Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T cells and ameliorates experimental autoimmune encephalomyelitis

Apoptosis

Volumn 18, Issue 9, 2013, Pages 1106-1119

  Yan, Yaping ^a   Li, Zichen ^a   Zhang, Guang Xian ^a   Williams, Mark S ^b   Carey, Gregory B ^b   Zhang, Jianke ^a   Rostami, Abdolmohamad ^a   Xu, Hui ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Antibody therapy; Apoptosis; EAE; MS4A; T cell

Indexed keywords

ANTIBODY; CASPASE 3; CASPASE 8; CASPASE 9; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MS4A4B PROTEIN; MS4A4B PROTEIN ANTIBODY; REGULATOR PROTEIN; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CYTOKINE; MEMBRANE PROTEIN; MS4A4B PROTEIN, MOUSE; SMALL INTERFERING RNA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FLOW CYTOMETRY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH17 CELL; ANIMAL; C57BL MOUSE; CYTOLOGY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE INACTIVATION; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PATHOPHYSIOLOGY; T LYMPHOCYTE; TH1 CELL;

MUS;

ANIMALS; ANTIBODIES; APOPTOSIS; CELL PROLIFERATION; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE KNOCKOUT TECHNIQUES; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TH1 CELLS; TH17 CELLS;

EID: 84881479854     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0870-2     Document Type: Article

References (36)

1. Reichert JM, Rosensweig CJ, Faden LB, Dewitz MC (2005) Monoclonal antibody successes in the clinic. Nat Biotechnol 23:1073-1078
2. Taylor RP, Lindorfer MA (2008) Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies. Curr Opin Immunol 20:444-449
3. Tedder TF, Engel P (1994) CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today 15:450-454
4. Buttmann M (2010) Treating multiple sclerosis with monoclonal antibodies: a 2010 update. Expert Rev Neurother 10:791-809
5. Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG et al (2010) T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 16:406-412
6. Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF (2008) Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Investig 118:3420-3430
7. Chatenoud L, Bluestone JA (2007) CD3-specific antibodies: a portal to the treatment of autoimmunity. Nat Rev Immunol 7:622-632
8. Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W (2008) CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat Med 14:528-535
9. Chatenoud L (2003) CD3-specific antibody-induced active tolerance: from bench to bedside. Nat Rev Immunol 3:123-132
10. Xu H, Williams MS, Spain LM (2006) Patterns of expression, membrane localization, and effects of ectopic expression suggest a function for MS4a4B, a CD20 homolog in Th1 T cells. Blood 107:2400-2408
11. Ishibashi K, Suzuki M, Sasaki S, Imai M (2001) Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 264:87-93
12. Liang Y, Tedder TF (2001) Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 72:119-127
13. Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H, Thompson C, Saunders NJ, Cobbold SP, Tone Y et al (2009) MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation. J Immunol 183:4197-4204
14. Venkataraman C, Schaefer G, Schindler U (2000) Cutting edge: Chandra, a novel four-transmembrane domain protein differentially expressed in helper type 1 lymphocytes. J Immunol 165:632-636
15. Xu H, Yan Y, Williams MS, Carey GB, Yang J, Li H, Zhang GX, Rostami AM (2010) MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by modulation of cell cycle. PLoS ONE 5:e13780
16. Yan Y, Zhang GX, Williams MS, Carey GB, Li H, Yang J, Rostami A, Xu H (2012) TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation. Mol Immunol 52:71-78
17. Steinman L, Zamvil SS (2006) How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60:12-21
18. Yan Y, Zhang GX, Gran B, Fallarino F, Yu S, Li H, Cullimore ML, Rostami A, Xu H (2010) IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis. J Immunol 185:5953-5961
19. Deans JP, Li H, Polyak MJ (2002) CD20-mediated apoptosis: signalling through lipid rafts. Immunology 107:176-182
20. Hofmeister JK, Cooney D, Coggeshall KM (2000) Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis. Blood Cells Mol Dis 26:133-143
21. Arens R, Schepers K, Nolte MA, van Oosterwijk MF, van Lier RA, Schumacher TN, van Oers MH (2004) Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation. J Exp Med 199:1595-1605
22. Dayde D, Ternant D, Ohresser M, Lerondel S, Pesnel S, Watier H, Le Pape A, Bardos P, Paintaud G, Cartron G (2009) Tumor burden influences exposure and response to rituximab: pharmacokinetic-pharmacodynamic modeling using a syngeneic bioluminescent murine model expressing human CD20. Blood 113:3765-3772
23. Halfteck GG, Elboim M, Gur C, Achdout H, Ghadially H, Mandelboim O (2009) Enhanced in vivo growth of lymphoma tumors in the absence of the NK-activating receptor NKp46/NCR1. J Immunol 182:2221-2230
24. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L et al (2001) Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410:549-554
25. Fan TJ, Han LH, Cong RS, Liang J (2005) Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai) 37:719-727
26. Krammer PH, Arnold R, Lavrik IN (2007) Life and death in peripheral T cells. Nat Rev Immunol 7:532-542
27. Xu H, Zhang GX, Wysocka M, Wu CY, Trinchieri G, Rostami A (2000) The suppressive effect of TGF-beta on IL-12-mediated immune modulation specific to a peptide Ac1-11 of myelin basic protein (MBP): a mechanism involved in inhibition of both IL-12 receptor beta1 and beta2. J Neuroimmunol 108:53-63
28. Zhang GX, Xu H, Kishi M, Calida D, Rostami A (2002) The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J Immunol 168:2501-2507
29. Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, Mao XQ, Beach D, Scadden DT, Sayegh MH, Adra CN (2002) Human HTm4 is a hematopoietic cell cycle regulator. J Clin Investig 109:51-58
30. Tedder TF, Forsgren A, Boyd AW, Nadler LM, Schlossman SF (1986) Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. Eur J Immunol 16:881-887
31. Janas E, Priest R, Wilde JI, White JH, Malhotra R (2005) Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Clin Exp Immunol 139:439-446
32. Zhan Y, Funda DP, Every AL, Fundova P, Purton JF, Liddicoat DR, Cole TJ, Godfrey DI, Brady JL, Mannering SI et al (2004) TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death. Int Immunol 16:1315-1321
33. Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati G, Riccardi C (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 94:6216-6221
34. Spinicelli S, Nocentini G, Ronchetti S, Krausz LT, Bianchini R, Riccardi C (2002) (GITR) interacts with the pro-apoptotic protein Siva and induces apoptosis. Cell Death Differ 9:1382-1384
35. Nishio J, Feuerer M, Wong J, Mathis D, Benoist C (2010) Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med 207:1879-1889
36. Penaranda C, Tang Q, Bluestone JA (2011) Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol 187:2015-2022