Beneficial effects of hormone replacement therapy on periodontitis are vitamin D associated

Journal of Periodontology

Volumn 84, Issue 8, 2013, Pages 1048-1057

  Jönsson, Daniel ^a   Aggarwal, Prerna ^b   Nilsson, Bengt Olof ^c   Demmer, Ryan T ^d  

^a MALMÖ UNIVERSITY   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LUND UNIVERSITY   (Sweden)

^d Department of Medicine   (United States)

Author keywords

Estrogen; Hormone replacement therapy; Monocytes; Periodontitis; Progesterone; Vitamin D

Indexed keywords

CALCITRIOL; CCL5 PROTEIN, HUMAN; CHEMOTACTIC FACTOR; ESTRADIOL; IL6 PROTEIN, HUMAN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROGESTERONE; RANTES; VITAMIN D;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; BLOOD; CELL LINE; CLASSIFICATION; COHORT ANALYSIS; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; DRUG EFFECT; ESCHERICHIA COLI; ESTROGEN THERAPY; FEMALE; HEALTH SURVEY; HORMONE SUBSTITUTION; HUMAN; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MONOCYTE; PERIODONTAL DISEASE; PERIODONTITIS; T LYMPHOCYTE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; B-LYMPHOCYTES; CALCITRIOL; CELL LINE; CHEMOKINE CCL5; CHEMOTACTIC FACTORS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; ESCHERICHIA COLI; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MONOCYTES; PERIODONTAL ATTACHMENT LOSS; PERIODONTITIS; POPULATION SURVEILLANCE; PROGESTERONE; T-LYMPHOCYTES; TOOTH LOSS; VITAMIN D;

EID: 84882242816     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2012.120434     Document Type: Article

References (51)

1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366:1809-1820.
2. Machtei EE, Mahler D, Sanduri H, Peled M. The effect of menstrual cycle on periodontal health. J Periodontol 2004;75:408-412.
3. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963; 21:533-551.
4. Tilakaratne A, Soory M, Ranasinghe AW, Corea SM, Ekanayake SL, de Silva M. Periodontal disease status during pregnancy and 3 months post-partum, in a rural population of Sri-Lankan women. J Clin Periodontol 2000;27:787-792.
5. Ronderos M, Jacobs DR, Himes JH, Pihlstrom BL. Associations of periodontal disease with femoral bone mineral density and estrogen replacement therapy: Cross-sectional evaluation of US adults from NHANES III. J Clin Periodontol 2000;27:778-786.
6. Haas AN, Rösing CK, Oppermann RV, Albandar JM, Susin C. Association among menopause, hormone replacement therapy, and periodontal attachment loss in southern Brazilian women. J Periodontol 2009;80:1380-1387.
7. Reinhardt RA, Masada MP, Payne JB, Allison AC, DuBois LM. Gingival fluid IL-1 beta and IL-6 levels in menopause. J Clin Periodontol 1994;21:22-25.
8. Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-FerrariHA.Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am J Clin Nutr 2004;80:108-113.
9. de Brito RB Jr., Scarel-Caminaga RM, Trevilatto PC, de Souza AP, Barros SP. Polymorphisms in the vitamin D receptor gene are associated with periodontal disease. J Periodontol 2004;75:1090-1095.
10. Ostensen M, Brucato A, Carp H, et al. Pregnancy and reproduction in autoimmune rheumatic diseases. Rheumatology (Oxford) 2011;50:657-664.
11. Pilz S, van den Hurk K, Nijpels G, et al. Vitamin D status, incident diabetes and prospective changes in glucose metabolism in older subjects: The Hoorn study. Nutr Metab Cardiovasc Dis 2012;22:883-889.
12. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017-2029.
13. Anderson GL, Limacher M, Assaf AR, et al; Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial. JAMA 2004;291:1701-1712.
14. Rossouw JE, Anderson GL, Prentice RL, et al; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-333.
15. Baker AR, McDonnell DP, Hughes M, et al. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci USA 1988;85: 3294-3298.
16. Green S, Walter P, Kumar V, et al. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A. Nature 1986;320:134-139.
17. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996; 93:5925-5930.
18. Cummings SR, Browner WS, Bauer D, et al; Study of Osteoporotic Fractures Research Group. Endogenous hormones and the risk of hip and vertebral fractures among older women. N Engl J Med 1998;339:733-738.
19. Clowes JA, Riggs BL, Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev 2005;208:207-227.
20. Nilsson BO. Modulation of the inflammatory response by estrogens with focus on the endothelium and its interactions with leukocytes. Inflamm Res 2007;56: 269-273.
21. Hayes CE, Nashold FE, Spach KM, Pedersen LB. The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand) 2003;49:277-300.
22. Cheema C, Grant BF, Marcus R. Effects of estrogen on circulating "free" and total 1,25-dihydroxyvitamin D and on the parathyroid-vitamin D axis in postmenopausal women. J Clin Invest 1989;83:537-542.
23. Barrera D, Avila E, Hernández G, et al. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. J Steroid Biochem Mol Biol 2007; 103:529-532.
24. Gilad LA, Bresler T, Gnainsky J, Smirnoff P, Schwartz B. Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol 2005;185:577-592.
25. Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey. Available at: http://www.cdc.gov/nchs/nhanes.htm.
26. Dye BA, Barker LK, Selwitz RH, et al. Overview and quality assurance for the National Health and Nutrition Examination Survey (NHANES) oral health component, 1999-2002. Community Dent Oral Epidemiol 2007;35:140-151.
27. Dye BA, Nowjack-Raymer R, Barker LK, et al. Overview and quality assurance for the oral health component of the National Health and Nutrition Examination Survey (NHANES), 2003-04. J Public Health Dent 2008; 68:218-226.
28. Page RC, Eke PI. Case definitions for use in populationbased surveillance of periodontitis. J Periodontol 2007;78(Suppl. 7)1387-1399.
29. Armitage GC; Research, Science and Therapy Committee of the American Academy of Periodontology. Diagnosis of periodontal diseases. J Periodontol 2003; 74:1237-1247.
30. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357:266-281.
31. Gould BJ, Hall PM, Cook JG. A sensitive method for the measurement of glycosylated plasma proteins using affinity chromatography. Ann Clin Biochem 1984;21: 16-21.
32. Cornil CA, Ball GF, Balthazart J. Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from? Brain Res 2006; 1126:2-26.
33. Jönsson D, Amisten S, Bratthall G, Holm A, Nilsson BO. LPS induces GROalpha chemokine production via NF-kappaB in oral fibroblasts. Inflamm Res 2009;58: 791-796.
34. Jönsson D, Nilsson BO. The antimicrobial peptide LL-37 is anti-inflammatory and proapoptotic in human periodontal ligament cells. J Periodontal Res 2012;47: 330-335.
35. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:2002-2007.
36. Demmer RT, Jacobs DR Jr., Desvarieux M. Periodontal disease and incident type 2 diabetes: Results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care 2008;31:1373-1379.
37. Demmer RT, Papapanou PN. Epidemiologic patterns of chronic and aggressive periodontitis. Periodontol 2000 2010;53:28-44.
38. Demmer RT, Papapanou PN, Jacobs DR Jr., Desvarieux M. Evaluating clinical periodontal measures as surrogates for bacterial exposure: The Oral Infections and Vascular Disease Epidemiology Study (INVEST). BMC Med Res Methodol 2010;10(2):1-7.
39. Demmer RT, Papapanou PN, Jacobs DR Jr., Desvarieux M. Bleeding on probing differentially relates to bacterial profiles: The Oral Infections and Vascular Disease Epidemiology Study. J Clin Periodontol 2008;35:479-486.
40. Demmer RT, Kocher T, Schwahn C, Völzke H, Jacobs DR Jr., Desvarieux M. Refining exposure definitions for studies of periodontal disease and systemic disease associations. Community Dent Oral Epidemiol 2008;36:493-502.
41. Vegeto E, Ghisletti S, Meda C, Etteri S, Belcredito S, Maggi A. Regulation of the lipopolysaccharide signal transduction pathway by 17beta-estradiol in macrophage cells. J Steroid BiochemMol Biol 2004;91:59-66.
42. Nebel D, Jönsson D, Norderyd O, Bratthall G, Nilsson BO. Differential regulation of chemokine expression by estrogen in human periodontal ligament cells. J Periodontal Res 2010;45:796-802.
43. Lim WC, Hanauer SB, Li YC. Mechanisms of disease: Vitamin D and inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol 2005;2:308-315.
44. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006;311:1770-1773.
45. Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337-342.
46. Trevilatto PC, Scarel-Caminaga RM, de Brito RB Jr., de Souza AP, Line SR. Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol 2003;30:438-442.
47. Kornman KS, Crane A, Wang HY, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol 1997;24:72-77.
48. Repeke CE, Ferreira SB Jr., Vieira AE, et al. Doseresponse met-RANTES treatment of experimental periodontitis: A narrow edge between the disease severity attenuation and infection control. PLoS ONE 2011;6: e22526.
49. Thunell DH, Tymkiw KD, Johnson GK, et al. A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy. J Periodontal Res 2010;45: 148-152.
50. Jönsson D, Ramberg P, Demmer RT, Kebschull M, Dahlén G, Papapanou PN. Gingival tissue transcriptomes in experimental gingivitis. J Clin Periodontol 2011;38:599-611.
51. Nakajima T, Amanuma R, Ueki-Maruyama K, et al. CXCL13 expression and follicular dendritic cells in relation to B-cell infiltration in periodontal disease tissues. J Periodontal Res 2008;43:635-641.