A new rodent model for obstructive sleep apnea: Effects on ATP-mediated dilations in cerebral arteries

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 305, Issue 4, 2013, Pages

  Crossland, Randy F ^a   Durgan, David J ^a   Lloyd, Eric E ^a   Phillips, Sharon C ^a   Reddy, Anilkumar K ^a   Marrelli, Sean P ^a   Bryan Jr , Robert M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cerebrovascular circulation; Endothelial dysfunction; Hypoxia reoxygenation; Obstructive sleep apnea; Sleep disordered breathing

Indexed keywords

ADENOSINE TRIPHOSPHATE; NITRIC OXIDE; PURINERGIC P2Y2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APNEA; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDOTHELIAL DYSFUNCTION; HEART FUNCTION; HYPERPOLARIZATION; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; RAT; SLEEP DISORDERED BREATHING; SLEEP PATTERN;

CEREBROVASCULAR CIRCULATION; ENDOTHELIAL DYSFUNCTION; HYPOXIA/REOXYGENATION; OBSTRUCTIVE SLEEP APNEA; SLEEP-DISORDERED BREATHING;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL FACTORS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; MIDDLE CEREBRAL ARTERY; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE III; PURINERGIC P2Y RECEPTOR AGONISTS; RATS; RATS, LONG-EVANS; RESPIRATION; SLEEP; SLEEP APNEA, OBSTRUCTIVE; TIME FACTORS; TRACHEA; VASODILATION; VASODILATOR AGENTS;

EID: 84881625069     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00244.2013     Document Type: Article

References (49)

1. Almendros I, Carreras A, Ramirez J, Montserrat JM, Navajas D, Farre R. Upper airway collapse and reopening induce inflammation in a sleep apnoea model. Eur Respir J 32: 399-404, 2008.
2. Andresen J, Shafi NI, Bryan RM Jr. Endothelial influences on cerebrovascular tone. J Appl Physiol 100: 318-327, 2006.
3. Baguet JP, Hammer L, Levy P, Pierre H, Launois S, Mallion JM, Pepin JL. The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest 128: 3407-3412, 2005.
4. Brooks D, Horner RL, Kozar LF, Render-Teixeira CL, Phillipson EA. Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J Clin Invest 99: 106-109, 1997.
5. Bryan RM Jr. A method for measuring regional cerebral blood flow in freely moving, unstressed rats. J Neurosci Methods 17: 311-322, 1986.
6. Bryan RM Jr, Eichler MY, Swafford MWG, Johnson TD, Suresh MS, Childres WF. Stimulation of 0(2 adrenoceptors dilates the rat middle cerebral artery. Anesthesiology 85: 82-90, 1996.
7. Bryan RM Jr., Lehman RA. Cerebral glucose utilization after aversive conditioning and during conditioned fear in the rat. Brain Res 444: 17-24, 1988.
8. Bryan RM Jr, You J, Golding EM, Marrelli SP. Endothelium-derived hyperpolarizing factor: a cousin to nitric oxide and prostacyclin. Anesthesiology 102: 1261-1277, 2005.
9. Bryan RM Jr, Marrelli SP, Steenberg ML, Schildmeyer LA, Johnson TD. Effects of luminal shear stress on cerebral arteries and arterioles. Am J Physiol Heart Circ Physiol 280: H2011-H2022, 2001.
10. Capone C, Faraco G, Coleman C, Pickel V, Anrather J, Iadecola C. Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension 60: 106-113, 2012.
11. Carreras A, Almendros I, Montserrat JM, Navajas D, Farre R. Mesenchymal stem cells reduce inflammation in a rat model of obstructive sleep apnea. Respir Physiol Neurobiol 172: 210-212, 2010.
12. Cartheuser CF. Standard and pH-affected hemoglobin-O2 binding curves of Sprague-Dawley rats under normal and shifted P50 conditions. Comp Biochem Physiol Comp Physiol 106: 775-782, 1993.
13. Cipolla MJ, Smith J, Kohlmeyer MM, Godfrey JA. SKCa and IKCa Channels, myogenic tone, and vasodilator responses in middle cerebral arteries and parenchymal arterioles: effect of ischemia and reperfusion. Stroke 40: 1451-1457, 2009.
14. Dematteis M, Godin-Ribuot D, Arnaud C, Ribuot C, Stanke-Labesque F, Pepin JL, Levy P. Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease. ILAR J 50: 262-281, 2009.
15. Dempsey JA, Veasey SC, Morgan BJ, O'Donnell CP. Pathophysiology of sleep apnea. Physiol Rev 90: 47-112, 2010.
16. Drager LF, Jun JC, Polotsky VY. Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea. Best Pract Res Clin Endocrinol Metab 24: 843-851, 2010.
17. Durgan DJ, Crossland RF, Lloyd EE, Bryan, RM Jr. Altered cerebro-vascular reactivity following one month of obstructive sleep apnea (Abstract). Arterioscler Thromb Vasc Biol 33, 2013.
18. Durgan DJ, Bryan RM. Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc 1: e000091, 2012.
19. Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, Sprague RS. Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology 24: 107-116, 2009.
20. Faraci FM. Protecting against vascular disease in brain. Am J Physiol Heart Circ Physiol 300: H1566-H1582, 2011.
21. Farre R, Montserrat JM, Navajas D. Morbidity due to obstructive sleep apnea: insights from animal models. Curr Opin Pulm Med 14: 530-536, 2008.
22. Farre R, Nacher M, Serrano-Mollar A, Galdiz JB, Alvarez FJ, Navajas D, Montserrat JM. Rat model of chronic recurrent airway obstructions to study the sleep apnea syndrome. Sleep 30: 930-933, 2007.
23. Farre R, Rotger M, Montserrat JM, Calero G, Navajas D. Collapsible upper airway segment to study the obstructive sleep apnea/hypopnea syndrome in rats. Respir Physiol Neurobiol 136: 199-209, 2003.
24. Fletcher EC, Brown DL. Nocturnal oxyhemoglobin desaturation following tracheostomy for obstructive sleep apnea. Am J Med 79: 35-42, 1985.
25. Fletcher EC, Lesske J, Culman J, Miller CC, Unger T. Sympathetic denervation blocks blood pressure elevation in episodic hypoxia. Hypertension 20: 612-619, 1992.
26. Fletcher EC, Lesske J, Qian W, Miller CC, III, Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension 19: 555-561, 1992.
27. Golding EM, You J, Robertson CS, Bryan RM Jr. Potentiated endo-thelium-derived hyperpolarizing factor-mediated dilations in cerebral arteries following mild head injury. J Neurotrauma 18: 691-697, 2001.
28. Golding EM, Marrelli SP, You J, Bryan RM Jr. Endothelium-derived hyperpolarizing factor in the brain: a new regulator of cerebral blood flow? Stroke 33: 661-663, 2002.
29. Halliwell B. Free radicals and antioxidants-quo vadis? Trends Pharmacol Sci 32: 125-130, 2011.
30. Hartley C, Reddy A, Entman M, Michael L, Taffet G, Madala S. Characterization of arterial wave propagation and reflection in mice. Conf Proc IEEE Eng Med Biol Soc 1: 601-604, 2005.
31. Hartley CJ, Taffet GE, Reddy AK, Entman ML, Michael LH. Non-invasive cardiovascular phenotyping in mice. ILAR J 43: 147-158, 2002.
32. Kimoff RJ, Makino H, Horner RL, Kozar LF, Lue F, Slutsky AS, Phillipson EA. Canine model of obstructive sleep apnea: model description and preliminary application. J Appl Physiol 76: 1810-1817, 1994.
33. Marrelli SP, Childres WF, Goddard-Finegold J, Bryan RM Jr. Potentiated EDHF-mediated dilations in the rat middle cerebral artery following ischemia/reperfusion. In: EDHF 2000, edited by Vanhoutte PM. New York: Taylor & Francis, 2001, p. 388-399.
34. Marrelli SP, Khorovets A, Johnson TD, Childres WF, Bryan RM Jr. P2 purinoceptor-mediated dilations in the rat middle cerebral artery after ischemia/reperfusion. Am J Physiol Heart Circ Physiol 276: H33-H41, 1999.
35. Neuzeret PC, Gormand F, Reix P, Parrot S, Sastre JP, Buda C, Guidon G, Sakai K, Lin JS. A new animal model of obstructive sleep apnea responding to continuous positive airway pressure. Sleep 34: 541-548, 2011.
36. Pack AI, Gislason T. Obstructive sleep apnea and cardiovascular disease: a perspective and future directions. Prog Cardiovasc Dis 51: 434-451, 2009.
37. Phillips SA, Olson EB, Morgan BJ, Lombard JH. Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries. Am J Physiol Heart Circ Physiol 286: H388-H393, 2004.
38. Prisby RD, Wilkerson MK, Sokoya EM, Bryan RM, Jr, Wilson E, Delp MD. Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms. J Appl Physiol 101: 348-353, 2006.
39. Rattan SI, Demirovic D. Hormesis can and does work in humans. Dose Response 8: 58-63, 2009.
40. Schoorlemmer GH, Rossi MV, Tufik S, Cravo SL. A new method to produce obstructive sleep apnoea in conscious unrestrained rats. Exp Physiol 96: 1010-1018, 2011.
41. Sokoya EM, Burns AR, Setiawan CT, Coleman HA, Parkington HC, Tare M. Evidence for the involvement of myoendothelial gap junctions in EDHF-mediated relaxation in the rat middle cerebral artery. Am J Physiol Heart Circ Physiol 291: H385-H393, 2006.
42. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96: 1897-1904, 1995.
43. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118: 1080-1111, 2008.
44. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm 5: 1047-1054, 2008.
45. Tagaito Y, Polotsky VY, Campen MJ, Wilson JA, Balbir A, Smith PL, Schwartz AR, O'Donnell CP. A model of sleep-disordered breathing in the C57BL/6J mouse. J Appl Physiol 91: 2758-2766, 2001.
46. van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XH. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension 55: 932-938, 2010.
47. You J, Johnson TD, Marrelli SP, Bryan RM Jr. Functional heterogeneity of endothelial P2 purinoceptors in the cerebrovascular tree of the rat. Am J Physiol Heart Circ Physiol 277: H893-H900, 1999.
48. You JP, Johnson TD, Childres WF, Bryan RM Jr. Endothelial-mediated dilations of rat middle cerebral arteries by ATP and ADP. Am J Physiol Heart Circ Physiol 273: H1472-H1477, 1997.
49. You JP, Johnson TD, Marrelli SP, Mombouli JV, Bryan RM Jr. P2u-receptor mediated release of endothelium-derived relaxing factor/ nitric oxide and endothelium-derived hyperpolarizing factor from cerebro-vascular endothelium in rats. Stroke 30: 1125-1133, 1999.