Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation

Biochemical and Biophysical Research Communications

Volumn 438, Issue 1, 2013, Pages 97-102

  Zhu, Houbao ^a   Xu, Wangyang ^b   Zhang, Hongxin ^a   Liu, Jianbing ^a,c   Xu, Haimin ^a   Lu, Shunyuan ^a   Dang, Suying ^a   Kuang, Ying ^c   Jin, Xiaolong ^a   Wang, Zhugang ^a,c  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c Shanghai Research Center for Model Organisms   (China)

Author keywords

Akt; AOM DSS model; Colitis associated cancer; Kinesin 8 Kif18a; Knock out mice; Tumorigenesis

Indexed keywords

AZOXYMETHANE; DOCUSATE SODIUM; KIF18A PROTEIN; KINESIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; COLITIS; COLON CARCINOGENESIS; COLORECTAL TUMOR; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE DELETION; GENE OVEREXPRESSION; GENE TARGETING; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR GROWTH; TUMOR PROMOTION;

AKT; AOM-DSS MODEL; COLITIS-ASSOCIATED CANCER; KINESIN-8 KIF18A; KNOCK-OUT MICE; TUMORIGENESIS;

ANIMALS; COLITIS; COLORECTAL NEOPLASMS; FEMALE; GENE DELETION; GENE TARGETING; KINESIN; MALE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-AKT;

MURINAE; MUS;

EID: 84881548206     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.032     Document Type: Article

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