CD8low T-cell subpopulation is increased in patients with chronic hepatitis B virus infection

Molecular Immunology

Volumn 56, Issue 4, 2013, Pages 698-704

  Ouyang, Lichen ^a   Li, Xiaoyi ^a   Liang, Zhihui ^a   Yang, Daofeng ^a   Gong, Feili ^a   Shen, Guanxin ^a   Weng, Xiufang ^a   Wu, Xiongwen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

CD8low T subpopulation; Chronic hepatitis B virus infection; HBc18 27 specific CD8+ T cell response; Membrane bound TGF 1

Indexed keywords

GAMMA INTERFERON; TRANSFORMING GROWTH FACTOR BETA1; CD3 ANTIGEN; CD8 ANTIGEN; HLA A2 ANTIGEN;

ADULT; ARTICLE; BLOOD ANALYSIS; CD8+ T LYMPHOCYTE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HEPATITIS B; HUMAN; INFECTION; LYMPHOCYTE COUNT; MALE; PERSISTENT INFECTION; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; AGED; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEPATITIS B VIRUS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; ANTIGENS, CD3; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HLA-A2 ANTIGEN; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84881486213     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.07.003     Document Type: Article

References (47)

1. Arimilli S., Sharma S.K., Yammani R., Reid S.D., Parks G.D., Alexander-Miller M.A. Pivotal advance: nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. Journal of Leukocyte Biology 2010, 87:977-988.
2. Barnaba V., Levrero M., Franco A., Zaccari C., Musca A., Balsano F. Antigen specific suppressor T cells from chronic hepatitis B virus (HBV) carriers inhibit the responsiveness to HBsAg of allogeneic high-responder lymphocytes. Journal of Clinical and Laboratory Immunology 1985, 16:137-142.
3. Barnaba V., Levrero M., Van Dyke A.D., Musca A., Cordova C., Balsano F. T-cell subsets in the hyporesponsiveness to hepatitis B surface antigen (HBsAg) and antigen-specific suppressor lymphocytes in chronic hepatitis B virus (HBV) infection. Clinical Immunology and Immunopathology 1985, 34:284-295.
4. Bertoletti A., Costanzo A., Chisari F.V., Levrero M., Artini M., Sette A., Penna A., Giuberti T., Fiaccadori F., Ferrari C. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. Journal of Experimental Medicine 1994, 180:933-943.
5. Bertoletti A., D'Elios M.M., Boni C., De Carli M., Zignego A.L., Durazzo M., Missale G., Penna A., Fiaccadori F., Del Prete G., Ferrari C. Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections. Gastroenterology 1997, 112:193-199.
6. Bertoletti A., Gehring A.J. The immune response during hepatitis B virus infection. Journal of General Virology 2006, 87:1439-1449.
7. Bertoletti A., Maini M.K., Ferrari C. The host-pathogen interaction during HBV infection: immunological controversies. Antiviral Therapy 2010, 15(Suppl. 3):15-24.
8. + T lymphocytes but fail to promote survival. European Journal of Immunology 1998, 28:221-236.
9. + T cells can persist and function in vivo. Journal of Immunology 1999, 163:155-164.
10. Boni C., Fisicaro P., Valdatta C., Amadei B., Di Vincenzo P., Giuberti T., Laccabue D., Zerbini A., Cavalli A., Missale G., Bertoletti A., Ferrari C. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. Journal of Virology 2007, 81:4215-4225.
11. Bowen D.G., Zen M., Holz L., Davis T., McCaughan G.W., Bertolino P. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. Journal of Clinical Investigation 2004, 114:701-712.
12. Bunce M., O'Neill C.M., Barnardo M.C., Krausa P., Browning M.J., Morris P.J., Welsh K.I. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995, 46:355-367.
13. Falasca K., Ucciferri C., Dalessandro M., Zingariello P., Mancino P., Petrarca C., Pizzigallo E., Conti P., Vecchiet J. Cytokine patterns correlate with liver damage in patients with chronic hepatitis B and C. Annals of Clinical Laboratory Science 2006, 36:144-150.
14. Fan Y.F., Lu C.C., Chen W.C., Yao W.J., Wang H.C., Chang T.T., Lei H.Y., Shiau A.L., Su I.J. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology 2001, 33:277-286.
15. Favre D., Stoddart C.A., Emu B., Hoh R., Martin J.N., Hecht F.M., Deeks S.G., McCune J.M. HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood 2011, 117:2189-2199.
16. + regulatory T cells in patients with hepatitis B virus infection. Journal of Virology 2005, 79:3322-3328.
17. + cells in Trypanosoma cruzi-infected chronic mice are down-regulated for T-cell receptor-alphabeta and CD8 molecules. Immunology 2001, 102:209-217.
18. Hosken N.A., Bevan M.J. Defective presentation of endogenous antigen by a cell line expressing class I molecules. Science 1990, 248:367-370.
19. Hunt C.M., McGill J.M., Allen M.I., Condreay L.D. Clinical relevance of hepatitis B viral mutations. Hepatology 2000, 31:1037-1044.
20. Iraburu M., Civeira M.P., Serrano M., Morte S., Castilla A., Prieto J. Suppressor T-cell activity in chronic hepatitis B-virus infection: relationship with the presence of HBV-DNA in serum. Journal of Medical Virology 1989, 27:39-43.
21. Jung M.C., Pape G.R. Immunology of hepatitis B infection. Lancet Infectious Diseases 2002, 2:43-50.
22. low thymocytes in the HIV type 1-infected thymus. Journal of Immunology 2002, 169:2788-2796.
23. Kienzle N., Baz A., Kelso A. Profiling the CD8low phenotype, an alternative career choice for CD8 T cells during primary differentiation. Immunology and Cell Biology 2004, 82:75-83.
24. Kienzle N., Buttigieg K., Groves P., Kawula T., Kelso A. A clonal culture system demonstrates that IL-4 induces a subpopulation of noncytolytic T cells with low CD8, perforin, and granzyme expression. Journal of Immunology 2002, 168:1672-1681.
25. + T cells to a poorly cytolytic CD8 low phenotype in the presence of IL-4. Journal of Immunology 2005, 174:2021-2029.
26. Kizaki T., Kobayashi S., Ogasawara K., Day N.K., Good R.A., Onoe K. Immune suppression induced by protoscoleces of Echinococcus multilocularis in mice. Evidence for the presence of CD8dull suppressor cells in spleens of mice intraperitoneally infected with E. multilocularis. Journal of Immunology 1991, 147:1659-1666.
27. Lok A.S., McMahon B.J. Chronic hepatitis B. Hepatology 2001, 34:1225-1241.
28. Maile R., Pop S.M., Tisch R., Collins E.J., Cairns B.A., Frelinger J.A. Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. European Journal of Immunology 2006, 36:397-410.
29. Maziarz R.T., Fraser J., Strominger J.L., Burakoff S.J. The human HLA-specific monoclonal antibody W6/32 recognizes a discontinuous epitope within the alpha 2 domain of murine H-2Db. Immunogenetics 1986, 24:206-208.
30. +CD8 low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance. Blood 2007, 110:3936-3948.
31. Norris B.A., Uebelhoer L.S., Nakaya H.I., Price A.A., Grakoui A., Pulendran B. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity 2013, 38:309-321.
32. Olver S., Apte S.H., Baz A., Kelso A., Kienzle N. Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo. Immunology 2013, 139:187-196.
33. Puppo F., Scudeletti M., Indiveri F., Ferrone S. Serum HLA class I antigens: markers and modulators of an immune response?. Immunology Today 1995, 16:124-127.
34. Radziewicz H., Ibegbu C.C., Fernandez M.L., Workowski K.A., Obideen K., Wehbi M., Hanson H.L., Steinberg J.P., Masopust D., Wherry E.J., Altman J.D., Rouse B.T., Freeman G.J., Ahmed R., Grakoui A. Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. Journal of Virology 2007, 81:2545-2553.
35. Reignat S., Webster G.J., Brown D., Ogg G.S., King A., Seneviratne S.L., Dusheiko G., Williams R., Maini M.K., Bertoletti A. Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection. Journal of Experimental Medicine 2002, 195:1089-1101.
36. Rossol S., Marinos G., Carucci P., Singer M.V., Williams R., Naoumov N.V. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. Journal of Clinical Investigation 1997, 99:3025-3033.
37. Rouse B.T., Sarangi P.P., Suvas S. Regulatory T cells in virus infections. Immunological Reviews 2006, 212:272-286.
38. Sakaguchi K., Koide N., Takenami T., Matsushima H., Takabatake H., Ferrone S., Tsuji T. Soluble HLA class I antigens in sera of patients with chronic hepatitis. Gastroenterologia Japonica 1992, 27:206-211.
39. Sakaguchi K., Koide N., Tsuji T. Elevation of soluble HLA class I antigens in sera of patients with acute and chronic hepatitis. Gastroenterologia Japonica 1991, 26:99.
40. Skipper J.C., Hendrickson R.C., Gulden P.H., Brichard V., Van Pel A., Chen Y., Shabanowitz J., Wolfel T., Slingluff C.L., Boon T., Hunt D.F., Engelhard V.H. An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. Journal of Experimental Medicine 1996, 183:527-534.
41. Stoop J.N., van der Molen R.G., Baan C.C., van der Laan L.J., Kuipers E.J., Kusters J.G., Janssen H.L. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005, 41:771-778.
42. Thomas H.C. T cell subsets in patients with acute and chronic HBV infection, primary biliary cirrhosis and alcohol induced liver disease. International Journal of Immunopharmacology 1981, 3:301-305.
43. + T cell exhaustion during chronic viral infection. Immunity 2007, 27:670-684.
44. + regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. Journal of Immunology 2006, 177:739-747.
45. Xu H., Wang X., Lackner A.A., Veazey R.S. CD8 down-regulation and functional impairment of SIV-specific cytotoxic T lymphocytes in lymphoid and mucosal tissues during SIV infection. Journal of Leukocyte Biology 2013, 93:943-950.
46. Yim H.J., Lok A.S. Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. Hepatology 2006, 43:S173-S181.
47. + T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection. Journal of Virology 2005, 79:10619-10626.