Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells

British Journal of Pharmacology

Volumn 170, Issue 1, 2013, Pages 58-66

  Karlstedt, K ^a   Jin, C ^a   Panula, P ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

blood brain barrier; Erk1 Erk2; GPCR; histamine; MAPK

Indexed keywords

HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE EXPRESSION; HRH3 GENE; HRH4 GENE; IN VITRO STUDY; IN VIVO STUDY; MALE; MULTICENTER STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR GENE; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

BLOOD-BRAIN BARRIER; ERK1/ERK2; GPCR; HISTAMINE; MAPK;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; HISTAMINE; IMIDAZOLES; INDOLES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PIPERAZINES; PIPERIDINES; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84881643874     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12173     Document Type: Article

References (26)

1. Akdis CA, Simons FE, (2006). Histamine receptors are hot in immunopharmacology. Eur J Pharmacol 533: 69-76.
2. Alexander, SPH, Mathie A, Peter JA, (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164 (Suppl. S1): S1-S324.
3. Buckland KF, Williams TJ, Conroy DM, (2003). Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol 140: 1117-1127.
4. Connelly WM, Shenton FC, Lethbridge N, Leurs R, Waldvogel HJ, Faull RL, et al. (2009). The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157: 55-63.
5. Drutel G, Peitsaro N, Karlstedt K, Wieland K, Smit MJ, Timmerman H, et al. (2001). Identification of rat H3 receptor isoforms with different brain expression and signaling properties. Mol Pharmacol 59: 1-8.
6. Durieu-Trautmann O, Federici C, Creminon C, Foignant-Chaverot N, Roux F, Claire M, et al. (1993). Nitric oxide and endothelin secretion by brain microvessel endothelial cells: regulation by cyclic nucleotides. J Cell Physiol 155: 104-111.
7. Gbahou F, Rouleau A, Arrang JM, (2012). The histamine autoreceptor is a short isoform of the H(3) receptor. Br J Pharmacol 166: 1860-1871.
8. Goverman J, (2009). Autoimmune T cell responses in the central nervous system. Nat Rev Immunol 9: 393-407.
9. Grammas P, Martinez J, Miller B, (2011). Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases. Expert Rev Mol Med 13: e19.
10. Gschwandtner M, Rossbach K, Dijkstra D, Baumer W, Kietzmann M, Stark H, et al. (2010). Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function. Allergy 65: 840-849.
11. Haas H, Panula P, (2003). The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci 4: 121-130.
12. Karlstedt K, Sallmen T, Eriksson KS, Lintunen M, Couraud PO, Joo F, et al. (1999). Lack of histamine synthesis and down-regulation of H1 and H2 receptor mRNA levels by dexamethasone in cerebral endothelial cells. J Cereb Blood Flow Metab 19: 321-330.
13. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). NC3Rs Reporting Guidelines Working Group. Br J Pharmacol 160: 1577-1579.
14. Ling P, Ngo K, Nguyen S, Thurmond RL, Edwards JP, Karlsson L, et al. (2004). Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol 142: 161-171.
15. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
16. Passani MB, Ballerini C, (2012). Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis. Front Syst Neurosci 6: 32.
17. van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, et al. (2008). Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. Biochem J 414: 121-131.
18. del Rio R, Noubade R, Saligrama N, Wall EH, Krementsov DN, Poynter ME, et al. (2012). Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system. J Immunol 188: 541-547.
19. Rosethorne EM, Charlton SJ, (2011). Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits beta-arrestin without activating G proteins. Mol Pharmacol 79: 749-757.
20. Roux F, Durieu-Trautmann O, Chaverot N, Claire M, Mailly P, Bourre JM, et al. (1994). Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol 159: 101-113.
21. Saligrama N, Noubade R, Case LK, del Rio R, Teuscher C, (2012). Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system. Eur J Immunol 42: 1536-1546.
22. Strakhova MI, Nikkel AL, Manelli AM, Hsieh GC, Esbenshade TA, Brioni JD, et al. (2009). Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res 1250: 41-48.
23. Teuscher C, Subramanian M, Noubade R, Gao JF, Offner H, Zachary JF, et al. (2007). Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS. Proc Natl Acad Sci U S A 104: 10146-10151.
24. Wu X, Pan W, Stone KP, Zhang Y, Hsuchou H, Kastin AJ, (2010). Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier. J Neurochem 114: 122-129.
25. Yang L, Fawcett JP, Ostergaard J, Zhang H, Tucker IG, (2012). Mechanistic studies of the effect of bile salts on rhodamine 123 uptake into RBE4 cells. Mol Pharm 9: 29-36.
26. Zampeli E, Tiligada E, (2009). The role of histamine H4 receptor in immune and inflammatory disorders. Br J Pharmacol 157: 24-33.