Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors α- And β-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft

Steroids

Volumn 78, Issue 11, 2013, Pages 1071-1086

  Saxena, Ruchi ^a   Fatima, Iram ^a   Chandra, Vishal ^a   Blesson, Chellakkan S ^a   Kharkwal, Geetika ^a   Hussain, Mohammad K ^a   Hajela, Kanchan ^a   Roy, Bal G ^b   Dwivedi, Anila ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Breast cancer; Estrogen receptor; G2 M cell cycle progression; PI3K Akt

Indexed keywords

2 [4 (2 PIPERIDINOETHOXY)PHENYL] 3 PHENYL 2H 1 BENZOPYRAN; ANTINEOPLASTIC AGENT; CASPASE 9; CYCLIN A1; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN P21; PROTEIN PS2; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MODULATION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TUMOR VOLUME; TUMOR XENOGRAFT; WESTERN BLOTTING;

MUS;

BREAST CANCER; ESTROGEN RECEPTOR; G2/M CELL CYCLE PROGRESSION; PI3K/AKT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOPYRANS; BINDING, COMPETITIVE; BREAST NEOPLASMS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CYCLIN D1; EPIDERMAL GROWTH FACTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MCF-7 CELLS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERIDINES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84881486307     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2013.07.004     Document Type: Article

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