δ-tocopherol is more active than α- or γ-tocopherol in inhibiting lung tumorigenesis in Vivo

Cancer Prevention Research

Volumn 4, Issue 3, 2011, Pages 404-413

  Li, Guang Xun ^a   Lee, Mao Jung ^a   Liu, Anna B ^a   Yang, Zhihong ^a   Lin, Yong ^b,c   Shih, Weichung J ^b,c   Yang, Chung S ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ALPHA TOCOPHEROL; CASPASE 3; DELTA TOCOPHEROL; GAMMA TOCOPHEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER TRANSPLANTATION; CONTROLLED STUDY; DEGRADATION; DIET SUPPLEMENTATION; DNA DAMAGE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG TISSUE LEVEL; DRUG URINE LEVEL; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR XENOGRAFT; VITAMIN BLOOD LEVEL;

ALPHA-TOCOPHEROL; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA DAMAGE; GAMMA-TOCOPHEROL; HUMANS; LUNG NEOPLASMS; MALE; MICE; NEOPLASM TRANSPLANTATION; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; TOCOPHEROLS; TYROSINE;

EID: 79955804829     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0130     Document Type: Article

References (47)

1. Traber MG. Vitamin E. In: Bowman BA, M. RR, editors. Present Knowledge in Nutrition . Washington DC: ILSI Press; 2006. p. 211-9.
2. Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, et al. Cancerpreventive activities of tocopherols and tocotrienols. Carcinogenesis 2010;31:533-42.
3. Taylor PR, Qiao YL, Abnet CC, Dawsey SM, Yang CS, Gunter EW, et al. Prospective study of serum vitamin E levels and esophageal and gastric cancers. J Natl Cancer Inst 2003;95:1414-6. (Pubitemid 37220461)
4. Greenwald P, Clifford CK, Milner JA. Diet and cancer prevention. Eur J Cancer 2001;37:948-65. (Pubitemid 32401123)
5. Knekt P, Aromaa A, Maatela J, Aaran RK, Nikkari T, Hakama M, et al. Vitamin E and cancer prevention. Am J Clin Nutr 1991;53:283S-6S.
6. Mahabir S, Schendel K, Dong YQ, Barrers SL, Spitz MR, Forman MR. Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk. Int J Cancer 2008;123:1173-80.
7. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35.
8. Lee IM, Cook NR, Gaziano JM, Gordon D, Ridker PM, Manson JE, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer:the Women's Health Study:a randomized controlled trial. Jama 2005;294:56-65. (Pubitemid 41002839)
9. Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009;301:39-51.
10. Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen J, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 2009;301:52-62.
11. Wolf G. gamma-Tocopherol: an efficient protector of lipids against nitric oxide-initiated peroxidative damage. Nutr Rev 1997;55:376-8.
12. Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol - an underestimated vitamin? Ann Nutr Metab 2004;48:169-88.
13. Jiang Q, Christen S, Shigenaga MK, Ames BN. gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001;74:714-22. (Pubitemid 33101790)
14. Grammas P, Hamdheydari L, Benaksas EJ, Mou S, Pye QN, Wechter WJ, et al. Anti-inflammatory effects of tocopherol metabolites. Biochem Biophys Res Commun 2004;319:1047-52. (Pubitemid 38739425)
15. Reiter E, Jiang Q, Christen S. Anti-inflammatory properties of alphaand gamma-tocopherol. Mol Aspects Med 2007;28:668-91.
16. Yu W, Park SK, Jia L, Tiwary R, Scott WW, Li J, et al. RRR-gammatocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Lett 2008;259:165-76. (Pubitemid 350251642)
17. Yu W, Jia L, Park SK, Li J, Gopalan A, Simmons-Menchaca M, et al. Anticancer actions of natural and synthetic vitamin E forms: RRR-alpha-tocopherol blocks the anticancer actions of gamma-tocopherol. Mol Nutr Food Res 2009;53:1573-81.
18. Ju J, Hao X, Lee MJ, Lambert JD, Lu G, Xiao H, et al. A gammatocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice. Cancer Prev Res 2009;2:143-52.
19. Newmark HL, Huang MT, Reddy BS. Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats. Nutr Cancer 2006;56:82-5. (Pubitemid 46173417)
20. Lee HJ, Ju J, Paul S, So JY, DeCastro A, Smolarek AK. Mixed tocopherols prevent mammary tumorigenesis by inhibiting estrogen action and activating PPAR-g. Clin Can Res 2009;15:4242-9.
21. Suh N, Paul S, Lee HJ, Ji Y, Lee MJ, Yang CS, et al. Mixed tocopherols inhibit N-methyl-N-nitrosourea-induced mammary tumor growth in rats. Nutr Cancer 2007;59:76-81. (Pubitemid 47549784)
22. Barve A, Khor TO, Nair S, Reuhl K, Suh N, Reddy B, et al. Gammatocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice. Int J Cancer 2009;124:1693-9.
23. Lambert JD, Lu G, Lee MJ, Hu J, Yang CS. Inhibition of lung cancer growth in mice by dietary mixed tocopherols. Mol Nutr Food Res 2009;53:1030-5.
24. Lu G, Xiao H, Li GX, Picinich SC, Chen YK, Liu A, et al. A gammatocopherol-rich mixture of tocopherols inhibits chemically induced lung tumorigenesis in A/J mice and xenograft tumor growth. Carcinogenesis 2010;31:687-94.
25. Zhao Y, Lee M-J, Cheng C, Ju JH, Chen YK, Liu B, et al. Analysis of multiple metabolites oftocopherols and tocotrienols in mice and humans. J Agri Food Chem 2010;58:4844-52.
26. Campbell S, Stone W, Whaley S, Krishnan K. Development of gammatocopherol as a colorectal cancer chemopreventive agent. Crit Rev Oncol Hematol 2003;47:249-59. (Pubitemid 37072117)
27. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2′ -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009;27:120-39.
28. Albino AP, Huang X, Jorgensen E, Yang J, Gietl D, Traganos F, et al. Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens. Cell Cycle 2004;3:1062-8. (Pubitemid 40268666)
29. Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 1991;51:794-8.
30. Choi MH, Lee IK, Kim GW, Kim BU, Han YH, Yu DY, et al. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 2005;435:347-53. (Pubitemid 40745544)
31. Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, et al. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005;16:667-75. (Pubitemid 41725103)
32. Boonstra J, Post JA. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 2004;337:1-13. (Pubitemid 38970100)
33. Wu WS. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 2006;25:695-705.
34. Handelman GJ, Machlin LJ, Fitch K, Weiter JJ, Dratz EA. Oral alphatocopherol supplements decrease plasma gamma-tocopherol levels in humans. J Nutr 1985;115:807-13.
35. Handelman GJ, Epstein WL, Peerson J, Spiegelman D, Machlin LJ, Dratz EA. Human adipose alpha-tocopherol and gamma-tocopherol kinetics during and after 1 y of alpha-tocopherol supplementation. Am J Clin Nutr 1994;59:1025-32.
36. Traber MG, Kayden HJ. Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins. Am J Clin Nutr 1989;49:517-26. (Pubitemid 19107266)
37. Huang HY, Appel LJ. Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans. J Nutr 2003;133:3137-40. (Pubitemid 37222228)
38. Yoshikawa S, Morinobu T, Hamamura K, Hirahara F, Iwamoto T, Tamai H. The effect of gamma-tocopherol administration on alphatocopherol levels and metabolism in humans. Eur J Clin Nutr 2005;59:900-5. (Pubitemid 41195205)
39. Traber MG, Burton GW, Hughes L, Ingold KU, Hidaka H, Malloy M, et al. Discrimination between forms of vitamin E by humans with and without genetic abnormalities of lipoprotein metabolism. J Lipid Res 1992;33:1171-82.
40. Sontag TJ, Parker RS. Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem 2002;277:25290-6. (Pubitemid 34951838)
41. Birringer M, Pfluger P, Kluth D, Landes N, Brigelius-Flohe R. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J Nutr 2002;132:3113-8.
42. Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L, et al. New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med 2004;36:1-15. (Pubitemid 38068287)
43. Swanson JE, Ben RN, Burton GW, Parker RS. Urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman is a major route of elimination of gamma-tocopherol in humans. J Lipid Res 1999;40:665-71.
44. Chiku S, Hamamura K, Nakamura T. Novel urinary metabolite of d-delta-tocopherol in rats. J Lipid Res 1984;25:40-8. (Pubitemid 14150292)
45. Wolf G. How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol. Nutr Rev 2006;64:295-9. (Pubitemid 43953294)
46. Newmark HL. Nutrient density: an important and useful tool for laboratory animal studies. Carcinogenesis 1987;8:871-3. (Pubitemid 17133573)
47. Schneider K, Oltmanns J, Hassauer M. Allometric principles for interspecies extrapolation in toxicological risk assessment - empirical investigations. Regul Toxicol Pharmacol 2004;39:334-47. (Pubitemid 38596769)