Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis

Atherosclerosis

Volumn 230, Issue 1, 2013, Pages 23-32

  Forbes, Scott P ^a   Alferiev, Ivan S ^a,b   Chorny, Michael ^a,b   Adamo, Richard F ^a   Levy, Robert J ^a,b   Fishbein, Ilia ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Gene therapy; Inducible nitric oxide synthase; L Arg; Nitric oxide; Restenosis; Smooth muscle cells; Tetrahydrobiopterin

Indexed keywords

ADENOVIRUS VECTOR; ARGININE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRITE; REACTIVE OXYGEN METABOLITE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; MALE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; RAT; RESTENOSIS; SUPPLEMENTATION; VASCULAR SMOOTH MUSCLE; VIRAL GENE THERAPY;

GENE THERAPY; INDUCIBLE NITRIC OXIDE SYNTHASE; L-ARG; NITRIC OXIDE; RESTENOSIS; SMOOTH MUSCLE CELLS; TETRAHYDROBIOPTERIN;

ADENOVIRIDAE; ANIMALS; AORTA; ARGININE; BIOPTERIN; CAROTID ARTERIES; CELL PROLIFERATION; CELL SURVIVAL; CORONARY RESTENOSIS; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; GENETIC THERAPY; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84881626773     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2013.06.002     Document Type: Article

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