D.10
  • 176
    • 84871568254 scopus 로고    scopus 로고
    • Enhanced expression of the PDGFR/Abl signaling pathway in aromatase inhibitor-resistant breast cancer
    • doi:10.1093/annonc/mds240
    • Weigel MT, Banerjee S, Arnedos M, Salter J, A'Hern R, Dowsett M & Martin LA 2013 Enhanced expression of the PDGFR/Abl signaling pathway in aromatase inhibitor-resistant breast cancer. Annals of Oncology 24 126-133. (doi:10.1093/annonc/mds240)
    • (2013) Annals of Oncology , vol.24 , pp. 126-133
    • Weigel, M.T.1    Banerjee, S.2    Arnedos, M.3    Salter, J.4    A'Hern, R.5    Dowsett, M.6    Martin, L.A.7
  • 177
    • 79960732694 scopus 로고    scopus 로고
    • PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs
    • doi:10.1038/onc.2011.42
    • Weigelt B, Warne PH & Downward J 2011 PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene 30 3222-3233. (doi:10.1038/onc.2011.42)
    • (2011) Oncogene , vol.30 , pp. 3222-3233
    • Weigelt, B.1    Warne, P.H.2    Downward, J.3
  • 178
    • 84867904099 scopus 로고    scopus 로고
    • Effects of vaginal estrogens on serum estradiol levels in postmenopausal breast cancer survivors and women at risk of breast cancer taking an aromatase inhibitor or a selective estrogen receptor modulator
    • doi:10.1200/JOP.2011.000352
    • Wills S, Ravipati A, Venuturumilli P, Kresge C, Folkerd E, Dowsett M, Hayes DF & Decker DA 2012 Effects of vaginal estrogens on serum estradiol levels in postmenopausal breast cancer survivors and women at risk of breast cancer taking an aromatase inhibitor or a selective estrogen receptor modulator. Journal of Oncology Practice 8 144-148. (doi:10.1200/JOP.2011.000352)
    • (2012) Journal of Oncology Practice , vol.8 , pp. 144-148
    • Wills, S.1    Ravipati, A.2    Venuturumilli, P.3    Kresge, C.4    Folkerd, E.5    Dowsett, M.6    Hayes, D.F.7    Decker, D.A.8
  • 179
    • 84872518645 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer
    • doi:10.1200/JCO.2011.38.3331
    • Wolff AC, Lazar AA, Bondarenko I, Garin AM, Brincat S, Chow L, Sun Y, Neskovic-Konstantinovic Z, Guimaraes RC, Fumoleau P et al. 2013 Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. Journal of Clinical Oncology 31 195-202. (doi:10.1200/JCO.2011. 38.3331)
    • (2013) Journal of Clinical Oncology , vol.31 , pp. 195-202
    • Wolff, A.C.1    Lazar, A.A.2    Bondarenko, I.3    Garin, A.M.4    Brincat, S.5    Chow, L.6    Sun, Y.7    Neskovic-Konstantinovic, Z.8    Guimaraes, R.C.9    Fumoleau, P.10
  • 180
    • 73949088959 scopus 로고    scopus 로고
    • Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: A phase II trial
    • doi:10.1200/JCO.2009.24.2669
    • Yao JC, Lombard-Bohas C, Baudin E, Kvols LK, Rougier P, Ruszniewski P, Hoosen S, St Peter J, Haas T, Lebwohl D et al. 2010 Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial. Journal of Clinical Oncology 28 69-76. (doi:10.1200/JCO.2009.24.2669)
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 69-76
    • Yao, J.C.1    Lombard-Bohas, C.2    Baudin, E.3    Kvols, L.K.4    Rougier, P.5    Ruszniewski, P.6    Hoosen, S.7    St Peter, J.8    Haas, T.9    Lebwohl, D.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.