Digestive physiology of the pig symposium: Involvement of gut chemosensing in the regulation of mucosal barrier function and defense mechanisms

Journal of Animal Science

Volumn 91, Issue 5, 2013, Pages 1957-1962

  Kaji, I ^a,b,c,d,e   Akiba, Y ^a,b,c,d   Kaunitz, J D ^a,b,c,d  

^a Greater Los Angeles Veteran Affairs Healthcare System   (United States)

^b Brentwood Biomedical Research   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anion secretion; Bicarbonate; Duodenum; Enteroendocrine cells; Glucagon like peptides; Serotonin

Indexed keywords

EID: 84882730137     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2012-5941     Document Type: Article

References (32)

1. Akiba, Y., P. H. Guth, E. Engel, I. Nastaskin, and J. D. Kaunitz. 2000. Dynamic regulation of mucus gel thickness in rat duodenum. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G437-G447.
2. Akiba, Y., and J. D. Kaunitz. 1999. Regulation of intracellular pH and blood flow in rat duodenal epithelium in vivo. Am. J. Physiol. Gastrointest. Liver Physiol. 276:G293-G302.
3. Akiba, Y., C. Watanabe, M. Mizumori, and J. D. Kaunitz. 2009. Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 297:G781-G791.
4. Bezençon, C., A. Furholz, F. Raymond, R. Mansourian, S. Metairon, J. le Coutre, and S. Damak. 2008. Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells. J. Comp. Neurol. 509:514-525.
5. Bezençon, C., J. le Coutre, and S. Damak. 2007. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem. Senses 32:41-49.
6. Bjerknes, M., C. Khandanpour, T. Moroy, T. Fujiyama, M. Hoshino, T. J. Klisch, Q. Ding, L. Gan, J. Wang, M. G. Martin, and H. Cheng. 2012. Origin of the brush cell lineage in the mouse intestinal epithelium. Dev. Biol. 362:194-218.
7. Braun, T., P. Voland, L. Kunz, C. Prinz, and M. Gratzl. 2007. Enterochromaffin cells of the human gut: Sensors for spices and odorants. Gastroenterology 132:1890-1901.
8. 2+-sensing receptor in rat intestine. Am. J. Physiol. 274:G122-G130.
9. Cheng, H. 1974. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am. J. Anat. 141:521-535.
10. Dumoulin, V., F. Moro, A. Barcelo, T. Dakka, and J. C. Cuber. 1998. Peptide YY, glucagon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum. Endocrinology 139:3780-3786.
11. Gerbe, F., J. H. van Es, L. Makrini, B. Brulin, G. Mellitzer, S. Robine, B. Romagnolo, N. F. Shroyer, J. F. Bourgaux, C. Pignodel, H. Clevers, and P. Jay. 2011. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J. Cell Biol. 192:767-780.
12. Guan, X., H. E. Karpen, J. Stephens, J. T. Bukowski, S. Niu, G. Zhang, B. Stoll, M. J. Finegold, J. J. Holst, D. Hadsell, B. L. Nichols, and D. G. Burrin. 2006. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology 130:150-164.
13. Hass, N., K. Schwarzenbacher, and H. Breer. 2010. T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res. 339:493-504.
14. Hofer, D., B. Puschel, and D. Drenckhahn. 1996. Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc. Natl. Acad. Sci. U. S. A. 93:6631-6634.
15. Inoue, T., J. H. Wang, M. Higashiyama, S. Rudenkyy, K. Higuchi, P. H. Guth, E. Engel, J. D. Kaunitz, and Y. Akiba. 2012. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acidinduced bicarbonate secretion in rat duodenum. Am. J. Physiol. Gastrointest. Liver Physiol. 303:G810-G816.
16. Kawamata, Y., R. Fujii, M. Hosoya, M. Harada, H. Yoshida, M. Miwa, S. Fukusumi, Y. Habata, T. Itoh, Y. Shintani, S. Hinuma, Y. Fujisawa, and M. Fujino. 2003. A G protein-coupled receptor responsive to bile acids. J. Biol. Chem. 278:9435-9440.
17. Kidd, M., I. M. Modlin, B. I. Gustafsson, I. Drozdov, O. Hauso, and R. Pfragner. 2008. Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants. Am. J. Physiol. Gastrointest. Liver Physiol. 295:G260-G272.
18. Kokrashvili, Z., D. Rodriguez, V. Yevshayeva, H. Zhou, R. F. Margolskee, and B. Mosinger. 2009. Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology 137:598-606.
19. Lambeir, A. M., C. Durinx, S. Scharpe, and I. De Meester. 2003. Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit. Rev. Clin. Lab. Sci. 40:209-294.
20. Mace, O. J., J. Affleck, N. Patel, and G. L. Kellett. 2007. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J. Physiol. 582:379-392.
21. +-glucose cotransporter 1. Proc. Natl. Acad. Sci. U. S. A. 104:15075-15080.
22. Reimann, F., A. M. Habib, G. Tolhurst, H. E. Parker, G. J. Rogers, and F. M. Gribble. 2008. Glucose sensing in L cells: A primary cell study. Cell Metab. 8:532-539.
23. Roura, E., B. Humphrey, G. Tedo, and I. Ipharraguerre. 2008. Unfolding the codes of short-term feed appetence in farm and companion animals. A comparative oronasal nutrient sensing biology review. Can. J. Anim. Sci. 88:535-558.
24. Rozengurt, N., S. V. Wu, M. C. Chen, C. Huang, C. Sternini, and E. Rozengurt. 2006. Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. Am. J. Physiol. Gastrointest. Liver Physiol. 291:G792-G802.
25. San Gabriel, A. M., T. Maekawa, H. Uneyama, S. Yoshie, and K. Torii. 2007. mGluR1 in the fundic glands of rat stomach. FEBS Lett. 581:1119-1123.
26. Shi, P., and J. Zhang. 2006. Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol. Biol. Evol. 23:292-300.
27. Sjölund, K., G. Sanden, R. Hakanson, and F. Sundler. 1983. Endocrine cells in human intestine: An immunocytochemical study. Gastroenterology 85:1120-1130.
28. Theodorakis, M. J., O. Carlson, S. Michopoulos, M. E. Doyle, M. Juhaszova, K. Petraki, and J. M. Egan. 2006. Human duodenal enteroendocrine cells: Source of both incretin peptides, GLP-1 and GIP. Am. J. Physiol. Endocrinol. Metab. 290:E550-E559.
29. Thomas, C., A. Gioiello, L. Noriega, A. Strehle, J. Oury, G. Rizzo, A. Macchiarulo, H. Yamamoto, C. Mataki, M. Pruzanski, R. Pellicciari, J. Auwerx, and K. Schoonjans. 2009. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 10:167-177.
30. Tsubouchi, S., and C. P. Leblond. 1979. Migration and turnover of entero-endocrine and caveolated cells in the epithelium of the descending colon, as shown by radioautography after continuous infusion of 3H-thymidine into mice. Am. J. Anat. 156:431-451.
31. van der Flier, L. G., and H. Clevers. 2009. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu. Rev. Physiol. 71:241-260.
32. Wang, J. H., T. Inoue, M. Higashiyama, P. H. Guth, E. Engel, J. D. Kaunitz, and Y. Akiba. 2011. Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J. Pharmacol. Exp. Ther. 339:464-73.