Investigation of the distribution of lymphocyte subsets and zinc levels in multitransfused β-thalassemia major patients

International Journal of Laboratory Hematology

Volumn 32, Issue 2, 2010, Pages 191-196

  Al Awadhi, A M ^a   Alfadhli, S M ^a   Al Khaldi, D ^b   Borhama, M ^b   Borusly, M ^c  

^a KUWAIT UNIVERSITY   (Kuwait)

^b AL SABAH HOSPITAL   (Kuwait)

^c Department of Hematology   (Kuwait)

Author keywords

Thalassemia major; Blood transfusion; Immunophenotyping; Iron chelation; Zinc

Indexed keywords

CD19 ANTIBODY; CD2 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DEFEROXAMINE MESYLATE; IRON;

ADOLESCENT; ADULT; ARTICLE; B LYMPHOCYTE; BETA THALASSEMIA; BLOOD TRANSFUSION; CELLULAR DISTRIBUTION; CHELATION THERAPY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; INFANT; IRON CHELATION; IRON STORAGE; KUWAIT; LYMPHOCYTE SUBPOPULATION; MALE; NATURAL KILLER CELL; PATIENT COMPLIANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; T LYMPHOCYTE; THALASSEMIA MAJOR; ZINC BLOOD LEVEL;

ADOLESCENT; ADULT; BETA-THALASSEMIA; BLOOD TRANSFUSION; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; LYMPHOCYTE SUBSETS; MALE; REFERENCE STANDARDS; ZINC;

EID: 77953582356     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2009.01161.x     Document Type: Article

References (23)

1. Akbar A.N., Fitzgerald-Bocarsly P.A., de Sousa M., Giardina P.J., Hilgartner M.W. & Grady R.W. (1986) Decreased natural killer activity in thalassemia major: a possible consequence of iron overload. Journal of Immunology 136, 1635-1640.
2. Al-Fuzae L., Aboolbacker K.C. & Al-Saleh Q. (1998) β-Thalassemia major in Kuwait. Journal of Tropical Pediatrics 44, 311-312.
3. Arcasoy A., Canatan D., Sinav B., Kutlay L., Oguz N. & Sen M. (2001) Serum zinc levels and zinc binding capacity in thalassemia. Journal of Trace Elements in Medicine and Biology 15, 85-87.
4. Bartakke S., Bavdekar S., Kondurkar P., Muranjan M., Manglani M. & Sharma R. (2005) Effect of deferiprone on urinary zinc excretion in multiply transfused children with thalassemia major. Indian Pediatrics 42, 150-154.
5. Consolini R., Calleri A., Legitimo A. & Massei F. (2001) Immunological evaluation of patients with beta-thalassemia major. Acta Haematologica 105, 7-12.
6. Cruz E., Melo G., Lacerda R., Almeida S. & Porto G. (2006) The CD8+ T-lymphocytes profile as a modifier of iron overload in HFE hemochromatosis: An update of clinical and immunological data from 70 C282Y homozygous subjects. Blood Cells, Molecules & Diseases 37, 33-39.
7. Cunningham-Rundles S., Bockman R.S., Lin A., Giardina P.V., Hilgartner M.W., Caldwell-Brown D. & Carter D.M. (1990) Physiological and pharmacological effects of zinc on the immune system. Annals of the New York Academy of Sciences 587, 113-122.
8. Cunningham-Rundles S., Giardina P.J., Grady R.W., Califano C., McKenzie P. & De Sousa M. (2000) Effects of transfusional iron overload on immune response. The Journal of Infectious Diseases 182(Suppl. 1), S115-S121.
9. De Montalembert M., Girot R., Mattlinger B. & Lefrere J. (1995) Transfusion dependent thalassemia: viral complications (epidemiology and follow-up). Seminars in Hematology 32, 280-287.
10. Dwyer J., Wood C., Mcnamara J., Williams A., Andiman W., Rink L., O'Conner T. & Pearson H. (1987) Abnormalities in the immune system of children with betathalassemia major. Clinical and experimental immunology 68, 621-629.
11. Ezner U., Gulderen F., Culha V.K., Akgul N. & Gurbuz O. (2002) Immunological status of thalassemia syndrome. Pediatric Hematology and Oncology 19, 51-58.
12. Grady R.W., Akbar A.N., Giardina P.J., Hilgartner M.W. & de Sousa M. (1985) Disproportionate lymphoid cell subsets in thalassemia major: the relative contributions of transfusion and splenectomy. British Journal of Haematology 59, 713-724.
13. Harmening D.M. (2002) Clinical Hematology and Fundamentals of Hemostasis, 4th edn. F.A. Davis Company, Philadelphia, PA.
14. Kajanachumpol S., Tatu T., Sasanakul W., Chuansumrit A. & Hathirat P. (1997) Zinc and copper status in thalassemic children. The Southeast Asian Journal of Tropical Medicine and Public Health 28, 877-880.
15. Li K., Li C.K., Wong R.P., Wong A., Shing M.M., Chik K.W. & Yuen P.M. (1997) Transfusion-related immunomodulation in Chinese children with thalassemia. Vox Sanguinis 73, 167-173.
16. Lombardi G., Matera R., Minervini M.M., Cascavilla N., D'Arcangelo P., Carotenuto M., Giorgio G.D. & Musto P. (1994) Serum levels of cytokines and soluble antigens in polytransfused patients with β-thalassemia major: relationship to immune status. Haematologica 79, 406-412.
17. Mehdizadeh M., Zamani G. & Tabatabaee S. (2008) Zinc status in patients with major beta-thalassemia. Pediatric Hematology and Oncology 25, 49-54.
18. Pattanapanyasat K., Thepthai C., Lamchiagdhase P., Lerdwana S., Tachavanich K., Thanomsuk P., Wanachiwanawin W., Fucharoen S. & Darden J.M. (2000) Lymphocyte subsets and specific T-cell immune response in thalassemia. Cytometry 42, 11-17.
19. Prati D. (2000) Benefits and complications of regular blood transfusion in patients with beta-thalassemia major. Vox Sanguinis 79, 129-137.
20. Rea F., Perrone L., Mastrobuono A., Toscano G. & D'Amico M. (1984) Zinc levels of serum, hair and urine in homozygous beta-thalassemic subjects under hypertransfusional treatment. Acta Haematologica 71, 139-142.
21. Umiel L., Friedman E., Luria D., Cohen I.J., Kaplinsky H., Netzer L., Pechet M., Trainin N. & Zaizov R. (1984) Impaired immune regulation in children and adolescents with hemophilia and thalassemia in Israel. The American Journal of Pediatric Hematology/Oncology 6, 371-387.
22. Walker E.M., Jr & Walker S.M. (2000) Effects of iron overload on the immune system. Annals of Clinical and Laboratory Science 30, 354-365.
23. Yadav S., Chattopadhya D., Prakash C., Kumari S. & Vergheese T. (1993) Role of transfusion-mediated viral infections on the lymphocyte subset profile in multi-transfused children. Journal of Tropical Pediatrics 39, 243-250.