Regulatory B-cell compartment in transfused alloimmunized and non-alloimmunized patients with sickle cell disease

American Journal of Hematology

Volumn 88, Issue 9, 2013, Pages 736-740

  Bao, Weili ^a   Zhong, Hui ^a   Manwani, Deepa ^b   Vasovic, Ljiljana ^b   Uehlinger, Joan ^b   Lee, Margaret T ^c   Sheth, Sujit ^d   Shi, Patricia ^a   Yazdanbakhsh, Karina ^a  

^a NEW YORK BLOOD CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NewYork Presbyterian Hospital   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD19 ANTIGEN; CD24 ANTIGEN; CD27 ANTIGEN; CD38 ANTIGEN; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ALLOIMMUNIZATION; ARTICLE; B LYMPHOCYTE; BLOOD TRANSFUSION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; LYMPHOCYTE DIFFERENTIATION; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SICKLE CELL ANEMIA;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; ANTIGENS, CD; B-LYMPHOCYTES, REGULATORY; BLOOD TRANSFUSION; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN ALLOTYPES; INTERLEUKIN-10; MALE; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84882676646     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23488     Document Type: Article

References (33)

1. Yazdanbakhsh K, Ware RE, Noizat-Pirenne F. Red blood cell alloimmunization in sickle cell disease: Pathophysiology, risk factors, and transfusion management. Blood 2012;120:528-537.
2. Vichinsky EP. Current issues with blood transfusions in sickle cell disease. Semin Hematol 2001;38:14-22.
3. Rosse WF, Gallagher D, Kinney TR, et al. Transfusion and alloimmunization in sickle cell disease. Blood 1990;76:1431-1437.
4. Gupta R, Singh DK, Singh B, et al. Alloimmunization to red cells in thalassemics: Emerging problem and future strategies. Transfus Apher Sci 2011;45:167-170.
5. Vichinsky EP, Earles A, Johnson RA, et al. Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood. N Engl J Med 1990;322:1617-1621.
6. Bauer MP, Wiersum-Osselton J, Schipperus M, et al. Clinical predictors of alloimmunization after red blood cell transfusion. Transfusion 2007;47:2066-2071.
7. Sarnaik S, Schornack J, Lusher JM. The incidence of development of irregular red cell antibodies in patients with sickle cell anemia. Transfusion 1986;26:249-252.
8. Cox JV, Steane E, Cunningham G, et al. Risk of alloimmunization and delayed hemolytic transfusion reactions in patients with sickle cell disease. Arch Intern Med 1988;148:2485-2489.
9. Higgins JM, Sloan SR. Stochastic modeling of human RBC alloimmunization: Evidence for a distinct population of immunologic responders. Blood 2008;112:2546-2553.
10. Tatari-Calderone Z, Minniti CP, Kratovil T, et al. rs660 Polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. Mol Immunol 2009;47:64-70.
11. Hendrickson JE, Chadwick TE, Roback JD, et al. Inflammation enhances consumption and presentation of transfused RBC antigens by dendritic cells. Blood 2007;110:2736-2743.
12. Yu J, Heck S, Yazdanbakhsh K. Prevention of red cell alloimmunization by CD25 regulatory T cells in mouse models. Am J Hematol 2007;82:691-696.
13. Smith NH, Hod EA, Spitalnik SL, et al. Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs. Blood 2012;119:1566-1569.
14. Mauri C, Bosma A. Immune regulatory function of B cells. Ann Rev Immunol 2012;30:221-241.
15. Fillatreau S, Sweenie CH, McGeachy MJ, et al. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 2002;3:944-950.
16. Moulin V, Andris F, Thielemans K, et al. B lymphocytes regulate dendritic cell (DC) function in vivo: Increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation. J Exp Med 2000;192:475-482.
17. Carter NA, Vasconcellos R, Rosser EC, et al. Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells. J Immunol 2011;186:5569-5579.
18. Amu S, Saunders SP, Kronenberg M, et al. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immun 2010;125:1114-1124.
19. Blair PA, Norena LY, Flores-Borja F, et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010;32:129-140.
20. Bouaziz JD, Calbo S, Maho-Vaillant M, et al. IL-10 produced by activated human B cells regulates CD4(+) T-cell activation in vitro. Eur J Immunol 2010;40:2686-2691.
21. Iwata Y, Matsushita T, Horikawa M, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117:530-541.
22. Bao W, Zhong H, Li X, et al. Immune regulation in chronically transfused allo-antibody responder and nonresponder patients with sickle cell disease and beta-thalassemia major. Am J Hematol 2011;86:1001-1006.
23. Pearson HA, McIntosh S, Ritchey AK, et al. Developmental aspects of splenic function in sickle cell diseases. Blood 1979;53:358-365.
24. Bao W, Bussel JB, Heck S, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood 2010;116:4639-4645.
25. Dwyer J, Wood C, McNamara J, et al. Abnormalities in the immune system of children with beta-thalassaemia major. Clin Exp Immunol 1987;68:621-629.
26. Pattanapanyasat K, Thepthai C, Lamchiagdhase P, et al. Lymphocyte subsets and specific T-cell immune response in thalassemia. Cytometry 2000;42:11-17.
27. Consolini R, Calleri A, Legitimo A, et al. Immunological evaluation of patients with beta-thalassemia major. Acta Haematol 2001;105:7-12.
28. Al-Awadhi AM, Alfadhli SM, Al-Khaldi D, et al. Investigation of the distribution of lymphocyte subsets and zinc levels in multitransfused beta-thalassemia major patients. Int J Lab Hematol 2010;32:191-196.
29. Wong WY, Powars DR, Operskalski EA, et al. Blood transfusions and immunophenotypic alterations of lymphocyte subsets in sickle cell anemia. The Transfusion Safety Study Group. Blood 1995;85:2091-2097.
30. Ballester OF, Abdallah JM, Prasad AS. Lymphocyte subpopulation abnormalities in sickle cell anemia: A distinctive pattern from that of AIDS. Am J Hematol 1986;21:23-27.
31. Taylor SC, Shacks SJ, Qu Z, et al. Type 2 cytokine serum levels in healthy sickle cell disease patients. J Natl Med Assoc 1997;89:753-757.
32. William BM, Corazza GR. Hyposplenism: A comprehensive review. Part I: Basic concepts and causes. Hematology 2007;12:1-13.
33. Carter NA, Rosser EC, Mauri C. Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Res Ther 2012;14:R32.