ABCB1 gene polymorphisms are associated with suicide in forensic autopsies

Pharmacogenetics and Genomics

Volumn 23, Issue 9, 2013, Pages 463-469

  Moreno, Samuel Boiso ^a   Zackrisson, Anna Lena ^b   Jakobsen Falk, Ingrid ^a   Karlsson, Louise ^a   Carlsson, Björn ^a,c   Tillmar, Andreas ^b   Kugelberg, Fredrik C ^a,b   Ahlner, Johan ^a,b   Hägg, Staffan ^a   Gréen, Henrik ^a,b,d  

^a LINKÖPING UNIVERSITY   (Sweden)

^b Department of Forensic Chemistry and Genetics   (Sweden)

^c County Council of Östergötland   (Sweden)

^d SCIENCE FOR LIFE LABORATORY   (Sweden)

Author keywords

ABCB1; autopsy; forensic material; genotype; postmortem; sex; suicide

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; AGED; ARTICLE; AUTOPSY; DNA POLYMORPHISM; FEMALE; FORENSIC GENETICS; FORENSIC PATHOLOGY; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PYROSEQUENCING; SUICIDE; TOXICOLOGY;

EID: 84882244375     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328363a9bf     Document Type: Article

References (25)

1. Wasserman D, Rihmer Z, Rujescu D, Sarchiapone M, Sokolowski M, Titelman D, et al. The European Psychiatric Association (EPA) guidance on suicide treatment and prevention. Eur Psychiatry 2012; 27:129-141.
2. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I,Willingham MC. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem 1989; 37:159-164.
3. Fojo AT, Ueda K, Slamon DJ, Poplack DG, Gottesman MM, Pastan I. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 1987; 84:265-269.
4. O'Brien FE, Dinan TG, Griffin BT, Cryan JF. Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings. Br J Pharmacol 2012; 165:289-312.
5. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989; 86:695-698.
6. Callen DF, Baker E, Simmers RN, Seshadri R, Roninson IB. Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum Genet 1987; 77:142-144.
7. Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metab Dispos 2005; 33:165-174.
8. Uhr M, Steckler T, Yassouridis A, Holsboer F. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption. Neuropsychopharmacology 2000; 22:380-387.
9. Karlsson L, Hiemke C, Carlsson B, Josefsson M, Ahlner J, Bengtsson F, et al. Effects on enantiomeric drug disposition and open-field behavior after chronic treatment with venlafaxine in the P-glycoprotein knockout mice model. Psychopharmacology (Berl) 2011; 215:367-377.
10. Silverton L, Dean M, Moitra K. Variation and evolution of the ABC transporter genes ABCB1, ABCC1, ABCG2, ABCG5 and ABCG8: implication for pharmacogenetics and disease. Drug Metabol Drug Interact 2011; 26:169-179.
11. Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, et al. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics 2003; 13:481-494.
12. Fujii T, Ota M, Hori H, Sasayama D, Hattori K, Teraishi T, et al. Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population. J Psychiatr Res 2012; 46:555-559.
13. Perroud N, Bondolfi G, Uher R, Gex-Fabry M, Aubry JM, Bertschy G, et al. Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample. Pharmacogenomics 2011; 12:365-377.
14. Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, et al. ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32:398-404.
15. Buchard A, Linnet K, Johansen SS, Munkholm J, Fregerslev M, Morling N. Postmortem blood concentrations of R-and S-enantiomers of methadone and EDDP in drug users: influence of co-medication and P-glycoprotein genotype. J Forensic Sci 2010; 55:457-463.
16. Neuvonen AM, Palo JU, Sajantila A. Post-mortem ABCB1 genotyping reveals an elevated toxicity for female digoxin users. Int J Legal Med 2011; 125:265-269.
17. Druid H, Holmgren P. A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J Forensic Sci 1997; 42:79-87.
18. Jones AW, Schuberth J. Computer-aided headspace gas chromatography applied to blood-alcohol analysis: importance of online process control. J Forensic Sci 1989; 34:1116-1127.
19. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81:559-575.
20. Bonferroni CE. Teoria statistica delle classi e calcolo delle probabilità . R Ist Super Sci Econ Commerciali Firenze 1936; 8:3-62.
21. Pariante CM. The role of multi-drug resistance P-glycoprotein in glucocorticoid function: studies in animals and relevance in humans. Eur J Pharmacol 2008; 583:263-271.
22. Menke A, Domschke K, Czamara D, Klengel T, Hennings J, Lucae S, et al. Genome-wide association study of antidepressant treatment-emergent suicidal ideation. Neuropsychopharmacology 2012; 37:797-807.
23. Lin KM, Chiu YF, Tsai IJ, Chen CH, Shen WW, Liu SC, et al. ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. Pharmacogenet Genomics 2011; 21:163-170.
24. Schneider B, Muller MJ, Philipp M. Mortality in affective disorders. J Affect Disord 2001; 65:263-274.
25. Tsirigotis K, Gruszczynski W, Tsirigotis M. Gender differentiation in methods of suicide attempts. Med Sci Monit 2011; 17:PH65-PH70.