Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 33, 2013, Pages 13374-13379

  Regan, Michael C ^a   Horanyi, Peter S ^a   Pryor Jr , Edward E ^a   Sarver, Jessica L ^b   Cafiso, David S ^b   Bushweller, John H ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR ERG;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISSOCIATION CONSTANT; DNA BINDING; DNA SEQUENCE; ELECTRON SPIN RESONANCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; CALORIMETRY; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DNA; DNA-BINDING PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; OLIGONUCLEOTIDES; PROTEIN STRUCTURE, TERTIARY; SPECTRUM ANALYSIS; TIME FACTORS; TRANS-ACTIVATORS;

EID: 84882359322     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1301726110     Document Type: Article

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