Inhaled dexamethasone differentially attenuates disease relapse and established allergic asthma in mice

Clinical Immunology

Volumn 110, Issue 1, 2004, Pages 13-21

  Jungsuwadee, Paiboon ^a   Dekan, Gerhard ^b   Stingl, Georg ^a   Epstein, Michelle M ^a,c  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Allergy; Asthma; Dexamethasone; Glucocorticoids; Mice; Mouse models; Overt; Relapse; Treatment

Indexed keywords

ANTIALLERGIC AGENT; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; GLUCOCORTICOID; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1;

ALLERGIC ASTHMA; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BLOOD; BRONCHUS MUCUS; CELL INFILTRATION; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFECT; HYPERSENSITIVITY; INFLAMMATION; INFLAMMATORY INFILTRATE; INHALATIONAL DRUG ADMINISTRATION; LEUKOCYTE; LUNG; LUNG LAVAGE; LUNG PARENCHYMA; MOUSE; MOUSE STRAIN; MUCUS; NEBULIZATION; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RELAPSE; REMISSION;

EID: 0842346897     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clim.2003.09.003     Document Type: Article

References (38)

1. Busse W., Sedgwick J.B. Eosinophils in asthma. Ann. Allergy. 68:1992;286-290.
2. Corrigan C., Kay A.B. The roles of inflammatory cells in the pathogenesis of asthma and of chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 143:1991;1165-1168.
3. Sears M. The definition and diagnosis of asthma. Allergy. 48:1993;12-16.
4. Jungsuwadee P., Dekan G., Stingl G., Epstein M.M. Recurrent aerosol antigen exposure induces distinct patterns of experimental allergic asthma in mice. Clin. Immunol. 102:2002;145-153.
5. Cronstein B., Weissmann G. Targets for antiinflammatory drugs. Annu. Rev. Pharmacol. Toxicol. 35:1995;449-462.
6. Barnes P.J. Inhaled glucocorticoids for asthma. N. Engl. J. Med. 332:1995;868-875.
7. de Kluijver J., Evertse C.E., Schrumpf J.A., van der Veen H., Zwinderman A.H., Hiemstra P.S., Rabe K.F., Sterk P.J. Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma: protection by inhaled steroids. Am. J. Respir. Crit. Care Med. 166:2002;294-300.
8. Ray A., Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U. S. A. 91:1994;752-756.
9. Schleimer R. Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma. Am. Rev. Respir. Dis. 141:1990;S59-S69.
10. Laitinen L., Laitinen A., Haahtela T.A. A comparative study of the effects of an inhaled corticosteroid, budesonide, and of a 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J. Allergy Clin. Immunol. 90:1992;32-42.
11. Djukanovic R., Wilson J.W., Britten K.M.et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am. Rev. Respir. Dis. 145:1992;669-674.
12. Shimura S., Sasaki T., Ikeda K., Yamauchi K., Sasaki H., Takishima T. Direct inhibitory action of glucocorticoid on glycoconjugate secretion from airway submucosal glands. Am. Rev. Respir. Dis. 141:1990;1044-1049.
13. Barnes P. Effect of corticosteroids on airway hyperresponsiveness. Am. Rev. Respir. Dis. 141:1990;S70-S76.
14. Bel E., Timmers M.C., Zwinderman A.H., Dijkman J.H., Sterk P.J. The effect of inhaled corticosteroids on the maximal degree of airway narrowing to methacholine in asthmatic subjects. Am. Rev. Respir. Dis. 143:1991;109-113.
15. Elwood W.L.J., Barnes P.J., Chung K.F. Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell responses in sensitized Brown-Norway rats. Am. Rev. Respir. Dis. 145:1992;1289-1294.
16. De Bie J.J., Hessel E.M., Van Ark I., Van Esch B., Hofman G., Nijkamp F.P., Van Oosterhout A.J. Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse. Br. J. Pharmacol. 119:1996;1484-1490.
17. Mathur M., Herrmann K., Li X.T., Qin Y.M., Weinstock J., Elliott D., Monahan J., Padrid P. TRFK-5 reverses established airway eosinophilia but not established hyperresponsiveness in a murine model of chronic asthma. Am. J. Respir. Crit. Care Med. 159:1999 (Feb.);580-587.
18. Blyth D.I., Wharton T.F., Pedrick M.S., Savage T.J., Sanjar S. Airway subepithelial fibrosis in a murine model of atopic asthma: suppression by dexamethasone or anti-Interleukin-5 antibody. Am. J. Respir. Cell Mol. Biol. 23:2000;241-246.
19. Vanacker N.J., Palmans E., Kips J.C., Pauwels R.A. Fluticasone inhibits but does not reverse allergen-induced structural airway changes. Am. J. Respir. Crit. Care Med. 163:2001;674-679.
20. Trifilieff A., El-Hashim A., Bertrand C. Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment. Am. J. Physiol. 279:2000;L1120-L1128.
21. Jeffery P., Godfrey R.W., Ädelroth E., Nelson F., Rogers A., Johansson S.-Å. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study. Am. Rev. Respir. Dis. 145:1992;890-899.
22. Burke C., Power C.K., Norris A., Condez A., Schmekel B., Poulter L.W. Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma. Eur. Respir. J. 5:1992;73-79.
23. Trigg C., Manolitsas N., Wang J., Calderon M., McAulay A., Jordan S., Herdman M., Jhalli N., Duddle J., Hamilton S. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am. J. Respir. Crit. Care Med. 150:1994;17-22.
24. Duddridge M., Ward C., Hendrick D.J., Walters E.H. Changes in bronchoalveolar lavage inflammatory cells in asthmatic patients treated with high dose inhaled beclomethasone dipropionate. Eur. Respir. J. 6:1993;489-497.
25. Ädelroth E., Rosenhall L., Johansson S.-A., Linden M., Venge P. Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. Am. Rev. Respir. Dis. 142:1990;91-99.
26. Wilson J.W., Djukanovic R., Howarth P.H., Holgate S.T. Inhaled beclomethasone diproprionate downregulates airway lymphocyte activation in atopic asthma. Am. J. Respir. Crit. Care Med. 149:1994;86-90.
27. Cox G. Glucocorticoid treatment inhibits apoptosis in human neutrophils. J. Immunol. 193:1995;4719-4725.
28. Meagher L.C., Cousin J.M., Seckl J.R., Haslett C. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J. Immunol. 156:1996;4422-4428.
29. Cronstein B.N., Kimmel S.C., Levin R.I., Martiniuk F., Weissmann G. A mechanism for the anti-inflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. U. S. A. 89:1992;9991-9995.
30. van de Stolpe A., Caldenhoven E., Raaijmakers J.A., van der Saag P.T., Koenderman L. Glucocorticoid-mediated repression of intercellular adhesion molecule-1 expression in human monocytic and bronchial epithelial cell lines. Am. J. Respir. Cell Mol. Biol. 8:1993;340-347.
31. Jahnsen F.L., Haye R., Gran E., Brandtzaeg P., Johansen F.-E. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. J. Immunol. 163:1999;1545-1551.
32. Hogaboam C.M., Blease K., Mehrad B., Steinhauser M.L., Standiford T.J., Kunkel S.L., Lukacs N.W. Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am. J. Pathol. 156:2000;723-732.
33. Temelkovski J., Hogan S.P., Shepherd D.P., Foster P.S., Kumar R.K. An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax. 53:1998;849-856.
34. Yiamouyiannis C.A., Schramm C.M., Puddington L., Stengel P., Baradaran-Hosseini E., Wolyniec W.W., Whiteley H.E., Thrall R.S. Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model. Am. J. Pathol. 154:1999;1911-1921.
35. Kumar R.K., Foster P.S. Modeling allergic asthma in mice: pitfalls and opportunities. Am. J. Respir. Cell Mol. Biol. 27:2002;267-272.
36. Palmans E., Kips J.C., Pauwels R.A. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am. J. Respir. Crit. Care Med. 161:2000;627-635.
37. Lundgren J.D., Hirata F., Marom Z., Logun C., Steel L., Kaliner M., Shelhamer J. Dexamethasone inhibits respiratory glycoconjugate secretion from feline airways in vitro by the induction of lipocortin (lipomodulin) synthesis. Am. Rev. Respir. Dis. 137:1988;353-357.
38. Kai H., Yoshitake K., Hisatsune A., Kido T., Isohama Y., Takahama K., Miyata T. Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells. Am. J. Physiol. 271:1996;L484-L488.