Evidence for a role of cholecystokinin as neurotransmitter in the guinea-pig enteric nervous system

Neuroscience Letters

Volumn 236, Issue 3, 1997, Pages 155-158

  Schutte, Irma W M ^a,c   Hollestein, Kees B C W ^a   Akkermans, Louis M A ^b   Kroese, Alfons B A ^b,c  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b Academic University Hospital   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antagonists; Cholecystokinin; Distal ileum; Enteric neurons; Neuropeptides; Slow exitatory postsynaptic potential

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEVAZEPIDE; NEUROTRANSMITTER;

ANIMAL CELL; CONTROLLED STUDY; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; GUINEA PIG; ILEUM; INTESTINE INNERVATION; MYENTERIC PLEXUS; NERVE FIBER MEMBRANE CONDUCTANCE; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0030694008     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00786-6     Document Type: Article

References (21)

1. Bornstein J.C., Furness J.B., Kunze W.A.A. Electrophysiological characterization of myenteric neurons: how do classification schemes relate? J. Autonomic Nerv. Syst. 48:1994;1-15.
2. Buffa R., Solcia E., Go V.L.W. Immunohistochemical identification of the cholecystokinin cell in the intestinal mucosa. Gastroenterology. 70:1976;528-532.
3. Chang R.S.L., Lotti V.J. Biochemical and pharmacological characterization of an extremely potent and selective non-peptide cholecystokinin antagonist. Proc. Natl. Acad. Sci. USA. 83:1986;4923-4926.
4. Crawley J.N., Corwin R.L. Biological actions of cholecystokinin. Peptides. 15:1994;731-755.
5. Dockray, G.J., Physiology of enteric neuropeptides. In L.R. Johnson (Ed.), Physiology of the Gastrointestinal Tract, 3rd edn., Raven Press, New York, 1994, pp. 169-209.
6. Furness J.B., Costa M., Keast J.R. Choline acetyltransferase- and peptide immunoreactivity of submucous neurons in the small intestine of the guinea-pig. Cell Tiss. Res. 237:1984;329-336.
7. Furness J.B., Young H.M., Pompolo S., Bornstein J.C., Kunze W.A.A., McConalogue K. Plurichemical transmission and chemical coding of neurons in the digestive tract. Gastroenterology. 108:1995;554-563.
8. Karaus M., Niederau C. Effects of CCK-receptor antagonist on colonic motor activity in dogs. Neurogastroenterol. Mot. 7:1995;63-71.
9. Larsson L.-I., Rehfeld J.J. Localization and molecular heterogeneity of cholecystokinin in the central and peripheral nervous system. Brain Res. 165:1979;201-218.
10. Lotti V.J., Chang R.S.L. A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur. J. Pharmacol. 162:1989;273-280.
11. McConalogue K., Furness J.B. Gastrointestinal neurotransmitters, Baillière's Clin. Endocrinol. Metabol. 8:1994;51-76.
12. Nemeth P.R., Zafirov D.H., Wood J.D. Effects of cholecystokinin, caerulein and pentagastrin on electrical behavior of myenteric neurons. Eur. J. Pharmacol. 116:1985;263-269.
13. Schultzberg M., Hökfelt T., Nilsson G., Terenius L., Rehfeld J.F., Brown M., Elde R., Goldstein M., Said S. Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine β-hydroxylase. Neuroscience. 5:1980;689-744.
14. Schumann M.A., Kreulen D.L. Action of cholecystokinin octapeptide and CCK-related peptides on neurons in inferior mesenteric ganglion of guinea pig. J. Pharmacol. Exp. Ther. 239:1986;618-625.
15. Schutte I.W.M., Kroese A.B.A., Akkermans L.M.A. Somal size and location within the ganglia for electrophysiologically identified myenteric neurons of the guinea pig ileum. J. Comp. Neurol. 355:1995;563-572.
16. B receptors mediate dissimilar effects of CCK on guinea-pig myenteric neurons. Neurogastroenterol. Mot. 8:1996;191.
17. B receptor subtypes both mediate the effects of CCK-8 on myenteric neurones in the guinea-pig ileum, J. Autonomic Nerv. Syst., (1997) in press.
18. Surprenant A. Control of the gastrointestinal tract by enteric neurons. Annu. Rev. Physiol. 56:1994;117-140.
19. Walsh, J.H., Gastrointestinal hormones. In L.R. Johnson (Ed.), Physiology of the Gastrointestinal Tract, 3rd edn., Raven Press, New York, 1994, pp. 1-128.
20. Wettstein, J.G., Bueno, L. and Junien, J.L., CCK antagonists: pharmacology and therapeutic interest, Pharmacol. Ther., 62, (1994) 267-282.
21. Wood, J.D., Physiology of the enteric nervous system. In L.R. Johnson (Ed.), Physiology of the Gastrointestinal Tract, 3rd edn., Raven Press, New York, 1994, pp. 423-482.