In vivo studies suggest that induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 9, 2013, Pages 4470-4480

  Kwun, Min Jung ^a   Novotna, Gabriela ^a   Hesketh, Andrew R ^a,b   Hill, Lionel ^c   Hong, Hee Jeon ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c JOHN INNES CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRO ALANYL DEXTRO ALANINE LIGASE; LIGASE; NUCLEASE S1; PEPTIDOGLYCAN; PHOSPHOTRANSFERASE; TEICOPLANIN; UNCLASSIFIED DRUG; VANCOMYCIN; VANS PROTEIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME ACTIVITY; GENE EXPRESSION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STREPTOMYCES COELICOLOR; TREATMENT RESPONSE; UPREGULATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL WALL; DIPEPTIDES; GENE EXPRESSION REGULATION, BACTERIAL; LIGASES; PEPTIDOGLYCAN; STREPTOMYCES COELICOLOR; TEICOPLANIN; TRANSCRIPTION, GENETIC; VANCOMYCIN; VANCOMYCIN RESISTANCE;

EID: 84882312630     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00523-13     Document Type: Article

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