Molecular Strategy to Reduce In Vivo Collagen Barrier Promotes Entry of NCX1 Positive Inducible Pluripotent Stem Cells (iPSCNCX1+) into Ischemic (or Injured) Myocardium

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Huang, Wei ^a   Dai, Bo ^a   Wen, Zhili ^a,b   Millard, Ronald W ^c   Yu, Xi Yong ^d   Luther, Kristin ^a   Xu, Meifeng ^a   Zhao, Ting C ^e   Yang, Huang Tian ^f   Qi, Zhihua ^g   LaSance, Kathleen ^g   Ashraf, Muhammad ^a   Wang, Yigang ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b NANCHANG UNIVERSITY   (China)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^g UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MICRORNA 29B; MIRNA 29B INHIBITOR; NCX1 PROTEIN; RNA ANTIBODY; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY DENSITY; CELL MIGRATION; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; ECHOCARDIOGRAPHY; EMBRYO; EMBRYO CELL; ENDOTHELIUM CELL; ENGRAFTMENT; FIBROBLAST; GENE OVEREXPRESSION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PERITONEUM; PLURIPOTENT STEM CELL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION; WESTERN BLOTTING;

ANIMALS; CELL MOVEMENT; COCULTURE TECHNIQUES; COLLAGEN; ECHOCARDIOGRAPHY; FIBROBLASTS; FIBROSIS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; INDUCED PLURIPOTENT STEM CELLS; LENTIVIRUS; MICE; MICRORNAS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NEOVASCULARIZATION, PATHOLOGIC; RATS; RATS, NUDE; SODIUM-CALCIUM EXCHANGER; TRANSFECTION; VENTRICULAR REMODELING; X-RAY MICROTOMOGRAPHY;

EID: 84882646441     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070023     Document Type: Article

References (33)

1. Nag AC, (1980) Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution. Cytobios 28: 41-61.
2. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, et al. (2008) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456: 980-984.
3. Diez J, (2009) Do microRNAs regulate myocardial fibrosis? Nat Clin Pract Cardiovasc Med 6: 88-89.
4. Huang W, Zhang D, Millard RW, Wang T, Zhao T, et al. (2010) Gene manipulated peritoneal cell patch repairs infarcted myocardium. J Mol Cell Cardiol 48: 702-712.
5. Simpson D, Liu H, Fan TH, Nerem R, Dudley SC Jr, (2007) A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling. Stem Cells 25: 2350-2357.
6. Dai B, Huang W, Xu M, Millard RW, Gao MH, et al. (2011) Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function. J Am Coll Cardiol 58: 2118-2127.
7. Samuel CS, Cendrawan S, Gao XM, Ming Z, Zhao C, et al. (2011) Relaxin remodels fibrotic healing following myocardial infarction. Lab Invest 91: 675-690.
8. van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, et al. (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 105: 13027-13032.
9. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
10. Catalucci D, Latronico MV, Condorelli G, (2008) MicroRNAs control gene expression: importance for cardiac development and pathophysiology. Ann N Y Acad Sci 1123: 20-29.
11. da Costa Martins PA, Bourajjaj M, Gladka M, Kortland M, van Oort RJ, et al. (2008) Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation 118: 1567-1576.
12. Takahashi K, Okita K, Nakagawa M, Yamanaka S, (2007) Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2: 3081-3089.
13. Stevens KR, Kreutziger KL, Dupras SK, Korte FS, Regnier M, et al. (2009) Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proc Natl Acad Sci U S A 106: 16568-16573.
14. Kusano KF, Pola R, Murayama T, Curry C, Kawamoto A, et al. (2005) Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med 11: 1197-1204.
15. Muller JG, Isomatsu Y, Koushik SV, O'Quinn M, Xu L, et al. (2002) Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model. Circ Res 90: 158-164.
16. Kammili RK, Taylor DG, Xia J, Osuala K, Thompson K, et al. (2010) Generation of novel reporter stem cells and their application for molecular imaging of cardiac-differentiated stem cells in vivo. Stem Cells Dev 19: 1437-1448.
17. Liang J, Huang W, Yu X, Ashraf A, Wary KK, et al. (2012) Suicide gene reveals the myocardial neovascularization role of mesenchymal stem cells overexpressing CXCR4 (MSC(CXCR4)). PLoS One 7: e46158.
18. Fleury S, Simeoni E, Zuppinger C, Deglon N, von Segesser LK, et al. (2003) Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo. Circulation 107: 2375-2382.
19. Dong S, Cheng Y, Yang J, Li J, Liu X, et al. (2009) MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem 284: 29514-29525.
20. Maubach G, Lim MC, Chen J, Yang H, Zhuo L, (2011) miRNA studies in in vitro and in vivo activated hepatic stellate cells. World J Gastroenterol 17: 2748-2773.
21. Iyer RK, Chiu LL, Reis LA, Radisic M, (2011) Engineered cardiac tissues. Curr Opin Biotechnol 22: 706-714.
22. Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, et al. (2010) Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res 107: 294-304.
23. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR, (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A 92: 7686-7689.
24. Pages G, Lenormand P, L'Allemain G, Chambard JC, Meloche S, et al. (1993) Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci U S A 90: 8319-8323.
25. Gaudesius G, Miragoli M, Thomas SP, Rohr S, (2003) Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin. Circ Res 93: 421-428.
26. Eghbali M, (1992) Cardiac fibroblasts: function, regulation of gene expression, and phenotypic modulation. Basic Res Cardiol 87 Suppl 2: 183-189.
27. Noseda M, Schneider MD, (2009) Fibroblasts inform the heart: control of cardiomyocyte cycling and size by age-dependent paracrine signals. Dev Cell 16: 161-162.
28. Sachse FB, Moreno AP, Abildskov JA, (2008) Electrophysiological modeling of fibroblasts and their interaction with myocytes. Ann Biomed Eng 36: 41-56.
29. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, et al. (1998) Mouse model of angiogenesis. Am J Pathol 152: 1667-1679.
30. Kwon HM, Sangiorgi G, Ritman EL, Lerman A, McKenna C, et al. (1998) Adventitial vasa vasorum in balloon-injured coronary arteries: visualization and quantitation by a microscopic three-dimensional computed tomography technique. J Am Coll Cardiol 32: 2072-2079.
31. Zagorchev L, Oses P, Zhuang ZW, Moodie K, Mulligan-Kehoe MJ, et al. (2010) Micro computed tomography for vascular exploration. J Angiogenes Res 2: 7.
32. Dufourcq P, Descamps B, Tojais NF, Leroux L, Oses P, et al. (2008) Secreted frizzled-related protein-1 enhances mesenchymal stem cell function in angiogenesis and contributes to neovessel maturation. Stem Cells 26: 2991-3001.
33. Rivard A, Isner JM, (1998) Angiogenesis and vasculogenesis in treatment of cardiovascular disease. Mol Med 4: 429-440.