-
1
-
-
0033119925
-
Analysis of a successful immune response against hepatitis C virus
-
Cooper S, Erickson AL, Adams EJ, et al.. Analysis of a successful immune response against hepatitis C virus. Immunity 1999;10: 439-449.
-
(1999)
Immunity
, vol.10
, pp. 439-449
-
-
Cooper, S.1
Erickson, A.L.2
Adams, E.J.3
-
2
-
-
17644444485
-
Analysis of successful immune responses in persons infected with hepatitis C virus
-
Lechner F, Wong DK, Dunbar PR, et al.. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000;191:1499-1512.
-
(2000)
J Exp Med
, vol.191
, pp. 1499-1512
-
-
Lechner, F.1
Wong, D.K.2
Dunbar, P.R.3
-
3
-
-
0035914925
-
Determinants of viral clearance and persistence during acute hepatitis C virus infection
-
Thimme R, Oldach D, Chang KM, et al.. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001;194:1395-1406.
-
(2001)
J Exp Med
, vol.194
, pp. 1395-1406
-
-
Thimme, R.1
Oldach, D.2
Chang, K.M.3
-
4
-
-
84863724325
-
T cell responses in hepatitis C: The good, the bad and the unconventional
-
Klenerman P, Thimme R. T cell responses in hepatitis C: the good, the bad and the unconventional. Gut 2012;61:1226-1234.
-
(2012)
Gut
, vol.61
, pp. 1226-1234
-
-
Klenerman, P.1
Thimme, R.2
-
5
-
-
68849111675
-
Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
-
Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009;119:1745-1754.
-
(2009)
J Clin Invest
, vol.119
, pp. 1745-1754
-
-
Rehermann, B.1
-
6
-
-
0035000769
-
+ T lymphocytes after infection with hepatitis C virus
-
Gruener NH, Lechner F, Jung MC, et al.. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus. J Virol 2001;75:5550-5558.
-
(2001)
J Virol
, vol.75
, pp. 5550-5558
-
-
Gruener, N.H.1
Lechner, F.2
Jung, M.C.3
-
7
-
-
25844470442
-
+ T-cell failure during chronic hepatitis C virus infection
-
Spangenberg HC, Viazov S, Kersting N, et al.. Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection. Hepatology 2005;42:828-837.
-
(2005)
Hepatology
, vol.42
, pp. 828-837
-
-
Spangenberg, H.C.1
Viazov, S.2
Kersting, N.3
-
8
-
-
0037105567
-
+ T cells in chronic hepatitis C virus infection
-
Wedemeyer H, He XS, Nascimbeni M, et al.. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 2002;169:3447-3458.
-
(2002)
J Immunol
, vol.169
, pp. 3447-3458
-
-
Wedemeyer, H.1
He, X.S.2
Nascimbeni, M.3
-
9
-
-
34548191951
-
+ T cells associated with reversible immune dysfunction
-
Golden-Mason L, Palmer B, Klarquist J, et al.. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol 2007;81:9249-9258.
-
(2007)
J Virol
, vol.81
, pp. 9249-9258
-
-
Golden-Mason, L.1
Palmer, B.2
Klarquist, J.3
-
10
-
-
40149094779
-
+ T cells during acute HCV infection, irrespective of clinical outcome
-
Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, et al.. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol 2008;82:3154-3160.
-
(2008)
J Virol
, vol.82
, pp. 3154-3160
-
-
Kasprowicz, V.1
Schulze Zur Wiesch, J.2
Kuntzen, T.3
-
11
-
-
44649188658
-
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
-
1937 e1-2
-
Nakamoto N, Kaplan DE, Coleclough J, et al.. Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 2008;134:1927-1937, 1937 e1-2.
-
(2008)
Gastroenterology
, vol.134
, pp. 1927-1937
-
-
Nakamoto, N.1
Kaplan, D.E.2
Coleclough, J.3
-
12
-
-
33947407689
-
Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression
-
Radziewicz H, Ibegbu CC, Fernandez ML, et al.. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 2007;81:2545-2553.
-
(2007)
J Virol
, vol.81
, pp. 2545-2553
-
-
Radziewicz, H.1
Ibegbu, C.C.2
Fernandez, M.L.3
-
14
-
-
33750691709
-
PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
-
Urbani S, Amadei B, Tola D, et al.. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J Virol 2006;80:11398-11403.
-
(2006)
J Virol
, vol.80
, pp. 11398-11403
-
-
Urbani, S.1
Amadei, B.2
Tola, D.3
-
15
-
-
78649903057
-
Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
-
McMahan RH, Golden-Mason L, Nishimura MI, et al.. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest 2010;120:4546-4557.
-
(2010)
J Clin Invest
, vol.120
, pp. 4546-4557
-
-
McMahan, R.H.1
Golden-Mason, L.2
Nishimura, M.I.3
-
16
-
-
61449181280
-
Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade
-
Nakamoto N, Cho H, Shaked A, et al.. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. PLoS Pathog 2009;5:e1000313.
-
(2009)
PLoS Pathog
, vol.5
-
-
Nakamoto, N.1
Cho, H.2
Shaked, A.3
-
17
-
-
39849088117
-
Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment
-
Urbani S, Amadei B, Tola D, et al.. Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment. J Hepatol 2008;48:548-558.
-
(2008)
J Hepatol
, vol.48
, pp. 548-558
-
-
Urbani, S.1
Amadei, B.2
Tola, D.3
-
18
-
-
77954674575
-
+ T cells is linked to antigen recognition and T cell differentiation
-
Bengsch B, Seigel B, Ruhl M, et al.. Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 2010;6:e1000947.
-
(2010)
PLoS Pathog
, vol.6
-
-
Bengsch, B.1
Seigel, B.2
Ruhl, M.3
-
19
-
-
73949109333
-
Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution
-
Kasprowicz V, Kang YH, Lucas M, et al.. Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. J Virol 2010;84:1656-1663.
-
(2010)
J Virol
, vol.84
, pp. 1656-1663
-
-
Kasprowicz, V.1
Kang, Y.H.2
Lucas, M.3
-
20
-
-
58849105469
-
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection
-
Rutebemberwa A, Ray SC, Astemborski J, et al.. High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. J Immunol 2008;181:8215-8225.
-
(2008)
J Immunol
, vol.181
, pp. 8215-8225
-
-
Rutebemberwa, A.1
Ray, S.C.2
Astemborski, J.3
-
21
-
-
62949087170
-
+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model
-
Jo J, Aichele U, Kersting N, et al.. Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model. Gastroenterology 2009;136:1391-1401.
-
(2009)
Gastroenterology
, vol.136
, pp. 1391-1401
-
-
Jo, J.1
Aichele, U.2
Kersting, N.3
-
22
-
-
33846090225
-
+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver
-
Bengsch B, Spangenberg HC, Kersting N, et al.. Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol 2007;81:945-953.
-
(2007)
J Virol
, vol.81
, pp. 945-953
-
-
Bengsch, B.1
Spangenberg, H.C.2
Kersting, N.3
-
23
-
-
46249090636
-
+ T-cell failure in chronic hepatitis C virus infection
-
Neumann-Haefelin C, Timm J, Spangenberg HC, et al.. Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection. Hepatology 2008;47:1824-1836.
-
(2008)
Hepatology
, vol.47
, pp. 1824-1836
-
-
Neumann-Haefelin, C.1
Timm, J.2
Spangenberg, H.C.3
-
24
-
-
34447544075
-
Optimizing a multicolor immunophenotyping assay
-
Mahnke YD, Roederer M. Optimizing a multicolor immunophenotyping assay. Clin Lab Med 2007;27:469-485.
-
(2007)
Clin Lab Med
, vol.27
, pp. 469-485
-
-
Mahnke, Y.D.1
Roederer, M.2
-
25
-
-
79952601074
-
+ T-cell differentiation in chronic HCV infection
-
Bengsch B, Thimme R. CD8+ T-cell differentiation in chronic HCV infection. Future Virol 2011;6:249-258.
-
(2011)
Future Virol
, vol.6
, pp. 249-258
-
-
Bengsch, B.1
Thimme, R.2
-
26
-
-
53749083074
-
+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection
-
Radziewicz H, Ibegbu CC, Hon H, et al.. Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection. J Virol 2008;82:9808-9822.
-
(2008)
J Virol
, vol.82
, pp. 9808-9822
-
-
Radziewicz, H.1
Ibegbu, C.C.2
Hon, H.3
-
27
-
-
33947421722
-
Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection
-
Penna A, Pilli M, Zerbini A, et al.. Dysfunction and functional restoration of HCV-specific CD8 responses in chronic hepatitis C virus infection. Hepatology 2007;45:588-601.
-
(2007)
Hepatology
, vol.45
, pp. 588-601
-
-
Penna, A.1
Pilli, M.2
Zerbini, A.3
-
28
-
-
0036191172
-
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs
-
Frese M, Schwarzle V, Barth K, et al.. Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology 2002;35:694-703.
-
(2002)
Hepatology
, vol.35
, pp. 694-703
-
-
Frese, M.1
Schwarzle, V.2
Barth, K.3
-
29
-
-
84862668461
-
+ T cells limits their hepatotoxic potential
-
Jo J, Bengsch B, Seigel B, et al.. Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential. J Hepatol 2012;57:9-16.
-
(2012)
J Hepatol
, vol.57
, pp. 9-16
-
-
Jo, J.1
Bengsch, B.2
Seigel, B.3
-
30
-
-
44649102065
-
Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: Potential for therapeutic application?
-
Radziewicz H, Hanson HL, Ahmed R, et al.. Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: potential for therapeutic application? Gastroenterology 2008;134: 2168-2171.
-
(2008)
Gastroenterology
, vol.134
, pp. 2168-2171
-
-
Radziewicz, H.1
Hanson, H.L.2
Ahmed, R.3
-
31
-
-
84857646605
-
The role of interleukin-2 during homeostasis and activation of the immune system
-
Boyman O, Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol 2012;12: 180-190.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 180-190
-
-
Boyman, O.1
Sprent, J.2
-
32
-
-
59649116097
-
IL-2, IL-7 and IL-15 as immunomodulators during SIV/HIV vaccination and treatment
-
Leone A, Picker LJ, Sodora DL. IL-2, IL-7 and IL-15 as immunomodulators during SIV/HIV vaccination and treatment. Curr HIV Res 2009;7:83-90.
-
(2009)
Curr HIV Res
, vol.7
, pp. 83-90
-
-
Leone, A.1
Picker, L.J.2
Sodora, D.L.3
-
33
-
-
79955418828
-
Harnessing the biology of IL-7 for therapeutic application
-
Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 2011;11:330-342.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 330-342
-
-
Mackall, C.L.1
Fry, T.J.2
Gress, R.E.3
-
34
-
-
78649516786
-
+ T cell function
-
Chevalier MF, Julg B, Pyo A, et al.. HIV-1-specific interleukin-21+CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function. J Virol 2011; 85:733-741.
-
(2011)
J Virol
, vol.85
, pp. 733-741
-
-
Chevalier, M.F.1
Julg, B.2
Pyo, A.3
-
35
-
-
79551690940
-
Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
-
Williams LD, Bansal A, Sabbaj S, et al.. Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers. J Virol 2011;85:2316-2324.
-
(2011)
J Virol
, vol.85
, pp. 2316-2324
-
-
Williams, L.D.1
Bansal, A.2
Sabbaj, S.3
-
36
-
-
2142702915
-
Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection
-
Accapezzato D, Francavilla V, Paroli M, et al.. Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest 2004;113:963-972.
-
(2004)
J Clin Invest
, vol.113
, pp. 963-972
-
-
Accapezzato, D.1
Francavilla, V.2
Paroli, M.3
-
37
-
-
34548050436
-
CD8 T cell dysfunction during chronic viral infection
-
Shin H, Wherry EJ. CD8 T cell dysfunction during chronic viral infection. Curr Opin Immunol 2007;19:408-415.
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 408-415
-
-
Shin, H.1
Wherry, E.J.2
-
38
-
-
77956852144
-
Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus
-
Abdel-Hakeem MS, Bedard N, Badr G, et al.. Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus. J Virol 2010;84:10429-10435.
-
(2010)
J Virol
, vol.84
, pp. 10429-10435
-
-
Abdel-Hakeem, M.S.1
Bedard, N.2
Badr, G.3
-
39
-
-
84861579810
-
Lack of full CD8 functional restoration after antiviral treatment for acute and chronic hepatitis C virus infection
-
Missale G, Pilli M, Zerbini A, et al.. Lack of full CD8 functional restoration after antiviral treatment for acute and chronic hepatitis C virus infection. Gut 2012;61:1076-1084.
-
(2012)
Gut
, vol.61
, pp. 1076-1084
-
-
Missale, G.1
Pilli, M.2
Zerbini, A.3
-
40
-
-
53749106026
-
+ memory T cells
-
Badr G, Bedard N, Abdel-Hakeem MS, et al.. Early interferon therapy for hepatitis C virus infection rescues polyfunctional, longlived CD8+ memory T cells. J Virol 2008;82:10017-10031.
-
(2008)
J Virol
, vol.82
, pp. 10017-10031
-
-
Badr, G.1
Bedard, N.2
Abdel-Hakeem, M.S.3
|