Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway in vitro and inhibits tumor growth in vivo

Cancer Letters

Volumn 313, Issue 1, 2011, Pages 44-53

  Xu, You zhi ^a   Zheng, Ren lin ^a   Zhou, Yan ^a   Peng, Feng ^a   Lin, Hong jun ^a   Bu, Qian ^a   Mao, Yong qiu ^a   Yu, Luo ting ^a   Yang, Li ^a   Yang, Sheng yong ^a   Zhao, Ying lan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Human hepatocellular carcinoma; Mitochondrial apoptotic pathway; SKLB703

Indexed keywords

3 AMINO N (4 CHLOROBENZYL) 6 (3 METHOXYPHENYL)THIENO[2,3 B]PYRIDINE 2 CARBOXAMIDE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SKLB 703; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; HEP G2 CELLS; HUMANS; K562 CELLS; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; THIOPHENES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 80054095560     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.08.025     Document Type: Article

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