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Volumn 11, Issue 3, 2013, Pages 349-356

Antiplatelet agents in clinical practice and their haemorrhagic risk

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (2,4 DICHLOROBENZYL) 5 FLUORO 3 METHYL 1H INDOL 7 YL] N [(4,5 DICHLORO 2 THIENYL)SULFONYL]ACRYLAMIDE; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; AJW 200; ALX 0081; ALX 0681; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; APTAMER; ARC 15105; ATOPAXAR; CLOPIDOGREL; CONVULXIN; CYCLOOXYGENASE 1; DZ 697B; EGAPTIVON PEGOL; EMS 16; EXP 2179; FIBRINOGEN RECEPTOR ANTAGONIST; GLYCOPROTEIN IB VON WILLEBRAND FACTOR INHIBITOR; GPG 290; HEPARIN; HIRULOG; NCX 6550; NCX 6560; NN PF 3; PRASUGREL; PROTEINASE ACTIVATED RECEPTOR 1; SNAKE VENOM; THROMBIN; THROMBIN RECEPTOR ANTAGONIST; THROMBOXANE A2; TICAGRELOR; TICLOPIDINE; TRIFUNISAL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VON WILLEBRAND FACTOR; VORAPAXAR; WARFARIN;

EID: 84882345322     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: 10.2450/2013.0248-12     Document Type: Review
Times cited : (25)

References (62)
  • 1
    • 0036165065 scopus 로고    scopus 로고
    • Novel approaches to the treatment of thrombosis
    • Gresele P, Agnelli G. Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci 2002; 23: 25-32.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 25-32
    • Gresele, P.1    Agnelli, G.2
  • 2
    • 45849092207 scopus 로고    scopus 로고
    • Potentiation and priming of platelet activation: A potential target for antiplatelet therapy
    • Gresele P, Falcinelli E, Momi S. Potentiation and priming of platelet activation: a potential target for antiplatelet therapy. Trends Pharmacol Sci 2008; 29: 352-60.
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 352-360
    • Gresele, P.1    Falcinelli, E.2    Momi, S.3
  • 3
    • 0036149842 scopus 로고    scopus 로고
    • Prostaglandin endoperoxides and thromboxane a2 activate the same receptor isoforms in human platelets
    • Vezza R, Mezzasoma AM, Venditti G, Gresele P. Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets. Thromb Haemost 2002; 87: 114-21.
    • (2002) Thromb Haemost , vol.87 , pp. 114-121
    • Vezza, R.1    Mezzasoma, A.M.2    Venditti, G.3    Gresele, P.4
  • 4
    • 0026032110 scopus 로고
    • Thromboxane synthase inhibitors, thromboxane receptor antagonists and dual blockers in thrombotic disorders
    • Gresele P, Deckmyn H, Nenci GG, Vermylen J. Thromboxane synthase inhibitors, thromboxane receptor antagonists and dual blockers in thrombotic disorders. Trends Pharmacol Sci 1991; 12: 158-63.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 158-163
    • Gresele, P.1    Deckmyn, H.2    Nenci, G.G.3    Vermylen, J.4
  • 7
    • 74249097306 scopus 로고    scopus 로고
    • Endothelium, venous thromboembolism and ischaemic cardiovascular events
    • Gresele P, Momi S, Migliacci R. Endothelium, venous thromboembolism and ischaemic cardiovascular events. Thromb Haemost 2010; 103: 56-61.
    • (2010) Thromb Haemost , vol.103 , pp. 56-61
    • Gresele, P.1    Momi, S.2    Migliacci, R.3
  • 8
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration
    • Antithrombotic Trialists' Collaboration. Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. BMJ 2002; 324: 71-86.
    • (2002) BMJ , vol.324 , pp. 71-86
  • 9
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
    • Antithrombotic Trialists' (ATT) Collaboration
    • Antithrombotic Trialists' (ATT) Collaboration. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009; 373: 1849-60.
    • (2009) Lancet , vol.373 , pp. 1849-1860
  • 10
    • 0036102091 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition: Between the devil and the deep blue sea
    • III25-30
    • Hawkey CJ. Cyclooxygenase inhibition: between the devil and the deep blue sea. Gut 2002; 50: III25-30.
    • (2002) Gut , vol.50
    • Hawkey, C.J.1
  • 11
    • 0035124920 scopus 로고    scopus 로고
    • Platelet-active drugs: The relationships among dose, effectiveness, and side effects
    • Patrono C, Coller B, Dalen JE, et al. Platelet-active drugs: The relationships among dose, effectiveness, and side effects. Chest 2001; 119: 39S-63S.
    • (2001) Chest , vol.119
    • Patrono, C.1    Coller, B.2    Dalen, J.E.3
  • 12
    • 34248352504 scopus 로고    scopus 로고
    • Aspirin dose for the prevention of cardiovascular disease: A systematic review
    • Campbell CL, Smyth S, Montalescot G, Steinhubl SR. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA 2007; 297: 2018-24.
    • (2007) JAMA , vol.297 , pp. 2018-2024
    • Campbell, C.L.1    Smyth, S.2    Montalescot, G.3    Steinhubl, S.R.4
  • 13
    • 0141919739 scopus 로고    scopus 로고
    • Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: Observations from the clopidogrel in unstable angina to prevent recurrent events (cure) study
    • Peters RJ, Mehta SR, Fox KA, et al. Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Circulation 2003; 108: 1682-7.
    • (2003) Circulation , vol.108 , pp. 1682-1687
    • Peters, R.J.1    Mehta, S.R.2    Fox, K.A.3
  • 14
    • 33845457204 scopus 로고    scopus 로고
    • Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin nonsteroidal anti-inflammatory drugs, aspirin and combinations
    • Lanas A, García-Rodríguez LA, Arroyo MT, et al. Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin nonsteroidal anti-inflammatory drugs, aspirin and combinations. Gut 2006; 55: 1731-8.
    • (2006) Gut , vol.55 , pp. 1731-1738
    • Lanas, A.1    García-Rodríguez, L.A.2    Arroyo, M.T.3
  • 15
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without st-segment elevation
    • Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345: 494-502.
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3
  • 16
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006; 354: 1706-17.
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1    Fox, K.A.2    Hacke, W.3
  • 17
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-15.
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    Mccabe, C.H.3
  • 18
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-57.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 19
    • 35348885588 scopus 로고    scopus 로고
    • Bleeding complications in acute coronary syndromes and percutaneous coronary intervention: Predictors, prognostic significance, and paradigms for reducing risk
    • II24-34
    • Manoukian SV, Voeltz MD, Eikelboom J. Bleeding complications in acute coronary syndromes and percutaneous coronary intervention: predictors, prognostic significance, and paradigms for reducing risk. Clin Cardiol 2007; 30: II24-34.
    • (2007) Clin Cardiol , vol.30
    • Manoukian, S.V.1    Voeltz, M.D.2    Eikelboom, J.3
  • 20
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom JW, Mehta SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006; 114: 774-82.
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3
  • 21
    • 27144475755 scopus 로고    scopus 로고
    • Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes
    • Rao SV, O'Grady K, Pieper KS, et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol 2005; 96: 1200-6.
    • (2005) Am J Cardiol , vol.96 , pp. 1200-1206
    • Rao, S.V.1    O'Grady, K.2    Pieper, K.S.3
  • 22
    • 0142041382 scopus 로고    scopus 로고
    • Predictors of major bleeding in acute coronary syndromes: The global registry of acute coronary events (grace)
    • Moscucci M, Fox KA, Cannon CP, et al. Predictors of major bleeding in acute coronary syndromes: The Global Registry of Acute Coronary Events (GRACE). Eur Heart J 2003; 24: 1815-23.
    • (2003) Eur Heart J , vol.24 , pp. 1815-1823
    • Moscucci, M.1    Fox, K.A.2    Cannon, C.P.3
  • 23
    • 67651099090 scopus 로고    scopus 로고
    • Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-stelevation acute coronary syndromes: A risk model from the acuity trial
    • Mehran R, Pocock SJ, Stone GW, et al. Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-STelevation acute coronary syndromes: a risk model from the ACUITY trial. Eur Heart J 2009; 30: 1457-66.
    • (2009) Eur Heart J , vol.30 , pp. 1457-1466
    • Mehran, R.1    Pocock, S.J.2    Stone, G.W.3
  • 24
    • 44249122195 scopus 로고    scopus 로고
    • Bivalirudin during primary pci in acute myocardial infarction
    • Stone GW, Witzenbichler B, Guagliumi G, et al. Bivalirudin during primary PCI in acute myocardial infarction. N Engl J Med 2008; 358: 2218-30.
    • (2008) N Engl J Med , vol.358 , pp. 2218-2230
    • Stone, G.W.1    Witzenbichler, B.2    Guagliumi, G.3
  • 25
    • 79959696572 scopus 로고    scopus 로고
    • Heparin plus a glycoprotein iib/iiia inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (horizons-ami): Final 3-year results from a multicentre, randomised controlled trial
    • Stone GW, Witzenbichler B, Guagliumi G, et al. Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trial. Lancet 2011; 377: 2193-204.
    • (2011) Lancet , vol.377 , pp. 2193-2204
    • Stone, G.W.1    Witzenbichler, B.2    Guagliumi, G.3
  • 26
    • 65649119646 scopus 로고    scopus 로고
    • Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: Implications for contemporary practice
    • Doyle BJ, Rihal CS, Gastineau DA, Holmes DR Jr. Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: implications for contemporary practice. J Am Coll Cardiol 2009; 53: 2019-27.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 2019-2027
    • Doyle, B.J.1    Rihal, C.S.2    Gastineau, D.A.3    Holmes, Jr.D.R.4
  • 27
    • 4644350897 scopus 로고    scopus 로고
    • Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes
    • Rao SV, Jollis JG, Harrington RA, et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 2004; 292: 1555-62.
    • (2004) JAMA , vol.292 , pp. 1555-1562
    • Rao, S.V.1    Jollis, J.G.2    Harrington, R.A.3
  • 28
    • 83555176025 scopus 로고    scopus 로고
    • Association between bleeding severity and long-term mortality in patients experiencing vascular complications after percutaneous coronary intervention
    • Romaguera R, Wakabayashi K, Laynez-Carnicero A, et al. Association between bleeding severity and long-term mortality in patients experiencing vascular complications after percutaneous coronary intervention. Am J Cardiol 2012; 109: 75-81.
    • (2012) Am J Cardiol , vol.109 , pp. 75-81
    • Romaguera, R.1    Wakabayashi, K.2    Laynez-Carnicero, A.3
  • 29
    • 77951551894 scopus 로고    scopus 로고
    • Duration of red cell storage before transfusion and in-hospital mortality
    • Eikelboom JW, Cook RJ, Liu Y, Heddle NM. Duration of red cell storage before transfusion and in-hospital mortality. Am Heart J 2010; 159: 737-43.
    • (2010) Am Heart J , vol.159 , pp. 737-743
    • Eikelboom, J.W.1    Cook, R.J.2    Liu, Y.3    Heddle, N.M.4
  • 30
    • 84862776674 scopus 로고    scopus 로고
    • The effect of blood storage duration on in-hospital mortality: A randomized controlled pilot feasibility trial
    • Heddle NM, Cook RJ, Arnold DM, et al. The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial. Transfusion 2012; 52: 1203-12.
    • (2012) Transfusion , vol.52 , pp. 1203-1212
    • Heddle, N.M.1    Cook, R.J.2    Arnold, D.M.3
  • 31
    • 80051533777 scopus 로고    scopus 로고
    • Bleeding in acute coronary syndromes and percutaneous coronary interventions: Position paper by the working group on thrombosis of the european society of cardiology
    • Steg PG, Huber K, Andreotti F, et al. Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J 2011; 32: 1854-64.
    • (2011) Eur Heart J , vol.32 , pp. 1854-1864
    • Steg, P.G.1    Huber, K.2    Andreotti, F.3
  • 32
    • 57449102051 scopus 로고    scopus 로고
    • Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding
    • Wang TY, Xiao L, Alexander KP, et al. Antiplatelet therapy use after discharge among acute myocardial infarction patients with in-hospital bleeding. Circulation 2008; 118: 2139-45.
    • (2008) Circulation , vol.118 , pp. 2139-2145
    • Wang, T.Y.1    Xiao, L.2    Alexander, K.P.3
  • 33
    • 28244459634 scopus 로고    scopus 로고
    • Low-dose aspirin for the prevention of atherothrombosis
    • Patrono C, García Rodríguez LA, Landolfi R, Baigent C. Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 2005; 353: 2373-83.
    • (2005) N Engl J Med , vol.353 , pp. 2373-2383
    • Patrono, C.1    García, R.L.A.2    Landolfi, R.3    Baigent, C.4
  • 34
    • 70350620822 scopus 로고    scopus 로고
    • Perioperative handling of antiplatelet therapy: Watching the two sides of the coin
    • Gresele P. Perioperative handling of antiplatelet therapy: watching the two sides of the coin. Intern Emerg Med 2009; 4: 275-6.
    • (2009) Intern Emerg Med , vol.4 , pp. 275-276
    • Gresele, P.1
  • 35
    • 78650223707 scopus 로고    scopus 로고
    • Patterns of discharge antiplatelet therapy and late outcomes among 8, 582 patients with bleeding during acute coronary syndrome: A pooled analysis from PURSUIT, PARAGON-A, PARAGON-B, and SYNERGY
    • Chan MY, Sun JL, Wang TY, et al. Patterns of discharge antiplatelet therapy and late outcomes among 8, 582 patients with bleeding during acute coronary syndrome: a pooled analysis from PURSUIT, PARAGON-A, PARAGON-B, and SYNERGY. Am Heart J 2010; 160: 1056-64.
    • (2010) Am Heart J , vol.160 , pp. 1056-1064
    • Chan, M.Y.1    Sun, J.L.2    Wang, T.Y.3
  • 36
    • 84867148888 scopus 로고    scopus 로고
    • The role of laboratory monitoring in antiplatelet therapy
    • Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Berlin: Springer
    • Cattaneo M. The role of laboratory monitoring in antiplatelet therapy. In: Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Handbook of Experimental Pharmacology. Berlin: Springer; 2012. p. 471-94.
    • (2012) Handbook of Experimental Pharmacology , pp. 471-494
    • Cattaneo, M.1
  • 37
    • 79954473617 scopus 로고    scopus 로고
    • Incomplete inhibition of platelet function as assessed by the platelet function analyzer (pfa-100) identifies a subset of cardiovascular patients with high residual platelet response while on aspirin
    • Crescente M, Mezzasoma AM, Del Pinto M, et al. Incomplete inhibition of platelet function as assessed by the platelet function analyzer (PFA-100) identifies a subset of cardiovascular patients with high residual platelet response while on aspirin. Platelets 2011; 22: 179-87.
    • (2011) Platelets , vol.22 , pp. 179-187
    • Crescente, M.1    Mezzasoma, A.M.2    Del Pinto, M.3
  • 38
    • 79959261917 scopus 로고    scopus 로고
    • Impact of chronic antiplatelet therapy before hospitalization on ischemic and bleeding events in invasively managed patients with acute coronary syndromes: The acuity trial
    • Ambrosio G, Steinhubl S, Gresele P, et al. Impact of chronic antiplatelet therapy before hospitalization on ischemic and bleeding events in invasively managed patients with acute coronary syndromes: The ACUITY trial. Eur J Cardiovasc Prev Rehabil 2011; 18: 121-8.
    • (2011) Eur J Cardiovasc Prev Rehabil , vol.18 , pp. 121-128
    • Ambrosio, G.1    Steinhubl, S.2    Gresele, P.3
  • 40
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for pci: A meta-analysis
    • Mega JL, Simon T, Collet JP, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 2010; 304: 1821-30.
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 41
    • 74749097435 scopus 로고    scopus 로고
    • Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement
    • Sibbing D, Schulz S, Braun S, et al. Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement. J Thromb Haemost 2010; 8: 250-6.
    • (2010) J Thromb Haemost , vol.8 , pp. 250-256
    • Sibbing, D.1    Schulz, S.2    Braun, S.3
  • 42
    • 84855384481 scopus 로고    scopus 로고
    • Correlation between point-of-care platelet function testing and bleeding after coronary artery surgery
    • Dalén M, van der Linden J, Lindvall G, Ivert T. Correlation between point-of-care platelet function testing and bleeding after coronary artery surgery. Scand Cardiovasc J 2012; 46: 32-8.
    • (2012) Scand Cardiovasc J , vol.46 , pp. 32-38
    • Dalén, M.1    Van Der Linden, J.2    Lindvall, G.3    Ivert, T.4
  • 43
    • 77950681902 scopus 로고    scopus 로고
    • Impact of highresponsiveness to dual antiplatelet therapy on bleeding complications in patients receiving drug-eluting stents
    • Tsukahara K, Kimura K, Morita S, et al. Impact of highresponsiveness to dual antiplatelet therapy on bleeding complications in patients receiving drug-eluting stents. Circ J 2010; 74: 679-85.
    • (2010) Circ J , vol.74 , pp. 679-685
    • Tsukahara, K.1    Kimura, K.2    Morita, S.3
  • 44
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2c19 17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing D, Koch W, Gebhard D, et al. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 2010; 121: 512-8.
    • (2010) Circulation , vol.121 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3
  • 45
    • 84863082704 scopus 로고    scopus 로고
    • The gain-of-function variant allele cyp2c1917: A double-edged sword between thrombosis and bleeding in clopidogrel-treated patients
    • Li Y, Tang HL, Hu YF, Xie HG. The gain-of-function variant allele CYP2C19*17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients. J Thromb Haemost 2012; 10: 199-206.
    • (2012) J Thromb Haemost , vol.10 , pp. 199-206
    • Li, Y.1    Tang, H.L.2    Hu, Y.F.3    Xie, H.G.4
  • 46
    • 80052617136 scopus 로고    scopus 로고
    • Anti-platelet therapy: Phosphodiesterase inhibitors
    • Gresele P, Momi S, Falcinelli E. Anti-platelet therapy: phosphodiesterase inhibitors. Br J Clin Pharmacol 2011; 72: 634-46.
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 634-646
    • Gresele, P.1    Momi, S.2    Falcinelli, E.3
  • 47
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 2005; 3: 1800-14.
    • (2005) J Thromb Haemost , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 48
    • 33846095378 scopus 로고    scopus 로고
    • Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
    • U S A
    • Vandendries ER, Hamilton JR, Coughlin SR, et al. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A 2007; 104: 288-92.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 288-292
    • Vandendries, E.R.1    Hamilton, J.R.2    Coughlin, S.R.3
  • 49
    • 84867163935 scopus 로고    scopus 로고
    • Par-1 inhibitors: A novel class of antiplatelet agents for the treatment of patients with atherothrombosis
    • Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Berlin: Springer
    • Leonardi S, Becker RC. PAR-1 Inhibitors: a novel class of antiplatelet agents for the treatment of patients with atherothrombosis. In: Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Handbook of Experimental Pharmacology. Berlin: Springer; 2012. p. 239-60.
    • (2012) Handbook of Experimental Pharmacology , pp. 239-260
    • Leonardi, S.1    Becker, R.C.2
  • 50
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of sch 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, doubleblind, placebo-controlled phase ii study
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, doubleblind, placebo-controlled phase II study. Lancet 2009; 373: 919-28.
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 51
    • 83655177669 scopus 로고    scopus 로고
    • Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
    • Tricoci P, Huang Z, Held C, et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med 2012; 366: 20-33.
    • (2012) N Engl J Med , vol.366 , pp. 20-33
    • Tricoci, P.1    Huang, Z.2    Held, C.3
  • 52
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • Morrow DA, Braunwald E, Bonaca MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012; 366: 1404-13.
    • (2012) N Engl J Med , vol.366 , pp. 1404-1413
    • Morrow, D.A.1    Braunwald, E.2    Bonaca, M.P.3
  • 53
    • 84867144010 scopus 로고    scopus 로고
    • Inhibitors of the interaction between von willebrand factor and platelet gpib/ix/v
    • Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Berlin: Springer
    • Gresele P, Momi S. Inhibitors of the interaction between von Willebrand factor and platelet GPIb/IX/V. In: Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Handbook of Experimental Pharmacology. Berlin: Springer 2012. p. 287-309.
    • (2012) Handbook of Experimental Pharmacology , pp. 287-309
    • Gresele, P.1    Momi, S.2
  • 54
    • 84882316231 scopus 로고    scopus 로고
    • Reperfusion of cerebral artery thrombosis by the GPIb/vWF blockade with nanobody ALX-0081 reduces brain infarct size in guinea pigs., DOI 10.1182/blood-2012-11-464545
    • Momi S, Tantucci M, Van Roy M, et al: Reperfusion of cerebral artery thrombosis by the GPIb/vWF blockade with nanobody ALX-0081 reduces brain infarct size in guinea pigs. Blood 2013; DOI 10.1182/blood-2012-11-464545.
    • (2013) Blood
    • Momi, S.1    Tantucci, M.2    Van Roy, M.3
  • 56
    • 79751508250 scopus 로고    scopus 로고
    • Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: Possible role in sustained platelet activation
    • Gresele P, Falcinelli E, Loffredo F, et al. Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation. Eur Heart J 2011; 32: 316-25.
    • (2011) Eur Heart J , vol.32 , pp. 316-325
    • Gresele, P.1    Falcinelli, E.2    Loffredo, F.3
  • 57
    • 70449711236 scopus 로고    scopus 로고
    • Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo
    • Momi S, Falcinelli E, Giannini S, et al. Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo. J Exp Med 2009; 206: 2365-79.
    • (2009) J Exp Med , vol.206 , pp. 2365-2379
    • Momi, S.1    Falcinelli, E.2    Giannini, S.3
  • 58
    • 0027340057 scopus 로고
    • Prostaglandin e2 potentiates platelet aggregation by priming protein kinase c
    • Vezza R, Roberti R, Nenci GG, Gresele P. Prostaglandin E2 potentiates platelet aggregation by priming protein kinase C. Blood 1993; 82: 2704-13.
    • (1993) Blood , vol.82 , pp. 2704-2713
    • Vezza, R.1    Roberti, R.2    Nenci, G.G.3    Gresele, P.4
  • 59
    • 84867169329 scopus 로고    scopus 로고
    • Intracellular signaling as a potential target for antiplatelet therapy
    • Gresele P, Born GVR, Patrono C, Page CP, editors. Berlin: Springer, Antiplatelet Agents
    • Andre P. Intracellular signaling as a potential target for antiplatelet therapy. In: Gresele P, Born GVR, Patrono C, Page CP, editors. Antiplatelet Agents. Handbook of Experimental Pharmacology. Berlin: Springer; 2012. p. 339-67.
    • (2012) Handbook of Experimental Pharmacology , pp. 339-367
    • Andre, P.1
  • 60
    • 84867168448 scopus 로고    scopus 로고
    • Novel targets for platelet inhibition
    • Gresele P, Born GVR, Patrono C, Page CP, Eds. Berlin: Springer, Antiplatelet Agents
    • Freson K, Van Geet C. Novel targets for platelet inhibition. In: Gresele P, Born GVR, Patrono C, Page CP, Eds. Antiplatelet Agents. Handbook of Experimental Pharmacology. Berlin: Springer; 2012. p. 369-94.
    • (2012) Handbook of Experimental Pharmacology , pp. 369-394
    • Freson, K.1    Van, G.C.2
  • 61
    • 34250019702 scopus 로고    scopus 로고
    • Explaining the decrease in U.S. Deaths from coronary disease
    • 1980-2000
    • Ford ES, Ajani UA, Croft JB, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. N Engl J Med 2007; 356: 2388-98.
    • (2007) N Engl J Med , vol.356 , pp. 2388-2398
    • Ford, E.S.1    Ajani, U.A.2    Croft, J.B.3
  • 62
    • 77952738970 scopus 로고    scopus 로고
    • A risk score to predict bleeding in patients with acute coronary syndromes
    • Mehran R, Pocock SJ, Nikolsky E, et al. A risk score to predict bleeding in patients with acute coronary syndromes. J Am Coll Cardiol 2010; 55: 2556-66.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2556-2566
    • Mehran, R.1    Pocock, S.J.2    Nikolsky, E.3


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