Receptors for collapsin/semaphorins

Current Opinion in Neurobiology

Volumn 8, Issue 5, 1998, Pages 587-592

  Fujisawa, Hajime ^a   Kitsukawa, Takashi ^b  

^a NAGOYA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CHEMOREPELLENT; HYBRID PROTEIN; MUTANT PROTEIN; NERVE GROWTH FACTOR; NEUROPILIN; SEMAPHORIN; VASCULOTROPIN;

CELL ADHESION; EMBRYO DEVELOPMENT; GENE EXPRESSION; GROWTH CONE; MOLECULAR CLONING; MOLECULAR INTERACTION; MOTOR NERVE; MOUSE; NERVE FIBER; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; SPINAL GANGLION;

EID: 0032191129     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80085-8     Document Type: Article

References (61)

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20. of outstanding interest Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron. 19:1997;995-1005 This paper reports the phenotype of neuropilin-1 null mutant mice, which were generated by targeted disruption of the neuropilin (neuropilin-1) gene. The neuropilin-1 mutant mice were embryonic lethal, probably owing to abnormal development of the vascular system. Live homozygous mutant embryos were observed as late as E12.5, and showed severe abnormalities in the trajectory of the cranial and spinal nerves that expressed neuropilin-1 in normal embryos. The paper also reports that DRG growth cones of the neuropilin-1 mutants are perfectly protected from Sema III-induced collapse in vitro.
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27. of special interest Feiner L, Koppel AM, Kobayashi H, Raper J. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but different subsets of neurons in situ. Neuron. 19:1997;539-545 The authors produced AP-tagged Coll-1, Coll-2, Coll-3, and Coll-5, and then tested their binding to tissue sections and recombinant neuropilin (neuropilin-1) protein. All of the AP-tagged collapsins bound to recombinant neuropilin-1 protein with similar affinities, whereas each collapsin exhibited a different binding profile in neuronal tissue. The authors also report that the carboxyl tail of each collapsin binds strongly to neuropilin-1 even though the profile of its binding to tissue sections is not specific for each collapsin member. In contrast, the semaphorin domain binds to tissue sections in a pattern specific for each collapsin.
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32. of outstanding interest Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 19:1997;519-530 This paper reports the phenotype of the Sema III mutant mouse, which was generated by targeted disruption of the Sema III gene. Sema III mutant mouse embryos exhibit a similar abnormality in the PNS as that observed in neuropilin-1 mutant mouse embryos (see [20]), even though the Sema III mutant mouse is viable after birth. This paper also reports the production of heterozygous knocked-in lacZ mice in which the lacZ gene was inserted into the Sema III locus, and shows that PNS axons avoid the lacZ-expressing areas. These findings indicate that Sema III is a chemorepulsive guidance signal for PNS axons in vivo.
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