Cellular Neurophysiology of Enteric Neurons

Physiology of the Gastrointestinal Tract

Volumn 1, Issue , 2012, Pages 629-669

  Wood, Jackie D ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882553979     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-382026-6.00021-X     Document Type: Chapter

References (334)

1. Wood JD Neuropathophysiology of functional gastrointestinal disorders. World J Gastroenterol 2007, 13:1313-1332.
2. Wood JD Enteric nervous system neuropathy: repair and restoration. Curr Opin Gastroenterol 2011, 27:106-111.
3. Antonucci A, Fronzoni L, Cogliandro L, Cogliandro RF, Caputo C, De Giorgio R, et al. Chronic intestinal pseudo-obstruction. World J Gastroenterol 2008, 14:2953-2961.
4. Buhner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, et al. Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology 2009, 137:1425-1434.
5. Di Nardo G, Blandizzi C, Volta U, Colucci R, Stanghellini V, Barbara G, et al. Review article: molecular, pathological and therapeutic features of human enteric neuropathies. Aliment Pharmacol Ther 2008, 28:25-42.
6. Vera G, Castillo M, Cabezos PA, Chiarlone A, Martin MI, Gori A, et al. Enteric neuropathy evoked by repeated cisplatin in the rat. Neurogastroenterol Motil 2011.
7. Larsson MH, Sapnara M, Thomas EA, Bornstein JC, Lindstrom E, Svensson DJ, et al. Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo. Am J Physiol Gastrointest Liver Physiol 2008, 294:G165-173.
8. Larsson MH, Simren M, Thomas EA, Bornstein JC, Lindstrom E, Sjovall H Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome. Neurogastroenterol Motil 2007, 19:812-820.
9. Lang IM, Sarna SK Motor and myoelectric activity associated with vomiting, regurgitation, and nausea. Handbook of Physiology, The Gastrointestinal System, Motility and Circulation 1989, 1179-1198. American Physiological Society, Bethesda, Maryland. J.D. Wood (Ed.).
10. Wood JD Enteric neuroimmunophysiology and pathophysiology. Gastroenterology 2004, 127:635-657.
11. Brookes SJH Classes of enteric nerve cells in the guinea-pig small intestine. Anat Rec 2001, 262(1):58-70.
12. Timmermans J-P, Adriaensen D, Cornelissen W, Scheuermann DW Structural organization and neuropeptide distribution in the mammalian enteric nervous system, with special attention to those components involved in mucosal reflexes. Comp Biochem Physiol 1997, 118:331-340.
13. Cooke HJ, Montakhab M, Wade PR, Wood JD Transmural fluxes of 5-hydroxytryptamine in guinea pig ileum. Am J Physiol 1983, 244:G421-425.
14. Song ZM, Brookes SJH, Costa M Identification of myenteric neurons which project to the mucosa of the guinea-pig small intestine. Neurosci Let 1991, 129:294-298. [Notes: English Article].
15. Hu HZ, Gao N, Zhu MX, Liu S, Ren J, Gao C, et al. Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system. J Physiol 2003, 550:493-504.
16. Jessen KR, Mirsky R Glial cells in the enteric nervous system contain glial fibrillary acidic protein. Nature 1980, 286:736-777.
17. Gabella G Glial cells in the myenteric plexus. Z. Naturforsch B 1971, 26:244-245.
18. Liu MT, Kuan YH, Wang J, Hen R, Gershon MD 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci 2009, 29:9683-9699.
19. Luo Y, Takaki M, Misawa H, Matsuyoshi H, Sasahira T, Chihara Y, et al. Determinants of the epithelial-muscular axis on embryonic stem cell-derived gut-like structures. Pathobiology 2010, 77:253-259.
20. Matsuyoshi H, Kuniyasu H, Okumura M, Misawa H, Katsui R, Zhang GX, et al. A 5-HT(4)-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult. Neurogastroenterol Motil 2010, 22. 806-13, e226.
21. Takaki M, Misawa H, Matsuyoshi H, Kawahara I, Goto K, Zhang GX, et al. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT(4)-receptor activation. Biochem Biophys Res Commun 2011.
22. Furness JB, Bornstein JC, Trussell DC Shapes of nerve cells in the myenteric plexus of the guinea-pig small intestine revealed by the intracellular injection of dye. Cell Tissue Res 1988, 254:561-571.
23. Furness JB, Robbins HL, Xiao J, Stebbing MJ, Nurgali K Projections and chemistry of Dogiel type II neurons in the mouse colon. Cell Tissue Res 2004, 317:1-12.
24. Bertrand PP, Kunze WA, Bornstein JC, Furness JB Electrical mapping of the projections of intrinsic primary afferent neurones to the mucosa of the guinea-pig small intestine. Neurogastroenterol Motil 1998, 10:533-541.
25. Chiocchetti R, Grandis A, Bombardi C, Clavenzani P, Costerbosa GL, Lucchi ML, et al. Characterisation of neurons expressing calbindin immunoreactivity in the ileum of the unweaned and mature sheep. Cell Tissue Res 2004.
26. Furness JB, Trussell DC, Pompolo S, Bornstein JC, Smith TK Calbindin neurons of the guinea-pig small intestine: quantitative analysis of their numbers and projections. Cell Tissue Res 1990, 260:261-272.
27. Hao S, Dulake M, Espero E, Sternini C, Raybould HE, Rinaman L Central Fos expression and conditioned flavor avoidance in rats following intragastric administration of bitter taste receptor ligands. Am J Physiol Regul Integr Comp Physiol 2009, 296:R528-536.
28. Raybould HE Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci 2010, 153:41-46.
29. Holzer P, Holzer-Petsche U Pharmacology of inflammatory pain: local alteration in receptors and mediators. Dig Dis 2009, 27(suppl 1):24-30.
30. Vergnolle N Postinflammatory visceral sensitivity and pain mechanisms. Neurogastroenterol Motil 2008, 20(suppl 1):73-80.
31. Blackshaw LA, Brookes SJ, Grundy D, Schemann M Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil 2007, 19:1-19.
32. Wood JD Enteric nervous system: sensory physiology, diarrhea and constipation. Curr Opin Gastroenterol 2010, 26:102-108.
33. Furness JB, Kunze WA, Bertrand PP, Clerc N, Bornstein JC Intrinsic primary afferent neurons of the intestine. Prog Neurobiol 1998, 54:1-18.
34. Clerc N, Gola M, Vogalis F, Furness JB Controlling the excitability of IPANs: a possible route to therapeutics. Curr Opin Pharmacol 2002, 2:657-664.
35. Pan H, Gershon MD Activitation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J.Neurosci 2000, 20:3295-3309.
36. Cervero F, Laird JM Visceral pain. Lancet 1999, 353:2145-2148.
37. Cervero F, Janig W Visceral nocireceptor: a new world order?. Trends Neurosci 1992, 15:374-378.
38. Wood JD Functional abdominal pain: the basic science. J Pediatr Gastroenterol Nutr 2008, 47:688-693.
39. Kirkup AJ, Brunsden AM, Grundy D Receptors and transmission in the brain-gut axis: I. Receptors on visceral afferents. Am J Physiology 2001, 280:G787-G794.
40. Collins SM Is the irritable gut an inflamed gut?. Scand J.Gastroenterol 1992, 27(suppl 192):102-105.
41. Gwee KA, Leong YL, Graham C, McKendrick MW, Collins SM, Walters SJ, et al. The role of psychological and biological factors in post-infective gut function. Gut 1999, 44:400-406.
42. Coelho AM, Fioramonti J, Bueno L. Mast cell degranulation induces delayed rectal allodynia in rats: Role of histamine and 5-HT. Dig Dis Sci. 43:727-737. 98.
43. Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 2010, 59:1213-1221.
44. Lembo T, Munakata J, Mertz H, Niazi N, Kodner A, Nikas V, et al. Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 1994, 107:1686-1696.
45. Whitehead WE, Holtkotter B, Enck P, Hoelzl R, Holmes KD, Anthony J, et al. Tolerance for rectosigmoid distention in iritable bowel syndrome. Gastroenterology 1990, 98:1187-1192.
46. Richter JE, Barish CF, Castell DO Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986, 91:845-862.
47. Mertz H, Morgan V, Tanner G, Pickens D, Price R, Shyr Y, et al. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distention. Gastroenterology 2000, 118:842-848.
48. Read NW Rectal distention: From sensation to feeling. Gastroenter-ology 2000, 118:972-974.
49. Silverman DHS, Munakata JA, Ennes H, Mandelkern MJCK, Mayer EA Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology 1997, 112:64-72.
50. Drossman DA, Ringel Y, Vogt BA, Leserman J, Lin W, Smith JK, et al. Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome. Gastroenterology 2003, 124:754-761.
51. Ringel Y, Drossman DA, Leserman JL, Suyenobu BY, Wilber K, Lin W, et al. Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an FMRI study. Gastroenterology 2008, 134:396-404.
52. Ringel Y, Drossman DA, Turkington TG, Bradshaw B, Hawk TC, Bangdiwala S, et al. Regional brain activation in response to rectal distension in patients with irritable bowel syndrome and the effect of a history of abuse. Dig Dis Sci 2003, 48:1774-1781.
53. Berthoud HR, Powley TL Vagal afferent innervation of the rat fundic stomach -morphological characterization of the gastric tension receptor. J Com Neur 1992, 319:261-276. [Notes: English Article].
54. Davison JS, Clarke GD Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors. Am J Physiol 1988, 255:G55-G61.
55. Li Y Sensory signal transduction in the vagal primary afferent neurons. Curr Med Chem 2007, 14:2554-2563.
56. Rogers RC, Hermann GE Mechanisms of action of CCK to activate central vagal afferent terminals. Peptides 2008, 29:1716-1725.
57. Cawston EE, Miller LJ Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor. Br J Pharmacol 2010, 159:1009-1021.
58. Teubner BJ, Bartness TJ Cholecystokinin-33 acutely attenuates food foraging, hoarding and intake in Siberian hamsters. Peptides 2010, 31:618-624.
59. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 2001, 121(3):526-535.
60. Bertrand PP, Kunze WAA, Bornstein JC, Furness JB. Smith ML. Analysis of the responses of myenteric neurons in the small intestine to chemical stimulation of the mucosa. Am J Physiol. 36:G422-G435. 97.
61. Bertrand PP, Kunze WA, Furness JB, Bornstein JC The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors. Neuroscience 2000, 101:459-469.
62. Bose M, Farthing MJ Irritable bowel syndrome: new horizons in pathophysiology and treatment. Br J Surg 2001, 88:1425-1426.
63. O'Sullivan M, Clayton N, Breslin NP, Harman I, Bountra C, McLaren A, et al. Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Mot 2000, 12:449-457.
64. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004, 126:693-702.
65. Bearcroft CP, Perrett D, Farthing MJ Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 1998, 42:42-46.
66. Kellum JM, Jaffe BM Release of immunoreactive serotonin following acid perfusion of the duodenum. Ann Surg 1976, 184:633-636.
67. Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomized, placebo-controlled trial. Lancet 2000, 355:1035-1040.
68. Furness JB The Enteric Nervous System 2006, Blackwell, Oxford.
69. Vanner S, Surprenant A Neural reflexes controlling intestinal microcirculation. Am J Physiol 1996, 271:G223-G230.
70. Neild TO, Shen KZ, Surprenant A Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. J Physiol 1990, 420:247-265.
71. Kotecha N, Neild TO Actions of vasodilator nerves on arteriolar smooth muscle and neurotransmitter release from sympathetic nerves in the guinea-pig small intestine. J Physiol 1995, 489(Pt 3):849-855.
72. Cooke HJ Neural and humoral regulation of small intestinal electrolyte transport. Physiology of the Gastrointestinal Tract 1987, 1307-1350. Raven Press, New York. L.R. Johnson, J. Christensen, M.J. Jackson, E.D. Jacobson, J.H. Walsh (Eds.).
73. North RA, Surprenant A Inhibitory synaptic potentials resulting from alpha 2 adrenoceptor activation in guinea-pig submucous plexus neurones. J Physiol (Lond) 1985, 358:17-33.
74. Zollinger RM, Ellison EH Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. 1955. CA Cancer J Clin 1989, 39:231-247.
75. Liu S, Xia Y, Hu H-Z, Ren J, Gao C, Wood JD Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the guinea-pig submucous plexus. Eur J Pharmacol 2000, 49-54.
76. North RA, Slack BE, Surprenant A Muscarinic M1 and M2 receptors mediate depolarization and presynaptic inhibition in guinea-pig enteric nervous system. J Physiol (Lond) 1985, 368:435-452.
77. Burcher E, Bornstein JC Localization of substance P binding sites in submucous plexus of guinea pig ileum, using whole-mount autoradiography. Synapse 1988, 2:232-239.
78. Frieling T, Dobreva G, Weber E, Becker K, Rupprecht C, Neunlist M, et al. Different tachykinin receptors mediate chloride secretion in the distal colon through activation of submucosal neurones. Naunyn Schmiedebergs Arch Pharmacol 1999, 359:71-79.
79. Johnson PJ, Bornstein JC, Furness JB, Woollard DJ, Orrman-Rossiter SL Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum. Br J Pharmacol 1994, 111:1240-1244.
80. Frieling T, Cooke HJ, Wood JD Serotonin receptors on submucous neurons in guinea pig colon. Am J Physiol 1991, 261:G1017-G1023.
81. Camilleri M, Chey WY, Mayer EA, Northcutt AR, Heath A, Dukes GE, et al. A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001, 161:1733-1740.
82. Chey WY, Jin HO, Lee MH, Sun SW, Lee KY Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol 2001, 96:1499-1506.
83. Thompson WG, Longstreth G, Drossman D, Heaton K, Irvine EJ, Muller-Lissner S Functional bowel disorders and functional abdominal pain. The Functional Gastrointestinal Disorders: Diagnosis, Pathophysiology and Treatment: A Multinational Consensus 2000, 351-432. McLean, Virginia: Degnon Associates. D.A. Drossman, N.J. Talley, W.G. Thompson, E. Corazziari, W.E. Whitehead (Eds.).
84. Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, et al. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci 2001, 21:6348-6361.
85. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, et al. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004, 126:1657-1664.
86. Eglen RM Muscarinic receptors and gastrointestinal tract smooth muscle function. Life Sci 2001, 68:2573-2578.
87. Matsui M, Motomura D, Fujikawa T, Jiang J, Takahashi S, Manabe T, et al. Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci 2002, 22:10627-10632.
88. Harrington AM, Peck CJ, Liu L, Burcher E, Hutson JM, Southwell BR Localization of muscarinic receptors M1R, M2R and M3R in the human colon. Neurogastroenterol Motil 2010, 22. 999-1008, e262-3.
89. Grider JR, Bitar KN, Makhlouf GM Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine. Gastroenterology 1987, 93:951-957.
90. Daniel EE, Parrish MB, Watson EG, Fox-Threlkeld JE, Regoli D, Rainsford KD The tachykinin receptors inducing contractile responses of canine ileum circular muscle. Am J Physiol 1995, 268:G161-170.
91. Mao YK, Wang YF, Daniel EE Characterization of neurokinin type 1 receptor in canine small intestinal muscle. Peptides 1996, 17:839-843.
92. Souquet JC, Bitar KN, Grider JR, Makhlouf GM Receptors for substance P on isolated intestinal smooth muscle cells of the guinea pig. Am J Physiol 1987, 253:G666-672.
93. Porter AJ, Wattchow DA, Brookes SJ, Costa M Cholinergic and nitrergic interneurones in the myenteric plexus of the human colon. Gut 2002, 51:70-75.
94. Simula ME, Brookes SJ, Meedeniya AC, Toouli J, Saccone GT Distribution of nitric oxide synthase and vasoactive intestinal polypeptide immunoreactivity in the sphincter of Oddi and duodenum of the possum. Cell Tissue Res 2001, 304:31-41.
95. Reiche D, Schemann M Ascending choline acetyltransferase and descending nitric oxide synthase immunoreactive neurones of the myenteric plexus project to the mucosa of the guinea pig gastric corpus. Neurosci Lett 1998, 241:61-64.
96. Schemann M, Schaaf C Differential projection of cholinergic and nitroxidergic neurons in the myenteric plexus of guinea pig stomach. Am J Physiol 1995, 269:G186-195.
97. Burnstock G Purinergic nerves. Pharmacol Rev 1972, 24:509-581.
98. Gourine AV, Wood JD, Burnstock G Purinergic signalling in autonomic control. Trends Neurosci 2009, 32:241-248.
99. Wang GD, Wang XY, Hu HZ, Liu S, Gao N, Fang X, et al. Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine. Am J Physiol Gastrointest Liver Physiol 2007, 292:G1483-1489.
100. Gil V, Gallego D, Grasa L, Martin MT, Jimenez M Purinergic and nitrergic neuromuscular transmission mediates spontaneous neuronal activity in the rat colon. Am J Physiol Gastrointest Liver Physiol 2010, 299:G158-169.
101. Grasa L, Gil V, Gallego D, Martin MT, Jimenez M P2Y(1) receptors mediate inhibitory neuromuscular transmission in the rat colon. Br J Pharmacol 2009, 158:1641-1652.
102. Gallego D, Vanden Berghe P, Farre R, Tack J, Jimenez M P2Y1 receptors mediate inhibitory neuromuscular transmission and enteric neuronal activation in small intestine. Neurogastroenterol Motil 2008, 20:159-168.
103. Gallego D, Hernandez P, Clave P, Jimenez M P2Y1 receptors mediate inhibitory purinergic neuromuscular transmission in the human colon. Am J Physiol Gastrointest Liver Physiol 2006, 291:G584-594.
104. Cayabyab FS, Jimenez M, Vergara P, deBruin H, Daniel EE Influence of nitric oxide and vasoactive intestinal peptide on the spontaneous and triggered electrical and mechanical activities of the canine ileum. Can J Physiol Pharmacol 1997, 75:383-397.
105. Christinck F, Jury J, Cayabyab F, Daniel EE Nitric oxide may be the final mediator of nonadrenergic, noncholinergic inhibitory junction potentials in the gut. Can J Physiol Pharmacol 1991, 69:1448-1458.
106. Grider JR, Cable MB, Said SI, Makhlouf GM Vasoactive intestinal peptide as a neural mediator of gastric relaxation. Am J Physiol 1985, 248:G73-78.
107. Grider JR, Makhlouf GM Colonic peristaltic reflex: identification of vasoactive intestinal peptide as mediator of descending relaxation. Am J Physiol 1986, 251:G40-45.
108. Jin JG, Murthy KS, Grider JR, Makhlouf GM Stoichiometry of neurally induced VIP release, NO formation, and relaxation in rabbit and rat gastric muscle. Am J Physiol 1996, 271:G357-369.
109. Murthy KS, Grider JR, Jin JG, Makhlouf GM Interplay of VIP and nitric oxide in the regulation of neuromuscular function in the gut. Ann N Y Acad Sci 1996, 805:355-362.
110. Murthy KS, Makhlouf GM Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2. J Biol Chem 1994, 269:15977-15980.
111. Fox-Threlkeld JA, McDonald TJ, Woskowska Z, Iesaki K, Daniel EE Pituitary adenylate cyclase-activating peptide as a neurotransmitter in the canine ileal circular muscle. J Pharmacol Exp Ther 1999, 290:66-75.
112. Sanders KM, Ordog T, Ward SM Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am J Physiol 2002, 282:G747-756.
113. Sanders KM Interstitial cells in smooth muscles. Review series. J Cell Mol Med 2010, 14:1197-1198.
114. Wood JD Excitation of intestinal muscle by atropine, tetrodotoxin, and xylocaine. Am J Physiol 1972, 222:118-125.
115. Wood JD Electrical activity from single neurons in Auerbach's plexus. Am J Physiol 1970, 219:159-169.
116. Wood JD Physiology of the enteric nervous system. Physiology of the Gastrointestinal Tract 1994, Raven Press, New York, pp. 423-482.
117. Manaka H, Manaka Y, Kostolanska F, Fox JE, Daniel EE Release of VIP and substance P from isolated perfused canine ileum. Am J Physiol 1989, 257:G182-190.
118. Vergara P, Woskowska Z, Cipris S, Fox-Threlkeld JE, Daniel EE Somatostatin excites canine ileum ex vivo: role for nitric oxide? Am. J Physiol 1995, 269:G12-21.
119. Ward SM, Sanders KM Interstitial cells of Cajal: primary targets of enteric motor innervation. Anat Rec 2001, 262:125-135.
120. 2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine. J Physiol 2010, 588:4453-4474.
121. Hukuhara T, Kotani S, Sato G Effects of destruction of intramural ganglion cells on colon motility: possible genesis of congenital megacolon. Jpn J Physiol 1961, 11:635-640.
122. Schiller WR, Suriyapa C, Mutchler JH, Anderson MC Surgical alteration of intestinal motility. Am J Surg 1973, 125:122-128.
123. Wood JD Electrical activity of the intestine of mice with hereditary megacolon and absence of enteric ganglion cells. Am J Dig Dis 1973, 18:477-488.
124. Schuffler MD, Baird HW, Fleming CR, Bell CE, Bouldin TW, Malagelada JR, et al. Intestinal pseudo-obstruction as the presenting manifestation of small-cell carcinoma of the lung. A paraneoplastic neuropathy of the gastrointestinal tract. Ann Intern Med 1983, 98:129-134.
125. Krishnamurthy S, Schuffler MD Pathology of neuromuscular disorders of the small intestine and colon. Gastroenterology 1987, 93:610-639.
126. Wood JD Neuropathophysiology of irritable bowel syndrome. J Clin Gastroenterol 2002, 35:S11-22.
127. Wood JD Neuropathy in the brain-in-the-gut. Eur J Gastroenterol Hepatol 2000, 12:597-600.
128. Stanghellini V, Camilleri M, Malagelada JR Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings. Gut 1987, 28:5-12.
129. Jean WC, Dalmau J, Ho A, Posner JB Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology 1994, 44:140-147.
130. Smith VV, Gregson N, Foggensteiner L, Neale G, Milla PJ Acquired intestinal aganglionosis and circulating autoantibodies without neoplasia or other neural involvement. Gastroenterology 1997, 112:1366-1371.
131. Tornblom H, Lindberg G, Nyberg B, Veress B Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002, 123:197-1972.
132. Camilleri M, Phillips SF Acute and chronic intestinal pseudo-obstruction. Adv Intern Med 1991, 36:287-306.
133. Munoz-Garcia D, Ludwin SK Adult-onset neuronal intranuclear hyaline inclusion disease. Neurology 1986, 36:785-790.
134. Palo J, Haltia M, Carpenter S, Karpati G, Mushynski W Neurofilament subunit-related proteins in neuronal intranuclear inclusions. Ann Neurol 1984, 15:322-328.
135. Mayer EA, Schuffler MD, Rotter JI, Hanna P, Mogard M Familial visceral neuropathy with autosomal dominant transmission. Gastroenterology 1986, 91:1528-1535.
136. Roy AD, Bharucha H, Nevin NC, Odling-Smee GW Idiopathic intestinal pseudo-obstruction: a familial visceral neuropathy. Clin Genet 1980, 18:291-297.
137. De Giorgio R, Bovara M, Barbara G, Canossa M, Sarnelli G, De Ponti F, et al. Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility. Gastroenterology 2003, 125:70-79.
138. Nguyen-tat M, Pohl J, Gunter E, Manner H, Plum N, Pech O, et al. Severe paraneoplastic gastroparesis associated with anti-Hu antibodies preceding the manifestation of small-cell lung cancer. Z Gastroenterol 2008, 46:274-278.
139. Lennon VA, Sas DF, Busk MF, Scheithauer B, Malagelada JR, Camilleri M, et al. Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma. Gastroenterology 1991, 100:137-142.
140. Kashyap P, Farrugia G Enteric autoantibodies and gut motility disorders. Gastroenterol Clin North Am 2008, 37. 397-410, vi-vii.
141. Altermatt HJ, Rodriguez M, Scheithauer BW, Lennon VA Paraneoplastic anti-Purkinje and type I anti-neuronal nuclear autoantibodies bind selectively to central, peripheral, and autonomic nervous system cells. Lab Invest 1991, 65:412-420.
142. Heidenreich F, Schober R, Brinck U, Hartung HP Multiple paraneoplastic syndromes in a patient with antibodies to neuronal nucleoproteins (anti-Hu). J Neurol 1995, 242:210-216.
143. Darnell RB, Posner JB Paraneoplastic syndromes involving the nervous system. N Engl J Med 2003, 349:1543-1554.
144. Rosenblum MK Paraneoplasia and autoimmunologic injury of the nervous system: the anti-Hu syndrome. Brain Pathol 1993, 3:199-212.
145. Wood JN, Hudson L, Jessell TM, Yamamoto M A monoclonal antibody defining antigenic determinants on subpopulations of mammalian neurones and Trypanosoma cruzi parasites. Nature 1982, 296:34-38.
146. De Giorgio R, Bassotti G, Stanghellini V, Barbara G, Tazzari P-L, Santini D Clinical, morpho-functional and immunological features of idiopathic myenteric ganglionitis. Gastroenterology 1996, 110:A655.
147. Verne GN, Sallustio JE, Eaker EY Anti-myenteric neuronal antibodies in patients with achalasia. A prospective study. Dig Dis Sci 1997, 42:307-313.
148. Hogan WJ, Greenen JE, Dodds WJ aradoxical motor response to cholecystokinin-octapeptide (CCK-OP) in patients with suspected sphincter of Oddi dysfunction. Gastroenterology 1982, 82:1085.
149. Rolny P, Arleback A, Funch-Jensen P, Kruse A, Ravnsbaeck J, Jarnerot G Paradoxical response of sphincter of Oddi to intravenous injection of cholecystokinin or ceruletide. Manometric findings and results of treatment in biliary dyskinesia. Gut 1986, 27:1507-1511.
150. Kunze WA, Furness JB, Bornstein JC Simultaneous intracellular recordings from enteric neurons reveal that myenteric AH neurons transmit via slow excitatory postsynaptic potentials. Neuroscience 1993, 55:685-694.
151. Thomas EA, Bertrand PP, Bornstein JC A computer simulation of recurrent, excitatory networks of sensory neurons of the gut in guinea-pig. Neurosci Lett 2000, 287:137-140.
152. Thomas EA, Bornstein JC Inhibitory cotransmission or after-hyperpolarizing potentials can regulate firing in recurrent networks with excitatory metabotropic transmission. Neuroscience 2003, 120:333-351.
153. Song ZM, Brookes SJH, Costa M All calbindin-immunoreactive myenteric neurons project to the mucosa of the guinea-pig small intestine. Neurosci Let 1994, 180:219-222.
154. Kunze WA, Bertrand PP, Furness JB, Bornstein JC Influence of the mucosa on the excitability of myenteric neurons. Neuroscience 1997, 76:619-634.
155. Hendriks R, Bornstein JC, Furness JB An electrophysiological study of the projections of putative sensory neurons within the myenteric plexus of the guinea pig ileum. Neurosci Lett 1990, 110:286-290.
156. Kirchgessner AL, Tamir H, Gershon MD Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut -activity-induced expression of fos immunoreactivity. J Neurosci 1992, 12:235-248. [Notes: English Article].
157. Chen JX, Pan H, Rothman TP, Wade PR, Gershon MD Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. Am J Physiol 1998, 275:G433-448.
158. Clerc N, Furness JB Intrinsic primary afferent neurones of the digestive tract. Neurogastroenterol Motil 2004, 16(suppl 1):24-27.
159. Mazzuoli G, Schemann M Multifunctional rapidly adapting mechanosensitive enteric neurons (RAMEN) in the myenteric plexus of the guinea pig ileum. J Physiol 2009, 587:4681-4694.
160. Schemann M, Mazzuoli G Multifunctional mechanosensitive neurons in the enteric nervous system. Auton Neurosci 2010, 153:21-25.
161. Gao C, Liu S, Hu HZ, Gao N, Kim GY, Xia Y, et al. Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine. Gastroenterology 2002, 123:1554-1564.
162. Liu S, Hu HZ, Gao N, Gao C, Wang G, Wang X, et al. Neuroimmune interactions in guinea pig stomach and small intestine. Am J Physiol 2003, 284:G154-164.
163. Liu S, Gao X, Gao N, Wang X, Fang X, Hu HZ, et al. Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system. J Comp Neurol 2005, 481:284-298.
164. Liu S, Ren W, Qu MH, Bishop GA, Wang GD, Wang XY, et al. Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon. Br J Pharmacol 2010, 159:222-236.
165. Holman ME, Hirst GDS, Spence I Preliminary studies of the neurones of Auerbach's plexus using intracellular microelectrodes. Aust J Exp Biol Med Sci 1972, 550:795-801.
166. Hirst.GDS, Holman ME, Spence I Two types of neurons in the myenteric plexus of duodenum in the guinea-pig. J Physiol (Lond) 1974, 236:303-326.
167. Akasu T, Tokimasa T Potassium currents in submucous neurones of guinea-pig caecum and their synaptic modification. J Physiol (Lond) 1989, 416:571-588.
168. Grafe P, Mayer CJ, Wood JD Synaptic modulation of calcium-dependent potassium conductance in myenteric neurons. J Physiol (Lond) 1980, 305:235-248.
169. North RA, Tokimasa T Persistent calcium-sensitive potassium current and the resting properties of guinea-pig myenteric neurones. J Physiol (Lond) 1987, 386:333-353.
170. Tatsumi H, Hirai K, Katayama Y Measurement of the intracellular calcium concentration in guinea-pig myenteric neurons by using fura-2. Brain Res 1988, 451:371-375.
171. Vogalis F, Harvey JR, Neylon CB, Furness JB Regulation of K+ channels underlying the slow afterhyperpolarization in enteric afterhyperpolarization-generating myenteric neurons: role of calcium and phosphorylation. Clin Exp Pharmacol Physiol 2002, 29:935-943.
172. Vogalis F, Harvey JR, Furness JB TEA-and apamin-resistant K(Ca) channels in guinea-pig myenteric neurons: slow AHP channels. J Physiol (Lond) 2002, 538:421-433.
173. Furness JB, Kearney K, Robbins HL, Hunne B, Selmer IS, Neylon CB, et al. Intermediate conductance potassium (IK) channels occur in human enteric neurons. Auton Neurosci 2004, 112:93-97.
174. Furness JB, Robbins HL, Selmer IS, Hunne B, Chen MX, Hicks GA, et al. Expression of intermediate conductance potassium channel immunoreactivity in neurons and epithelial cells of the rat gastrointestinal tract. Cell Tissue Res 2003, 314:179-189.
175. Morita K, North RA Opiate activation of potassium conductance in myenteric neurons: inhibition by calcium ion. Brain Res 1982, 242:145-150.
176. Morita K, North RA, Tokimasa T The calcium-activated potassium conductance in guinea-pig myenteric neurones. J Physiol (Lond) 1982, 329:341-354.
177. Palmer JM, Wood JD, Zafirov DH Purinergic inhibition in the small intestinal myenteric plexus of the guinea-pig. J Physiol (Lond) 1987, 387:357-369.
178. Johnson SM, Katayama Y, North RA Multible actions of 5-hyeroxytryptamine on myenteric neurones of the guinea-pig ielum. J Physiol (Lond) 1980, 304:459-470.
179. Starodub AM, Wood JD Histamine H(2) receptor activated chloride conductance in myenteric neurons from guinea pig small intestine. J Neurophysiol 2000, 83:1809-1816.
180. Katayama Y, North RA, Williams JT The action of substance P on neurons of the myenteric plexus of the guinea-pig small intestine. Proc R Soc (Lond) 1979, 206:191-208.
181. Baidan LV, Zholos AV, Wood JD Modulation of calcium currents by G-proteins and adenosine receptors in myenteric neurones cultured from adult guinea-pig small intestine. Br J Pharmacol 1995, 116:1882-1886.
182. Zholos AV, Baidan LV, Wood JD Sodium conductance in cultured myenteric AH-type neurons from guinea-pig small intestine. Auton Neurosci 2002, 96:93-102.
183. North RA. The calcium-dependent slow after-hyperpolarization in myenteric plexus neurones with tetrodotoxin-resistant action potentials. Br J Pharmacol. 49:709-711. 73.
184. Wood JD, Mayer CJ Intracellular study of electrical activity of auerbach's plexus in guinea-pig small intestine. Pflug Arch 1978, 374:265-275.
185. Starodub AM, Wood JD A-type potassium current in myenteric neurons from guinea-pig small intestine. Neuroscience 2000, 99:389-396.
186. Zholos AV, Baidan LV, Starodub AM, Wood JD Potassium channels of myenteric neurons in guinea-pig small intestine. Neuroscience 1999, 89:603-618.
187. Hirst GD, Johnson SM, van Helden DF The slow calcium-dependent potassium current in a myenteric neurone of the guinea-pig ileum. J Physiol 1985, 361:315-337.
188. Christofi FL, Guan Z, Lucas JH, Rosenbergschaffer LJ, Stokes BT Responsiveness to ATP with an increase in intracellular free Ca2+ is not a distinctive feature of calbindin-D-28 immunoreactive neurons in myenteric ganglia. Brain Res 1996, 725:241-246.
189. Vogalis F, Hillsley K, Smith T Recording ionic events from cultured, DiI-labelled myenteric neurons in the guinea-pig proximal colon. J Neurosci Methods 2000, 96:25-34.
190. Tamura K, Wood JD Electrical and synaptic properties of myenteric plexus neurones in the terminal large intestine of the guinea-pig. J Physiol (Lond) 1989, 415:275-298.
191. Hirst GD, McKirdy HC Synaptic potentials recorded from some neurones of the submucous plexus of guinea-pig intestine. J Physiol (Lond) 1975, 244:35P-36P.
192. Nishi S, North RA Intracellular recording from the myenteric plexus of the guinea-pig ileum. J Physiol (Lond) 1973, 231.
193. Galligan JJ, LePard KJ, Schneider DA, Zhou X Multiple mechanisms of fast excitatory synaptic transmission in the enteric nervous system. J Auton Nerv Syst 2000, 81:97-103.
194. Hu HZ, Gao N, Lin Z, Gao C, Liu S, Ren J, et al. P2X(7) receptors in the enteric nervous system of guinea-pig small intestine. J Comp Neurol 2001, 440:299-310.
195. Galligan JJ, Bertrand PP ATP mediates fast synaptic potentials in enteric neurons. J Neurosci 1994, 14:7563-7571.
196. Ren J, Bian X, DeVries M, Schnegelsberg B, Cockayne DA, Ford AP, et al. P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol (Lond) 2003, 552:809-821.
197. Galligan JJ, North RA Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system. Neurogastroenterol Motil 2004, 16(suppl 1):64-70.
198. Nurgali K, Furness JB, Stebbing MJ Analysis of purinergic and cholinergic fast synaptic transmission to identified myenteric neurons. Neuroscience 2003, 116:335-347.
199. Xiang Z, Burnstock G P2X2 and P2X3 purinoceptors in the rat enteric nervous system. Histochem Cell Biol 2004, 121:1691-1779.
200. Castelucci P, Robbins HL, Poole DP, Furness JB The distribution of purine P2X(2) receptors in the guinea-pig enteric nervous system. Histochem. Cell Biol 2002, 117:415-422.
201. Castelucci P, Robbins HL, Furness JB P2X(2) purine receptor immunoreactivity of intraganglionic laminar endings in the mouse gastrointestinal tract. Cell Tissue Res 2003, 312:167-174.
202. Poole DP, Castelucci P, Robbins HL, Chiocchetti R, Furness JB The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system. Auton Neurosci 2002, 101:39-47.
203. Van Nassauw L, Brouns I, Adriaensen D, Burnstock G, Timmermans JP Neurochemical identification of enteric neurons expressing P2X(3) receptors in the guinea-pig ileum. Histochem Cell Biol 2002, 118:193-203.
204. Hu H-Z, Lin Z, Ren J, Peck OC, Gao C, Liu S, et al. P2X7 receptors in the enteric nervous system of guinea-pig small intestine. Neurogastroenterol Mot 2001, 13:399-400.
205. Tack JF, Janssens J, Vantrappen G, Wood JD Actions of 5-hydroxytryptamine on myenteric neurons in guinea pig gastric antrum. Am J Physiol 1992, 263:G838-846.
206. Derkach V, Surprenant A, North RA 5-Ht3 receptors are membrane ion channels. Nature 1989, 339:706-709. [Notes: English Article].
207. Galligan JJ Ligand-gated ion channels in the enteric nervous system. Neurogastroenterol Motil 2002, 14:611-623.
208. Schemann M, Wood JD Synaptic behavior of myenteric neurones in the gastric corpus of the guinea-pig. J Physio (Lond) 1989, 417:519-535.
209. Tack JD, Wood JD Synaptic behavior in the myenteric plexus of the guinea-pig gastric antrum. J Physiol (Lond) 1992, 445:389-406.
210. Mawe GM Intracellular recording from gall-bladder neurones of the guinea-pig gall bladder. J Physiol (Lond) 1990, 429:323-338.
211. Frieling T, Palmer JM, Cooke HJ, Wood JD Neuroimmune communication in the submucous plexus of guinea-pig colon after infection with Trichinella spiralis. Gastroenterology 1994, 107:1602-1609.
212. Wade PR, Wood JD Synaptic behavior of myenteric neurons in guinea pig distal colon. Am J Physiol 1988, 255:G184-890.
213. Liu MT, Kirchgessner AL Guinea pig pancreatic neurons: morphology, neurochemistry, electrical properties, and response to 5-HT. Am J Physiol 1997, 273:G1273-1289.
214. King BF, Love JA, Szurszewski JH Intracellular recordings from pancreatic ganglia of the cat. J Physiol (Lond) 1989, 419:379-403.
215. Morita K, Katayama Y Substance P inhibits activation of calcium-dependent potassium conductances in guinea-pig myenteric neurones. J Physiol (Lond) 1992, 447:203-308.
216. Bertrand PP, Galligan JJ Contribution of chloride conductance increase to slow EPSC and tachykinin current in guinea-pig myenteric neurones. J Physiol (Lond) 1994, 481:47-60.
217. Clapham DE, Julius D, Montell C, Schultz G International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev 2005, 57:427-450.
218. Wood JD, Hu H-Z, Gao N, Zhu M, Liu S, Gao X, et al. Transient receptor potential channel 6 in guinea-pig small intestinal submucosal plexus. Neurogastroenterol Motil 2002, 14:590-591.
219. Liu S, Qu MH, Ren W, Hu HZ, Gao N, Wang GD, et al. Differential expression of canonical (classical) transient receptor potential channels in guinea pig enteric nervous system. J Comp Neurol 2008, 511:847-862.
220. Gershon MD Plasticity in serotonin control mechanisms in the gut. Curr Opin Pharmacol 2003, 3:600-607.
221. Wade PR, Tamir H, Kirchgessner AL, Gershon MD Analysis of the role of 5-HT in the enteric nervous system using anti-idiotopic antibodies to 5-HT receptors. Am J Physiol 1994, 266:G403-416.
222. Beubler E, Schirgi-Degen A Serotonin antagonists inhibit sennoside-induced fluid secretion and diarrhea. Pharmacology 1993, 47(suppl 1):64-69.
223. Christofi FL, Kim M, Wunderlich JE, Xue J, Suntres Z, Cardounel A, et al. Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model. Gastroenterology 2004, 127:188-202.
224. Cervo F Afferent activity evoked by natural stimulation of the biliary system in the ferret. Pain 1982, 13:137-151.
225. Bornstein JC, North RA, Costa M, Furness JB Excitatory synaptic potentials due to activation of neurons with short projections in the myenteric plexus. Neuroscience 1984, 11:723-731.
226. Takaki M, Nakayama S Effects of mesenteric nerve stimulation on the electrical activity of myenteric neurons in the guinea pig ileum. Brain Res 1988, 442:351.
227. Grider JR, Jin JG Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation. J Neurosci 1994, 14:2854-2860.
228. Schemann M, Kayser H Effects of tachykinins on myenteric neurones of the guinea-pig gastric corpus: involvement of NK-3 receptors. Pflug Arch 1991, 419:566-571.
229. Jenkinson KM, Morgan JM, Furness JB, Southwell BR Neurons bearing NK(3) tachykinin receptors in the guinea-pig ileum revealed by specific binding of fluorescently labelled agonists. Histochem Cell Biol 1999, 112:233-246.
230. Bian XC, Bertrand PP, Furness JB, Bornstein JC Evidence for functional NK1-tachykinin receptors on motor neurones supplying the circular muscle of guinea-pig small and large intestine. Neurogastroenterol Motil 2000, 12:307-315.
231. Southwell BR, Woodman HL, Murphy R, Royal SJ, Furness JB Characterisation of substance P-induced endocytosis of NK1 receptors on enteric neurons. Histochem Cell Biol 1996, 106:563-571.
232. Jenkinson KM, Mann PT, Southwell BR, Furness JB Independent endocytosis of the NK(1) and NK(3) tachykinin receptors in neurons of the rat myenteric plexus. Neuroscience 2000, 100:191-199.
233. Southwell BR, Woodman HL, Royal SJ, Furness JB Movement of villi induces endocytosis of NK1 receptors in myenteric neurons from guinea-pig ileum. Cell Tissue Res 1998, 292:37-45.
234. Branchek TA, Mawe GM, Gershon MD Characterization and localization of a peripheral neural 5-hydroxytryptamine receptor subtype (5-HT1P) with a selective agonist, 3H-5-hydroxyindalpine. J Neurosci 1988, 8:2582-2595.
235. Branchek T, Kates M, Gershon MD Enteric receptors for 5-hydroxytryptamine. Brain Res 1984, 324:107-118.
236. Monro RL, Bornstein JC, Bertrand PP Slow excitatory post-synaptic potentials in myenteric AH neurons of the guinea-pig ileum are reduced by the 5-hydroxytryptamine7 receptor antagonist SB 269970. Neuroscience 2005, 134:975-986.
237. Johnson PJ, Bornstein JC Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input. Neuroscience 2004, 126:137-147.
238. Christofi FL, Palmer JM, Wood JD Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur J Pharmacol 1991, 195:333-339.
239. Nemeth PR, Ort CA, Wood JD Intracellular study of effects of histamine on electrical behavior of myenteric neurons in guinea-pig small intestine. J Physiol (Lond) 1984, 355:411-425.
240. Linden DR, Manning BP, Bunnett NW, Mawe GM Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons. Eur J Pharmacol 2001, 431:311-314.
241. Vantrappen G, Peeters TL, Bloom SR, Christofides N, Hellemans J Motilin and the interdigestive migrating motor complex in man. Am J Dig Dis 1979, 24:497-500.
242. Tack J, Janssens J, Vantrappen G, Peeters T, Annese V, Depoortere I, et al. Effect of erythromycin on gastric motility in controls and diabetic gastroparesis. Gastroenterology 1992, 103:72-79.
243. Wood JD, Tack JF Motilin excites myenteric neurons in the gastric antrum of the guinea-pig. Gastroenterology 1990, 99:A1236.
244. Clerc N, Furness JB, Kunze WA, Thomas EA, Bertrand PP Long-term effects of synaptic activation at low frequency on excitability of myenteric AH neurons. Neuroscience 2000, 90:279-289.
245. Xia Y, Baidan LV, Fertel RH, Wood JD Determination of levels of cyclic AMP in the myenteric plexus of guinea-pig small intestine. Eur J Pharmacol 1991, 206:231-236.
246. Nemeth PR, Palmer JM, Wood JD, Zafirov DH Effects of forskolin on electrical behavior of myenteric neurones in guinea-pig small intestine. J Physiol (Lond) 1986, 376:439-450.
247. Palmer JM, Wood JD, Zafirov DH Elevation of cyclic adenosine monophosphate mimics slow synaptic excitation in myenteric neurones of the guinea-pig. J Physiol (Lond) 1986, 376:451-460.
248. Xia Y, Fertel RH, Wood JD Stimulation of formation of cAMP by 5-hydroxytryptamine in myenteric ganglia isolated from guinea pig small intestine. Life Sci 1994, 55:685-692.
249. Wang HY, Fiorica-Howells E, Pan H, Gershon MD, Friedman E Myenteric ganglionic 5-hydroxytryptamine(1P) signal transmission is mediated via Go protein. J Pharmacol Exp Ther 1996, 277:518-524.
250. Xia Y, Fertel RH, Wood JD Stimulation of formation of adenosine 3',5'-phosphate by histamine in myenteric ganglia isolated from guinea-pig small intestine. Eur J Pharmacol 1996, 316:81-85.
251. + channel underlies the slow after-hyperpolarization in enteric AH neurons. J Physiol (Lond) 2003, 548:801-814.
252. Vogalis F, Harvey JR, Furness JB Suppression of a slow post-spike afterhyperpolarization by calcineurin inhibitors. Eur J Neurosci 2004, 19:2650-2658.
253. Bertrand PP, Galligan JJ Signal-transduction pathways causing slow synaptic excitation in guinea pig myenteric AH neurons. Am J Physiol 1995, 269:G710-720.
254. Pan H, Wang HY, Friedman E, Gershon MD Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT. J Neurosci 1997, 17:1011-1024.
255. Poole DP, Hunne B, Robbins HL, Furness JB Protein kinase C isoforms in the enteric nervous system. Histochem Cell Biol 2003, 120:51-61.
256. Kawai M, Nguyen TV, Stebbing MJ, Clerc N, Komori S, Furness JB Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons. Pflugers Arch 2003, 447:298-304.
257. Newton AC Regulation of protein kinase C. Curr Opin Cell Biol 1997, 9:161-167.
258. Zimmermann H Extracellular metabolism of ATP and other nucleotides. Naunyn Schmiedebergs Arch Pharmacol 2000, 362:299-309.
259. Christofi FL, Wood JD Presynaptic inhibition by adenosine A1 receptors on guinea-pig small intestinal myenteric neurons. Gastroenterology 1993, 104:1420-1429.
260. Zafirov DH, Palmer JM, Wood JD Adenosine inhibits forskolin-induced excitation in myenteric neurons. Eur J Pharmacol 1985, 113:143-144.
261. Christofi FL, Wood JD Electrophysiological subtypes of inhibitory P1 purinoceptors on myenteric neurones of guinea-pig small bowel. Br J Pharmacol 1994, 113:703-710.
262. Palmer JM, Wood JD, Zafirov DH Transduction of aminergic and peptidergic signals in enteric neurones of the guinea-pig. J Physiol (Lond) 1987, 387:371-383.
263. Tamura K, Itoh H, Wood JD G-proteins couple excitatory and inhibitory receptors to adenylate cyclase in AH/type myenteric neurons of guinea-pig small intestine. Gastroenterology 1995, 108:A1010.
264. Cooke HJ, Wang Y, Liu CY, Zhang H, Christofi FL Activation of neuronal adenosine A1 receptors suppresses secretory reflexes in the guinea pig colon. Am J Physiol 1999, 276:G451-462.
265. Bozarov A, Wang YZ, Yu JG, Wunderlich J, Hassanain HH, Alhaj M, et al. Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine. Am J Physiol Gastrointest Liver Physiol 2009, 297:G1147-1162.
266. Xia Y, Fertel RH, Wood JD Suppression of cAMP formation by adenosine in myenteric ganglia of guinea-pig small intestine. Eur J Pharmacol 1997, 32:95-101.
267. Gao N, Hu HZ, Liu S, Gao C, Xia Y, Wood JD Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine. Am J Physiol Gastrointest Liver Physiol 2007, 292:G492-500.
268. Duarte-Araujo M, Nascimento C, Alexandrina Timoteo M, Magalhaes-Cardoso T, Correia-de-Sa P Dual effects of adenosine on acetylcholine release from myenteric motoneurons are mediated by junctional facilitatory A(2A) and extrajunctional inhibitory A(1) receptors. Br J Pharmacol 2004, 141:925-934.
269. Hu HZ, Gao N, Liu S, Ren J, Xia Y, Wood JD Metabotropic signal transduction for bradykinin in submucosal neurons of guinea pig small intestine. J Pharmacol Exp Ther 2004, 309:310-319.
270. Wood JD, Kirchgessner A Slow excitatory metabotropic signal transmission in the enteric nervous system. Neurogastroenterol Motil 2004, 16(suppl 1):71-80.
271. Hu HZ, Liu S, Gao N, Xia Y, Mostafa R, Ren J, et al. Actions of bradykinin on electrical and synaptic behavior of neurones in the myenteric plexus of guinea-pig small intestine. Br J Pharmacol 2003, 138:1221-1232.
272. Hu HZ, Gao N, Liu S, Ren J, Wang X, Xia Y, et al. Action of bradykinin in the submucosal plexus of guinea pig small intestine. J Pharmacol Exp Ther 2004, 309:320-327.
273. Hu HZ, Gao N, Gao C, Liu S, Xia Y, Wood JD. Calmodulin (CaM) and CaM kinase signaling in the enteric nervous system. Neurosci Abst. 2001;27:839.11.
274. Gao N, Hu H-Z, Arlin SW, Cook CH, Needleman BJ, Muscarella P, et al. Calmodulin kinase IIalpha in the signal transduction pathway for slow synaptic excitation in enteric neurons of guinea pig, rat and human small intestine. Gastroenterology 2003, 124:A467.
275. Javed NH, Cooke HJ Acetylcholine release from colonic submucous neurons in the guinea pig associated with Cl secretion. Am J Physiol 1992, 262:G1331-1336.
276. Vizi VA, Vizi ES Direct evidence for acetylcholine releasing effect of serotonin in the Auerbach's plexus. J Neural Trans 1978, 42:127-138.
277. Yau WM, Youther ML Direct evidence for a release of acetylcholine from myenteric plexus of guinea pig small intestine by substance P. Eur J Pharmacol 1982, 81:665-668.
278. Quinson N, Robbins HL, Clark MJ, Furness JB Calbindin immunoreactivity of enteric neurons in the guinea-pig ileum. Cell Tissue Res 2001, 305:3-9.
279. Zafirov DH, Cooke HJ, Wood JD Elevation of cAMP facilitates noradrenergic transmission in submucous neurons of guinea pig ileum. Am J Physiol 1993, 264:G442-446.
280. Johnson SMKY, North RA Slow synaptic potentials in neurones of the myenteric plexus. J Physiol (Lond) 1980, 301:505-516.
281. North RA, Tokimasa T Depression of calcium-dependent potassium conductance of guinea-pig myenteric neurones by muscarinic agonists. J Physiol (Lond) 1983, 342:253-266.
282. Wood JD, Mayer CJ Intracellular study of tonic-type enteric neurons in guinea pig small intestine. J Neurophysiol 1979, 42:569-581.
283. Mihara S, North RA Opioids increase potassium conductance in submucous neurones of guinea-pig caecum by activating delta receptors. Br J Pharmacol 1986, 88:315-382.
284. Shen K-Z, North RA, Surprenant A Potassium channels opened by noradrenaline and other transmitters in excised membrane patches of guinea-pig submucosal neurones. J Physiol (Lond) 1992, 445:581-599.
285. Mihara S, Hirai K, Katayama Y, Nishi S Mechanisms underlying intracellular signal transduction of the slow ipsp in submucous neurones of the guinea-pig caecum. J Physiol (Lond) 1991, 436:621-641.
286. Liu S, Hu HZ, Ren J, Gao C, Gao N, Lin Z, et al. Pre-and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro. Am J Physiol Gastrointest Liver Physiol 2001, 281(1):G237-G246.
287. Wood JD, Galligan JJ Function of opioids in the enteric nervous system. Neurogastroenterol Motil 2004, 16(suppl 2):17-28.
288. North RA, Karras PJ Opiate tolerance and dependence induced in vitro in single myenteric neurones. Nature 1978, 272:73-75.
289. North RA, Zieglgansberger W Opiate withdrawal signs in single myenteric neurones. Brain Res 1978, 144:208-211.
290. Liu S, Hu H-Z, Ren J, Gao C, Wood JD Pre-and postsynaptic inhibition by nociceptin in guinea pig myenteric plexus in vitro. Am J Physiol 2001, 281:G237-246.
291. Surprenant A, North RA Mechanism of synaptic inhibition by noradrenaline acting at alpha 2-adrenoceptors. Proc R Soc (Lond) 1988, 234:85-114.
292. Hirst GDS, Silinsky EM Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine. J Physiol (Lond) 1975, 251:817-832.
293. Shen KZ, Surprenant A Somatostatin-mediated inhibitory postsynaptic potential in sympathetically denervated guinea-pig submucosal neurones. J Physiol (Lond) 1993, 470:619-665.
294. Foong JP, Parry LJ, Gwynne RM, Bornstein JC 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Am J Physiol Gastrointest Liver Physiol 2010, 298:G384-394.
295. Palmer JM, Schemann M, Tamura K, Wood JD Galanin mimics slow synaptic inhibition in myenteric neurons. Eur J Pharmacol 1986, 124:379-380.
296. Tamura K, Palmer JM, Winkelmann CK, Wood JD Mechanism of action of galanin on myenteric neurons. J Neurophysiol 1988, 60:966-979.
297. Ren J, Hu HZ, Starodub AM, Wood JD Galanin suppresses calcium conductance and activates inwardly rectifying potassium channels in myenteric neurones from guinea-pig small intestine. Neurogastroenterol Motil 2001, 13:247-254.
298. Wood JD, Liu S Galanin receptors and actions. Drugs Future 2004, 29:149-161.
299. Nemeth PR, Zafirov DH, Wood JD Effects of cholecystokinin, caerulein and pentagastrin on electrical behavior of myenteric neurons. Eur J Pharmacol 1985, 116:263-269.
300. Schutte IW, Hollestein KB, Akkermans LM, Kroese AB Evidence for a role of cholecystokinin as neurotransmitter in the guinea-pig enteric nervous system. Neurosci Lett 1997, 236:155-158.
301. Schutte IW, Akkermans LM, Kroese AB CCKA and CCKB receptor subtypes both mediate the effects of CCK-8 on myenteric neurons in the guinea-pig ileum. J Auton Nerv Syst 1997, 67:51-59.
302. Christofi FL, Baidan LV, Fertel RH, Wood JD Adenosine A2 receptor-mediated excitation of a subset of AH/Type 2 neurons and elevation of cAMP levels in myenteric ganglia of guinea-pig ileum. Neurogastroenterol Mot 1994, 6:67-78.
303. Mawe GM The role of cholecystokinin in ganglionic transmission in the guinea-pig gall-bladder. J Physiol (Lond) 1991, 439:89-102.
304. Wang GD, Wang XY, Hu HZ, Fang XC, Liu S, Gao N, et al. Angiotensin receptors and actions in guinea pig enteric nervous system. Am J Physiol Gastrointest Liver Physiol 2005, 289:G614-626.
305. Wiseman LR, Faulds D Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs 1994, 47:116-152.
306. Baker DE Tegaserod for the treatment of constipation-predominant irritable bowel syndrome. Rev Gastroenterol Disord 2001, 1:187-198.
307. Corsetti M, Tack J Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome. Expert Opin Pharmacother 2002, 3:1211-1218.
308. Tonini M, Galligan JJ, North RA Effects of cisapride on cholinergic neurotransmission and propulsive motility in the guinea pig ileum. Gastroenterology 1989, 96:1257-1264.
309. Bran S, Murray WA, Hirsch IB, Palmer JP Long QT syndrome during high-dose cisapride. Arch Intern Med 1995, 155:765-768.
310. Pan H, Galligan JJ 5-HT1A and 5-HT4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 1994, 266:G230-238.
311. Hirst GD, McKirdy HC Presynaptic inhibition at mammalian peripheral synapse?. Nature 1974, 250:430-431.
312. North RA, Henderson G, Katayama Y, Johnson SM Electrophysiological evidence for presynaptic inhibition of acetylcholine release by 5-hydroxytryptamine in the enteric nervous system. Neuroscience 1980, 5:581-586.
313. Wood JD Neurotransmission at the interface of sympathetic and enteric divisions of the autonomic nervous system. Chin J Physiol 1999, 42:201-210.
314. Wood JD, Mayer CJ Adrenergic inhibition of serotonin release from neurons in guinea pig Auerback's plexus. J Neurophysiol 1979, 42:594-603.
315. Bartho L, Holzer P, Lembeck F Sympathetic control of substance P releasing enteric neurones in the guinea pig ileum. Neurosci Lett 1983, 38:291-296.
316. Jonakait GM, Tamir H, Gintzler AR, Gershon MD Release of [3H] serotonin and its binding protein from enteric neurons. Brain Res 1979, 174:55-69.
317. Manber L, Gershon MD A reciprocal adrenergic-cholinergic axoaxonic synapse in the mammalian gut. Am J Physiol 1979, 5:E738-745.
318. Del Tacca M, Soldani G, Selli M, Crema A Action of catecholamines on release of acetylcholine from human taenia coli. Eur J Pharmacol 1970, 9:80-84.
319. Knoll J, Vizi ES Presynaptic inhibition of acetylcholine release by endogenous and exogenous noradrenaline at high rate of stimulation. Br J Pharmacol 1970, 40:400-412.
320. Paton WDM, Vizi ES The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br J Pharmacol 1969, 35:10-28.
321. Wood JD. Histamine signals in enteric neuroimmune interactions. In: Perdue MH, Barrett KE, Cooke HJ, Powell DW, eds. Neuroimmunophysiology of Gastrointestinal Mucosa. 91. New York: Annals New York Academy Sciences. [In Press].
322. Wood JD. Physiological and pathophysiological paracrine functions of intestinal mast cells in enteric neuroimmune signaling. In: Singer MF, Ziegler R, and Rohr, G. Gastrointestinal Tract and Endocrine System. 254-263. 95. London, Kluwer Academic.
323. Tamura K, Palmer JM, Wood JD Presynaptic inhibition produced by histamine at nicotinic synapses in enteric ganglia. Neuroscience 1987, 25:171-179.
324. Breunig E, Michel K, Zeller F, Seidl S, Weyhern CW, Schemann M Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. J Physiol 2007, 583:731-742.
325. Frieling T, Cooke HJ, Wood JD Neuroimmune communication in the submucous plexus of guinea-pig colon after sensitization to milk antigen. Am J Physiol 1994, 267:G1087-G1093.
326. Galligan JJ, Surprenant A, Tonini M, North RA Differential localization of 5-HT1 receptors on myenteric and submucosal neurons. Am J Physiol 1988, 255:G603-611.
327. Surprenant A, Crist J Electrophysiological characterization of functionally distinct 5-hydroxytryptamine receptors on guinea-pig submucous plexus. Neuroscience 1988, 24:283-295.
328. Harrington AM, Hutson JM, Southwell BR Cholinergic neurotransmission and muscarinic receptors in the enteric nervous system. Prog Histochem Cytochem 2010, 44:173-202.
329. Harrington AM, Peck CJ, Liu L, Burcher E, Hutson JM, Southwell BR Localization of muscarinic receptors M1R, M2R and M3R in the human colon. Neurogastroenterol Motil 2010, 22. 999-1008, e262-3.
330. Harrington AM, Hutson JM, Southwell BR Immunohistochemical localisation of pre-synaptic muscarinic receptor subtype-2 (M2r) in the enteric nervous system of guinea-pig ileum. Cell Tissue Res 2008, 332:37-48.
331. Schemann M, Tamura K Presynaptic inhibitory effects of the peptides NPY, PYY, and PP on nicotinic EPSPs in guinea-pig gastric myenteric neurones. J Physiol (Lond) 1992, 451:79-89.
332. Barajas-Lopez C, Surprenant A, North RA Adenosine A1 and A2 receptors mediate presynaptic inhibition and postsynaptic excitation in guinea pig submucosal neurons. J Pharmacol Exp Ther 1991, 258:490-495.
333. Christofi FL, Tack J, Wood JD Suppression of nicotinic synaptic transmission by adenosine in myenteric ganglia of the guinea-pig gastric antrum. Eur J Pharmacol 1992, 216:17-22.
334. Liu S, Hu HZ, Gao C, Gao N, Xia Y, Wood JD Actions of galanin on neurotransmission in the submucous plexus of guinea pig small intestine. Eur J Pharmacol 2003, 471:49-58.