Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl) thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol moiety as a sugar mimic

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6700-6704

  Popsavin, Mirjana ^a   Spaić, Saša ^a   Svirčev, Miloš ^a   Kojić, Vesna ^b   Bogdanović, Gordana ^b   Popsavin, Velimir ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

^b ONCOLOGY INSTITUTE OF VOJVODINA   (Serbia)

Author keywords

Analogue synthesis; Antitumour agent; C Nucleosides; Thiazole; Tiazofurin

Indexed keywords

2 (BETA DEXTRO XYLOFURANOSYL)THIAZOLE 4 CARBOXAMIDE; ANTINEOPLASTIC AGENT; SUGAR; THIAZOLE DERIVATIVE; TIAZOFURIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; BREAST ADENOCARCINOMA; CHLORINATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DEACETYLATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FETUS; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA CELL LINE; LUNG FIBROBLAST; MYELOID LEUKEMIA; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; NUCLEOSIDES; RIBAVIRIN; THIAZOLES; XYLOSE;

EID: 84867575872     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.093     Document Type: Article

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