Smart drug release systems based on stimuli-responsive polymers

Mini-Reviews in Medicinal Chemistry

Volumn 13, Issue 9, 2013, Pages 1369-1380

  Qing, Guangyan ^a   Li, Minmin ^a   Deng, Lijing ^b   Lv, Ziyu ^a   Ding, Peng ^a   Sun, Taolei ^a  

^a WUHAN UNIVERSITY OF TECHNOLOGY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Controllable drug release; Drug release devices; Responsive polymers; Smart materials; Targeted drug delivery

Indexed keywords

ALIZARIN; AZOBENZENE; CHITOSAN; DENDRIMER; DOXORUBICIN; FLUOROURACIL; GENTAMICIN; GLUTATHIONE; GROWTH HORMONE; HEPARIN; INSULIN; LEVOTHYROXINE; MICROSPHERE; NALIDIXIC ACID; NALTREXONE; NANOCAGE; NANOCARRIER; NANOROD; PACLITAXEL; POLYACRYLIC ACID; POLYGLACTIN; POLYMER; POLYMERIC MICELLE; POLYVINYL ALCOHOL; PREDNISONE ACETATE; RECOMBINANT EPIDERMAL GROWTH FACTOR; SILICON DIOXIDE; SILVER NANOPARTICLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

DISPERSION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG RELEASE DEVICE; ELECTRIC FIELD; GENE TARGETING; HUMAN; HYDROGEL; INFRARED RADIATION; LIGHT; PH; REVIEW; TEMPERATURE; ULTRAVIOLET IRRADIATION;

DRUG CARRIERS; DRUG DELIVERY SYSTEMS; PHARMACOKINETICS; POLYMERS;

EID: 84881495023     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/13895575113139990062     Document Type: Review

References (104)

1. Steffansen, B.; Brodin, B.; Nielsen, C.U. Molecular Biopharmaceutics: Aspects of Drug Characterisation, Drug Delivery, and Dosage form Evaluation. Pharmaceutical Press: London, 2010.
2. Li, X.L.; Jasti, B.R. Design of Controlled Release Drug Delivery Systems. McGraw-Hill Professional: New York, 2005.
3. Hoare, T.R.; Kohane, D.S. Hydrogels in drug delivery: Progress and challenges. Polymer, 2008, 49, 1993-2007.
4. Chourasia, M.K.; Jain, S.K. Pharmaceutical approaches to colon targeted drug delivery systems. J. Pharm. Pharm. Sci., 2003, 6, 33-66.
5. Katti, D.S.; Lakshmi, S.; Langer, R.; Laurencin, C.T. Toxicity, biodegradation and elimination of polyanhydrides. Adv. Drug Delivery Rev., 2002, 54, 933-61.
6. Bajpai, A.K.; Shukla, S.K.; Bhanu, S.; Kankane, S. Responsive polymers in controlled drug delivery. Prog. Polym. Sci., 2008, 33, 1088-118.
7. Roy, D.; Cambre, J.N.; Sumerlin, B.S. Future perspective and recent advances in stimuli-responsive materials. Prog. Polym. Sci., 2010, 35, 278-301.
8. Alexander, C.; Shakesheff, K.M. Responsive polymers at the biology/materials science interface. Adv. Mater., 2006, 18, 3321-8.
9. Sun, T.L.; Qing, G.Y. Biomimetic smart interface materials for biological applications. Adv. Mater., 2011, 23, H57-77.
10. Jeong, B.; Gutowska, A. Lessons from nature: Stimuli-responsive polymers and their biomedical applications. Trends Biotechnol., 2002, 20, 305-11.
11. Matsuda, N.; Shimizu, T.; Yamato, M.; Okano, T. Tissue engineering based on cell sheet technology. Adv. Mater., 2007, 19, 3089-99.
12. Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Controlled Release, 2008, 126, 187-204.
13. Wei, H.; Cheng, S.X.; Zhang, X.Z.; Zhuo, R.X. Thermo-sensitive polymeric micelles based on poly(N-isopropylacrylamide) as drug carriers. Prog. Polym. Sci., 2009, 34, 893-910.
14. Timko, B.P.; Dvir, T.; Kohane, D.S. Remotely triggerable drug delivery systems. Adv. Mater., 2010, 22, 4925-43.
15. Mendes, P.M. Stimuli-responsive surfaces for bio-applications. Chem. Soc. Rev., 2008, 37, 2512-29.
16. He, C.L.; Kim, S.W.; Lee, D.S. In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery. J. Controlled Release, 2008, 127, 189-207.
17. des Rieux, A.; Fievez, V.; Garinot, M.; Schneider, Y.-J.; Préat, V. Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. J. Controlled Release, 2006, 116, 1-27.
18. Inomata, H.; Wada, N.; Yagi, Y.; Goto, S.; Saito, S. Swelling behaviors of N-alkylacrylamide gels in water: Effects of copolymerization and crosslinking density. Polymer, 1995, 36, 875-7.
19. Zhang, X.Z.; Wu, D.-Q.; Chu, C.-C. Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials, 2004, 25, 3793-805.
20. 2+/PNIPAAm hydrogels. Macromol. Symp., 2008; 266, 108-13.
21. Zhang, J.T.; Petersen, S.; Thunga, M.; Leipold, E.; Weidisch, R.; Liu, X.L.; Fahr, A.; Jandt, K.D. Micro-structured smart hydrogels with enhanced protein loading and release efficiency. Acta Biomater., 2010, 6, 1297-1306.
22. Doleski, S.; Yao, L.; Pandit, A.; Elvira, C. NGF release from thermo-responsive collagen-polyNIPAAm polymer networks supports neuronal cell growth and differentiation. J. Biomed. Mater. Res. Part A, 2010, 94A, 457-65.
23. Salehi, R.; Nowruzi, K.; Entezami, A.A.; Asgharzadeh, V.; Davaran, S. Thermosensitive polylactide-glycolide delivery systems for treatment of narcotic addictions. Polym. Adv. Technol., 2009, 20, 416-22.
24. Xu, F.J.; Zhu, Y.; Liu, F.S.; Nie, J.; Ma, J. and Yang, W.T. Comb-shaped conjugates comprising hydroxypropyl cellulose backbones and low-molecular-weight poly(N-isopropylacryamide) side chains for smart hydrogels: Synthesis, characterization, and biomedical applications. Bioconjugate Chem., 2010, 21, 456-64.
25. Azarbayjani, A.F.; Venugopal, J.R.; Ramakrishna, S.; Lim, P.F.C.; Chan, Y.W.; Chan, S.Y. Smart polymeric nanofibers for topical delivery of levothyroxine. J. Pharm. Pharm. Sci., 2010, 13, 400-10.
26. Contreras-García, A.; Bucio, E.; Concheiro, A.; Alvarez-Lorenzo, C. Polypropylene grafted with NIPAAm and APMA for creating hemocompatible surfaces that load/elute nalidixic acid. React. Funct. Polym., 2010, 70, 836-42.
27. Betre, H.; Liu, W.; Zalutsky, M.R.; Chilkoti, A.; Kraus, V.B.; Setton, L.A. A thermally responsive biopolymer for intra-articular drug delivery. J. Controlled Release, 2006, 115, 175-82.
28. Swierczewska, M.; Hajicharalambous, C.S.; Janorkar, A.V.; Megeed, Z.; Yarmush, M.L.; Rajagopalan, P. Cellular response to nanoscale elastin-like polypeptide polyelectrolyte multilayers. Acta Biomater., 2008, 4, 827-37.
29. Na, K.; Jung, J.Y.; Lee, J.H. and Hyun, J.H. Thermoresponsive pore structure of biopolymer microspheres for a smart drug carrier. Langmuir, 2010, 26, 11165-9.
30. Qin, L.; He, X.W.; Yuan, X.; Li, W.Y.; Zhang, Y.K. Molecularly imprinted beads with double thermosensitive gates for selective recognition of proteins. Anal. Bioanal. Chem., 2011, 399, 3375-85.
31. Gupta, P.; Vermani, K.; Garg, S. Hydrogels: from controlled release to pH-responsive drug delivery. Drug Discovery Today, 2002, 7, 569-79.
32. Nishiyama, N.; Kataoka, K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol. Therapeut., 2006, 112, 630-48.
33. Hua, D.B.; Jiang, J.L.; Kuang, L.J.; Jiang, J.; Zheng, W.; Liang, H.J. Smart chitosan-based stimuli-responsive nanocarriers for the controlled delivery of hydrophobic pharmaceuticals. Macromolecules, 2011, 44, 1298-302.
34. Chang, G.T.; Li, C.; Lu, W.Y.; Ding, J.D. N-Boc-Histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH. Macromol. Biosci., 2010, 10, 1248-56.
35. Chen, W.; Meng, F.H.; Li, F.; Ji, S.-J.; Zhong, Z.Y. pH-Responsive biodegradable micelles based on acid-labile polycarbonate hydrophobe: Synthesis and triggered drug release. Biomacromolecules, 2009, 10, 1727-35.
36. Durbin E.W.; Buxton G.A. A coarse-grained model of targeted drug delivery from responsive polymer nanoparticles. Soft Matter, 2010, 6, 762-7.
37. Shi, J.; Alves, N.M.; Mano, J.F. Chitosan coated alginate beads containing poly(N-isopropylacrylamide) for dual-stimuliresponsive drug release. J. Biomed. Mater. Res. Part B, 2008, 84B, 595-603.
38. Vasile, C.; Dumitriu, R.P.; Cheaburu, C.N.; Oprea, A.M. Architecture and composition influence on the properties of some smart polymeric materials designed as matrices in drug delivery systems: A comparative study. Appl. Surf. Sci., 2009, 256, S65-71.
39. El-Din, H.M.N. Characterization and caffeine release properties of N-isopropyl-acrylamide/hydroxypropyl methacrylate copolymer hydrogel synthesized by gamma radiation. J. Appl. Polym. Sci., 2011, 119, 577-85.
40. Abdelaal, M.Y.; Abdel-Razik, E.A.; Abdel-Bary, E.M.; El-Sherbiny, I.M. Chitosan based interpolymeric pH-responsive hydrogels for in vitro drug release. J. Appl. Polym. Sci., 2007, 103, 2864-74.
41. Liu, Y.Y.; Fan, X.D.; Wei, B.R.; Si, Q.F.; Chen, W.X.; Sun, L. pH-responsive amphiphilic hydrogel networks with IPN structure: A strategy for controlled drug release. Int. J. Pharm., 2006, 308, 205-9.
42. Wu, W.; Wang, D.S. A fast pH-responsive IPN hydrogel: Synthesis and controlled drug delivery. React. Funct. Polym., 2010, 70, 684-91.
43. Yuan, H.; Luo, K.; Lai, Y.S.; Pu, Y.J.; He, B.; Wang, G.; Wu, Y.; Gu, Z.W. A novel poly(L-glutamic acid) dendrimer based drug delivery system with both pH-sensitive and targeting functions. Mol. Pharmacol., 2010, 7, 953-62.
44. Tekade, R.K.; Dutta, T.; Gajbhiye, V.; Jain, N.K. Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics. J. Microencapsulation, 2009; 26, 287-96.
45. Tekade, R.K.; Dutta, T.; Tyagi, A.; Bharti, A.C.; Das, B.C.; Jain, N.K. Surface-engineered dendrimers for dual drug delivery: A receptor up-regulation and enhanced cancer targeting strategy. J. Drug Targeting, 2008, 16, 758-72.
46. Yuan, W.Y.; Li, C.M. Exponentially growing layer-by-layer assembly to fabricate pH-responsive hierarchical nanoporous polymeric film and its superior controlled release performance. Chem. Commun., 2010, 9161-3.
47. Ruiz, J.-C.; Alvarez-Lorenzo, C.; Taboada, P.; Burillo, G.; Bucio, E.; De Prijck, K.; Nelis, H.J.; Coenye, T.; Concheiro, A. Polypropylene grafted with smart polymers (PNIPAAm/PAAc) for loading and controlled release of vancomycin. Eur. J. Pharm. Biopharm., 2008, 70, 467-77.
48. Muñoz-Muñoz, F.; Ruiz J.-C.; Alvarez-Lorenzo, C.; Concheiro, A.; Bucio, E. Novel interpenetrating smart polymer networks grafted onto polypropylene by gamma radiation for loading and delivery of vancomycin. Eur. Polym. J., 2009, 45, 1859-67.
49. Gong, C.B.; Lam, M.H.W.; Yu, H.X. The fabrication of a photoresponsive molecularly imprinted polymer for the photoregulated uptake and release of caffeine. Adv. Funct. Mater., 2006, 16, 1759-67.
50. Gong, C.B.; Wong, K.-L.; Lam, M.H.W. Photoresponsive molecularly imprinted hydrogels for the photoregulated release and uptake of pharmaceuticals in the aqueous media. Chem. Mater., 2008, 20, 1353-8.
51. Shi, D.J.; Matsusaki, M.; Akashi, M. Photo-tunable protein release from biodegradable nanoparticles composed of cinnamic acid derivatives. J. Controlled Release, 2011, 149, 182-9.
52. Schmidt, D.J.; Moskowitz, J.S.; Hammond, P.T. Electrically triggered release of a small molecule drug from a polyelectrolyte multilayer coating. Chem. Mater., 2010, 22, 6416-25.
53. Wong I.Y.; Melosh, N.A. Directed hybridization and melting of DNA linkers using counterion-screened electric field. Nano Lett., 2009, 9, 3521-6.
54. Aili, D.; Stevens, M.M. Bioresponsive peptide-inorganic hybrid nanomaterials. Chem. Soc. Rev., 2010, 39, 3358-70.
55. Hendrickson, G.R.; Lyon, L.A. Bioresponsive hydrogels for sensing applications. Soft Matter, 2009, 5, 29-35.
56. Hardwicke, J.; Ferguson, E.L.; Moseley, R.; Stephens, P.; Thomas, D.W. Duncan, R. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. J. Controlled Release, 2008, 130, 275-83.
57. Tang, M.; Zhang, R.; Bowyer, A.; Eisenthal, R.; Hubble, J. A reversible hydrogel membrane for controlling the delivery of macromolecules. Biotechnol. Bioeng., 2003, 82, 47-53.
58. Traitel, T.; Cohen, Y.; Kost, J. Characterization of glucosesensitive insulin release systems in simulated in vivo conditions. Biomaterials, 2000, 21, 1679-87.
59. Jayant, R.D.; McShane, M.J.; Srivastava, R. In vitro and in vivo evaluation of anti-inflammatory agents using nanoengineered alginate carriers: Towards localized implant inflammation suppression. Int. J. Pharm., 2011, 403, 268-75.
60. Qing, G.Y.; Wang, X.; Jiang, L.; Fuchs, H.; Sun, T.L. Saccharide-sensitive wettability switching on a smart polymer surface. Soft Matter, 2009, 5, 2759-65.
61. Qing, G.Y.; Sun, T.L. Chirality-triggered wettability switching on a smart polymer surface. Adv. Mater., 2011, 23, 1615-20.
62. Qing, G.Y.; Wang, X.; Fuchs, H.; Sun, T.L. Nucleotide-responsive wettability on a smart polymer surface. J. Am. Chem. Soc., 2009, 131, 8370-1.
63. Zhu, C.-L.; Lu, C.-H.; Song, X.-Y.; Yang, H.-H.; Wang, X.-R. Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate. J. Am. Chem. Soc., 2011, 133, 1278-81.
64. Garripelli, V.K.; Kim, J.-K.; Son, S.; Kim, W.J.; Repka, M.A.; Jo, S. Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery. Acta Biomater., 2011, 7, 1984-92.
65. Hardwicke, J.; Song, B.; Moseley, R.; Thomas, D.W. Investigation of the potential of polymer therapeutics in corneal reepithelialisation. Brit. J. Ophthalmol., 2010, 94, 1566-70.
66. Apostolovic B.; Deacon, S.P.E.; Duncan, R.; Klok, H.-A. Hybrid polymer therapeutics incorporating bioresponsive coiled coil peptide linkers. Biomacromolecules, 2010, 11, 1187-95.
67. 2: Synthesis and evaluation as a bioresponsive anticancer conjugate. Biomacromolecules, 2009, 10, 1358-64.
68. Kim, J.-K.; Anderson, J.; Jun, H.-W.; Repka, M.A.; Jo, S.B. Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery. Mol. Pharmacol., 2009, 6, 978-85.
69. Saeed, A.O.; Magnusson, J.P.; Moradi, E.; Soliman, M.; Wang, W.X.; Stolnik, S.; Thurecht, K.J.; Howdle, S.M.; Alexander, C. Modular construction of multifunctional bioresponsive celltargeted nanoparticles for gene delivery. Bioconjugate Chem., 2011, 22, 156-68.
70. Meyer, M.; Dohmen, C.; Philipp, A.; Kiener, D.; Maiwald, G.; Scheu, C.; Ogris, M.; Wagner, E. Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate. Mol. Pharmacol., 2009, 6, 752-62.
71. Motornov, M.; Roiter, Y.; Tokarev, I.; Minko, S. Stimuli-responsive nanoparticles, nanogels and capsules for integrated multifunctional intelligent systems. Prog. Polym. Sci., 2010, 35, 174-211.
72. Schärtl, W. Current directions in core-shell nanoparticle design. Nanoscale, 2010, 2, 829-43.
73. Timko, B.P.; Dvir, T.; Kohane, D.S. Remotely triggerable drug delivery systems. Adv. Mater., 2010, 22, 4925-43.
74. Wei, Q.S.; Ji, J.; Shen, J.C. Synthesis of near-infrared responsive gold nanorod/PNIPAAM core/shell nanohybrids via surface initiated atrp for smart drug delivery. Macromol. Rapid Commun., 2008, 29, 645-50.
75. Sershen, S.R.; Westcott, S.L.; Halas, N.J.; West, J.L. Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery. J. Biomed. Mater. Res., 2000, 51, 293-8.
76. Gorelikov, I.; Field, L.M.; Kumacheva, E. Hybrid microgels photoresponsive in the near-infrared spectral range. J. Am. Chem. Soc., 2004, 126, 15938-9.
77. Shiotani, A.; Mori, T.; Niidome, T.; Niidome, Y.; Katayama, Y. Stable incorporation of gold nanorods into N-isopropylacrylamide hydrogels and their rapid shrinkage induced by near-infrared laser irradiation. Langmuir, 2007, 23, 4012-8.
78. Li, D.X.; He, Q.; Cui, Y.; Li, J.B. Fabrication of pH-responsive nanocomposites of gold nanoparticles/poly(4-vinyl-pyridine). Chem. Mater., 2007, 19, 412-7.
79. Li, D.X.; He, Q.; Yang, Y.; Möhwald, H.; Li, J.B. Two-stage pH response of poly(4-vinylpyridine) grafted gold nanoparticles. Macromolecules, 2008, 41, 7254-6.
80. Skrabalak, S.E.; Chen, J.Y.; Au, L.; Lu, X.M.; Li, X.D.; Xia, Y.N.; Gold nanocages for biomedical applications. Adv. Mater., 2007, 19, 3177-84.
81. Chen, J.Y.; Yang, M.X.; Zhang, Q.; Cho, E.C.; Cobley, C.M.; Kim, C.; Glaus, C.; Wang, L.H.V.; Welch, M.J.; Xia, Y.N. Gold nanocages: a novel class of multifunctional nanomaterials for theranostic applications. Adv. Funct. Mater., 2010, 20, 3684-94.
82. Cobley, C.M.; Au, L.; Chen, J.Y.; Xia, Y.N. Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery. Expert Opin. Drug Del., 2010, 7, 577-87.
83. Yavuz, M.S.; Cheng, Y.Y.; Cheng, J.Y.; Cobley, C.M.; Zhang, Q.; Rycenga, M.; Xie, J.W.; Kim, C.; Song, K.H.; Schwartz, A.G.; Wang, L.H.V.; Xia, Y.N. Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nat. Mater., 2009, 8, 935-9.
84. Rosenholm, J.M.; Sahlgren, C.; Lindén, M. Towards multifunctional, targeted drug delivery system using mesoporous silica nanoparticles-opportunities & challenges. Nanoscale, 2010, 2, 1870-83.
85. Vivero-Escoto, J.L.; Slowing, I.I.; Trewyn, B.G.; Lin, V.S.-Y. Mesoporous silica nanoparticles for intracellular controlled drug delivery. Small, 2010, 6, 1952-67.
86. Cotí, K.K.; Belowich, M.E.; Liong, M.; Ambrogio, M.W.; Lau, Y.A.; Khatib, H.A.; Zink, J.I.; Khashab, N.M.; Stoddart, J.F. Mechanised nanoparticles for drug delivery. Nanoscale, 2009, 1, 16-39.
87. You, Y.-Z.; Kalebaila, K.K.; Brock, S.L.; Oupický, D. Temperature-controlled uptake and release in PNIPAM-modified porous silica nanoparticles. Chem. Mater., 2008, 20, 3354-9.
88. Fu, Q.; Rao, G.V.R.; Ista, L.K.; Wu, Y.; Andrzejewski, B.P.; Sklar, L.A.; Ward, T.L.; López, G.P. Control of molecular through stimuli-responsive ordered mesoporous materials. Adv. Mater., 2003, 15, 1262-6.
89. Fu, Q.; Rao, G.V.R.; Ward, T.L.; Lu, Y.F.; López, G.P. Thermoresponsive transport through ordered mesoporous silica/PNIPAAm copolymer membranes and microspheres. Langmuir, 2007, 23, 170-4.
90. Lai, J.P.; Mu, X.; Xu, Y.Y.; Wu, X.L.; Wu, C.L.; Li, C.; Chen, J.B.; Zhao, Y.B. Light-responsive nanogated ensemble based on polymer grafted mesoporous silica hybrid nanoparticles. Chem. Commun., 2010, 7370-2.
91. Yuan, L.; Tang, Q.Q.; Yang, D.; Zhong, J.Z.; Zhang, F.Y.; Hu, J.H. Preparation of pH-responsive mesoporous silica nanoparticles and their application in controlled drug delivery. J. Phys. Chem. C, 2011, 115, 9926-32.
92. Wang, X.J.; Zhang, G.Y.; Liu, S.Y. pH-disintegrable polyelectrolyte multilayer-coated mesoporous silica nanoparticles exhibiting triggered co-release of cisplatin and model drug molecules. Macromol. Rapid Commun., 2011, 32, 1082-9.
93. Bernardos, A.; Mondragón, L.; Aznar, E.; Marcos, M.D.; Martínez-Máñez, R.; Sancenón, F.; Soto, J.; Barat, J.M.; Pérez-Payá, E.; Guillem, C.; Amorós, P. Enzyme-responsive intracellular controlled release using nanometric silica mesoporous supports capped with "saccharides". ACS Nano, 2010, 11, 6353-68.
94. Liu, R.; Zhang, Y.; Zhao, X.; Agarwal, A.; Mueller, L.J.; Feng, P.Y. pH-responsive nanogated ensemble based on gold-capped mesoporous silica through an acid-labile acetal linker. J. Am. Chem. Soc., 2010, 132, 1500-1.
95. Ruiz-Hernández, E.; Baeza, A.; Vallet-Regí, M. Smart drug delivery through DNA/magnetic nanoparticle gates. ACS Nano, 2011, 5, 1259-66.
96. Lai, C.-Y.; Trewyn, B.G.; Jeftinija, D.M.; Jeftinija, K.; Xu, S.; Jeftinija, S.; Lin, V.S.-Y. A mesoporous silica nanoparticles-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neuroteansmitters and drug molecules. J. Am. Chem. Soc., 2003, 125, 4451-9.
97. Aznar, E.; Marcos, M.D.; Martínez-Máñez, R.; Sancenón, F.; Soto, J.; Amorós, P.; Guillem, C. pH-and photo-switched release of guest molecules from mesoporous silica supports. J. Am. Chem. Soc., 2009, 131, 6833-43.
98. Vivero-Escoto, J.L.; Slowing, I.I.; Wu, C.-W.; Lin, V.S.-Y. Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere. J. Am. Chem. Soc., 2009, 131, 3462-3.
99. Schlossbauer, A.; Kecht, J.; Bein, T. Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica. Angew. Chem. Int. Ed., 2009, 48, 3092-5.
100. Jang, J.-H.; Jhaveri, S.J.; Rasin, B.; Koh, C.Y.; Ober, C.K.; Thomas, E.L. Three-dimensionally-patterned submicrometer-scale hydrogel/air networks that offer a new platform for biomedical applications. Nano Lett., 2008, 8, 1456-60.
101. Yang, S.Y.; Yang, J.-A.; Kim, E.-S.; Jeon, G.; Oh, E.J.; Choi, K.Y.; Hahn, S.K.; Kim, J.K. Single-file diffusion of protein drugs through cylindrical nanochannels. Nano Lett., 2010, 4, 3817-22.
102. Jeon, G.; Yang, S.Y.; Byun, J.; Kim, J.K. Electrically actuatable smart nanoporous membrane for pulsatile drug release. Nano Lett., 2011, 11, 1284-8.
103. Hoare, T.; Timko, B.P.; Santamaria, J.; Goya, G.F.; Irusta, S.; Lau, S.; Stefanescu, C.F.; Lin, D.; Langer, R.; Kohane, D.S. Magnetically triggered nanocomposite membranes: A versatile platform for triggered drug release. Nano Lett., 2011, 11, 1395-1400.
104. Qing, G.; Sun, T. The transformation of chiral signals into macroscopic properties of materials using chirality-responsive polymers. NPG Asia Materials, 2012, 4, e4. DOI: 10.1038/am.2012.6.