Gene-eluting stents: Non-viral, liposome-based gene delivery of eNOS to the blood vessel wall in vivo results in enhanced endothelialization but does not reduce restenosis in a hypercholesterolemic model

Gene Therapy

Volumn 19, Issue 3, 2012, Pages 321-328

  Sharif, F ^a   Hynes, S O ^a   McCullagh, K J A ^a,b   Ganley, S ^a   Greiser, U ^a   McHugh, P ^a   Crowley, J ^a   Barry, F ^a   O'Brien, T ^a  

^a UNIVERSITY HOSPITAL GALWAY   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

coronary artery stents; endothelialization; late stent thrombosis; liposome; restenosis

Indexed keywords

BETA GALACTOSIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LIPOFECTIN; LIPOPLEX; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; BARE METAL STENT; CELL POPULATION; CONTROLLED STUDY; CORONARY STENT; ENDOTHELIALIZATION; EXPERIMENTAL RABBIT; GENE ELUTING STENT; GENE EXPRESSION; HISTOCHEMISTRY; HISTOLOGY; HUMAN; HYPERCHOLESTEROLEMIA; ILIAC ARTERY; IN VIVO STUDY; IN-STENT RESTENOSIS; LIPOSOMAL GENE DELIVERY SYSTEM; MACROPHAGE; MALE; MOLECULAR CLONING; NEOINTIMA; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SCANNING ELECTRON MICROSCOPY; STENT; TISSUE REGENERATION; TRANSGENE;

ADENOVIRIDAE; ANIMALS; CONSTRICTION, PATHOLOGIC; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; HYPERCHOLESTEROLEMIA; LIPOSOMES; MALE; NITRIC OXIDE SYNTHASE TYPE III; PLASMIDS; RABBITS; REGENERATION; STENTS; TRANSGENES; TUNICA INTIMA;

ORYCTOLAGUS CUNICULUS;

EID: 84858004765     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.92     Document Type: Article

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