Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 4, 2013, Pages

  Shimura, Daisuke ^a   Nakai, Gaku ^a   Jiao, Qibin ^a,b   Osanai, Kota ^a   Kashikura, Kasumi ^c   Endo, Keiko ^c   Soga, Tomoyoshi ^c   Goda, Nobuhito ^a   Minamisawa, Susumu ^a,b  

^a WASEDA UNIVERSITY   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Chamber specific; Comprehesive analysis; Energy production; Lactate

Indexed keywords

ACETYL COENZYME A; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE; ARGININE; ASPARAGINE; ASPARTIC ACID; CITRULLINE; CREATINE; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; LACTIC ACID; LYSINE; NUCLEOTIDE; ORNITHINE; PHENYLALANINE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROLINE; PYRUVATE DEHYDROGENASE KINASE 4; S ADENOSYLHOMOCYSTEINE; SERINE; THREONINE; TYROSINE;

AEROBIC METABOLISM; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY ELECTROPHORESIS; CELL ENERGY; CITRIC ACID CYCLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENERGY YIELD; GLYCOLYSIS; HEART ATRIUM; HEART MUSCLE METABOLISM; HEART VENTRICLE; HIGH ENERGY PHOSPHATE; ISOLATED HEART; MALE; MASS SPECTROMETRY; METABOLITE; METABOLOME; METABOLOMICS; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UREA CYCLE; WESTERN BLOTTING;

CHAMBER SPECIFIC; COMPREHESIVE ANALYSIS; ENERGY PRODUCTION; LACTATE;

ADENINE NUCLEOTIDES; AMINO ACIDS; ANIMALS; ATRIAL FUNCTION; BLOTTING, WESTERN; ELECTROPHORESIS, CAPILLARY; ENERGY METABOLISM; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART ATRIA; HEART VENTRICLES; LACTIC ACID; MALE; METABOLOMICS; MICE; MICE, INBRED C57BL; MYOCARDIUM; OXIDATION-REDUCTION; PYRUVIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VENTRICULAR FUNCTION;

EID: 84881657248     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00867.2012     Document Type: Article

References (43)

1. Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ. Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. FEBS J 272: 3004-3014, 2005.
2. Abel ED, Doenst T. Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc Res 90: 234-242, 2011.
3. Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, Steinmeyer K, Bleich M, Kaab S, Pfeufer A, Uberfuhr P, Dugas M, Steinbeck G, Nabauer M. Functional profiling of human atrial and ventricular gene expression. Pflügers Arch 450: 201-208, 2005.
4. Bonen A. The expression of lactate transporters (MCT1 and MCT4) in heart and muscle. Eur J Appl Physiol 86: 6-11, 2001.
5. Bonen A, Miskovic D, Tonouchi M, Lemieux K, Wilson MC, Marette A, Halestrap AP. Abundance and subcellular distribution of MCT1 and MCT4 in heart and fast-twitch skeletal muscles. Am J Physiol Endocrinol Metab 278: E1067-E1077, 2000.
6. Bowker-Kinley MM, Davis WI, Wu P, Harris RA, Popov KM. Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J 329: 191-196, 1998.
7. Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R, Zera P, Menlove R, Shah P, Jamieson S, et al. Beta 1-and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res 59: 297-309, 1986.
8. 2+ efflux in liver and heart mitochondria. J Biol Chem 257: 8696-8704, 1982.
9. Daneshrad Z, Verdys M, Birot O, Troff F, Bigard AX, Rossi A. Chronic hypoxia delays myocardial lactate dehydrogenase maturation in young rats. Exp Physiol 88: 405-413, 2003.
10. De Souza AI, Cardin S, Wait R, Chung YL, Vijayakumar M, Maguy A, Camm AJ, Nattel S. Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure. J Mol Cell Cardiol 49: 851-863, 2010.
11. Depre C, Vanoverschelde JL, Taegtmeyer H. Glucose for the heart. Circulation 99: 578-588, 1999.
12. Ellinghaus P, Scheubel RJ, Dobrev D, Ravens U, Holtz J, Huetter J, Nielsch U, Morawietz H. Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays. J Thorac Cardiovasc Surg 129: 1383-1390, 2005.
13. Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res 105: 1118-1127, 2009.
14. Enoki T, Yoshida Y, Lally J, Hatta H, Bonen A. Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle. J Physiol 577: 433-443, 2006.
15. Hammond GL, Nadal-Ginard B, Talner NS, Markert CL. Myocardial LDH isozyme distribution in the ischemic and hypoxic heart. Circulation 53: 637-643, 1976.
16. Hatta H, Tonouchi M, Miskovic D, Wang Y, Heikkila JJ, Bonen A. Tissue-specific and isoform-specific changes in MCT1 and MCT4 in heart and soleus muscle during a 1-yr period. Am J Physiol Endocrinol Metab 281: E749-E756, 2001.
17. Heazell AE, Brown M, Dunn WB, Worton SA, Crocker IP, Baker PN, Kell DB. Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. Placenta 29: 691-698, 2008.
18. Huang B, Wu P, Popov KM, Harris RA. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Diabetes 52: 1371-1376, 2003.
19. Javaheri S, Parker TJ, Liming JD, Corbett WS, Nishiyama H, Wexler L, Roselle GA. Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation 97: 2154-2159, 1998.
20. Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Tamaki Y, Iwanaga Y, Narazaki M, Matsuda T, Soga T, Kita T, Kimura T, Shioi T. Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. Circ Heart Fail 3: 420-430, 2010.
21. Kolwicz SC Jr, Tian R. Glucose metabolism and cardiac hypertrophy. Cardiovasc Res 90: 194-201, 2011.
22. Marazzi G, Rosanio S, Caminiti G, Dioguardi FS, Mercuro G. The role of amino acids in the modulation of cardiac metabolism during ischemia and heart failure. Curr Pharm Des 14: 2592-2604, 2008.
23. Nagoshi T, Yoshimura M, Rosano GM, Lopaschuk GD, Mochizuki S. Optimization of cardiac metabolism in heart failure. Curr Pharm Des 17: 3846-3853, 2011.
24. Nouette-Gaulain K, Malgat M, Rocher C, Savineau JP, Marthan R, Mazat JP, Sztark F. Time course of differential mitochondrial energy metabolism adaptation to chronic hypoxia in right and left ventricles. Cardiovasc Res 66: 132-140, 2005.
25. Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int 47: 13-18, 2005.
26. Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. J Mol Med (Berl) 88: 47-60, 2010.
27. Piao L, Marsboom G, Archer SL. Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. J Mol Med (Berl) 88: 1011-1020, 2010.
28. Roche TE, Hiromasa Y. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Cell Mol Life Sci 64: 830-849, 2007.
29. Sang Q, Yao Z, Wang H, Feng R, Zhao X, Xing Q, Jin L, He L, Wu L, Wang L. Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo. J Clin Endocrinol Metab; doi: 10.1210/jc.2013-1715. 2013 May 10. [Epub ahead of print]
30. Smith AC, Robinson AJ. A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle. BMC Syst Biol 5: 102, 2011.
31. Soga T, Baran R, Suematsu M, Ueno Y, Ikeda S, Sakurakawa T, Kakazu Y, Ishikawa T, Robert M, Nishioka T, Tomita M. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J Biol Chem 281: 16768-16776, 2006.
32. Sugden MC, Holness MJ. Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases. Arch Physiol Biochem 112: 139-149, 2006.
33. Tabibiazar R, Wagner RA, Liao A, Quertermous T. Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Circ Res 93: 1193-1201, 2003.
34. Taegtmeyer H, Harinstein ME, Gheorghiade M. More than bricks and mortar: comments on protein and amino acid metabolism in the heart. Am J Cardiol 101: 3E-7E, 2008.
35. Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation 97: 686-691, 1998.
36. Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, Moriyama M. MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta. Cancer Res 70: 2339-2349, 2010.
37. Tuganova A, Boulatnikov I, Popov KM. Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoylbearing domain of transacetylase component of pyruvate dehydrogenase complex. Biochem J 366: 129-136, 2002.
38. Turer AT, Stevens RD, Bain JR, Muehlbauer MJ, van der Westhuizen J, Mathew JP, Schwinn DA, Glower DD, Newgard CB, Podgoreanu MV. Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. Circulation 119: 1736-1746, 2009.
39. Tynan MJ, Becker AE, Macartney FJ, Jimenez MQ, Shinebourne EA, Anderson RH. Nomenclature and classification of congenital heart disease. Br Heart J 41: 544-553, 1979.
40. Walden AP, Dibb KM, Trafford AW. Differences in intracellular calcium homeostasis between atrial and ventricular myocytes. J Mol Cell Cardiol 46: 463-473, 2009.
41. Walsh RA. Microtubules and pressure-overload hypertrophy. Circ Res 80: 295-296, 1997.
42. Wan B, LaNoue KF, Cheung JY, Scaduto RC Jr. Regulation of citric acid cycle by calcium. J Biol Chem 264: 13430-13439, 1989.
43. Zhao XS, Gallardo TD, Lin L, Schageman JJ, Shohet RV. Transcriptional mapping and genomic analysis of the cardiac atria and ventricles. Physiol Genomics 12: 53-60, 2002.