Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 286, Issue 1 55-1, 2004, Pages

  Phillips, Shane A ^a   Olson, E B ^b   Morgan, Barbara J ^c   Lombard, Julian H ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Acetylcholine; Gracilis artery; Middle cerebral artery; Vascular reactivity

Indexed keywords

ACETYLCHOLINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN ARTERY; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM; GRACILIS MUSCLE; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; RESISTANCE BLOOD VESSEL; SKELETAL MUSCLE; VASODILATATION;

EID: 0346998122     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00683.2003     Document Type: Article

References (32)

1. Amezcua JL, Dusting GJ, Palmer RM, and Moncada S. Acetylcholine induces vasodilatation in the rabbit isolated heart through the release of nitric oxide, the endogenous nitrovasodilator. Br J Pharmacol 95: 830-834, 1988.
2. Auch-Schwelk W and Vanhoutte PM. Endothelium-derived contracting factor released by serotonin in the aorta of the spontaneously hypertensive rat. Am J Hypertens 4: 769-772, 1991.
3. Bao G, Metreveli N, and Fletcher EC. Acute and chronic blood pressure response to recurrent acoustic arousal in rats. Am J Hypertens 12: 504-510, 1999.
4. Brooks D, Horner RL, Kozar LF, Render-Teixeira CL, and Phillipson EA. Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J Clin Invest 99: 106-109, 1997.
5. Carlson JT, Rangemark C, and Hedner JA. Attenuated endothelium-dependent vascular relaxation in patients with sleep apnoea. J Hypertens 14: 577-584, 1996.
6. Chen G, Suzuki H, and Weston AH. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br J Pharmacol 95: 1165-1174, 1988.
7. Dart RA, Gregoire JR, Gutterman DD, and Woolf SH. The association of hypertension and secondary cardiovascular disease with sleep-disordered breathing. Chest 123: 244-260, 2003.
8. Fletcher EC and Bao G. The rat as a model of chronic recurrent episodic hypoxia and effect upon systemic blood pressure. Sleep 19: S210-S212, 1996.
9. Fletcher EC, Bao G, and Miller CC III. Effect of recurrent episodic hypocapnic, eucapnic, and hypercapnic hypoxia on systemic blood pressure. J Appl Physiol 78: 1516-1521, 1995.
10. 2. Am J Physiol Heart Circ Physiol 267: H706-H715, 1994.
11. Frisbee JC. Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats. Am J Physiol Heart Circ Physiol 281: H1568-H1574, 2001.
12. Frisbee JC and Lombard JH. Development and reversibility of altered skeletal muscle arteriolar structure and reactivity with high salt diet and reduced renal mass hypertension. Microcirculation 6: 215-225, 1999.
13. Frisbee JC, Roman RJ, Falck JR, Linderman JR, and Lombard JH. Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats. Microvasc Res 60: 37-48, 2000.
14. Frisbee JC, Roman RJ, Krishna UM, Falck JR, and Lombard JH. Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. Microcirculation 8: 115-127, 2001.
15. Jaiswal N and Malik KU. Prostacyclin synthesis elicited by cholinergic agonists is linked to activation of M2 alpha and M2 beta muscarinic receptors in the rabbit aorta. Prostaglandins 39: 267-280, 1990.
16. Kato M, Roberts-Thomson P, Phillips BG, Haynes WG, Winnicki M, Accurso V, and Somers VK. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation 102: 2607-2610, 2000.
17. Keef KD and Bowen SM. Effect of ACh on electrical and mechanical activity in guinea pig coronary arteries. Am J Physiol Heart Circ Physiol 257: H1096-H1103, 1989.
18. Komori K and Suzuki H. Heterogeneous distribution of muscarinic receptors in the rabbit saphenous artery. Br J Pharmacol 92: 657-664, 1987.
19. Lenda DM, Sauls BA, and Boegehold MA. Reactive oxygen species may contribute to reduced endothelium-dependent dilation in rats fed high salt. Am J Physiol Heart Circ Physiol 279: H7-H14, 2000.
20. 2 and vasodilators during hypertension and elevated salt intake. Am J Physiol Heart Circ Physiol 273: H869-H877, 1997.
21. 2 and prostacyclin. Am J Physiol Heart Circ Physiol 276: H509-H516, 1999.
22. Panza JA, Casino PR, Badar DM, and Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 87: 1475-1481, 1993.
23. Peppard PE, Young T, Palta M, and Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342: 1378-1384, 2000.
24. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lucke C, Mayer K, Olschewski H, Seeger W, and Grimminger F. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: response to CPAP therapy. Thorax 55: 1046-1051, 2000.
25. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier NF, O'Connor GT, Boland LL, Schwartz JE, and Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 163: 19-25, 2001.
26. Sica AL, Greenberg HE, Ruggiero DA, and Scharf SM. Chronic-intermittent hypoxia: a model of sympathetic activation in the rat. Respir Physiol 121: 173-184, 2000.
27. Steiner DR, Gonzalez NC, and Wood JG. Interaction between reactive oxygen species and nitric oxide in the microvascular response to systemic hypoxia. J Appl Physiol 93: 1411-1418, 2002.
28. 2 receptor blockade restores vasoreactivity in a new rodent model of genetic hypertension. J Appl Physiol 88: 1983-1988, 2000.
29. Sylvester FA, Stepp DW, Frisbee JC, and Lombard JH. High-salt diet depresses acetylcholine reactivity proximal to NOS activation in cerebral arteries. Am J Physiol Heart Circ Physiol 283: H353-H363, 2002.
30. Tahawi Z, Orolinova N, Joshua IG, Bader M, and Fletcher EC. Altered vascular reactivity in arterioles of chronic intermittent hypoxic rats. J Appl Physiol 90: 2007-2013, 2001.
31. Vaziri ND and Wang ZQ. Sustained systemic arterial hypertension induced by extended hypobaric hypoxia. Kidney Int 49: 1457-1463, 1996.
32. Young T, Peppard P, Palta M, Hla KM, Finn L, Morgan B, and Skatrud J. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 157: 1746-1752, 1997.