Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-(14C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs

Journal of Pharmaceutical and Biomedical Analysis

Volumn 85, Issue , 2013, Pages 138-144

  Grunwald, Helge ^a   Hargreaves, Patrick ^a   Gebhardt, Klaus ^a   Klauer, Dominique ^a   Serafyn, Arnaud ^a   Schmitt Hoffmann, Anne ^a   Schleimer, Michael ^a   Schlotterbeck, Goetz ^b   Wind, Mathias ^a  

^a BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

Author keywords

Drug metabolism; Mass spectrometry; Radiolabeling; Stable isotope labeling; Structure elucidation

Indexed keywords

CARBON 14; DEUTERIUM; DICLOFENAC; KETOCONAZOLE; OLANZAPINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG FORMULATION; DRUG METABOLISM; DRUG STABILITY; DRUG TRANSFORMATION; IN VITRO STUDY; INCUBATION TIME; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; LIVER CELL; LIVER MICROSOME; METABOLITE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DETECTION; TANDEM MASS SPECTROMETRY;

DRUG METABOLISM; MASS SPECTROMETRY; RADIOLABELING; STABLE-ISOTOPE LABELING; STRUCTURE ELUCIDATION;

ANIMALS; BENZODIAZEPINES; CARBON RADIOISOTOPES; DEUTERIUM; DICLOFENAC; HEPATOCYTES; ISOTOPE LABELING; KETOCONAZOLE; MALE; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR;

EID: 84881526811     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.07.004     Document Type: Article

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