Influence of cellular ERα/ERβ ratio on the ERα-agonist induced proliferation of human T47D breast cancer cells

Toxicological Sciences

Volumn 105, Issue 2, 2008, Pages 303-311

  Covaleda, Ana M Sotoca ^a   Van den Berg, Hans ^a   Vervoort, Jacques ^a   Van der Saag, Paul ^b   Ström, Anders ^c   Gustafsson, Jan Åke ^c   Rietjens, Ivonne ^a   Murk, Albertinka J ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b HUBRECHT INSTITUTE   (Netherlands)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Breast cancer cells; ER U2OS Luc; Estrogen receptors; Inducible; SERM; T47D ER

Indexed keywords

1,3,5 TRIS(4 HYDROXYPHENYL) 4 PROPYLPYRAZOLE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; TETRACYCLINE; DIARYLPROPIONITRILE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; NITRILE; PROPIONIC ACID DERIVATIVE; PYRAZOLE DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; WILD TYPE; BREAST TUMOR; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; FLUOROMETRY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FLUOROMETRY; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; NITRILES; PROPIONATES; PYRAZOLES; RNA, MESSENGER; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TRANSFECTION;

EID: 51849152437     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn141     Document Type: Article

References (45)

1. Acconcia, F., Totta, P., Ogawa, S., Cardillo, I., Inoue, S., Leone, S., Trentalance, A., Muramatsu, M., and Marino, M. (2004). Survival versus apoptotic 17b-estradiol effect: Role of ERa and ERb activated non-genomic signaling. J. Cell. Physiol. 203, 193-201.
2. Adams, M., Jones, J. L., Walker, R. A., Pringle, J. H., and Bell, S. C. (2002). Changes in tenascin-C isoform expression in invasive and preinvasive breast disease. Cancer Res. 62, 3289-3297.
3. Bardin, A., Boulle, N., Lazennec, G., Vignon, F., and Pujol, P. (2004). Loss of ER{beta} expression as a common step in estrogen-dependent tumor progression. Endocr. Relat. Cancer 11, 537-551.
4. Buterin, T., Koch, C., and Naegeli, H. (2006). Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis 27, 1567-1578.
5. Cowley, S. M., Hoare, S., Mosselman, S., and Parker, M. G. (1997). Estrogen receptors alpha and beta form heterodimers on DNA. J. Biol. Chem. 272, 19858-19862.
6. Douchi, T., Yonehara, Y., Kosha, S., Iwamoto, I., Rai, Y., Sagara, Y., and Umekita, Y. (2007). Bone mineral density in breast cancer patients with positive estrogen receptor tumor status. Maturitas 57, 221-225.
7. Effenberger, K. E., Johnsen, S. A., Monroe, D. G., Spelsberg, T. C., and Westendorf, J. J. (2005). Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens. J. Steroid Biochem. Mol. Boil. 96, 387-399.
8. Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., Fried, G., Nordenskjöld, M., and Gustafsson, J. A. (1997). Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. J. Clin. Endocrinol. Metab. 82, 4258-4265.
9. Escande, A., Pillon, A., Servant, N., Cravedi, J.-P., Larrea, F., Muhnd, P., Nicolas, J.-C., Cavaillés, V., and Balaguer, P. (2006). Evaluation of ligand selectivity using reporter cell lines stably expressing estrogen receptor alpha or beta. Biochem. Pharmacol. 71, 1459-1469.
10. Galluzo, P., and Marino, M. (2006). Nutritional flavonoids impact on nuclear and extracellular estrogen receptor activities. Genes Nutr. 1, 161-176.
11. Glover, J. F., Irwin, J. T., and Darbre Philippa, D. (1988). Interaction of phenol red with estrogenic and antiestrogenic action on growth of human breast cancer cells ZR-75-1 and T-47-D. Cancer Res. 48 3693-3697.
12. Gutendorf, B., and Westendorf, J. (2001). Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology 166, 79-89.
13. Harris, H. A. (2006). Estrogen receptor-β: Recent lessons from in vivo studies. Mol. Endocrinol. 21, 1-13.
14. Hartman, J., Lindberg, K., Morani, A., Inzunza, J., Strom, A., and Gustafsson, J. A. (2006). Estrogen receptor {beta} inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res. 66, 11207-11213.
15. Helguero, L. A., Faulds, M. H., Gustafsson, J. A., and Haldosén, L. A. (2005). Estrogen receptors alpha (ERα) and beta (ERβ) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene 24, 6605-6616.
16. Horwitz, K. B., and McGuire, W. L. (1978). Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen recpetor. J. Biol. Chem. 253, 2223-2228.
17. Kim, S. H., Tamrazi, A., Carlson, K. E., and Katzenellenbogen, J. A. (2005). A proteomic microarray approach for exploring ligand-initiated nuclear hormone receptor pharmacology, receptor selectivity, and heterodimer functionality. Mol. Cell. Proteomics 4, 267-277.
18. Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., and Gustafsson, J. A. (1998). Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor {beta}. Endocrinology 139, 4252-4263.
19. Lazennec, G. (2006). Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis. Cancer Lett. 231, 151-157.
20. Lazennec, G., Bresson, D., Lucas, A., Chauveau, C., and Vignon, F. (2001). ER beta inhibits proliferation and invasion of breast cancer cells. Endocrinology 142, 4120-4130.
21. Li, X., Huang, J., Yi, P., Bambara, R. A., Hilf, R., and Muyan, M. (2004). Single-chain estrogen receptors (ERs) reveal that the ERalpha/ beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol. Cell. Biol. 24, 7681-7694.
22. Mäkinen, S., Mäkelä, S., Weihua, Z., Warner, M., Rosenlund, B., Salmi, S., Hovatta, O., and Gustafsson, J. A. (2001). Localization of oestrogen receptors alpha and beta in human testis. Mol. Hum. Reprod. 7, 497-503.
23. Matthews, J., and Gustafsson, J. A. (2003). Estrogen signaling: A subtle balance between ER{alpha} and ER{beta}. Mol. Interv. 3, 281-292.
24. Meyers, M. J., Sun, J., Carlson, K. E., Marrinet, G. A., Katzenellenbogen, B. S., and Katzenellenbogen, J. A. (2001). Estrogen receptor-beta; potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J. Med. Chem. 44, 4230-4251.
25. Monroe, D. G., Secreto, F. J., Subramaniam, M., Getz, B. J., Khosla, S., and Spelsberg, T. C. (2005). Estrogen receptor {alpha} and {beta} heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells. Mol. Endocrinol. 19, 1555-1568.
26. Murphy, L. C., Peng, B., Lewis, A., Davie, J. R., Leygue, E., Kemp, A., Ung, K., Vendetti, M., and Shin, R. (2005). Inducible upregulation of oestrogen receptor-{beta} 1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells. J. Mol. Endocrinol. 34, 553-566.
27. Nilsson, S., Makela, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., and Gustafsson, J. A. (2001). Mechanisms of estrogen action. Physiol. Rev. 81 1535-1565.
28. Nomoto, S., Arao, Y., Horiguchi, H., Ikeda, K., and Kayama, F. (2002). Oestrogen causes G2/M arrest and apoptosis in breast cancer cells MDA-MB-231. Oncol. Rep. 9, 773-776.
29. Pearce, S. T., and Jordan, V. C. (2004). The biological role of estrogen receptors alpha and beta in cancer. Crit. Rev. Oncol. Hematol. 50, 3-22.
30. Pedram, A., Razandi, M., Wallace, D. C., and Levin, E. R. (2006). Functional estrogen receptors in the mitochondria. of breast cancer cells. Mol. Biol. Cell. 17, 2125-2137.
31. Pettersson, K., Delaunay, F., and Gustafsson, J. A. (2000). Estrogen receptor beta acts as a dominant regulator of estrogen signaling. Oncogene 19, 4970-4978.
32. Quaedackers, M. E., Van Den Brink, C. E., Wissink, S., Schreurs, R. H. M. M., Gustafsson, J. A., Van Der Saag, P. T., and Van Der Burg, B. (2001). 4-hydroxytamoxifen trans-represses nuclear factor-{kappa}B activity in human osteoblastic U2-OS cells through estrogen receptor (ER) {alpha}, and not through ER{beta}. Endocrinology 142, 1156-1166.
33. Sartippour, M. R., Pietras, R., Marquez-Garban, D. C., Chen, H.-W., Heber, D., Henning, S. M., Sartippour, G., Zhang, L., Lu, M., Weinberg, O., et al. (2006). The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis 27, 2424-2433.
34. Schriks, M., Vrabie, C. M., Gutleb, A. C., Faassen, E. J., Rietjens, I. M. C. M., and Murk, A. J. (2006). T-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of poly halogenated aromatic hydrocarbons (PHAHs). Toxicol. In Vitro 20 490.
35. Sonneveld, E., Riteco, J. A. C., Jansen, H. J., Pieterse, B., Brouwer, A., Schoonen, W. G., and van der Burg, B. (2006). Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities. Toxicol. Sci. 89, 173-187.
36. Stauffer, S. R., Coletta, C. J., Tedesco, R., Nishiguchi, G., Carlson, K., Sun, J., Katzenellenbogen, B. S., and Katzenellenbogen, J. A. (2000). Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J. Med. Chem. 43, 4934-4947.
37. Stossi, F., Barnett, D. H., Frasor, J., Komm, B., Lyttle, C. R., and Katzenellenbogen, B. S. (2004). Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ER beta in human osteosarcoma cells: Distinct and common target genes for these receptors. Endocrinology 154, 3473-3486.
38. Ström, A., Hartman, J., Foster, J. S., Kietz, S., Wimalasena, J., and Gustafsson, J. A. (2004). Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc. Natl. Acad. Sci. U.S.A. 101, 1566-1571.
39. Sun, J., Baudry, J., Katzenellenbogen, J. A., and Katzenellenbogen, B. S. (2003). Molecular basis for the subtype discrimination of the estrogen receptor-{beta}-selective ligand, diarylpropionitrile. Mol. Endocrinol. 17, 247-258.
40. Svensson, S., Nilsson, K., Ringberg, A., and Landberg, G. (2003). Invade or proliferate? Two contrasting events in malignant behavior governed by p161NK4a and an intact Rb pathway illustrated by a model system of basal cell carcinoma. Cancer Res. 63, 1737-1742.
41. Veld, M. G. R., Schouten, B., Louisse, I., van Es, D. S., van der Saag, P. T., Rietjens, I. M. C. M., and Murk, A. J. (2006). Estrogenic potency of food-packaging-associated plasticizers and antioxidants as detected in ER and ER reporter gene cell lines. J. Agric. Food Chem. 54 4407-4416.
42. van der Woude, H., ter Veld, M. G. R., Jacobs, N., van der Saag, P. T., Murk, A. J., and Rietjens, I. M. C. M. (2005). The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Mol. Nutr. Food Res. 49, 763-771.
43. Wang, J. M., Irwin, R. W., and Brinton, R. D. (2006). Activation of estrogen receptor {alpha} increases and estrogen receptor {beta} decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 103, 16983-16988.
44. Warner, M., and. Gustafsson, J. A. (2006). Nongenomic effects of estrogen: Why all the uncertainty? Steroids 71, 91-95.
45. Weitzmann, M. N., and Pacifici, R. (2006). Estrogen deficiency and bone loss: An inflammatory tale. J. Clin. Invest. 116, 1186-1194.