PHLPP-1 negatively regulates Akt activity and survival in the heart

Circulation Research

Volumn 107, Issue 4, 2010, Pages 476-484

  Miyamoto, Shigeki ^a   Purcell, Nicole H ^a   Smith, Jeffrey M ^a   Gao, Tianyan ^b   Whittaker, Ross ^c   Huang, Katherine ^a   Castillo, Rene ^a   Glembotski, Chris C ^c   Sussman, Mark A ^c   Newton, Alexandra C ^a   Heller Brown, Joan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Akt; heart; PHLPP; phosphatase; protection

Indexed keywords

DOXORUBICIN; HEXOKINASE; HEXOKINASE 2; HYDROGEN PEROXIDE; LEUKEMIA INHIBITORY FACTOR; PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART INFARCTION SIZE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; TISSUE HOMOGENATE;

ANIMALS; CELL SURVIVAL; DOWN-REGULATION; ENZYME ACTIVATION; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EID: 77956227207     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.215020     Document Type: Article

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