Inhibition of pancreatic lipase, α-glucosidase, α-amylase, and hypolipidemic effects of the total flavonoids from Nelumbo nucifera leaves

Journal of Ethnopharmacology

Volumn 149, Issue 1, 2013, Pages 263-269

  Liu, Song ^a,b   Li, Dong ^a   Huang, Bo ^a   Chen, Yuxin ^a   Lu, Xiaocong ^c   Wang, Youwei ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Hubei Center for Disease Control and Prevention   (China)

Author keywords

Diabetes; Flavonoids; Hyperlipidemia; Lipids; Nelumbo nucifera

Indexed keywords

ALPHA GLUCOSIDASE; AMYLASE; FLAVONOID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; SIMVASTATIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; HYPERLIPIDEMIA; IC 50; LIPID STORAGE; MALE; MOUSE; NELUMBO NUCIFERA; NONHUMAN; PLANT LEAF; RAT; SINGLE DRUG DOSE;

ANIMALIA; MUS; NELUMBO NUCIFERA; RATTUS NORVEGICUS; SUS;

2,4-DINITROPHENYL BUTYRATE; A; ABSORBANCE; AI; ALT; AS; ASPARTATE AMINOTRANSFERASE; AST; ATHEROGENIC INDEX; ATHEROSCLEROSIS; BODY WEIGHT; BW; C; CARDIOVASCULAR DISEASE; CHDS; COMMITTEE FOR THE PURPOSE OF CONTROL AND SUPERVISION OF EXPERIMENTS ON ANIMALS; CONCENTRATION; CORONARY HEART DISEASES; CPCSEA; CVD; DIABETES; DNPB; FLAVONOIDS; GLUTAMATE PYRUVATE TRANSAMINASE; HDL-C; HFD; HIGH FAT DIET; HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL; HYPERLIPIDEMIA; IAEC; INSTITUTIONAL ANIMAL ETHICAL COMMITTEE; KM; KUN MING; LDL-C; LIPIDS; LOW-DENSITY LIPOPROTEIN-CHOLESTEROL; MALONDIALDEHYDE; MDA; NELUMBO NUCIFERA; NELUMBO NUCIFERA LEAF FLAVONOIDS; NLF; OECD; ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT; P-NITROPHENYL-Α-D-GLUCOPYRANOSIDE; PNPG; PORCINE PANCREATIC LIPASE; POTASSIUM PHOSPHATE BUFFER; PPB; PPL; T2DM; TC; TG; TOTAL CHOLESTEROL; TRIGLYCERIDE; TYPE 2 DIABETES MELLITUS; ZBT; ZHI-BI-TUO;

ALPHA-GLUCOSIDASES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ETHNOPHARMACOLOGY; FLAVONOIDS; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; LIPASE; LIPIDS; MALE; MEDICINE, CHINESE TRADITIONAL; MICE; MICE, INBRED STRAINS; NELUMBO; PANCREAS; PANCREATIC ALPHA-AMYLASES; PLANT LEAVES; RATS; RATS, WISTAR; TOXICITY TESTS, ACUTE;

EID: 84882272020     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.06.034     Document Type: Article

References (48)

1. R.D. Abbott, P.W. Wilson, W.B. Kannel, and W.P. Castelli High density lipoprotein-cholesterol, total cholesterol screening and myocardial infarction. The Framingham Study Atherosclerosis 8 1988 207 211
2. K. Alagesan, P. Thennarasu, V. Kumar, S. Sankarnarayanan, and T. Balsamy Identification of α-glucosidase inhibitors from Psidium guajava leaves and Syzygium cumini Linn. seeds International Journal of Pharma Sciences and Research 3 2012 316 322
3. S.M. Alvarez, S. Vega, C. Mingorance, E. Marhuenda, and M.D. Herrera Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats Pharmacology 82 2008 89 96
4. C.J. Bailey, and C. Day Avandamet: combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes International Journal of Clinical Practice 58 2004 867 876
5. D. Bensky, S. Clavey, and E. Stöger Chinese Herbal Medicine: Materia Medica Third ed. 2004 Eastland Press Inc. Seattle
6. M.R. Bhandari, J.A. Nilubon, G. Hong, and J. Kawabata α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw.) Food Chemistry 106 2008 247 252
7. R.B. Birari, and K.K. Bhutani Pancreatic lipase inhibitors from natural sources: unexplored potential Drug Discovery Today 12 2007 879 889
8. Chinese Pharmacopoeia Commission Pharmacopoeia of People's Republic of China, Part I. China 2010 Medical Science Press Beijing 258
9. S. Dai Mi Chuan Zheng Zhi Yao Jue Ji Lei Fang 1955 The Commercial Press Beijing 41 (Appeared in print for the first time: 1443 AD)
10. H.Q. Dong, M. Li, F. Zhu, F.L. Liu, and J.B. Huang Inhibitory potential of trilobatin from Lithocarpus polystachyus Rehd. against α-glucosidase and α-amylase linked to type 2 diabetes Food Chemistry 130 2012 261 266
11. J.R. Downs, M. Clearfield, S. Weis, E. Whitney, D.R. Shapiro, P.A. Beere, A. Langendorfer, E.A. Stein, W. Kruyer, and A.M. GottoF Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels Journal of the American Medical Association 279 1998 1659 1661
12. A.A. Elegami, C. Bates, A.I. Gray, S.P. Mackay, G.G. Skellern, and R.D. Waigh Two very unusual macrocyclic flavonoids from the water lily Nymphaea lotus Phytochemistry 63 2003 727 731
13. C.B. Etoundi, D. Kuaté, J.L. Ngondi, and J. Oben Anti-amylase, anti-lipase and antioxidant effects of aqueous extracts of some Cameroonian spices Journal of Natural Products 3 2010 165 171
14. F. Hadaegh, D. Khalili, A. Ghasemi, M. Tohidi, F. Sheikholeslami, and F. Azizi Triglyceride/HDL-cholesterol ratio is an independent predictor for coronary heart disease in a population of Iranian men Nutrition Metabolism and Cardiovascular Diseases 19 2009 401 408
15. A. Hamsten, A. Silveira, S. Boquist, R.M. Tang, B. Gene, and J. Ulf de Faire, Björkegren The apolipoprotein CI content of triglyceride-rich lipoproteins independently predicts early atherosclerosis in healthy middle-aged men Journal of the American College of Cardiology 45 2005 1013 1017
16. B. Huang, X.Q. Ban, J.S. He, J. Tong, J. Tian, and Y.W. Wang Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves Food Chemistry 120 2010 873 878
17. M. Iqbal, S. Choudhary, J.S. Naheeda, J.M. Alam, and Atta-ur-Rahman Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet Journal of Ethnopharmacology 98 2005 217 220
18. L. James The Chinese Classics IV: The She King (1100-600 BC) 1991 SMC Publishing Inc. Taipei 213 214
19. M.P. John Obesity, hyperlipidemia and non-insulin-dependent diabetes: a unified theory Neuroscience and Biobehavioral Reviews 17 1993 85 89
20. T.H. Kim, J.K. Kim, H. Ito, and C. Jo Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation Bioorganic and Medicinal Chemistry Letters 21 2011 1512 1514
21. J.S. Kim, T.K. Hyun, and M.J. Kim The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activities Food Chemistry 124 2011 1647 1651
22. J.S. Kim, C.S. Kwon, and K.H. Son Inhibition of alpha-glucosidase and amylase by lutelin, a flavonoid Bioscience Biotechnology and Biochemistry 64 2000 2458 2461
23. D.E. Kleiner, E.M. Brunt, M.V. Natta, C. Behling, M.J. Contos, O.W. Cummings, L.D. Ferrell, Y.C. Liu, M.S. Torbenson, A. Unalp-Arida, M. Yeh, J.M.C. Arthur, and A.J. Sanyal Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
24. M.C. Lin, S.H. Kao, P.J. Chung, K.C. Chan, M.Y. Yang, and C.J. Wang Improvement for high fat diet-induced hepatic injuries and oxidative stress by flavonoid-enriched extract from Nelumbo nucifera leaf Journal of Agricultural and Food Chemistry 57 2009 5925 5932
25. M.E. Lowe Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion Gastroenterology 107 1994 1524 1536
26. M.I.N. Moreno, M.I. Isla, and A.R. Sampietro Comparison of the free radical-scavenging activity of propolis from several regions of Argentina Journal of Ethnopharmacology 71 2000 109 114
27. E.W.J. Mosmuller, J.D.H. Van Heemst, C.J Van Delden, M.C.R. Franssen, and J.F.J. Engbersen A new spectrophotometric method for the detection of lipase activity using 2,4-dinitrophenyl butyrate as a substrate Biocatalysis and Biotransformation 5 1992 279 287
28. N. Nishibori, M. Sawaguchi, T. Hiroi, T. Sagara, M. Itoh, S. Her, M.S. Lee, and K. Morita Inhibitory effects of aqueous extract prepared from joint part of lotus root on α-amylase and α-glucosidase activities Phytopharmacology 3 2012 1 11
29. OECD, 2001. Guideline for the Testing of Chemicals, no. 420, Acute Oral Toxicity-Fixed Dose Procedure. Organization for Economic Cooperation and Development, Paris (adopted 17th December 2001).
30. G. Oboh, A.O. Ademiluyi, A.J. Akinyemi, T. Henle, J.A. Saliu, and U. Schwarzenbolz Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro Journal of Functional Foods 4 2012 450 458
31. Y. Ono, E. Hattori, Y. Fukaya, S. Imai, and Y. Ohizumi Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats Journal of Ethnopharmacology 106 2006 238 244
32. M. Ou Chinese-English Manual of Common-Used in Traditional Chinese Medicine 1989 Joint Publishing Co.; Ltd. Hong Kong
33. A.M. Palmer, E. Nova, E. Anil, K. Jackson, P. Bateman, E. Wolstencroft, M.W. Christine, and P. Yaqoob Differential uptake of subfractions of triglyceride-rich lipoproteins by THP-1 macrophages Atherosclerosis 180 2005 233 244
34. O.S. Philippe, and J.R. Daniel The triglyceride-high-density lipoprotein axis: an important target of therapy American Heart Journal 148 2004 211 221
35. R. Rhabasa-Lhoret, and J.L. Chiasson Alpha-glucosidase inhibitiors 3rd ed. R.A. Defronzo, E. Ferrannini, H. Keen, P. Zimmet, International Textbook of Diabetes Mellitus Vol. 1 2004 John Wiley Chichester 901 914
36. H. Shamseddeen, J.Z. Getty, I.N. Hamdallah, and M.R. Ali Epidemiology and economic impact of obesity and type 2 diabetes Surgical Clinics of North America 91 2011 1163 1172
37. N. Shoji, A. Umeyama, N. Saito, A. Iuchi, T. Takemoto, A. Kajiwara, and Y. Ohizumi Asimilobine and lirinidine, serotonergic receptor antagonists, from Nelumbo nucifera Journal of Natural Products 50 1987 773 774
38. K.R. Sridhar, and R. Bhat Lotus: a potential nutraceutical source Journal of Agricultural Science and Technology 3 2007 143 155
39. P.J. Talmud, E. Hawe, G.J. Miller, and S.E. Humphries Are plasma triglycerides a good predictor of CHD risk? International Congress Series 1262 2004 207 210
40. B. Tao, M.Y. Chen, W.N. Li, Z.G. W, and S.Y. Yao The medicinal research of Nelumbo nucifera leaves Information on Traditional Chinese Medicine 18 2001 2 3
41. H. Wang, Y.J. Du, and H.C. Song α-Glucosidase and α-amylase inhibitory activities of guava leaves Food Chemistry 123 2010 6 13
42. S.Y. Wang, M.J. Camp, and M.K. Ehlenfeldt Antioxidant capacity and α-glucosidase inhibitory activity in peel and flesh of blueberry (Vaccinium spp.) cultivars Food Chemistry 132 2012 1759 1768
43. P. Wongsa, J. Chaiwarit, and A. Zamaludien In vitro screening of phenolic compounds, potential inhibition against α-amylase and α-glucosidase of culinary herbs in Thailand Food Chemistry 131 2012 964 971
44. World Health Organization, 1999. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Report of WHO Consultation, Geneva, p. 66.
45. World Health Organization, 2002. Traditional Medicine Strategy 2002-2005. WHO Publications, pp. 1-6.
46. H. Xie Materia Medica for Dietotherap 1984 People's Medical Publishing House Beijing 30 31 (The original authors: Meng, S.; Zhang, D.; 701-739 AD)
47. T. Yokozawa, A. Ishida, E.J. Cho, and T. Nakagawa The effects of Coptidis rhizoma extract on a hypercholesterolemic animal model Phytomedicine 10 2003 17 22
48. C.D. Zheng, Y.Q. Duan, J.M. Gao, and Z.G. Ruan Screening of anti-lipase properties of 37 traditional Chinese medicinal herbs Journal of the Chinese Medical Association 73 2010 319 324