Airway secretions and mucociliary function

Equine Respiratory Medicine and Surgery

Volumn , Issue , 2007, Pages 55-69

  Gerber, Vincent ^a   Robinson, N Edward ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882543817     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7020-2759-8.50010-6     Document Type: Chapter

References (89)

1. Anon International Workshop on Equine Chronic Airway Disease. Proceedings of Workshop at Michigan State University, June 2000. Equine Veterinary Journal 2001, 33:5-19.
2. Anon International Workshop on Inflammatory Airway Disease: Defining the Syndrome. Proceedings of Workshop in Boston, October 2002. Equine Veterinary Education 2002, 15:61-63.
3. Art T, Kirschvink N, Smith N, et al. Indices of oxidative stress in blood and pulmonary epithelium lining fluid in horses suffering from recurrent airway obstruction. Equine Veterinary Journal 1999, 31:397-401.
4. Bartner LR, Tesfaigzi Y, Robinson NE 2006 Persistent mucus accumulation: A consequence of delayed mucous cell death in heaves-affected horses? American Journal of Physiology. Lung Cell Molecular Physiology: 171: in press.
5. Basbaum C, Lemjabbar H, Longphre M, et al. Control of mucin transcription by diverse injury-induced signaling pathways. American Journal of Respiratory and Critical Care Medicine 1999, 160:S44-S48.
6. Broadstone RV, Scott JS, Derksen FJ, et al. Effects of atropine in ponies with recurrent airway obstruction. Journal of Applied Physiology 1988, 65:2720-2725.
7. Bureau F, Bonizzi G, Kirschvink N, et al. Correlation between nuclear factor-kappaB activity in bronchial brushing samples and lung dysfunction in an animal model of asthma. American Journal of Respiratory and Critical Care Medicine 2000, 161:1314-1321.
8. Burrell MH Endoscopic and virological observations on respiratory disease in a group of young thoroughbred horses in training. Equine Veterinary Journal 1985, 17:99-103.
9. Chapman PS, Green C, Main JP, et al. Retrospective study of the relationships between age, inflammation and the isolation of bacteria from the lower respiratory tract of thoroughbred horses. Veterinary Record 2000, 146:91-95.
10. Christley RM, Hodgson DR, Rose RJ, et al. Coughing in thoroughbred racehorses: risk factors and tracheal endoscopic and cytological findings. Veterinary Record 2001, 148:99-104.
11. Coombs SL, Webbon PM Observations on tracheal mucociliary clearance in horses. Tierärztliche Praxis Supplement 1987, 2:5-9.
12. Del Donno M, Bittesnich D, Chetta A, et al. The effect of inflammation on mucociliary clearance in asthma: an overview. Chest 2000, 118:1142-1149.
13. Derksen FJ, Robinson NE, Berney CE Aerosol pirbuterol: bronchodilator activity and side effects in ponies with recurrent airway obstruction (heaves). Equine Veterinary Journal 1992, 24:107-112.
14. Dieckmann MP 1987 Zur Wirksamkeit von Ambroxolhydrochlorid (Mukovent) bei lungenkranken Pferden-klinische, funktionelle und zytologische Untersuchungen, Inaugural Dissertation (Dr. med. vet.), Tierärztliche Hochschule Hannover, Germany.
15. Dixon PM Respiratory mucociliary clearance in the horse in health and disease, and its pharmaceutical modification. Veterinary Record 1992, 131:229-235.
16. Dixon PM, Railton DI, McGorum BC Equine pulmonary disease: a case control study of 300 referred cases. Part 1: Examination techniques, diagnostic criteria and diagnoses. Equine Veterinary Journal 1995, 27:416-421.
17. Dixon PM, Railton DI, McGorum BC Equine pulmonary disease: a case control study of 300 referred cases. Part 2: details of animals and historical and clinical findings. Equine Veterinary Journal 1995, 27:422-427.
18. Dixon PM, Railton DI, McGorum BC Equine pulmonary disease: a case control study of 300 referred cases. Part 3: Ancillary diagnostic findings. Equine Veterinary Journal 1995, 27:428-435.
19. Dorwald M, Vanden Bosche G, Gerull A Zura Surfactantphospholipidzusammensetzung im Tracheobronchialsekret des Pferdes und ihrer klinischen relevanz fuer die Beurteilung des Lungenstatus bei chronisch lungenkranken Pferden. Wiener Tierärztliche Wochenschrift 1991, 78:118-126.
20. Fahy JV, Boushey HA Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation. European Respiratory Journal 1998, 11:1240-1247.
21. Fanucchi MV, Hotchkiss JA, Harkema JR Endotoxin potentiates ozone-induced mucous cell metaplasia in rat nasal epithelium. Toxicology and Applied Pharmacology 1998, 152:1-9.
22. Galati P, Roperto F, De Vico G, et al. Atypical cilia in the tracheal epithelium of healthy horses. Journal of Comparative Pathology 1991, 105:185-190.
23. Gerber V 1995 Untersuchungen über die mukoziliäre Clearance in der Luftröhre des Pferdes [Investigation of mucociliary clearance in equine trachea]. Inaugural Dissertation (Dr. med. vet.), University of Berne, Switzerland.
24. Gerber V 2003 Nature and causes of mucus accumulation in equine lower airway disease. PhD thesis, Michigan State University, USA.
25. Gerber V, Gehr P, Straub R, et al. Influence of gravity on tracheal mucus velocity in excised horse tracheas. American Journal of Respiratory and Critical Care Medicine 1996, 153:A483.
26. Gerber V, Gehr P, Straub R, et al. Mucus quality on horse tracheal epithelium: microscopic grading based on transparency. Respiration Physiology 1997, 107:67-74.
27. Gerber V, King M, Lee M et al 1998 Rheology of mucus in horses with moderate COPD. World Equine Airways Symposium CD-ROM, Lifelearn, Guelph, Canada.
28. Gerber V, King M, Schneider DA, et al. Tracheobronchial mucus viscoelasticity during environmental challenge in horses with recurrent airway obstruction. Equine Veterinary Journal 2000, 32:411-417.
29. Gerber V, Robinson NE, Rawson J et al 2001 Equine mucin genes: MUC5AC but not MUC2 is expressed in equine airways. Proceedings of the Annual Veterinary Medical Forum. American College of Veterinary Internal Medicine. CD-ROM, Omnipress, Chicago.
30. Gerber V, Robinson NE, Luethi S, et al. Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses. Equine Veterinary Journal 2003, 35:491-495.
31. Gerber V, Robinson NE, Venta RJ, et al. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Veterinary Journal 2003, 35:252-257.
32. Gerber V, Schott HC, Carr E et al 2003c Oral dexamethasone resolves owner complaints but inconsistently improves clinical parameters of equine lower airway disease in a randomized, double-blind placebo-controlled study. Proceedings of the Annual Veterinary Medical Forum. American College of Veterinary Internal Medicine. CD-ROM, Omnipress, Chicago.
33. Gerber V, Lindberg A, Berney C, et al. Airway mucus in recurrent airway obstruction-short-term response to environmental challenge. Journal of Veterinary Internal Medicine 2004, 18:92-97.
34. Gerber V, Straub R, Marti E, et al. Endoscopic scoring of mucus: Reproducibility, and relation to mucus viscosity and airway inflammation. Equine Veterinary Journal 2004, 36:576-582.
35. Gordon T, Nadziejko C, Plant M, et al. One-month exposure to inhaled endotoxin produces a dose-dependent increase in stored mucosubstances in rat intrapulmonary airways. Experimental Lung Research 1996, 22:509-523.
36. Harkema JR, Wagner JG Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways. Novartis Foundation Symposium 2002, 248:181-197. discussion 197-200, 277-182.
37. Harkema JR, Plopper CG, Hyde DM, et al. Regional differences in quantities of histochemically detectable mucosubstances in nasal, paranasal, and nasopharyngeal epithelium of the bonnet monkey. Journal of Histochemistry and Cytochemistry 1987, 35:279-286.
38. Haschek WM Respiratory system. Fundamentals of Toxicologic Pathology 1998, 108-122. Academic Press, San Diego. W.M. Haschek, C.G. Rousseaux (Eds.).
39. Hobo S, Yoshihara T, Oikawa M, et al. Surfactant proteins in bronchoalveolar lavage fluid of horses: assay technique and changes following road transport. Veterinary Record 2001, 148:74-80.
40. Holcombe SJ, Jackson C, Gerber V, et al. Stabling is associated with airway inflammation in young Arabian horses. Equine Veterinary Journal 2001, 33:244-249.
41. Holcombe SJ, Robinson NE, Derksen FJ et al 2004 Tracheal mucus is associated with poor racing performance in thoroughbred horses. Proceedings of the 50th Annual Convention of the American Association of Equine Practitioners, AAEP, Lexington, USA, pp. 272-273.
42. Houtmeyers E, Gosselink R, Gayan-Ramirez G, et al. Regulation of mucociliary clearance in health and disease. European Respiratory Journal 1999, 13:1177-1188.
43. Im Hof V, Gerber V, Gehr P, et al. Exogenous surfactant accelerates tracheal mucus velocity in spontaneously breathing non-anaesthetized horses. American Journal of Respiratory and Critical Care Medicine 1996, 153:A109.
44. Im Hof V, Gehr P, Gerber V, et al. In vivo determination of surface tension in the horse trachea and in vitro model studies. Respiration Physiology 1997, 109:81-93.
45. Jefcoat AM, Hotchkiss JA, Gerber V, et al. Persistent mucin glycoprotein alterations in equine recurrent airway obstruction. American Journal of Physiology. Lung Cell Molecular Physiology 2001, 281:L704-L712.
46. Jeffery PK, Li D Airway mucosa: secretory cells, mucus, and mucin genes. European Respiratory Journal 1997, 10:1655-1662.
47. Jungsuwadee P, Dekan G, Stingl G, et al. Inhaled dexamethasone differentially attenuates disease relapse and established allergic asthma in mice. Clinical Immunology 2004, 110:13-21.
48. Kaup FJ, Drommer W, Damsch S, et al. Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD). II: Pathomorphological changes of the terminal airways and the alveolar region. Equine Veterinary Journal 1990, 22:349-355.
49. Kaup FJ, Drommer W, Deegen E Ultrastructural findings in horses with chronic obstructive pulmonary disease (COPD). I: Alterations of the larger conducting airways. Equine Veterinary Journal 1990, 22:343-348.
50. Keller H, Faulstich M, Elker M, et al. Klinische Studie zur Wirksamkeit und Verträglichkeit von N-Acetylcystein bei der Behandlung der COB/COPD des Pferdes [efficacy and tolerance study of acetylcysteine in the COB/COPD therapy in horses]. Praktischer Tierarzt 2001, 82:108-117.
51. Kibe A, Inoue H, Fukuyama S, et al. Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. American Journal of Respiratory and Critical Care Medicine 2003, 167:50-56.
52. Kim WD Lung mucus: a clinician's view. European Respiratory Journal 1997, 10:1914-1917.
53. King M, Rubin BK Rheology of airway mucus: relationship with clearance function. Airway Secretion: Physiological Bases for the Control of Mucous Hypersecretion 1994, 283-314. Marcel Dekker, Inc., New York. T. Takashima, S. Shimura (Eds.).
54. Lindberg A, Nasman-Glaser B, Lindgren JA, et al. Evaluation of leukotriene biosynthetic capacity in lung tissues from horses with recurrent airway obstruction. American Journal of Veterinary Research 2002, 63:794-798.
55. Luft J 1987 Der Einfluss koerperlicher Belastung auf die Zytologie des Tracheobronchialsekretes beim Pferd [The effect of exercise of the composition of tracheobronchial secretions in the horse]. Inaugural Dissertation (Dr. med. vet.), Tierärztliche Hochschule Hannover, Germany.
56. Lugo J, Harkema J, Defeijter-Rupp H et al 2006 Airway inflammation is associated with mucous cell metaplasia and increased epithelial stored mucosubstances in horses. The Veterinary Journal (in press).
57. MacNamara B, Bauer S, Iafe J Endoscopic evaluation of exercise-induced pulmonary hemorrhage and chronic obstructive pulmonary disease in association with poor performance in racing Standardbreds. Journal of the American Veterinary Medical Association 1990, 196:443-445.
58. Matthews AG, Hackett IJ, Lawton WA The mucolytic effect of Sputolosin in horses with respiratory disease. Veterinary Record 1988, 122:106-108.
59. Matthews LM, Spector S, Lemm J, et al. Studies on pulmonary secretions. American Review of Respiratory Disease 1963, 88:199-204.
60. Maxson AD, Soma LR, May LL, et al. Effects of furosemide, exercise, and atropine on tracheal mucus transport rate in horses. American Journal of Veterinary Research 1995, 56:908-912.
61. Moreno RH, Hogg JC, Pare PD Mechanics of airway narrowing. American Review of Respiratory Disease 1986, 133:1171-1180.
62. Nakanishi A, Morita S, Iwashita H, et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proceedings of the National Academy of Sciences, USA 2001, 98:5175-5180.
63. Pearce HG, Wyburn RS, Goulden BE A clinical evaluation of Bisolvon® for the treatment of some equine respiratory diseases. New Zealand Veterinary Journal 1978, 26:28-30.
64. Pietra M, Guglielmini C, Forni M, et al. In vitro mucolytic activity of recombinant human deoxyribonuclease on equine tracheobronchial mucus. Veterinary Record 2000, 147:627-629.
65. Pirie RS In: Role of inhaled endotoxin in the pathogenesis of equine COPD. Proceedings of Workshop on Allergic Diseases of the Horse 1998, 10. Lipica, Slovenia. P.M. Dixon, K. Schmallenbach, P. Maisi (Eds.).
66. Pirie RS, Dixon PM, Collie DD, et al. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. Equine Veterinary Journal 2001, 33:311-318.
67. Raidal SL The incidence and consequences of failure of passive transfer of immunity on a thoroughbred breeding farm. Australian Veterinary Journal 1996, 73:201-206.
68. Raidal SL, Love DN, Bailey GD Inflammation and increased numbers of bacteria in the lower respiratory tract of horses within 6 to 12 hours of confinement with the head elevated. Australian Veterinary Journal 1995, 72:45-50.
69. Robinson NE, Derksen FJ, Olszewski MA, et al. The pathogenesis of chronic obstructive pulmonary disease of horses. British Veterinary Journal 1996, 152:283-306.
70. Robinson NE, Berney C, Eberhart S, et al. Cough, mucus, airway obstruction, and inflammation in heaves-affected and control horses. American Journal of Veterinary Research 2003, 64:550-557.
71. Robinson NE, Kamaus W, Holcombe SJ et al 2006 Airway inflammation in Michigan pleasure horses: prevalence and risk factors. Equine Veterinary Journal (in press).
72. Sasse W, Deegen E Zur Wirksamkeit von Sputolysin bei Pferden mit chronischen Bronchialerkrankungen [On the efficacy of sputolysin in horses with chronic bronchial diseases]. Tierärztliche Umschau 1984, 39:941-949.
73. Schlesinger RB Clearance from the respiratory tract. Fundamental and Applied Toxicology 1985, 5:435-450.
74. Shi ZO, Fischer MJ, De Sanctis GT, et al. IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis. Journal of Immunology 2002, 168:4764-4771.
75. Shim JJ, Dabbagh K, Ueki IF, et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. American Journal of Physiology. Lung Cellular and Molecular Physiology 2001, 280:L134-L140.
76. Sonea IM, Bowker RM, Robinson NE Distribution of substance P binding sites in equine airways. Equine Veterinary Journal 1999, 31:238-242.
77. Sweeney CR Tracheal mucus transport rate in healthy horses. American Journal of Veterinary Research 1989, 50:2135-2137.
78. Sweeney CR, Beech J, Roby KA Bacterial isolates from tracheobronchial aspirates of healthy horses. American Journal of Veterinary Research 1985, 46:2562-2565.
79. Sweeney CR, Leary HJ, Ziemer EL, et al. Effect of water vapor-saturated air therapy on bronchoalveolar lavage and tracheal mucus transport rate in clinically normal horses. American Journal of Veterinary Research 1989, 50:276-279.
80. Takeyama K, Dabbagh K, Jeong Shim J, et al. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. Journal of Immunology 2000, 164:1546-1552.
81. Tesfaigzi Y, Fischer MJ, Martin AJ, et al. Bcl-2 in LPS- and allergen-induced hyperplastic mucous cells in airway epithelia of Brown Norway rats. American Journal of Physiology: Lung Cellular and Molecular Physiology 2000, 279:L1210-L1217.
82. Toda M, Tulic MK, Levitt RC, et al. A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. Journal of Allergy and Clinical Immunology 2002, 109:246-250.
83. Turgut K, Sasse HH Influence of clenbuterol on mucociliary transport in healthy horses and horses with chronic obstructive pulmonary disease. Veterinary Record 1989, 125:526-530.
84. Viel L 1980 Structural-functional correlations of the lung in the normal light horse. MSc thesis, University of Guelph, Canada.
85. Walley EA, Thornton DJ, Corfield AP et al 2001 Characterization of equine respiratory tract mucins. World Equine Airway Symposium, CD-ROM, Lifelearn, Guelph, Canada.
86. Widdicombe JH, Pecson IS Distribution and numbers of mucous glands in the horse trachea. Equine Veterinary Journal 2002, 34:630-633.
87. Willoughby R, Ecker G, McKee S, et al. The effects of equine rhinovirus, influenza virus and herpesvirus infection on tracheal clearance rate in horses. Canadian Journal of Veterinary Research 1992, 56:115-121.
88. Willoughby RA, Ecker GL, McKee SL, et al. Use of scintigraphy for the determination of mucociliary clearance rates in normal, sedated, diseased and exercised horses. Canadian Journal of Veterinary Research 1991, 55:315-320.
89. Zhou Y, Dong Q, Louahed J, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. American Journal of Respiratory Cell and Molecular Biology 2001, 25:486-491.