Tocopherols and tocotrienols as anticancer treatment for lung cancer: Future nutrition

Journal of Thoracic Disease

Volumn 5, Issue 3, 2013, Pages 349-352

  Zarogoulidis, Paul ^a,b   Cheva, Aggeliki ^c   Zarampouka, Katerina ^c   Huang, Haidong ^d   Li, Chen ^e   Huang, Yong ^f   Katsikogiannis, Nikolaos ^g   Zarogoulidis, Konstantinos ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b RUHRLANDKLINIK   (Germany)

^c G PAPANICOLAOU HOSPITAL   (Greece)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e PR China   (China)

^f ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^g UNIVERSITY GENERAL HOSPITAL OF ALEXANDROUPOLIS   (Greece)

Author keywords

Lung cancer; Nanomedicine; Nutrition; Tocopherol; Tocotrienol; Vitamin E

Indexed keywords

6 O CARBOXYPROPYL ALPHA TOCOTRIENOL; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ALPHA TOCOPHERYL OXYACETIC ACID; ALPHA TOCOTRIENOL; ANTISENSE OLIGONUCLEOTIDE; BETA TOCOPHEROL; BETA TOCOTRIENOL; DELTA TOCOPHEROL; DELTA TOCOTRIENOL; EZN 3920; GAMMA TOCOPHEROL; GAMMA TOCOTRIENOL; GEFITINIB; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NOTCH1 RECEPTOR; PACLITAXEL; PARTHENOLIDE; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE; SURVIVIN; TOCOPHEROL; TRANSCRIPTION FACTOR HES 1; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; HUMAN; LUNG CANCER; LUNG INJURY; NONHUMAN;

EID: 84881498683     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2013.04.03     Document Type: Article

References (36)

1. Mahabir S, Schendel K, Dong YQ, et al. Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk. Int J Cancer 2008;123:1173-80.
2. Ju J, Picinich SC, Yang Z, et al. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis 2010;31:533-42.
3. Lambert JD, Lu G, Lee MJ, et al. Inhibition of lung cancer growth in mice by dietary mixed tocopherols. Mol Nutr Food Res 2009;53:1030-5.
4. Li GX, Lee MJ, Liu AB, et al. d-tocopherol is more active than α - or γ - tocopherol in inhibiting lung tumorigenesis in vivo. Cancer Prev Res (Phila) 2011;4:404-13.
5. Ji X, Wang Z, Geamanu A, et al. Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J Cell Biochem 2011;112:2773-83.
6. Slattery ML, Edwards SL, Anderson K, et al. Vitamin E and colon cancer: is there an association?. Nutr Cancer 1998;30:201-6.
7. Bostick RM, Potter JD, McKenzie DR, et al. Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study. Cancer Res 1993;53:4230-7.
8. Ratnasinghe D, Tangrea JA, Forman MR, et al. Serum tocopherols, selenium and lung cancer risk among tin miners in China. Cancer Causes Control 2000;11:129-35.
9. Woodson K, Albanes D, Tangrea JA, et al. Association between alcohol and lung cancer in the alpha-tocopherol, beta-carotene cancer prevention study in Finland. Cancer Causes Control 1999;10:219-26.
10. Nomura AM, Stemmermann GN, Lee J, et al. Serum micronutrients and prostate cancer in Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev 1997;6:487-91.
11. Wright ME, Weinstein SJ, Lawson KA, et al. Supplemental and dietary vitamin E intakes and risk of prostate cancer in a large prospective study. Cancer Epidemiol Biomarkers Prev 2007;16:1128-35.
12. Ronco A, De Stefani E, Boffetta P, et al. Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. Nutr Cancer 1999;35:111-9.
13. Männistö S, Pietinen P, Virtanen M, et al. Diet and the risk of breast cancer in a case-control study: does the threat of disease have an influence on recall bias?. J Clin Epidemiol 1999;52:429-39.
14. Dietary reference intakes. Washington D.C.: Institute of Medicine, National Academy Press, 1998.
15. Terasawa Y, Ladha Z, Leonard SW, et al. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A 2000;97:13830-4.
16. Jiang Q, Christen S, Shigenaga MK, et al. gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001;74:714-22.
17. Ogawa Y, Saito Y, Nishio K, et al. Gamma-tocopheryl quinone, not alphatocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4. Free Radic Res 2008;42:674-87.
18. Wang X, Thomas B, Sachdeva R, et al. Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress. Proc Natl Acad Sci U S A 2006;103:3604-9.
19. Cornwell DG, Williams MV, Wani AA, et al. Mutagenicity of tocopheryl quinones: evolutionary advantage of selective accumulation of dietary alpha-tocopherol. Nutr Cancer 2002;43:111-8.
20. Christen S, Jiang Q, Shigenaga MK, et al. Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection. J Lipid Res 2002;43:1978-85.
21. Bittrich H, Mátzig AK, Kráker I, et al. NO2-induced DNA single strand breaks are inhibited by antioxidative vitamins in V79 cells. Chem Biol Interact 1993;86:199-211.
22. Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol--an underestimated vitamin?. Ann Nutr Metab 2004;48:169-88.
23. Yu W, Jia L, Wang P, et al. In vitro and in vivo evaluation of anticancer actions of natural and synthetic vitamin E forms. Mol Nutr Food Res 2008;52:447-56.
24. Mukherjee S, Stone WL, Yang H, et al. Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes. J Biochem Mol Toxicol 2009;23:143-53.
25. Slatore CG, Littman AJ, Au DH, et al. Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. Am J Respir Crit Care Med 2008;177:524-30.
26. Chen ZL, Tao J, Yang J, et al. Vitamin E modulates cigarette smoke extract-induced cell apoptosis in mouse embryonic cells. Int J Biol Sci 2011;7:927-36.
27. Kim Y, Chongviriyaphan N, Liu C, et al. Combined a-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets. Lung Cancer 2012;75:15-23.
28. Fanger GR, Gerwins P, Widmann C, et al. MEKKs, GCKs, MLKs, PAKs,TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?. Curr Opin Genet Dev 1997;7:67-74.
29. Force T, Bonventre JV. Growth factors and mitogen-activated protein kinases. Hypertension 1998;31:152-61.
30. Hahn T, Bradley-Dunlop DJ, Hurley LH, et al. The vitamin E analog, alphatocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer. BMC Cancer 2011;11:471.
31. Wu Y, Zhang Y, Wang M, et al. Downregulation of HER3 by a Novel Antisense Oligonucleotide, EZN-3920, Improves the Antitumor Activity of EGFR and HER2 Tyrosine Kinase Inhibitors in Animal Models. Mol Cancer Ther 2013. [Epub ahead of print].
32. Kashiwagi K, Harada K, Yano Y, et al. A redox-silent analogue of tocotrienol inhibits hypoxic adaptation of lung cancer cells. Biochem Biophys Res Commun 2008;365:875-81.
33. Latimer P, Menchaca M, Snyder RM, et al. Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases. Exp Biol Med (Maywood) 2009;234:1244-52.
34. Fu JY, Blatchford DR, Tetley L, et al. Tumor regression after systemic administration of tocotrienol entrapped in tumor-targeted vesicles. J Control Release 2009;140:95-9.
35. Wang G, Yu B, Wu Y, et al. Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel. Int J Pharm 2013;446:24-33.
36. Gill KK, Kaddoumi A, Nazzal S. Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines. Eur J Pharm Sci 2012;46:64-71.