Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis

Neurobiology of Disease

Volumn 59, Issue , 2013, Pages 111-125

  Mey, Lilli ^a   Hörmann, Mareike ^a,b   Schleicher, Nadine ^c,d   Reuter, Peter ^c,d   Dönges, Simone ^c,d   Kinscherf, Ralf ^a   Gassmann, Max ^e   Gerriets, Tibo ^c,d   Al Fakhri, Nadia ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d KERCKHOFF HEART CENTER   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Apoptosis; Cerebral ischemia; Cerebrovascular disease; Neuropilin 1; PARP; Rat middle cerebral artery occlusion model; Vascular endothelial growth factor

Indexed keywords

ALPHA5 INTEGRIN; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLYCOGEN; MESSENGER RNA; NEUROPILIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; INDOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; SEMAXANIB; BOVINE SERUM ALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CELL ADHESION; CEREBROVASCULAR APOPTOSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; HEMISPHERE; HUMAN; HUMAN CELL; MESSENGER RNA SYNTHESIS; NERVE CELL; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TIME; UMBILICAL VEIN; WISTAR RAT; %HLV(EC); ΑV-INTEGRIN INHIBITOR CYCLO-[ARG-GLY-ASP-D-PHE-VAL]; A7R; B-CELL LYMPHOMA 2 PROTEIN; BCL-2; BSA; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR DISEASE; CRGDFV; DRUG EFFECT; EC; EDEMA-CORRECTED ISCHEMIC LESION VOLUME; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HUVEC; IN SITU-LIGATION ASSAY; IO; IR; ISCHEMIA-OCCLUSION MODEL; ISCHEMIA-REPERFUSION MODEL; ISL ASSAY; MCAO; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPILIN-1 INHIBITOR [ATWLPPR]; NF-ΚB; NP-1; NUCLEAR FACTOR Κ-LIGHT-CHAIN-ENHANCER OF ACTIVATED B-CELLS; PARP; PAS; PERIODIC ACID-SCHIFF REACTION STAINING; POLY(ADP-RIBOSE)-POLYMERASE; RAT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL; SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION; SOD-1; STATS; SUPEROXIDE DISMUTASE-1; TYROSINE-KINASE INHIBITOR OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 [3-[(2,4-DI-METHYLPYRROL-5-YL)-METHYLIDENE]-INDOLIN-2-ONE]; UMBILICAL VEIN ENDOTHELIAL CELL; VEGFR-2;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INDOLES; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEURONS; NEUROPILIN-1; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; PYRROLES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TIME FACTORS; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

%HLV(EC); ΑV-INTEGRIN INHIBITOR CYCLO-[ARG-GLY-ASP-D-PHE-VAL]; A7R; APOPTOSIS; B-CELL LYMPHOMA 2 PROTEIN; BCL-2; BOVINE SERUM ALBUMIN; BSA; CEREBRAL ISCHEMIA; CEREBROVASCULAR DISEASE; CRGDFV; EC; EDEMA-CORRECTED ISCHEMIC LESION VOLUME; ENDOTHELIAL CELLS; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUVEC; IN SITU-LIGATION ASSAY; IO; IR; ISCHEMIA-OCCLUSION MODEL; ISCHEMIA-REPERFUSION MODEL; ISL ASSAY; MCAO; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPILIN-1; NEUROPILIN-1 INHIBITOR [ATWLPPR]; NF-ΚB; NP-1; NUCLEAR FACTOR Κ-LIGHT-CHAIN-ENHANCER OF ACTIVATED B-CELLS; PARP; PAS; PERIODIC ACID-SCHIFF REACTION STAINING; POLY(ADP-RIBOSE)-POLYMERASE; RAT MIDDLE CEREBRAL ARTERY OCCLUSION MODEL; SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION; SOD-1; STATS; SU5416; SUPEROXIDE DISMUTASE-1; TYROSINE-KINASE INHIBITOR OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 [3-[(2,4-DI-METHYLPYRROL-5-YL)-METHYLIDENE]-INDOLIN-2-ONE]; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VEGF; VEGFR-2;

EID: 84881625912     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.06.009     Document Type: Article

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