Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension

Pulmonary Circulation

Volumn 1, Issue 1, 2011, Pages 111-114

  Kuang, Tuguang ^a   Wang, Jun ^a   Zeifman, Amy ^b   Pang, Baosen ^a   Huang, Xiuxia ^a   Burg, Elyssa D ^c   Yuan, Jason X J ^a,b   Wang, Chen ^a,d  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d BEIJING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882375823     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.4103/2045-8932.78102     Document Type: Article

References (30)

1. Nohe A, Keating E, Knaus P, Petersen NO. Signal transduction of bone morphogenetic protein receptors. Cell Signal 2004;16:291-9.
2. Yu PB, Beppu H, Kawai N, Li E, Bloch KD. Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. J Biol Chem 2005;280:24443-50.
3. Machado RD, Pauciulo MW, Thomson JR, Lane KB, Morgan NV, Wheeler L, et al. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. Am J Hum Genet 2001;68:92-102.
4. Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA 3rd, et al. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 2001;345:319-24.
5. Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, Henis YI, et al. The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem 2002;277:5330-8.
6. Mandegar M, Fung YC, Huang W, Remillard CV, Rubin LJ, Yuan JX. Cellular and molecular mechanisms of pulmonary vascular remodeling: Role in the development of pulmonary hypertension. Microvasc Res 2004;68:75-103.
7. Kuang T, Wang J, Pang B, Huang X, Burg ED, Yuan JX, et al. Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats. Pulm Pharmacol Ther 2010;23:456-64.
8. Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, et al. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2006;290:L450-8.
9. Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-a in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 2003;85-A:59-66.
10. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, et al. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2003;285:L740-54.
11. Ramos M, Lame MW, Segall HJ, Wilson DW. The BMP type II receptor is located in lipid raft s, including caveolae, of pulmonary endothelium in vivo and in vitro. Vascul Pharmacol 2006;44:50-9.
12. Garcia-Cardena G, Oh P, Liu J, Schnitzer JE, Sessa WC. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling. Proc Natl Acad Sci U S A 1996;93:6448-53.
13. Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, et al. Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 1996;271:6518-22.
14. Fiorica-Howells E, Hen R, Gingrich J, Li Z, Gershon MD. 5-HT2A receptors: Location and functional analysis in intestines of wild-type and 5-HT2A knockout mice. Am J Physiol Gastrointest Liver Physiol 2002;282:G877-93.
15. Dreja K, Voldstedlund M, Vinten J, Tranum-Jensen J, Hellstrand P, Sward K. Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction. Arterioscler Thromb Vasc Biol 2002;22:1267-72.
16. Bhatnagar A, Sheffler DJ, Kroeze WK, Compton-Toth B, Roth BL. Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Gaq-coupled protein receptors. J Biol Chem 2004;279:34614-23.
17. Lockwich TP, Liu X, Singh BB, Jadlowiec J, Weiland S, Ambudkar IS. Assembly of Trp1 in a signaling complex associated with caveolinscaffolding lipid raft domains. J Biol Chem 2000;275:11934-42.
18. 2+ entry dependent on TRPC1. Circ Res 2003;93:839-47.
19. Chun M, Liyanage UK, Lisanti MP, Lodish HF. Signal transduction of a G protein-coupled receptor in caveolae: Colocalization of endothelin and its receptor with caveolin. Proc Natl Acad Sci U S A 1994;91:11728-32.
20. Okamoto Y, Ninomiya H, Miwa S, Masaki T. Cholesterol oxidation switches the internalization pathway of endothelin receptor type A from caveolae to clathrin-coated pits in Chinese hamster ovary cells. J Biol Chem 2000;275:6439-46.
21. Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim DK, et al. Altered bone morphogenetic protein and transforming growth factor-b signaling in rat models of pulmonary hypertension: Potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease. Circulation 2009;119:566-76.
22. Schwappacher R, Weiske J, Heining E, Ezerski V, Marom B, Henis YI, et al. Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMPR receptor and Smad activity. EMBO J 2009;28:1537-50.
23. Morrell NW. Pulmonary hypertension due to BMPR2 mutation: A new paradigm for tissue remodeling? Proc Am Thorac Soc 2006;3:680-6.
24. Davies RJ, Morrell NW. Molecular mechanisms of pulmonary arterial hypertension: Role of mutations in the bone morphogenetic protein type II receptor. Chest 2008;134:1271-7.
25. Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, et al. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res 2005;97:496-504.
26. Ramos MF, Lame MW, Segall HJ, Wilson DW. Smad signaling in the rat model of monocrotaline pulmonary hypertension. Toxicol Pathol 2008;36:311-20.
27. Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, et al. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol 2007;27:1072-8.
28. Eickelberg O, Morty RE. Transforming growth factor b/bone morphogenic protein signaling in pulmonary arterial hypertension: Remodeling revisited. Trends Cardiovasc Med 2007;17:263-9.
29. Rubin LJ. Pulmonary arterial hypertension. Proc Am Thorac Soc 2006;3:111-5.
30. El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, et al. SM22a-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development 2008;135:2981-91.