메뉴 건너뛰기




Volumn 23, Issue 5, 2013, Pages 472-478

Actionable mutations in muscle-invasive bladder cancer

Author keywords

Actionable mutations; Bladder cancer; Personalized medicine; Targeted therapy; Urothelial cancer

Indexed keywords

AURORA A KINASE; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLIN D1; DOCETAXEL; DOVITINIB; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; EVEROLIMUS; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GEFITINIB; GEMCITABINE; LAPATINIB; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; METHOTREXATE; PACLITAXEL; PALBOCICLIB; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; POLO LIKE KINASE; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; TRASTUZUMAB; TYROSINE KINASE RECEPTOR; VINBLASTINE;

EID: 84881649977     PISSN: 09630643     EISSN: 14736586     Source Type: Journal    
DOI: 10.1097/MOU.0b013e328363a3cd     Document Type: Review
Times cited : (14)

References (62)
  • 2
    • 73349127164 scopus 로고    scopus 로고
    • Bladder cancer: Narrowing the gap between evidence and practice
    • Hussain MH, Wood DP, Bajorin DF, et al. Bladder cancer: Narrowing the gap between evidence and practice. J Clin Oncol 2009; 27:5680-5684
    • (2009) J Clin Oncol , vol.27 , pp. 5680-5684
    • Hussain, M.H.1    Wood, D.P.2    Bajorin, D.F.3
  • 3
  • 4
    • 85014013850 scopus 로고    scopus 로고
    • Neoadjuvant cisplatin methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: A randomised controlled trial
    • Neoadjuvant cisplatin methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: A randomised controlled trial. International collaboration of trialists Lancet 1999; 354:533-540
    • (1999) International Collaboration of Trialists Lancet , vol.354 , pp. 533-540
  • 5
    • 0041429507 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer
    • Grossman HB, Natale RB, Tangen CM, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med 2003; 349:859-866
    • (2003) N Engl J Med , vol.349 , pp. 859-866
    • Grossman, H.B.1    Natale, R.B.2    Tangen, C.M.3
  • 7
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase iii, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced nonsmall-cell lung cancer in asia (ipass
    • Fukuoka M, Wu YL, Thongprasert S, et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced nonsmall-cell lung cancer in Asia (IPASS). J Clin Oncol 2011; 29:2866-2874
    • (2011) J Clin Oncol , vol.29 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3
  • 8
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011; 29:2011-2019
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 9
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 2010; 376:687-697
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 10
    • 34250218955 scopus 로고    scopus 로고
    • Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: Results of a multicenter phase ii national cancer institute trial
    • Hussain MH, MacVicar GR, Petrylak DP, et al. Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: Results of a multicenter phase II National Cancer Institute trial. J Clin Oncol 2007; 25:2218-2224
    • (2007) J Clin Oncol , vol.25 , pp. 2218-2224
    • Hussain, M.H.1    MacVicar, G.R.2    Petrylak, D.P.3
  • 11
    • 84881619488 scopus 로고    scopus 로고
    • Trastuzumab (t) combined with standard chemotherapy in her metastatic bladder cancer (bc) patients: Interim safety results of a prospective randomized phase ii study, 2007 asco annual meeting
    • abstract 15565
    • P. Beuzeboc EB, Voog E, Bousquet G,et al. Trastuzumab (T) combined with standard chemotherapy in HER metastatic bladder cancer (BC) patients: Interim safety results of a prospective randomized phase II study, 2007 ASCO Annual Meeting; J Clin Oncol 2007; 25,18S, abstract 15565
    • (2007) J Clin Oncol , vol.25
    • Beuzeboc, E.B.P.1    Voog, E.2    Bousquet, G.3
  • 12
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010; 363:411-422
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 13
    • 84881635853 scopus 로고    scopus 로고
    • HER2 expression in patients with surgically resected urothelial cancer at high risk of recurrence screened for the phase II randomized, open-label trial of DN24-02, an autologous cellular immunotherapy targeting HER2. 2013 ASCO Genitourinary Cancers Symposium; Orlando, Florida
    • abstract 292
    • Press MF, O'Donnell PH, Plimack ER, et al. HER2 expression in patients with surgically resected urothelial cancer at high risk of recurrence screened for the phase II randomized, open-label trial of DN24-02, an autologous cellular immunotherapy targeting HER2. 2013 ASCO Genitourinary Cancers Symposium; Orlando, Florida. J Clin Oncol 2013; 31, 6S, abstract 292
    • (2013) J Clin Oncol , vol.31
    • Press, M.F.1    O'Donnell, P.H.2    Plimack, E.R.3
  • 14
    • 77956895978 scopus 로고    scopus 로고
    • HER2 diagnostics in gastric cancerguideline validation and development of standardized immunohistochemical testing
    • Ruschoff J, Dietel M, Baretton G, et al. HER2 diagnostics in gastric cancerguideline validation and development of standardized immunohistochemical testing. Virchows Arch 2010; 457:299-307
    • (2010) Virchows Arch , vol.457 , pp. 299-307
    • Ruschoff, J.1    Dietel, M.2    Baretton, G.3
  • 15
    • 77951471947 scopus 로고    scopus 로고
    • Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients
    • Lae M, Couturier J, Oudard S, et al. Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients. Ann Oncol 2010; 21:815-819
    • (2010) Ann Oncol , vol.21 , pp. 815-819
    • Lae, M.1    Couturier, J.2    Oudard, S.3
  • 16
    • 84866482706 scopus 로고    scopus 로고
    • High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: A study using formalinfixed, paraffin-embedded archival tissues
    • Chaux A, Cohen JS, Schultz L, et al. High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: A study using formalinfixed, paraffin-embedded archival tissues. Human Pathol 2012; 43:1590-1595
    • (2012) Human Pathol , vol.43 , pp. 1590-1595
    • Chaux, A.1    Cohen, J.S.2    Schultz, L.3
  • 17
    • 84867083523 scopus 로고    scopus 로고
    • Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma
    • Wong YN, Litwin S, Vaughn D, et al. Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma. J Clin Oncol 2012; 30:3545-3551
    • (2012) J Clin Oncol , vol.30 , pp. 3545-3551
    • Wong, Y.N.1    Litwin, S.2    Vaughn, D.3
  • 18
    • 84881637755 scopus 로고    scopus 로고
    • Randomized phase ii trial of gemcitabine/cisplatin (gc) with or without cetuximab (cet) in patients (pts) with advanced urothelial carcinoma 2012 asco annual meeting; chicago, il
    • suppl; abstr 4506
    • Grivas P, Agarwal N, Siefker-Radtke AO, et al. Randomized phase II trial of gemcitabine/cisplatin (GC) with or without cetuximab (CET) in patients (pts) with advanced urothelial carcinoma 2012 ASCO Annual Meeting; Chicago, IL. J Clin Oncol 30, 2012 (suppl; abstr 4506
    • (2012) J Clin Oncol , vol.30
    • Grivas, P.1    Agarwal, N.2    Siefker-Radtke, A.O.3
  • 19
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361:947-957
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 20
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (EURTAC): A multicentre, openlabel, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (EURTAC): A multicentre, openlabel, randomised phase 3 trial. Lancet Oncol 2012; 13:239-246
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 21
    • 33748076132 scopus 로고    scopus 로고
    • Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: Implications for therapy
    • Blehm KN, Spiess PE, Bondaruk JE, et al. Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: Implications for therapy. Clin Cancer Res 2006; 12:4671-4677
    • (2006) Clin Cancer Res , vol.12 , pp. 4671-4677
    • Blehm, K.N.1    Spiess, P.E.2    Bondaruk, J.E.3
  • 22
    • 75149171017 scopus 로고    scopus 로고
    • Results of the Southwest Oncology Group phase II evaluation (study S0031) of ZD1839 for advanced transitional cell carcinoma of the urothelium
    • Petrylak DP, Tangen CM, Van Veldhuizen PJ Jr, et al. Results of the Southwest Oncology Group phase II evaluation (study S0031) of ZD1839 for advanced transitional cell carcinoma of the urothelium. BJU Int 2010; 105:317-321
    • (2010) BJU Int , vol.105 , pp. 317-321
    • Petrylak, D.P.1    Tangen, C.M.2    Van Veldhuizen Jr., P.J.3
  • 23
    • 66149084012 scopus 로고    scopus 로고
    • A phase ii trial of cisplatin (c), gemcitabine (g) and gefitinib for advanced urothelial tract carcinoma: Results of cancer and leukemia group b (calgb 90102
    • Philips GK, Halabi S, Sanford BL, et al. A phase II trial of cisplatin (C), gemcitabine (G) and gefitinib for advanced urothelial tract carcinoma: Results of Cancer and Leukemia Group B (CALGB) 90102. Ann Oncol 2009; 20:1074-1079
    • (2009) Ann Oncol , vol.20 , pp. 1074-1079
    • Philips, G.K.1    Halabi, S.2    Sanford, B.L.3
  • 24
    • 34548407864 scopus 로고    scopus 로고
    • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
    • Tomlinson DC, Baldo O, Harnden P, Knowles MA. FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol 2007; 213:91-98
    • (2007) J Pathol , vol.213 , pp. 91-98
    • Tomlinson, D.C.1    Baldo, O.2    Harnden, P.3    Knowles, M.A.4
  • 25
  • 26
    • 84933676022 scopus 로고    scopus 로고
    • Final results of a multicenter, openlabel phase II trial of dovitinib (TKI258) in patients with advanced urothelial carcinoma with either mutated or nonmutated FGFR3; ASCO 2013 Genitourinary Cancers Symposium, Orlando, FL
    • abstr 255
    • Milowsky MI, Dittrich C, Martinez ID, et al. Final results of a multicenter, openlabel phase II trial of dovitinib (TKI258) in patients with advanced urothelial carcinoma with either mutated or nonmutated FGFR3; ASCO 2013 Genitourinary Cancers Symposium, Orlando, FL; J Clin Oncol 31, 2013 (suppl 6; abstr 255
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 6
    • Milowsky, M.I.1    Dittrich, C.2    Martinez, I.D.3
  • 27
    • 84881640314 scopus 로고    scopus 로고
    • Alterations in the pi3k/akt signaling pathway and association with outcome in invasive high-grade urothelial cancer american society of clinical oncology 2012 genitourinary cancers symposium; san francisco, cl
    • abstr 277
    • Balar AV, Iyer G, Al-Ahmadie H, et al. Alterations in the PI3K/Akt signaling pathway and association with outcome in invasive high-grade urothelial cancer American Society of Clinical Oncology 2012 Genitourinary Cancers Symposium; San Francisco, CL, J Clin Oncol 30, 2012 (suppl 5; abstr 277
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 5
    • Balar, A.V.1    Iyer, G.2    Al-Ahmadie, H.3
  • 28
    • 77957288035 scopus 로고    scopus 로고
    • Expanding therapeutic targets in bladder cancer: The PI3K/Akt/mTOR pathway
    • Ching CB, Hansel DE. Expanding therapeutic targets in bladder cancer: The PI3K/Akt/mTOR pathway. Lab Invest 2010; 90:1406-1414
    • (2010) Lab Invest , vol.90 , pp. 1406-1414
    • Ching, C.B.1    Hansel, D.E.2
  • 29
    • 84864369495 scopus 로고    scopus 로고
    • Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: Clinical activity, molecular response, and biomarkers
    • Seront E, Rottey S, Sautois B, et al. Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: Clinical activity, molecular response, and biomarkers. Ann Oncol 2012; 23:2663-2670
    • (2012) Ann Oncol , vol.23 , pp. 2663-2670
    • Seront, E.1    Rottey, S.2    Sautois, B.3
  • 30
    • 84867333656 scopus 로고    scopus 로고
    • Genome sequencing identifies a basis for everolimus sensitivity
    • Iyer G, Hanrahan AJ, Milowsky MI, et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 2012; 338:221
    • (2012) Science , vol.338 , pp. 221
    • Iyer, G.1    Hanrahan, A.J.2    Milowsky, M.I.3
  • 31
    • 84871968444 scopus 로고    scopus 로고
    • PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials
    • Janku F, Wheler JJ, Naing A, et al. PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials. Cancer Res 2013; 73:276-284
    • (2013) Cancer Res , vol.73 , pp. 276-284
    • Janku, F.1    Wheler, J.J.2    Naing, A.3
  • 32
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 33
    • 84886561381 scopus 로고    scopus 로고
    • Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer
    • In Press
    • Iyer G, Al-Ahmadie H, Schultz N, et al. Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer. J Clin Oncol 2013; In Press
    • (2013) J Clin Oncol
    • Iyer, G.1    Al-Ahmadie, H.2    Schultz, N.3
  • 34
    • 84869457757 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4/6 inhibition in cancer therapy
    • Johnson N, Shapiro GI. Cyclin-dependent kinase 4/6 inhibition in cancer therapy. Cell Cycle 2012; 11:3913
    • (2012) Cell Cycle , vol.11 , pp. 3913
    • Johnson, N.1    Shapiro, G.I.2
  • 35
    • 84875697676 scopus 로고    scopus 로고
    • Results of a randomized phase 2 study of pd 0332991 a cyclin dependent kinase (cdk) 46 inhibitor in combination with letrozole vs letrozole alone for first-line treatment of erher2-Advanced breast cancer (bc); san antonio breast cancer symposium 2012; san antonio texas usa
    • Suppl): Abstract nr
    • Finn RS, Crown JP, Lang I, et al. Results of a randomized phase 2 study of PD 0332991, a cyclin dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER/HER2-Advanced breast cancer (BC); San Antonio Breast Cancer Symposium 2012; San Antonio, Texas, USA; Cancer Res 2012; 72(24 Suppl): Abstract nr S1-6
    • (2012) Cancer Res , vol.72 , Issue.24
    • Finn, R.S.1    Crown, J.P.2    Lang, I.3
  • 36
    • 84861210266 scopus 로고    scopus 로고
    • Selective cdk4/6 inhibition with tumor responses by pd0332991 in patients with mantle cell lymphoma
    • Leonard JP, LaCasce AS, Smith MR, et al. Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood 2012; 119:4597-4607
    • (2012) Blood , vol.119 , pp. 4597-4607
    • Leonard, J.P.1    LaCasce, A.S.2    Smith, M.R.3
  • 37
    • 84880695940 scopus 로고    scopus 로고
    • Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-Amplified well differentiated or dedifferentiated liposarcoma
    • Dickson MA, Tap WD, Keohan ML, et al. Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-Amplified well differentiated or dedifferentiated liposarcoma. J Clin Onco 2013
    • (2013) J Clin Onco
    • Dickson, M.A.1    Tap, W.D.2    Keohan, M.L.3
  • 38
    • 84864387137 scopus 로고    scopus 로고
    • Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors
    • Dean JL, McClendon AK, Hickey TE, et al. Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Cell Cycle 2012; 11:2756-2761
    • (2012) Cell Cycle , vol.11 , pp. 2756-2761
    • Dean, J.L.1    McClendon, A.K.2    Hickey, T.E.3
  • 39
    • 84864378859 scopus 로고    scopus 로고
    • CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy
    • McClendon AK, Dean JL, Rivadeneira DB, et al. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle 2012; 11:2747-2755
    • (2012) Cell Cycle , vol.11 , pp. 2747-2755
    • McClendon, A.K.1    Dean, J.L.2    Rivadeneira, D.B.3
  • 40
    • 21844450899 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy in invasive bladder cancer: Update of a systematic review and meta-Analysis of individual patient data advanced bladder cancer (ABC) meta-Analysis collaboration
    • Advanced Bladder Cancer Meta-Analysis C.
    • Advanced Bladder Cancer Meta-Analysis C. Neoadjuvant chemotherapy in invasive bladder cancer: Update of a systematic review and meta-Analysis of individual patient data advanced bladder cancer (ABC) meta-Analysis collaboration European Urology 2005; 48:202-206
    • (2005) European Urology , vol.48 , pp. 202-206
  • 41
    • 20244368343 scopus 로고    scopus 로고
    • Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling
    • Takata R, Katagiri T, Kanehira M, et al. Predicting response to methotrexate, vinblastine, doxorubicin, and cisplatin neoadjuvant chemotherapy for bladder cancers through genome-wide gene expression profiling. Clin Cancer Res 2005; 11:2625-2636
    • (2005) Clin Cancer Res , vol.11 , pp. 2625-2636
    • Takata, R.1    Katagiri, T.2    Kanehira, M.3
  • 42
    • 33751345359 scopus 로고    scopus 로고
    • Validation study of the prediction system for clinical response of M-VAC neoadjuvant chemotherapy
    • Takata R, Katagiri T, Kanehira M, et al. Validation study of the prediction system for clinical response of M-VAC neoadjuvant chemotherapy. Cancer Sci 2007; 98:113-117
    • (2007) Cancer Sci , vol.98 , pp. 113-117
    • Takata, R.1    Katagiri, T.2    Kanehira, M.3
  • 43
    • 78751611811 scopus 로고    scopus 로고
    • Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant chemotherapy through genomewide gene expression profiling
    • Kato Y, Zembutsu H, Takata R, et al. Predicting response of bladder cancers to gemcitabine and carboplatin neoadjuvant chemotherapy through genomewide gene expression profiling. Exp Ther Med 2011; 2:47-56
    • (2011) Exp Ther Med , vol.2 , pp. 47-56
    • Kato, Y.1    Zembutsu, H.2    Takata, R.3
  • 44
    • 84873418606 scopus 로고    scopus 로고
    • Neoadjuvant gemcitabine plus carboplatin for locally advanced bladder cancer
    • Iwasaki K, Obara W, Kato Y, et al. Neoadjuvant gemcitabine plus carboplatin for locally advanced bladder cancer. Jpn J Clin Oncol 2013; 43:193-199
    • (2013) Jpn J Clin Oncol , vol.43 , pp. 193-199
    • Iwasaki, K.1    Obara, W.2    Kato, Y.3
  • 45
    • 84864423349 scopus 로고    scopus 로고
    • A systematic review of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer
    • Meeks JJ, Bellmunt J, Bochner BH, et al. A systematic review of neoadjuvant and adjuvant chemotherapy for muscle-invasive bladder cancer. Eur Urol 2012; 62:523-533
    • (2012) Eur Urol , vol.62 , pp. 523-533
    • Meeks, J.J.1    Bellmunt, J.2    Bochner, B.H.3
  • 46
    • 70350536600 scopus 로고    scopus 로고
    • Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy
    • Williams PD, Cheon S, Havaleshko DM, et al. Concordant gene expression signatures predict clinical outcomes of cancer patients undergoing systemic therapy. Cancer Res 2009; 69:8302-8309
    • (2009) Cancer Res , vol.69 , pp. 8302-8309
    • Williams, P.D.1    Cheon, S.2    Havaleshko, D.M.3
  • 47
    • 84858226599 scopus 로고    scopus 로고
    • Progress in personalizing chemotherapy for bladder cancer
    • Chang JS, Lara PN Jr, Pan CX. Progress in personalizing chemotherapy for bladder cancer. Adv Urol 2012; 2012:364919
    • (2012) Adv Urol , vol.2012 , pp. 364919
    • Chang, J.S.1    Lara Jr., P.N.2    Pan, C.X.3
  • 48
    • 78650376422 scopus 로고    scopus 로고
    • BRCA1 mRNA expression and outcome to neoadjuvant cisplatin-based chemotherapy in bladder cancer
    • Font A, Taron M, Gago JL, et al. BRCA1 mRNA expression and outcome to neoadjuvant cisplatin-based chemotherapy in bladder cancer. Ann Oncol 2011; 22:139-144
    • (2011) Ann Oncol , vol.22 , pp. 139-144
    • Font, A.1    Taron, M.2    Gago, J.L.3
  • 49
    • 78851472038 scopus 로고    scopus 로고
    • Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers
    • Richardson PG, Mitsiades CS, Laubach JP, et al. Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers. Brit J Haematol 2011; 152:367-379
    • (2011) Brit J Haematol , vol.152 , pp. 367-379
    • Richardson, P.G.1    Mitsiades, C.S.2    Laubach, J.P.3
  • 50
    • 71049173726 scopus 로고    scopus 로고
    • Heat-shock protein 70-2(HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion
    • Garg M,Kanojia D,Seth A, et al.Heat-shock protein 70-2(HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion. Eur J Cancer 2010; 46:207-215
    • (2010) Eur J Cancer , vol.46 , pp. 207-215
    • Garg, M.1    Kanojia, D.2    Seth, A.3
  • 51
    • 84856934940 scopus 로고    scopus 로고
    • Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells
    • Tatokoro M, Koga F, Yoshida S, et al. Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells. Int J Cancer 2012; 131:987-996
    • (2012) Int J Cancer , vol.131 , pp. 987-996
    • Tatokoro, M.1    Koga, F.2    Yoshida, S.3
  • 52
    • 33846821658 scopus 로고    scopus 로고
    • Hsp27 knockdown using nucleotidebased therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells
    • Kamada M, So A, Muramaki M, et al. Hsp27 knockdown using nucleotidebased therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells. Mol Cancer Ther 2007; 6:299-308
    • (2007) Mol Cancer Ther , vol.6 , pp. 299-308
    • Kamada, M.1    So, A.2    Muramaki, M.3
  • 53
    • 48749115689 scopus 로고    scopus 로고
    • Intravesically administered antisense oligonucleotides targeting heat-shock protein-27 inhibit the growth of nonmuscle-invasive bladder cancer
    • Hadaschik BA, Jackson J, Fazli L, et al. Intravesically administered antisense oligonucleotides targeting heat-shock protein-27 inhibit the growth of nonmuscle-invasive bladder cancer. BJU Int 2008; 102:610-616
    • (2008) BJU Int , vol.102 , pp. 610-616
    • Hadaschik, B.A.1    Jackson, J.2    Fazli, L.3
  • 54
    • 84874092965 scopus 로고    scopus 로고
    • Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells
    • Kim SJ, Jang JE, Cheong JW, et al. Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells. Korean J Hematol 2012; 47:178-185
    • (2012) Korean J Hematol , vol.47 , pp. 178-185
    • Kim, S.J.1    Jang, J.E.2    Cheong, J.W.3
  • 55
    • 53149125697 scopus 로고    scopus 로고
    • Gene expression study of Aurora-A reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer
    • Comperat E, Bieche I, Dargere D, et al. Gene expression study of Aurora-A reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer. Urology 2008; 72:873-877
    • (2008) Urology , vol.72 , pp. 873-877
    • Comperat, E.1    Bieche, I.2    Dargere, D.3
  • 56
    • 79955468461 scopus 로고    scopus 로고
    • Prognostic significance of Aurora-A expression in human bladder cancer
    • Lei Y, Yan S, Ming-De L, et al. Prognostic significance of Aurora-A expression in human bladder cancer. Acta Histochemica 2011; 113:514-518
    • (2011) Acta Histochemica , vol.113 , pp. 514-518
    • Lei, Y.1    Yan, S.2    Ming-De, L.3
  • 57
    • 84865681647 scopus 로고    scopus 로고
    • Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
    • Matulonis UA, Sharma S, Ghamande S, et al. Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. Gynec Oncol 2012; 127: 63-69
    • (2012) Gynec Oncol , vol.127 , pp. 63-69
    • Matulonis, U.A.1    Sharma, S.2    Ghamande, S.3
  • 58
    • 33746622832 scopus 로고    scopus 로고
    • Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer
    • Yamamoto Y, Matsuyama H, Kawauchi S, et al. Overexpression of polo-like kinase 1 (PLK1) and chromosomal instability in bladder cancer. Oncology 2006; 70:231-237
    • (2006) Oncology , vol.70 , pp. 231-237
    • Yamamoto, Y.1    Matsuyama, H.2    Kawauchi, S.3
  • 59
    • 84863923381 scopus 로고    scopus 로고
    • High expression of polo-like kinase 1 is associated with the metastasis and recurrence in urothelial carcinoma of bladder
    • Zhang Z, Zhang G, Kong C. High expression of polo-like kinase 1 is associated with the metastasis and recurrence in urothelial carcinoma of bladder. Urol Oncol 2011
    • (2011) Urol Oncol
    • Zhang, Z.1    Zhang, G.2    Kong, C.3
  • 60
    • 84860242308 scopus 로고    scopus 로고
    • Clinical outcome of single agent volasertib (bi 6727) as second-line treatment of patients (pts) with advanced or metastatic urothelial cancer (uc) asco annual meeting; 2011
    • suppl; abstr 4567
    • Stadler WM, Vaughn DJ, Sonpavde G, et al. Clinical outcome of single agent volasertib (BI 6727) as second-line treatment of patients (pts) with advanced or metastatic urothelial cancer (UC) ASCO Annual Meeting; 2011. J Clin Oncol 29: 2011 (suppl; abstr 4567
    • (2011) J Clin Oncol , vol.29
    • Stadler, W.M.1    Vaughn, D.J.2    Sonpavde, G.3
  • 61
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367:1694-1703
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 62
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366:520-529
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.