-
2
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361:947-957, 2009.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
3
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al: Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363:1693-1703, 2010.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
4
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al: Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819, 2010.
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
5
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364: 2507-2516, 2011.
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
6
-
-
77955046517
-
Genomic and biological characterization of exon 4 KRAS mutations in human cancer
-
Janakiraman M, Vakiani E, Zeng Z, et al: Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer Res 70: 5901-5911, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 5901-5911
-
-
Janakiraman, M.1
Vakiani, E.2
Zeng, Z.3
-
7
-
-
79955788046
-
Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma
-
Al-Ahmadie HA, Iyer G, Janakiraman M, et al: Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma. J Pathol 224:270-279, 2011.
-
(2011)
J Pathol
, vol.224
, pp. 270-279
-
-
Al-Ahmadie, H.A.1
Iyer, G.2
Janakiraman, M.3
-
8
-
-
58149112821
-
Functional copy-number alterations in cancer
-
Taylor BS, Barretina J, Socci ND, et al: Functional copy-number alterations in cancer. PLoS One 3:e3179, 2008.
-
(2008)
PLoS One
, vol.3
, pp. e3179
-
-
Taylor, B.S.1
Barretina, J.2
Socci, N.D.3
-
9
-
-
0037316303
-
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
-
Bolstad BM, Irizarry RA, Astrand M, et al: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19:185-193, 2003.
-
(2003)
Bioinformatics
, vol.19
, pp. 185-193
-
-
Bolstad, B.M.1
Irizarry, R.A.2
Astrand, M.3
-
10
-
-
84866002291
-
The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
-
Cerami E, Gao J, Dogrusoz U, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401-404, 2012.
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
-
11
-
-
84882242988
-
-
Memorial Sloan-Kettering Cancer Center
-
Memorial Sloan-Kettering Cancer Center: cBioPortal for Cancer Genomics. http://www.cbioportal.Org.
-
CBioPortal for Cancer Genomics
-
-
-
12
-
-
33747506490
-
Understanding urothelial carcinoma through cancer pathways
-
Schulz WA: Understanding urothelial carcinoma through cancer pathways. Int J Cancer 119: 1513-1518, 2006.
-
(2006)
Int J Cancer
, vol.119
, pp. 1513-1518
-
-
Schulz, W.A.1
-
13
-
-
33745608442
-
High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers
-
Kawanishi H, Takahashi T, Ito M, et al: High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers. Cancer Sci 97:746-752, 2006.
-
(2006)
Cancer Sci
, vol.97
, pp. 746-752
-
-
Kawanishi, H.1
Takahashi, T.2
Ito, M.3
-
14
-
-
77951471947
-
Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients
-
Laé M, Couturier J, Oudard S, et al: Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients. Ann Oncol 21:815-819, 2010.
-
(2010)
Ann Oncol
, vol.21
, pp. 815-819
-
-
Laé, M.1
Couturier, J.2
Oudard, S.3
-
15
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
-
Marty M, Cognetti F, Maraninchi D, et al: Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 23:4265-4274, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
-
16
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2- positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2- positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial. Lancet 376:687-697, 2010.
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
17
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M, Leyland- Jones B, et al: Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353:1659-1672, 2005.
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland- Jones, B.3
-
18
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner JD, Kinzler KW, Meltzer PS, et al: Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83, 1992.
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
-
19
-
-
0029020147
-
Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status
-
McCann AH, Kirley A, Carney DN, et al: Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status. Br J Cancer 71:981-985, 1995.
-
(1995)
Br J Cancer
, vol.71
, pp. 981-985
-
-
McCann, A.H.1
Kirley, A.2
Carney, D.N.3
-
20
-
-
77249119762
-
The landscape of somatic copy-number alteration across human cancers
-
Beroukhim R, Mermel CH, Porter D, et al: The landscape of somatic copy-number alteration across human cancers. Nature 463:899-905, 2010.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
-
21
-
-
40749120501
-
A comprehensive modular map of molecular interactions in RB/E2F pathway
-
Calzone L, Gelay A, Zinovyev A, et al: A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol 4:173, 2008.
-
(2008)
Mol Syst, Biol
, vol.4
, pp. 173
-
-
Calzone, L.1
Gelay, A.2
Zinovyev, A.3
-
22
-
-
80051725013
-
Characterization of the cell of origin for small cell lung cancer
-
Park KS, Liang MC, Raiser DM, et al: Characterization of the cell of origin for small cell lung cancer. Cell Cycle 10:2806-2815, 2011.
-
(2011)
Cell, Cycle
, vol.10
, pp. 2806-2815
-
-
Park, K.S.1
Liang, M.C.2
Raiser, D.M.3
-
23
-
-
78049510428
-
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
-
Krueger DA, Care MM, Holland K, et al: Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 363:1801- 1811, 2010.
-
(2010)
N Engl J Med
, vol.363
, pp. 1801-1811
-
-
Krueger, D.A.1
Care, M.M.2
Holland, K.3
-
24
-
-
84867333656
-
Genome sequencing identifies a basis for everolimus sensitivity
-
Iyer G, Hanrahan AJ, Milowsky MI, et al: Genome sequencing identifies a basis for everolimus sensitivity. Science 338:221, 2012.
-
(2012)
Science
, vol.338
, pp. 221
-
-
Iyer, G.1
Hanrahan, A.J.2
Milowsky, M.I.3
-
25
-
-
84865758081
-
Genomic complexity and AKT dependence in serous ovarian cancer
-
Hanrahan AJ, Schultz N, Westfal ML, et al: Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov 2:56-67, 2012.
-
(2012)
Cancer Discov
, vol.2
, pp. 56-67
-
-
Hanrahan, A.J.1
Schultz, N.2
Westfal, M.L.3
-
26
-
-
9444228344
-
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
-
Fry DW, Harvey PJ, Keller PR, et al: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther 3:1427-1438, 2004.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1427-1438
-
-
Fry, D.W.1
Harvey, P.J.2
Keller, P.R.3
-
27
-
-
33746646758
-
Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcriptionindependent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
-
Kojima K, Konopleva M, McQueen T, et al: Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcriptionindependent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 108:993-1000, 2006.
-
(2006)
Blood
, vol.108
, pp. 993-1000
-
-
Kojima, K.1
Konopleva, M.2
McQueen, T.3
-
28
-
-
77956271440
-
The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
-
Li M, Fang X, Baker DJ, et al: The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A 107:14188-14193, 2010.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 14188-14193
-
-
Li, M.1
Fang, X.2
Baker, D.J.3
-
29
-
-
27744541445
-
Mechanisms of disease: Genetic and epigenetic alterations that drive bladder cancer
-
Wolff EM, Liang G, Jones PA: Mechanisms of Disease: Genetic and epigenetic alterations that drive bladder cancer. Nat Clin Pract Urol 2:502-510, 2005.
-
(2005)
Nat Clin Pract Urol
, vol.2
, pp. 502-510
-
-
Wolff, E.M.1
Liang, G.2
Jones, P.A.3
-
30
-
-
52449092107
-
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling
-
She QB, Chandarlapaty S, Ye Q, et al: Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PloS One 3:e3065, 2008.
-
(2008)
PloS One
, vol.3
, pp. e3065
-
-
She, Q.B.1
Chandarlapaty, S.2
Ye, Q.3
-
31
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, et al: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 359:1757- 1765, 2008.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
32
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, et al: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23:5900-5909, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
-
33
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, et al: Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366:883-892, 2012.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
|