IFNγ influences type i interferon response and susceptibility to Theiler's virus-induced demyelinating disease

Viral Immunology

Volumn 26, Issue 4, 2013, Pages 223-238

  Bowen, Jenna L ^a   Olson, Julie K ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; DEMYELINATING DISEASE; FEMALE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MICROGLIA; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; RNA ISOLATION; VIRUS LOAD;

ANIMALS; CARDIOVIRUS INFECTIONS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; CYTOKINES; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; FEMALE; IMMUNITY, INNATE; INFLAMMATION; INTERFERON REGULATORY FACTOR-1; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MULTIPLE SCLEROSIS; THEILOVIRUS; VIRAL LOAD;

EID: 84882348529     PISSN: 08828245     EISSN: 15578976     Source Type: Journal    
DOI: 10.1089/vim.2013.0004     Document Type: Review

References (43)

1. Akbar SM, Inaba K, and Onji M. Upregulation of MHC class II antigen on dendritic cells from hepatitis B virus transgenic mice by interferon-gamma: Abrogation of immune response defect to a T-cell-dependent antigen. Immunol 1996;87:519-527.
2. Allegretta M, Nicklas JA, Sriram S, and Albertini RJ. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990;247:718-721.
3. Barnett MH, Parratt JD, Pollard JD, and Prineas JW. MS: Is it one disease? Int MS J 2009;16:57-65.
4. Bernard CC, and de Rosbo NK. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol.( Napoli) 1991;13:171-178.
5. Biron CA. Interferons alpha and beta as immune regulators-A new look. Immunity 2001;14:661-664.
6. Biron CA, Nguyen KB, Pien GC, Cousens LP, and Salazar-Mather TP. Natural killer cells in antiviral defense: Function and regulation by innate cytokines. Annu Rev Immunol 1999;17:189-220.
7. Bowen JL,and Olson JK. Innate immune CD11b + Gr-1 + cells, suppressor cells, affect the immune response during Theiler's virus-induced demyelinating disease. J Immunol 2009;183:6971-6980.
8. Darnell JE, Jr, Kerr IM, and Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264:1415-1421.
9. Der SD, Zhou A, Williams BR, and Silverman RH. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 1998;95:15623-15628.
10. Desimone R, Giampaolo A, Giometto B, et al. The costimulatory molecule B7 Is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neuropathol Exp Neurol 1995;54:175-187.
11. Ferber IA, Brocke S, Taylor-Edwards C, et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 1996;156:5-7.
12. Fiette L, Aubert C, Muller U, et al. Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors. J Exp Med 1995;181:2069-2076.
13. Gajewski TF, and Fitch FW. Anti-proliferative effect of IFNgamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988;140:4245-4252.
14. Katz-Levy Y, Neville KL, Padilla J, et al. Temporal development of autoreactive Th1 responses and endogenous antigen presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice. J Immunol 2000;165: 5304-5314.
15. Kimura T, Nakayama K, Penninger J, et al. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 1994;264:1921-1924.
16. Krakowski M, and Owens T. Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 1996;26:1641-1646.
17. Kumar V, and Sercarz E. Induction or protection from experimental autoimmune encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells. J Immunol 1998;161:6585-6591.
18. Kurtzke J.F. Epidemiologic evidence for multiple sclerosis as an infection. Clin Microbiol Rev 1993;6:382-427.
19. Le Bon A, Schiavoni G, D'Agostino G, Gresser I, Belardelli F, and Tough DF. Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 2001;14:461-470.
20. Lees,JR, Golumbek PT, Sim J, Dorsey D, and Russell JH. Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. J Exp Med 2008;205:2633-2642.
21. Link H, Baig S, Olsson O, Yu-Ping J, Ho jeberg B, and Olsson T. Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid. J Neuroimmunol 1990;28:237-248.
22. Lipton HL, Twaddle G, and Jelachich ML. The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 1995;69:2525-2533.
23. Liu SY, Sanchez DJ, Aliyari R, Lu S, and Cheng G. Systematic identification of type I and type II interferon-induced antiviral factors. Proc Natl Acad Sci USA 2012;109:4239-4244.
24. Liu T, and Chambers TJ. Yellow fever virus encephalitis: Properties of the brain-associated T-cell response during virus clearance in normal and gamma interferon-deficient mice and requirement for CD4 + lymphocytes. J Virol 2001;75:2107-2118.
25. Lyman MA, Myoung J, Mohindru M, and Kim BS. Quantitative, not qualitative, differences in CD8( + ) T cell responses to Theiler's murine encephalomyelitis virus between resistant C57BL/6 and susceptible SJL/J mice. Eur J Immunol 2004;34:2730-2739.
26. Miller SD, Vanderlugt CL, Begolka WS, et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nature Med 1997;3:1133-1136.
27. Mosca PJ, Hobeika AC, Clay TM, et al. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood 2000;96:3499-3504.
28. Muller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM, and Aguet M. Functional role of type I and type II interferons in antiviral defense. Science 1994;264: 1918-1921.
29. Murray PD, Pavelko KD, Leibowitz J, Lin X, and Rodriguez M. CD4+ and CD8+ T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis. J Virol 1998;72:7320-7329.
30. Negishi H, Fujita Y, Yanai H, et al. Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program. Proc Natl Acad Sci USA 2006;103:15136-15141.
31. Negishi H, Osawa T, Ogami K, et al. 2008. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci USA 2008;105:20446-20451.
32. Olson JK, Girvin AM, and Miller SD. Direct activation of innate and antigen presenting functions of microglia following infection with Theiler's virus. J Virol 2001;75:9780-9789.
33. Olson JK, and Miller SD. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol 2004;173:3916-3924.
34. Olson JK, and Miller SD. The innate immune response affects the development of the autoimmune response in Theiler's virus-induced demyelinating disease. J Immunol 2009;182:5712-5722.
35. Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, and Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990; 346:183-187.
36. Patterson CE, Lawrence DM, Echols LA, and Rall GF. 2002. Immune-mediated protection from measles virus-induced central nervous system disease is noncytolytic and gamma interferon dependent. J Virol 2002;76:4497-4506.
37. RodriguezM, Zoecklein LJ,Howe CL, Pavelko KD, Gamez JD, Nakane S, and Papke LM. Gamma interferon is critical for neuronal viral clearance and protection in a susceptiblemouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol 2003;77:12252-12265.
38. Stevens TL, Bossie A, Sanders VM, et al. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 1988;334:255-258.
39. Tough DF, Borrow P, and Sprent J. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 1996;272:1947-1950.
40. Tough DF, Sun S, and Sprent J. T cell stimulation in vivo by lipopolysaccharide (LPS). J Exp Med 1997;185:2089-2094.
41. Trojano M, and Avolio C. Epstein-Barr virus (EBV) and multiple sclerosis association: EBV has a primary or secondary role? J Neurol Neurosurg Psychiatry 2009;80:469.
42. Waksman BH. Multiple sclerosis: More genes versus environment. Nature 1995;377:105-106.
43. Wong LH, Sim H, Chatterjee-Kishore M, et al. Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1. J Biol.Chem 2002;277:19408-19417.