Suicide Gene Reveals the Myocardial Neovascularization Role of Mesenchymal Stem Cells Overexpressing CXCR4 (MSCCXCR4)

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Liang, Jialiang ^a,b   Huang, Wei ^a   Yu, Xiyong ^b   Ashraf, Atif ^a   Wary, Kishore K ^c   Xu, Meifeng ^a   Millard, Ronald W ^a   Ashraf, Muhammad ^a   Wang, Yigang ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GANCICLOVIR; HYPOXIA INDUCIBLE FACTOR 1; MESSENGER RNA; THYMIDINE KINASE; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN A;

ANGIOGENESIS; ANGIOPIOETIN 1 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD31 GENE; CELL DIFFERENTIATION; CONTROLLED STUDY; ECHOCARDIOGRAPH; GENE; GENE FUNCTION; GENE OVEREXPRESSION; HEART INFARCTION; HEART INFARCTION SIZE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUICIDE GENE; THYMIDINE KINASE GENE; VASCULAR ENDOTHELIAL CADHERIN GENE; VASCULAR ENDOTHELIAL GROWTH FACTOR A GENE; WESTERN BLOTTING;

ANIMALS; ANOXIA; ANTIGENS, CD; CADHERINS; CELL DIFFERENTIATION; ENDOTHELIAL CELLS; GENE EXPRESSION; GENES, TRANSGENIC, SUICIDE; GENETIC VECTORS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LENTIVIRUS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4; STAT3 TRANSCRIPTION FACTOR; TRANSDUCTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

LENTIVIRUS; RATTUS;

EID: 84867005792     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046158     Document Type: Article

References (44)

1. Rivard A, Isner JM, (1998) Angiogenesis and vasculogenesis in treatment of cardiovascular disease. Mol Med 4: 429-440.
2. Ziebart T, Yoon CH, Trepels T, Wietelmann A, Braun T, et al. (2008) Sustained persistence of transplanted proangiogenic cells contributes to neovascularization and cardiac function after ischemia. Circ Res 103: 1327-1334.
3. Ripa RS, Haack-Sorensen M, Wang Y, Jorgensen E, Mortensen S, et al. (2007) Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial. Circulation 116: I24-I30.
4. Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, et al. (2006) Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 355: 1210-1221.
5. Jiang YH, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, et al. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. NATURE 418: 41-49.
6. Nombela-Arrieta C, Ritz J, Silberstein LE, (2011) The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol 12: 126-131.
7. Quevedo HC, Hatzistergos KE, Oskouei BN, Feigenbaum GS, Rodriguez JE, et al. (2009) Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A 106: 14022-14027.
8. Gnecchi M, Zhang Z, Ni A, Dzau VJ, (2008) Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 103: 1204-1219.
9. Yoon CH, Koyanagi M, Iekushi K, Seeger F, Urbich C, et al. (2010) Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment. Circulation 121: 2001-2011.
10. Oswald J, Boxberger S, Jorgensen B, Feldmann S, Ehninger G, et al. (2004) Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22: 377-384.
11. Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, et al. (2001) Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7: 430-436.
12. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, et al. (2003) Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 108S: 253-258.
13. Ziegelhoeffer T, Fernandez B, Kostin S, Heil M, Voswinckel R, et al. (2004) Bone marrow-derived cells do not incorporate into the adult growing vasculature. Circ Res 94: 230-238.
14. O'Neill TT, Wamhoff BR, Owens GK, Skalak TC, (2005) Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells. Circ Res 97: 1027-1035.
15. Perry TE, Song M, Despres DJ, Kim SM, San H, et al. (2009) Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction. Cardiovasc Res 84: 317-325.
16. Zhang D, Huang W, Dai B, Zhao T, Ashraf A, et al. (2010) Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts. Am J Physiol Heart Circ Physiol 299: H1339-H1347.
17. Huang W, Zhang D, Millard RW, Wang T, Zhao T, et al. (2010) Gene manipulated peritoneal cell patch repairs infarcted myocardium. J Mol Cell Cardiol 48: 702-712.
18. Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, et al. (2008) Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol 44: 281-292.
19. Ben-Shoshan J, Schwartz S, Luboshits G, Maysel-Auslender S, Barzelay A, et al. (2008) Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties. Stem Cells 26: 2634-2643.
20. Eun LY, Song BW, Cha MJ, Song H, Kim IK, et al. (2010) Overexpression of phosphoinositide-3-kinase class II alpha enhances mesenchymal stem cell survival in infarcted myocardium. Biochem Biophys Res Commun 402: 272-279.
21. Xu J, Liu X, Jiang Y, Chu L, Hao H, et al. (2008) MAPK/ERK signalling mediates VEGF-induced bone marrow stem cell differentiation into endothelial cell. J Cell Mol Med 12: 2395-2406.
22. Shabbir A, Zisa D, Lin H, Mastri M, Roloff G, et al. (2010) Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair. Am J Physiol Heart Circ Physiol 299: H1428-H1438.
23. Mullen CA, (1994) Metabolic suicide genes in gene therapy. Pharmacol Ther 63: 199-207.
24. Mavria G, Porter CD, (2001) Reduced growth in response to ganciclovir treatment of subcutaneous xenografts expressing HSV-tk in the vascular compartment. Gene Ther 8: 913-920.
25. Cowan CE, Kohler EE, Dugan TA, Mirza MK, Malik AB, et al. (2010) Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function. Circ Res 107: 959-966.
26. Dai B, Huang W, Xu M, Millard RW, Gao MH, et al. (2011) Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function. J Am Coll Cardiol 58: 2118-2127.
27. Wang Y, Zhang D, Ashraf M, Zhao T, Huang W, et al. (2010) Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol 298: H275-H286.
28. Caplan AI, Correa D, (2011) The MSC: An Injury Drugstore. Cell Stem Cell 9: 11-15.
29. Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, et al. (2007) Autocrine VEGF signaling is required for vascular homeostasis. Cell 130: 691-703.
30. Walshe TE, D'Amore PA, (2008) The role of hypoxia in vascular injury and repair. Annu Rev Pathol 3: 615-643.
31. Mohyeldin A, Garzon-Muvdi T, Quinones-Hinojosa A, (2010) Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 7: 150-161.
32. Majmundar AJ, Wong WJ, Simon MC, (2010) Hypoxia-Inducible Factors and the Response to Hypoxic Stress. Mol Cell 40: 294-309.
33. Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, et al. (2004) Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 117: 941-952.
34. Huber P, Dalmon J, Engiles J, Breviario F, Gory S, et al. (1996) Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Genomics 32: 21-28.
35. Gory S, Vernet M, Laurent M, Dejana E, Dalmon J, et al. (1999) The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice. Blood 93: 184-192.
36. Ganju RK, Brubaker SA, Meyer J, Dutt P, Yang Y, et al. (1998) The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 273: 23169-23175.
37. Zhang Y, Foudi A, Geay JF, Berthebaud M, Buet D, et al. (2004) Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells. Stem Cells 22: 1015-1029.
38. Venkatesan S, Rose JJ, Lodge R, Murphy PM, Foley JF, (2003) Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4. Mol Biol Cell 14: 3305-3324.
39. Huang C, Gu H, Zhang W, Manukyan MC, Shou W, et al. (2011) SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol 301: H1496-H1505.
40. Iwakura T, Mohri T, Hamatani T, Obana M, Yamashita T, et al. (2011) STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo. J Mol Cell Cardiol 51: 207-214.
41. Le Bras A, Lionneton F, Mattot V, Lelievre E, Caetano B, et al. (2007) HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites. Oncogene 26: 7480-7489.
42. Gory S, Dalmon J, Prandini MH, Kortulewski T, de Launoit Y, et al. (1998) Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription. J Biol Chem 273: 6750-6755.
43. Yin L, Ohanyan V, Pung YF, Delucia A, Bailey E, et al. (2012) Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth. Circ Res 110: 241-252.
44. Herbert SP, Stainier DY, (2011) Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol 12: 551-564.